{"id":"https://openalex.org/W4361814945","doi":"https://doi.org/10.1158/1078-0432.c.6530396","title":"Data from VLA4-Targeted Nanoparticles Hijack Cell Adhesion\u2013Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival","display_name":"Data from VLA4-Targeted Nanoparticles Hijack Cell Adhesion\u2013Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361814945","doi":"https://doi.org/10.1158/1078-0432.c.6530396"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6530396","doi":"https://doi.org/10.1158/1078-0432.c.6530396","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6530396","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6530396","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110967864","display_name":"Francesca Fontana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Fontana","raw_affiliation_strings":["Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri","Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael J. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Scott","raw_affiliation_strings":["Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032476425","display_name":"John S. Allen","orcid":"https://orcid.org/0000-0002-7539-7415","observed_orcids":["https://orcid.org/0000-0002-7539-7415"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Allen","raw_affiliation_strings":["Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415177","display_name":"Xiaoxia Yang","orcid":"https://orcid.org/0000-0002-5587-5555","observed_orcids":["https://orcid.org/0000-0002-5587-5555"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxia Yang","raw_affiliation_strings":["Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065529332","display_name":"Grace Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Cui","raw_affiliation_strings":["Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055819205","display_name":"Dipanjan Pan","orcid":"https://orcid.org/0000-0003-0175-4704","observed_orcids":["https://orcid.org/0000-0003-0175-4704"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipanjan Pan","raw_affiliation_strings":["University of Maryland School of Medicine, Baltimore, Maryland","University of Maryland, Baltimore County,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"University of Maryland, Baltimore County,","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013955617","display_name":"Noriko Yanaba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noriko Yanaba","raw_affiliation_strings":["Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021003906","display_name":"Mark Aaron Fiala","orcid":"https://orcid.org/0000-0002-0208-5023","observed_orcids":["https://orcid.org/0000-0002-0208-5023"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Fiala","raw_affiliation_strings":["Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":"https://orcid.org/0000-0002-0208-5023","affiliations":[{"raw_affiliation_string":"Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037713496","display_name":"Julie O\u2019Neal","orcid":"https://orcid.org/0000-0002-4770-8052","observed_orcids":["https://orcid.org/0000-0002-4770-8052"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie O'Neal","raw_affiliation_strings":["Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025894619","display_name":"Anne H. Schmieder-Atteberry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne H. Schmieder-Atteberry","raw_affiliation_strings":["Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048491248","display_name":"Julie Ritchey","orcid":"https://orcid.org/0009-0000-3964-504X","observed_orcids":["https://orcid.org/0009-0000-3964-504X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Ritchey","raw_affiliation_strings":["Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060952145","display_name":"Michael P. Rettig","orcid":"https://orcid.org/0000-0002-1091-0564","observed_orcids":["https://orcid.org/0000-0002-1091-0564"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Rettig","raw_affiliation_strings":["Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kathleen Simons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Simons","raw_affiliation_strings":["SUNY Downstate Health Sciences University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Health Sciences University, New York, New York","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033946508","display_name":"Steven Fletcher","orcid":"https://orcid.org/0000-0002-4429-8334","observed_orcids":["https://orcid.org/0000-0002-4429-8334"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Fletcher","raw_affiliation_strings":["University of Maryland School of Pharmacy, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland School of Pharmacy, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026151069","display_name":"Ravi Vij","orcid":"https://orcid.org/0000-0001-8795-3610","observed_orcids":["https://orcid.org/0000-0001-8795-3610","https://orcid.org/0000-0001-6358-2392"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Vij","raw_affiliation_strings":["Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065066309","display_name":"John F. DiPersio","orcid":"https://orcid.org/0000-0002-0429-3133","observed_orcids":["https://orcid.org/0000-0002-0429-3133"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. DiPersio","raw_affiliation_strings":["Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107415016","display_name":"Gregory M. Lanza","orcid":"https://orcid.org/0000-0003-3170-0395","observed_orcids":["https://orcid.org/0000-0003-3170-0395"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M. Lanza","raw_affiliation_strings":["Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3292999863624573,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cell-adhesion-mediated-drug-resistance","display_name":"cell adhesion-mediated drug resistance","score":0.875},{"id":"https://openalex.org/keywords/vla-4","display_name":"VLA-4","score":0.8849999904632568},{"id":"https://openalex.org/keywords/integrin-alpha4beta1","display_name":"alpha4beta1 integrin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/micellar-nanoparticles","display_name":"micellar nanoparticles","score":0.8650000095367432},{"id":"https://openalex.org/keywords/camptothecin-prodrug","display_name":"camptothecin prodrug","score":0.9559999704360962},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.925000011920929},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.7770000100135803},{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.6610000133514404},{"id":"https://openalex.org/keywords/nanoparticle-tracking-analysis","display_name":"nanoparticle tracking analysis","score":0.5299999713897705},{"id":"https://openalex.org/keywords/orthotopic-mouse-model","display_name":"orthotopic mouse model","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5282273292541504},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5013346672058105},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4885435998439789},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4867687225341797},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.4859870374202728},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.4732266664505005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4527010917663574},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4506731331348419},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42927446961402893},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3561139702796936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2725619971752167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2153080701828003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19757142663002014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08820974826812744},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6530396","doi":"https://doi.org/10.1158/1078-0432.c.6530396","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6530396","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6530396.v1","doi":"https://doi.org/10.1158/1078-0432.c.6530396.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6530396.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6530396","doi":"https://doi.org/10.1158/1078-0432.c.6530396","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6530396","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1480527484","https://openalex.org/W1528751727","https://openalex.org/W1723444490","https://openalex.org/W1882160969","https://openalex.org/W1963880672","https://openalex.org/W1990518937","https://openalex.org/W2011387568","https://openalex.org/W2027104819","https://openalex.org/W2033393138","https://openalex.org/W2037825770","https://openalex.org/W2040043856","https://openalex.org/W2046251791","https://openalex.org/W2056172893","https://openalex.org/W2058583904","https://openalex.org/W2096048221","https://openalex.org/W2104102293","https://openalex.org/W2109653455","https://openalex.org/W2112464509","https://openalex.org/W2140050472","https://openalex.org/W2146749911","https://openalex.org/W2173742377","https://openalex.org/W2194404144","https://openalex.org/W2301776058","https://openalex.org/W2340686730","https://openalex.org/W2483925606","https://openalex.org/W2494443970","https://openalex.org/W2588784130","https://openalex.org/W2774876650","https://openalex.org/W2783733874","https://openalex.org/W2783965560","https://openalex.org/W2784211356","https://openalex.org/W2787166138","https://openalex.org/W2789319463","https://openalex.org/W2884648149","https://openalex.org/W2912696061","https://openalex.org/W2915631299","https://openalex.org/W2928272073","https://openalex.org/W2940720641","https://openalex.org/W2953067954","https://openalex.org/W2969931905","https://openalex.org/W3014588757"],"related_works":["https://openalex.org/W3115993039","https://openalex.org/W3083117158","https://openalex.org/W2011387568","https://openalex.org/W1969940766","https://openalex.org/W1981408233","https://openalex.org/W2561723667","https://openalex.org/W4361815468","https://openalex.org/W4361815466","https://openalex.org/W4361815048","https://openalex.org/W4361815601"],"abstract_inverted_index":{"AbstractPurpose:":[0],"In":[1],"multiple":[2,125],"myeloma,":[3],"drug-resistant":[4],"cells":[5,24,216],"underlie":[6],"relapse":[7],"or":[8,106,113,117,161,206,209],"progression":[9],"following":[10],"chemotherapy.":[11],"Cell":[12],"adhesion\u2013mediated":[13],"drug":[14,55],"resistance":[15,224],"(CAM-DR)":[16],"is":[17,45],"an":[18],"established":[19],"mechanism":[20],"used":[21,128],"by":[22,73,156],"myeloma":[23,126],"(MMC)":[25],"to":[26,62,129,136,144,204,222],"survive":[27],"chemotherapy":[28,152],"and":[29,51,88,120,134,148,151,169,201],"its":[30,52,64],"markers":[31],"are":[32],"upregulated":[33],"in":[34,146,149,162,172,186,225],"residual":[35],"disease.":[36],"The":[37],"integrin":[38],"very":[39],"late":[40],"antigen":[41],"4":[42],"(VLA4;":[43],"\u03b14\u03b21)":[44],"a":[46,107,199,219],"key":[47],"mediator":[48],"of":[49,57,71,82,90,132,214],"CAM-DR":[50],"expression":[53],"affects":[54],"sensitivity":[56],"MMCs.":[58,158],"Rather":[59],"than":[60],"trying":[61],"inhibit":[63],"function,":[65],"here,":[66],"we":[67],"hypothesized":[68],"that":[69],"upregulation":[70],"VLA4":[72],"resistant":[74,215],"MMCs":[75,145],"could":[76],"be":[77,198],"exploited":[78],"for":[79,104,181],"targeted":[80],"delivery":[81,131],"drugs,":[83],"which":[84],"would":[85],"improve":[86],"safety":[87],"efficacy":[89],"treatments.":[91,137],"Experimental":[92],"Design:":[93],"We":[94],"synthetized":[95],"20":[96],"nm":[97],"VLA4-targeted":[98],"micellar":[99],"nanoparticles":[100],"(V-NP)":[101],"carrying":[102],"DiI":[103],"tracing":[105],"novel":[108],"camptothecin":[109],"prodrug":[110],"(V-CP).":[111],"Human":[112],"murine":[114],"MMCs,":[115],"alone":[116,160],"with":[118,123,164,188],"stroma,":[119],"immunocompetent":[121],"mice":[122],"orthotopic":[124],"were":[127],"track":[130],"NPs":[133],"response":[135],"Results:":[138],"V-NPs":[139],"selectively":[140],"delivered":[141],"their":[142,154],"payload":[143],"vitro":[147],"vivo,":[150],"increased":[153],"uptake":[155],"surviving":[157],"V-CP,":[159],"combination":[163],"melphalan,":[165,182],"was":[166],"well":[167],"tolerated":[168],"prolonged":[170],"survival":[171],"myeloma-bearing":[173],"mice.":[174],"V-CP":[175,196],"also":[176],"reduced":[177],"the":[178],"dose":[179],"requirement":[180],"reducing":[183],"tumor":[184],"burden":[185],"association":[187],"suboptimal":[189],"dosing":[190],"without":[191],"increasing":[192],"overall":[193],"toxicity.":[194],"Conclusions:":[195],"may":[197,217],"safe":[200],"effective":[202],"strategy":[203],"prevent":[205],"treat":[207],"relapsing":[208],"refractory":[210],"myeloma.":[211],"V-NP":[212],"targeting":[213],"suggest":[218],"new":[220],"approach":[221],"environment-induced":[223],"cancer.":[226]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-05T00:00:00"}