{"id":"https://openalex.org/W4361809697","doi":"https://doi.org/10.1158/0008-5472.22397105","title":"Supplementary Figure 5 from Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial \u03b15 Integrin","display_name":"Supplementary Figure 5 from Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial \u03b15 Integrin","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361809697","doi":"https://doi.org/10.1158/0008-5472.22397105"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22397105","doi":"https://doi.org/10.1158/0008-5472.22397105","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22397105","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Neuropilin-2_Promotes_Extravasation_and_Metastasis_by_Interacting_with_Endothelial_5_Integrin/22397105/1/files/39842807.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Neuropilin-2_Promotes_Extravasation_and_Metastasis_by_Interacting_with_Endothelial_5_Integrin/22397105/1/files/39842807.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101873042","display_name":"Ying Cao","orcid":"https://orcid.org/0000-0001-8637-9987","observed_orcids":["https://orcid.org/0000-0001-8637-9987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039813047","display_name":"Luke H. Hoeppner","orcid":"https://orcid.org/0000-0003-3948-4244","observed_orcids":["https://orcid.org/0000-0003-3948-4244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke H. Hoeppner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088205284","display_name":"Steven Bach","orcid":"https://orcid.org/0000-0003-2145-942X","observed_orcids":["https://orcid.org/0000-0003-2145-942X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Bach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061130980","display_name":"E Guangqi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangqi E","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056796466","display_name":"Yan Ping Guo","orcid":"https://orcid.org/0000-0001-5252-3960","observed_orcids":["https://orcid.org/0000-0001-5252-3960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068240871","display_name":"Enfeng Wang","orcid":"https://orcid.org/0009-0002-8676-3801","observed_orcids":["https://orcid.org/0009-0002-8676-3801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enfeng Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108140465","display_name":"Jianmin Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianmin Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076066174","display_name":"Mark J. Cowley","orcid":"https://orcid.org/0000-0002-9519-5714","observed_orcids":["https://orcid.org/0000-0002-9519-5714","https://orcid.org/0000-0001-5078-6687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J. Cowley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009039019","display_name":"David Kuang-Fu Chang","orcid":"https://orcid.org/0000-0002-4821-3078","observed_orcids":["https://orcid.org/0000-0002-4821-3078","https://orcid.org/0000-0003-4341-1283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David K. Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003002360","display_name":"Nicola Waddell","orcid":"https://orcid.org/0000-0002-3950-2476","observed_orcids":["https://orcid.org/0000-0002-3950-2476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola Waddell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040120471","display_name":"Sean Michael Grimmond","orcid":"https://orcid.org/0000-0002-8102-7998","observed_orcids":["https://orcid.org/0000-0002-8102-7998"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean M. Grimmond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089677089","display_name":"Andrew Victor Biankin","orcid":"https://orcid.org/0000-0002-0362-5597","observed_orcids":["https://orcid.org/0000-0002-0362-5597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew V. Biankin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060521527","display_name":"Roger J. Daly","orcid":"https://orcid.org/0000-0002-5739-8027","observed_orcids":["https://orcid.org/0000-0002-5739-8027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger J. Daly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027786290","display_name":"Xiaohui Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaohui Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107946843","display_name":"Debabrata Mukhopadhyay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debabrata Mukhopadhyay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.10599999874830246,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropilin-2","display_name":"neuropilin-2","score":0.972000002861023},{"id":"https://openalex.org/keywords/aspc-1-cells","display_name":"AsPC-1 cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7549999952316284},{"id":"https://openalex.org/keywords/primary-tumor-growth","display_name":"primary tumor growth","score":0.8700000047683716},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/integrin-alpha5","display_name":"integrin alpha5","score":0.7360000014305115},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tumor-cell-extravasation","display_name":"tumor cell extravasation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.815340518951416},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7195029258728027},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7019950747489929},{"id":"https://openalex.org/C34425596","wikidata":"https://www.wikidata.org/wiki/Q18033463","display_name":"Neuropilin 1","level":4,"score":0.5743497610092163},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5018446445465088},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.4409487843513489},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4188951551914215},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4111778438091278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39554181694984436},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3641219437122345},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35180458426475525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33579587936401367},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2435472011566162},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19414153695106506},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1825633943080902},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.13647061586380005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1042708158493042},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.07421818375587463}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22397105","doi":"https://doi.org/10.1158/0008-5472.22397105","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22397105","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Neuropilin-2_Promotes_Extravasation_and_Metastasis_by_Interacting_with_Endothelial_5_Integrin/22397105/1/files/39842807.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22397105.v1","doi":"https://doi.org/10.1158/0008-5472.22397105.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22397105.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22397105","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Neuropilin-2_Promotes_Extravasation_and_Metastasis_by_Interacting_with_Endothelial_5_Integrin/22397105","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22397105","doi":"https://doi.org/10.1158/0008-5472.22397105","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22397105","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Neuropilin-2_Promotes_Extravasation_and_Metastasis_by_Interacting_with_Endothelial_5_Integrin/22397105/1/files/39842807.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4361809697.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005467912","https://openalex.org/W4392685248","https://openalex.org/W2042855108","https://openalex.org/W4252167935","https://openalex.org/W7095855224","https://openalex.org/W2901514518","https://openalex.org/W2112633723","https://openalex.org/W2995764017","https://openalex.org/W4366988868","https://openalex.org/W2577407126"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"164K,":[3],"Supplemental":[4],"Fig.":[5],"5.":[6],"The":[7,70],"effect":[8],"of":[9,59],"NRP-2":[10,23,38,64],"knock":[11],"down":[12],"on":[13],"ASPC-1":[14,29,40,66,71],"cell":[15],"primary":[16,30],"tumor":[17,31,52,67],"growth":[18],"and":[19,48,63,75],"liver":[20,82],"metastasis.":[21],"A.":[22],"knockdown":[24,65],"did":[25],"not":[26],"significantly":[27],"reduce":[28],"growth.":[32],"2":[33],"x":[34],"106":[35],"control":[36,62],"or":[37],"shRNA":[39],"cells":[41,72],"were":[42],"injected":[43],"into":[44],"SCID":[45],"mice":[46],"pancreas,":[47],"after":[49],"15":[50],"days,":[51],"weight":[53],"was":[54,83],"analyzed.":[55],"B.":[56],"Total":[57],"images":[58],"livers":[60],"from":[61],"burden":[68],"mice.":[69],"contain":[73],"GFP":[74,77],"the":[76,81],"fluoresce":[78],"signal":[79],"in":[80],"examined":[84],"by":[85],"IVIS":[86],"Imaging":[87],"System":[88],"200.":[89]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-05T00:00:00"}
