{"id":"https://openalex.org/W4361815250","doi":"https://doi.org/10.1158/0008-5472.c.6507677","title":"Data from Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle","display_name":"Data from Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361815250","doi":"https://doi.org/10.1158/0008-5472.c.6507677"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507677","doi":"https://doi.org/10.1158/0008-5472.c.6507677","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6507677","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6507677","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110504271","display_name":"Pubudu M. Peiris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pubudu M. Peiris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007578842","display_name":"Aaron Abramowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron Abramowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016739106","display_name":"James Mcginnity","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Mcginnity","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091220555","display_name":"Elizabeth Doolittle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Doolittle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077469767","display_name":"Randall Toy","orcid":"https://orcid.org/0000-0003-4182-5714","observed_orcids":["https://orcid.org/0000-0003-4182-5714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Randall Toy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109368413","display_name":"Ramamurthy Gopalakrishnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramamurthy Gopalakrishnan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037331031","display_name":"Shruti Shah","orcid":"https://orcid.org/0000-0002-0715-3187","observed_orcids":["https://orcid.org/0000-0002-0715-3187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shruti Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lisa Bauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Bauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002648895","display_name":"Ketan B. Ghaghada","orcid":"https://orcid.org/0000-0003-1012-8668","observed_orcids":["https://orcid.org/0000-0003-1012-8668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ketan B. Ghaghada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070016877","display_name":"Christopher J. Hoimes","orcid":"https://orcid.org/0000-0001-8980-2410","observed_orcids":["https://orcid.org/0000-0001-8980-2410"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Hoimes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065482075","display_name":"Susann M. Brady\u2010Kalnay","orcid":"https://orcid.org/0000-0003-4635-4093","observed_orcids":["https://orcid.org/0000-0003-4635-4093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susann M. Brady-Kalnay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067133924","display_name":"James P. Basilion","orcid":"https://orcid.org/0000-0002-8659-3307","observed_orcids":["https://orcid.org/0000-0002-8659-3307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James P. Basilion","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009828582","display_name":"Mark Alan Griswold","orcid":"https://orcid.org/0000-0002-3011-6747","observed_orcids":["https://orcid.org/0000-0002-3011-6747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark A. Griswold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015095804","display_name":"Efstathios Karathanasis","orcid":"https://orcid.org/0000-0001-7484-7552","observed_orcids":["https://orcid.org/0000-0001-7484-7552"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Efstathios Karathanasis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/drug-loaded-liposomes","display_name":"drug-loaded liposomes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/alphavbeta3-integrin-targeting","display_name":"\u03b1v\u03b23 integrin targeting","score":0.8429999947547913},{"id":"https://openalex.org/keywords/vascular-targeting","display_name":"vascular targeting","score":0.6449999809265137},{"id":"https://openalex.org/keywords/blood-tumor-barrier","display_name":"blood-tumor barrier","score":0.7490000128746033},{"id":"https://openalex.org/keywords/brain-tumor-drug-delivery","display_name":"brain tumor drug delivery","score":0.7350000143051147},{"id":"https://openalex.org/keywords/orthotopic-mouse-model","display_name":"orthotopic mouse model","score":0.671999990940094},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.656075119972229},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6122320294380188},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.5747644901275635},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5673678517341614},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5631745457649231},{"id":"https://openalex.org/C2994463257","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain cancer","level":3,"score":0.5614862442016602},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5363565683364868},{"id":"https://openalex.org/C2778889443","wikidata":"https://www.wikidata.org/wiki/Q6073014","display_name":"Iron oxide nanoparticles","level":3,"score":0.5041080713272095},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.4840680658817291},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4710794985294342},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4709271788597107},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4496838450431824},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4451451003551483},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.399705708026886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37697112560272217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36531341075897217},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33795058727264404},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2686119079589844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2508234977722168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1609739363193512},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14521703124046326},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6507677","doi":"https://doi.org/10.1158/0008-5472.c.6507677","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6507677","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507677","doi":"https://doi.org/10.1158/0008-5472.c.6507677","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6507677","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059759972","https://openalex.org/W2231446594","https://openalex.org/W2725823577","https://openalex.org/W2331328856","https://openalex.org/W2948402182","https://openalex.org/W2971380049","https://openalex.org/W3165168339","https://openalex.org/W3099854551","https://openalex.org/W2069314299","https://openalex.org/W4306361587"],"abstract_inverted_index":{"Abstract":[0],"Glioblastoma":[1],"multiforme":[2],"is":[3],"generally":[4],"recalcitrant":[5],"to":[6,74,77,87,100,136],"current":[7],"surgical":[8],"and":[9,47,78,118],"local":[10],"radiotherapeutic":[11],"approaches.":[12],"Moreover,":[13],"systemic":[14],"chemotherapeutic":[15],"approaches":[16],"are":[17],"impeded":[18],"by":[19,146,155,183],"the":[20,27,88,115,124,126,151,156,159,164,184],"blood\u2013tumor":[21],"barrier.":[22],"To":[23],"circumvent":[24],"limitations":[25],"in":[26,93,123,150,171],"latter":[28],"area,":[29],"we":[30],"developed":[31],"a":[32,54,71,94,197],"multicomponent,":[33],"chain-like":[34,56],"nanoparticle":[35],"that":[36],"can":[37],"penetrate":[38],"brain":[39,101],"tumors,":[40],"composed":[41],"of":[42,85,128,158,163,177],"three":[43],"iron":[44,160],"oxide":[45,161],"nanospheres":[46],"one":[48],"drug-loaded":[49],"liposome":[50],"linked":[51],"chemically":[52],"into":[53],"linear":[55],"assembly.":[57],"Unlike":[58],"traditional":[59],"small-molecule":[60],"drugs":[61],"or":[62],"spherical":[63],"nanotherapeutics,":[64],"this":[65],"oblong-shaped,":[66],"flexible":[67],"nanochain":[68,185],"particle":[69],"possessed":[70],"unique":[72],"ability":[73],"gain":[75],"access":[76],"accumulate":[79],"at":[80,120],"glioma":[81],"sites.":[82],"Vascular":[83],"targeting":[84,182],"nanochains":[86,112],"\u03b1v\u03b23":[89],"integrin":[90],"receptor":[91],"resulted":[92],"18.6-fold":[95],"greater":[96],"drug":[97,140,189],"dose":[98],"administered":[99],"tumors":[102],"than":[103],"standard":[104],"chemotherapy.":[105],"By":[106],"2":[107],"hours":[108],"after":[109],"injection,":[110],"when":[111],"had":[113],"exited":[114],"blood":[116],"stream":[117],"docked":[119],"vascular":[121],"beds":[122],"brain,":[125],"application":[127],"an":[129],"external":[130],"low-power":[131],"radiofrequency":[132],"field":[133],"was":[134,144],"sufficient":[135],"remotely":[137],"trigger":[138],"rapid":[139],"release.":[141],"This":[142],"effect":[143],"produced":[145],"mechanically":[147],"induced":[148],"defects":[149],"liposomal":[152],"membrane":[153],"caused":[154],"oscillation":[157],"portion":[162],"nanochain.":[165],"In":[166],"vivo":[167],"efficacy":[168],"studies":[169],"conducted":[170],"two":[172],"different":[173],"mouse":[174],"orthotopic":[175],"models":[176],"glioblastoma":[178,202],"illustrated":[179],"how":[180],"enhanced":[181],"facilitates":[186],"widespread":[187],"site-specific":[188],"delivery.":[190],"Our":[191],"findings":[192],"offer":[193],"preclinical":[194],"proof-of-concept":[195],"for":[196,201],"broadly":[198],"improved":[199],"method":[200],"treatment.":[203],"Cancer":[204],"Res;":[205],"75(7);":[206],"1356\u201365.":[207],"\u00a92015":[208],"AACR.":[209]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}