{"id":"https://openalex.org/W4361809352","doi":"https://doi.org/10.1158/0008-5472.c.6512451","title":"Data from Systematic Analysis of Intronic miRNAs Reveals Cooperativity within the Multicomponent FTX Locus to Promote Colon Cancer Development","display_name":"Data from Systematic Analysis of Intronic miRNAs Reveals Cooperativity within the Multicomponent FTX Locus to Promote Colon Cancer Development","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361809352","doi":"https://doi.org/10.1158/0008-5472.c.6512451"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6512451","doi":"https://doi.org/10.1158/0008-5472.c.6512451","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512451","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6512451","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016100009","display_name":"Zhi Hao Kwok","orcid":"https://orcid.org/0000-0002-6469-0050","observed_orcids":["https://orcid.org/0000-0002-6469-0050"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zhi Hao Kwok","raw_affiliation_strings":["National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100392792","display_name":"Bin Zhang","orcid":"https://orcid.org/0000-0001-8835-8370","observed_orcids":["https://orcid.org/0000-0001-8835-8370"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bin Zhang","raw_affiliation_strings":["National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore"],"raw_orcid":"https://orcid.org/0000-0001-8835-8370","affiliations":[{"raw_affiliation_string":"National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005285186","display_name":"Xiao Hong Chew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xiao Hong Chew","raw_affiliation_strings":["National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013823592","display_name":"Jia Jia Chan","orcid":"https://orcid.org/0000-0001-6110-4979","observed_orcids":["https://orcid.org/0000-0001-6110-4979"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jia Jia Chan","raw_affiliation_strings":["National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore"],"raw_orcid":"https://orcid.org/0000-0001-6110-4979","affiliations":[{"raw_affiliation_string":"National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034855204","display_name":"Velda Teh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Velda Teh","raw_affiliation_strings":["National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008473414","display_name":"Henry He Yang","orcid":"https://orcid.org/0000-0002-1155-8216","observed_orcids":["https://orcid.org/0000-0002-1155-8216"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Henry Yang","raw_affiliation_strings":["National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034479642","display_name":"Dennis Kappei","orcid":"https://orcid.org/0000-0002-3582-2253","observed_orcids":["https://orcid.org/0000-0002-3582-2253"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Dennis Kappei","raw_affiliation_strings":["National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-3582-2253","affiliations":[{"raw_affiliation_string":"National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007122608","display_name":"Yvonne Tay","orcid":"https://orcid.org/0000-0003-4989-9101","observed_orcids":["https://orcid.org/0000-0003-4989-9101"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Yvonne Tay","raw_affiliation_strings":["National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Singapore, 14 Medical Drive, # 12-01, Singapore 117599, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007122608"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.301800012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intronic-microrna","display_name":"intronic microRNA","score":0.9319999814033508},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9020000100135803},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/a-to-i-rna-editing","display_name":"A-to-I RNA editing","score":0.9079999923706055},{"id":"https://openalex.org/keywords/dhx9","display_name":"DHX9","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dicer","display_name":"Dicer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mir-421","display_name":"miR-421","score":1.0},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.972000002861023},{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":1.0},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-regulation","display_name":"tumor suppressor regulation","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7841767072677612},{"id":"https://openalex.org/C2779867133","wikidata":"https://www.wikidata.org/wiki/Q21111297","display_name":"Dicer","level":5,"score":0.7270525097846985},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6745866537094116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6555194854736328},{"id":"https://openalex.org/C2776802755","wikidata":"https://www.wikidata.org/wiki/Q261483","display_name":"Drosha","level":5,"score":0.5398480296134949},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.5279024243354797},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.5026373863220215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4782235324382782},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.45631372928619385},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.44110068678855896},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4249618947505951},{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.4208371341228485},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.27164363861083984}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6512451","doi":"https://doi.org/10.1158/0008-5472.c.6512451","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512451","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6512451","doi":"https://doi.org/10.1158/0008-5472.c.6512451","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512451","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1174042017","display_name":null,"funder_award_id":"MOE2014- T3-1-006","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G3882347383","display_name":null,"funder_award_id":"Tier 3","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G4019076671","display_name":null,"funder_award_id":"MOE2014- T3-1-006","funder_id":"https://openalex.org/F4320320698","funder_display_name":"National University of Singapore"},{"id":"https://openalex.org/G7016736585","display_name":null,"funder_award_id":"MOE2014-T3-1-006","funder_id":"https://openalex.org/F4320336974","funder_display_name":"Cancer Science Institute of Singapore, National University of Singapore"},{"id":"https://openalex.org/G7844527391","display_name":null,"funder_award_id":"MOE2014-T3-1-006","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"},{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320336974","display_name":"Cancer Science Institute of Singapore, National University of Singapore","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1584433563","https://openalex.org/W1752426110","https://openalex.org/W1969296875","https://openalex.org/W1970771790","https://openalex.org/W1972150532","https://openalex.org/W1975849543","https://openalex.org/W1992970284","https://openalex.org/W2001630698","https://openalex.org/W2036897871","https://openalex.org/W2041825143","https://openalex.org/W2045685910","https://openalex.org/W2058303505","https://openalex.org/W2073617329","https://openalex.org/W2078577465","https://openalex.org/W2080752012","https://openalex.org/W2093557716","https://openalex.org/W2099551708","https://openalex.org/W2102619694","https://openalex.org/W2105686255","https://openalex.org/W2109731329","https://openalex.org/W2110957978","https://openalex.org/W2112581947","https://openalex.org/W2116187463","https://openalex.org/W2119015197","https://openalex.org/W2138207763","https://openalex.org/W2142718844","https://openalex.org/W2143355329","https://openalex.org/W2146924046","https://openalex.org/W2147346503","https://openalex.org/W2151911276","https://openalex.org/W2151993669","https://openalex.org/W2153961241","https://openalex.org/W2157793936","https://openalex.org/W2158811981","https://openalex.org/W2163169629","https://openalex.org/W2171230529","https://openalex.org/W2179438025","https://openalex.org/W2180388440","https://openalex.org/W2330520103","https://openalex.org/W2400568765","https://openalex.org/W2415523739","https://openalex.org/W2521852091","https://openalex.org/W2560972968","https://openalex.org/W2581781017","https://openalex.org/W2583952707","https://openalex.org/W2626289400","https://openalex.org/W2765219164","https://openalex.org/W2765241643","https://openalex.org/W2768704196","https://openalex.org/W2784570320","https://openalex.org/W2802733018","https://openalex.org/W2803902474","https://openalex.org/W2809248139","https://openalex.org/W2898440040","https://openalex.org/W2899533839","https://openalex.org/W2900014058","https://openalex.org/W2912709534","https://openalex.org/W2974631135","https://openalex.org/W2980163489","https://openalex.org/W4234586755","https://openalex.org/W4247053599","https://openalex.org/W4309908782"],"related_works":["https://openalex.org/W3102637418","https://openalex.org/W3135686215","https://openalex.org/W1506461815","https://openalex.org/W2061171614","https://openalex.org/W2045620168","https://openalex.org/W2993686559","https://openalex.org/W2142718844","https://openalex.org/W2069642741","https://openalex.org/W2362929605","https://openalex.org/W3013032119"],"abstract_inverted_index":{"Abstract":[0],"Approximately":[1],"half":[2],"of":[3,21,32,48,68,86,97,157,206,220,233],"all":[4],"miRNA":[5,23,133,198],"reside":[6],"within":[7,114],"intronic":[8,22,87,105,177,197],"regions":[9],"and":[10,34,62,103,112,125,127,132,163,169,186,199,210],"are":[11],"often":[12],"cotranscribed":[13],"with":[14,123],"their":[15,76,200],"host":[16,201],"genes.":[17],"However,":[18],"most":[19,30],"studies":[20,31],"focus":[24],"on":[25,184],"individual":[26,46,231],"miRNA,":[27,106],"while":[28],"conversely":[29],"protein-coding":[33],"noncoding":[35,100,145,159],"genes":[36],"frequently":[37],"ignore":[38],"any":[39],"intron-derived":[40],"miRNA.":[41],"We":[42],"hypothesize":[43],"that":[44,63,142],"the":[45,65,139,154,193,204,217,227],"components":[47,70,232],"such":[49],"multigenic":[50,221,234],"loci":[51,89,235],"may":[52,179],"play":[53],"cooperative":[54],"or":[55],"competing":[56],"roles":[57],"in":[58,90,110,203,236],"driving":[59],"disease":[60,211],"progression":[61],"examining":[64],"combinatorial":[66],"effect":[67,183],"these":[69],"would":[71],"uncover":[72],"deeper":[73],"insights":[74],"into":[75],"functional":[77,155,218,228],"importance.":[78],"To":[79],"address":[80],"this,":[81],"we":[82],"performed":[83],"systematic":[84],"analyses":[85],"miRNA:host":[88],"colon":[91],"cancer.":[92],"The":[93],"FTX":[94,102,121],"locus,":[95],"comprising":[96],"a":[98,143],"long":[99,144,158],"RNA":[101,130,146,150],"multiple":[104],"was":[107],"highly":[108],"upregulated":[109],"cancer,":[111],"cooperativity":[113],"this":[115],"multicomponent":[116],"locus":[117],"promoted":[118],"cancer":[119,238],"growth.":[120],"interacted":[122],"DHX9":[124],"DICER":[126],"regulated":[128],"A-to-I":[129,149],"editing":[131],"expression.":[134],"These":[135],"results":[136],"show":[137],"for":[138],"first":[140],"time":[141],"can":[147],"regulate":[148],"editing,":[151],"further":[152],"expanding":[153],"repertoire":[156],"RNA.":[160],"Intronic":[161],"miR-374b":[162,185],"miR-545":[164],"inhibited":[165],"tumor":[166],"suppressors":[167],"PTEN":[168],"RIG-I":[170],"to":[171,216],"enhance":[172],"proto-oncogenic":[173],"PI3K-AKT":[174],"signaling.":[175],"Furthermore,":[176],"miR-421":[178],"exert":[180],"an":[181],"autoregulatory":[182],"miR-545.":[187],"Taken":[188],"together,":[189],"our":[190],"data":[191],"unveil":[192],"intricate":[194],"interplay":[195],"between":[196,230],"transcripts":[202],"modulation":[205],"key":[207],"signaling":[208],"pathways":[209],"progression,":[212],"adding":[213],"new":[214],"perspectives":[215],"landscape":[219],"loci.":[222],"Significance:":[223],"This":[224],"study":[225],"illustrates":[226],"relationships":[229],"regulating":[237],"progression.":[239],"See":[240],"related":[241],"commentary":[242],"by":[243],"Calin,":[244],"p.":[245],"1212":[246]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}