{"id":"https://openalex.org/W4361815442","doi":"https://doi.org/10.1158/0008-5472.c.6507768","title":"Data from Tissue Factor Induced by Epithelial\u2013Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells","display_name":"Data from Tissue Factor Induced by Epithelial\u2013Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361815442","doi":"https://doi.org/10.1158/0008-5472.c.6507768"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507768","doi":"https://doi.org/10.1158/0008-5472.c.6507768","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6507768","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6507768","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006765213","display_name":"Morgane Bourcy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morgane Bourcy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053186841","display_name":"Meggy Suarez\u2010Carmona","orcid":"https://orcid.org/0000-0002-8892-1546","observed_orcids":["https://orcid.org/0000-0002-8892-1546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meggy Suarez-Carmona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Justine Lambert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justine Lambert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026390578","display_name":"Marie\u2010Emilie Francart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie-Emilie Francart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004138406","display_name":"H\u00e9l\u00e8ne Schroeder","orcid":"https://orcid.org/0000-0002-0219-0755","observed_orcids":["https://orcid.org/0000-0002-0219-0755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Schroeder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043210925","display_name":"C\u00e9line Delierneux","orcid":"https://orcid.org/0000-0003-2638-0104","observed_orcids":["https://orcid.org/0000-0003-2638-0104"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9line Delierneux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082334504","display_name":"Nicolas Skrypek","orcid":"https://orcid.org/0000-0002-9648-8033","observed_orcids":["https://orcid.org/0000-0002-9648-8033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolas Skrypek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029344208","display_name":"Erik W. Thompson","orcid":"https://orcid.org/0000-0002-9723-4924","observed_orcids":["https://orcid.org/0000-0002-9723-4924"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik W. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071675004","display_name":"Guy J\u00e9rusalem","orcid":"https://orcid.org/0000-0002-8845-0043","observed_orcids":["https://orcid.org/0000-0002-8845-0043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guy J\u00e9rusalem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042838758","display_name":"Geert Berx","orcid":"https://orcid.org/0000-0001-5770-2458","observed_orcids":["https://orcid.org/0000-0001-5770-2458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geert Berx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008132946","display_name":"Marc Thiry","orcid":"https://orcid.org/0000-0002-4944-584X","observed_orcids":["https://orcid.org/0000-0002-4944-584X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Thiry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058601352","display_name":"Silvia Blacher","orcid":"https://orcid.org/0000-0001-5839-5541","observed_orcids":["https://orcid.org/0000-0001-5839-5541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia Blacher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057835466","display_name":"Brett G. Hollier","orcid":"https://orcid.org/0000-0002-1204-6001","observed_orcids":["https://orcid.org/0000-0002-1204-6001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brett G. Hollier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084744120","display_name":"Agn\u00e8s No\u00ebl","orcid":"https://orcid.org/0000-0002-7670-6179","observed_orcids":["https://orcid.org/0000-0002-7670-6179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agn\u00e8s No\u00ebl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044474574","display_name":"C\u00e9cile Oury","orcid":"https://orcid.org/0000-0002-7561-0132","observed_orcids":["https://orcid.org/0000-0002-7561-0132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9cile Oury","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047035945","display_name":"Myriam Polette","orcid":"https://orcid.org/0000-0001-8173-3246","observed_orcids":["https://orcid.org/0000-0001-8173-3246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myriam Polette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102969515","display_name":"Christine Gilles","orcid":"https://orcid.org/0000-0002-6891-4920","observed_orcids":["https://orcid.org/0000-0002-6891-4920","https://orcid.org/0000-0003-4738-5924"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Gilles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/procoagulant-activity","display_name":"procoagulant activity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.777999997138977},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/zeb1","display_name":"ZEB1","score":0.984000027179718},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.7919999957084656},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lung-colonization","display_name":"lung colonization","score":0.5929999947547913},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.8094915151596069},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7011338472366333},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.6644371747970581},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6457270383834839},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6375702023506165},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.6334530115127563},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5413306951522827},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5122568011283875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45812758803367615},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.3967123329639435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3947422206401825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3649561405181885},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32437437772750854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31380635499954224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23210594058036804},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.14831972122192383},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.055864036083221436},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6507768","doi":"https://doi.org/10.1158/0008-5472.c.6507768","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6507768","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6507768.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507768.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507768.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507768","doi":"https://doi.org/10.1158/0008-5472.c.6507768","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6507768","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2396652017","https://openalex.org/W2740047551","https://openalex.org/W2737468719","https://openalex.org/W6981569406","https://openalex.org/W2235133067","https://openalex.org/W3082661018","https://openalex.org/W3000046306","https://openalex.org/W2282953599","https://openalex.org/W3009615913","https://openalex.org/W4284711399"],"abstract_inverted_index":{"Abstract":[0],"Epithelial\u2013mesenchymal":[1],"transition":[2],"(EMT)":[3],"is":[4,20],"prominent":[5],"in":[6,17,69,91,123,173],"circulating":[7],"tumor":[8,30,141],"cells":[9,118,142],"(CTC),":[10],"but":[11],"how":[12],"it":[13],"influences":[14],"metastatic":[15,145,177,203],"spread":[16],"this":[18],"setting":[19],"obscure.":[21],"Insofar":[22],"as":[23],"blood":[24,175],"provides":[25],"a":[26,34,59,86,120,132,165,189],"specific":[27],"microenvironment":[28],"for":[29,89],"cells,":[31,84],"we":[32,51,163],"explored":[33],"potential":[35],"link":[36,111],"between":[37,112],"EMT":[38,54,96,113,151],"and":[39,65,105,114,159,171],"coagulation":[40,64,199],"that":[41,53,194],"may":[42],"provide":[43],"EMT-positive":[44,83,117,206],"CTCs":[45],"with":[46,143,182],"enhanced":[47],"colonizing":[48],"properties.":[49],"Here":[50],"report":[52],"induces":[55],"tissue":[56],"factor":[57,98,153],"(TF),":[58],"major":[60],"cell-associated":[61],"initiator":[62],"of":[63,82,126,149,167,176,198,205],"related":[66],"procoagulant":[67,80],"properties":[68],"the":[70,79,95,110,124,150,174],"blood.":[71],"TF":[72,90,103,136,172],"blockade":[73],"by":[74,135],"antibody":[75],"or":[76,137],"shRNA":[77],"diminished":[78,134],"activity":[81],"confirming":[85],"functional":[87],"role":[88],"these":[92],"processes.":[93],"Silencing":[94],"transcription":[97,152],"ZEB1":[99,138],"inhibited":[100],"both":[101],"EMT-associated":[102],"expression":[104,148],"coagulant":[106,157],"activity,":[107],"further":[108],"strengthening":[109],"coagulation.":[115],"Accordingly,":[116],"exhibited":[119],"higher":[121],"persistance/survival":[122],"lungs":[125],"mice":[127],"colonized":[128],"after":[129],"intravenous":[130],"injection,":[131],"feature":[133],"silencing.":[139],"In":[140],"limited":[144],"capability,":[146],"enforcing":[147],"Snail":[154],"increased":[155],"TF,":[156],"properties,":[158],"early":[160],"metastasis.":[161],"Clinically,":[162],"identified":[164],"subpopulation":[166],"CTC":[168],"expressing":[169],"vimentin":[170],"breast":[178],"cancer":[179],"patients":[180],"consistent":[181],"our":[183,186],"observations.":[184],"Overall,":[185],"findings":[187],"define":[188],"novel":[190],"EMT\u2013TF":[191],"regulatory":[192],"axis":[193],"triggers":[195],"local":[196],"activation":[197],"pathways":[200],"to":[201],"support":[202],"colonization":[204],"CTCs.":[207],"Cancer":[208],"Res;":[209],"76(14);":[210],"4270\u201382.":[211],"\u00a92016":[212],"AACR.":[213]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
