{"id":"https://openalex.org/W43615101","doi":null,"title":"ROLE OF GSH METABOLISM IN MEDIATING STROMAL-LEUKEMIA INTERACTION AND PROMOTING CELL SURVIVAL AND DRUG RESISTANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA","display_name":"ROLE OF GSH METABOLISM IN MEDIATING STROMAL-LEUKEMIA INTERACTION AND PROMOTING CELL SURVIVAL AND DRUG RESISTANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W43615101","mag":"43615101"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1129","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/113","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100706672","display_name":"Wan Zhang","orcid":"https://orcid.org/0000-0003-1896-8186","observed_orcids":["https://orcid.org/0000-0003-1896-8186","https://orcid.org/0009-0001-2814-3543"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wan Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1896-8186","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100706672"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glutathione-metabolism","display_name":"glutathione metabolism","score":0.9020000100135803},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7450000047683716},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7820000052452087},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cystine-uptake","display_name":"cystine uptake","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":0.847000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.8413940668106079},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6749267578125},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6073616147041321},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5299264788627625},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.45687001943588257},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4268980324268341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4104347825050354},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2871074378490448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27296870946884155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26997432112693787},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13812255859375}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1129","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/113","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:43615101","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1129&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9534000158309937}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":132,"referenced_works":["https://openalex.org/W128841889","https://openalex.org/W147593198","https://openalex.org/W154103547","https://openalex.org/W336373995","https://openalex.org/W1485481901","https://openalex.org/W1486056595","https://openalex.org/W1489024087","https://openalex.org/W1492263161","https://openalex.org/W1498909884","https://openalex.org/W1514403557","https://openalex.org/W1527161131","https://openalex.org/W1531083786","https://openalex.org/W1535345009","https://openalex.org/W1566062118","https://openalex.org/W1674310412","https://openalex.org/W1723444490","https://openalex.org/W1875498845","https://openalex.org/W1948303502","https://openalex.org/W1953101143","https://openalex.org/W1964223606","https://openalex.org/W1966207848","https://openalex.org/W1967183073","https://openalex.org/W1970102243","https://openalex.org/W1971372405","https://openalex.org/W1971436806","https://openalex.org/W1976366028","https://openalex.org/W1980058210","https://openalex.org/W1980505675","https://openalex.org/W1981354539","https://openalex.org/W1981478275","https://openalex.org/W1983579522","https://openalex.org/W1985322186","https://openalex.org/W1985561510","https://openalex.org/W1987212294","https://openalex.org/W1991128724","https://openalex.org/W1993986769","https://openalex.org/W1994220134","https://openalex.org/W1994833789","https://openalex.org/W1994979282","https://openalex.org/W1996511520","https://openalex.org/W1996991960","https://openalex.org/W2005150159","https://openalex.org/W2006958922","https://openalex.org/W2008308389","https://openalex.org/W2009593167","https://openalex.org/W2010235407","https://openalex.org/W2010451857","https://openalex.org/W2012666942","https://openalex.org/W2013155366","https://openalex.org/W2013294222","https://openalex.org/W2013553819","https://openalex.org/W2013763814","https://openalex.org/W2013822870","https://openalex.org/W2020085126","https://openalex.org/W2022628608","https://openalex.org/W2023400811","https://openalex.org/W2024261139","https://openalex.org/W2024968355","https://openalex.org/W2025375528","https://openalex.org/W2030763326","https://openalex.org/W2038407276","https://openalex.org/W2041675180","https://openalex.org/W2041992938","https://openalex.org/W2045795253","https://openalex.org/W2049584121","https://openalex.org/W2050782389","https://openalex.org/W2052260390","https://openalex.org/W2052830369","https://openalex.org/W2057411341","https://openalex.org/W2058411331","https://openalex.org/W2059744762","https://openalex.org/W2061728585","https://openalex.org/W2061970902","https://openalex.org/W2065294001","https://openalex.org/W2066513801","https://openalex.org/W2078161165","https://openalex.org/W2078410199","https://openalex.org/W2080166898","https://openalex.org/W2080328815","https://openalex.org/W2082771303","https://openalex.org/W2083657712","https://openalex.org/W2083698008","https://openalex.org/W2088100213","https://openalex.org/W2090265589","https://openalex.org/W2090396694","https://openalex.org/W2090880672","https://openalex.org/W2094925578","https://openalex.org/W2095999343","https://openalex.org/W2096245406","https://openalex.org/W2103006179","https://openalex.org/W2103238599","https://openalex.org/W2104235597","https://openalex.org/W2105473269","https://openalex.org/W2107615815","https://openalex.org/W2108999808","https://openalex.org/W2113346253","https://openalex.org/W2114680779","https://openalex.org/W2117775564","https://openalex.org/W2120695887","https://openalex.org/W2120878830","https://openalex.org/W2125655694","https://openalex.org/W2127675410","https://openalex.org/W2129778797","https://openalex.org/W2130177169","https://openalex.org/W2133339616","https://openalex.org/W2134139148","https://openalex.org/W2137749199","https://openalex.org/W2142544974","https://openalex.org/W2152432261","https://openalex.org/W2155680682","https://openalex.org/W2156591820","https://openalex.org/W2159117510","https://openalex.org/W2162420845","https://openalex.org/W2165535625","https://openalex.org/W2166337262","https://openalex.org/W2168257591","https://openalex.org/W2170101247","https://openalex.org/W2171429277","https://openalex.org/W2221262359","https://openalex.org/W2258939519","https://openalex.org/W2278421311","https://openalex.org/W2303045765","https://openalex.org/W2315340600","https://openalex.org/W2395470388","https://openalex.org/W2399834522","https://openalex.org/W2408955560","https://openalex.org/W2409154206","https://openalex.org/W2418788097","https://openalex.org/W2437107568","https://openalex.org/W2473650964","https://openalex.org/W4233375858","https://openalex.org/W4312734170"],"related_works":["https://openalex.org/W2326642898","https://openalex.org/W2058376258","https://openalex.org/W2985731262","https://openalex.org/W2078177962","https://openalex.org/W2020511303","https://openalex.org/W2502217303","https://openalex.org/W2316272921","https://openalex.org/W4401876929","https://openalex.org/W2770899258","https://openalex.org/W4310106555"],"abstract_inverted_index":{"Chronic":[0],"lymphocytic":[1],"leukemia":[2,9,35,80,301],"(CLL)":[3],"is":[4,25,184,192],"the":[5,11,20,34,51,61,84,118,167,201,209,240,251,254,271,291,300,344,354],"most":[6],"common":[7],"adult":[8],"in":[10,32,103,110,117,139,175,287,290,353,380],"western":[12],"countries.":[13],"The":[14,284],"interaction":[15],"between":[16],"CLL":[17,66,88,125,151,176,221,279,288,336,352],"cells":[18,55,67,81,126,152,171,177,222,258,280,289,297,302,337,368],"and":[19,38,68,76,107,142,158,165,191,204,212,263,306,317,341,349,370],"bone":[21,52,121,168,255,294],"marrow":[22,53,122,169,256,295],"stromal":[23,54,123,170,257,296,357],"environment":[24,211],"thought":[26],"to":[27,72,215,226,235,247,266,274,310,338,376],"play":[28],"a":[29,45,57,100,137,179,185,331,362,372],"major":[30,92],"role":[31],"promoting":[33],"cell":[36,145],"survival":[37],"drug":[39,77,339,378],"resistance.":[40],"My":[41],"dissertation":[42],"works":[43],"proved":[44],"novel":[46,180],"biochemical":[47,181,364],"mechanism":[48,324,365],"by":[49,199,278,325],"which":[50],"exert":[56],"profound":[58],"influence":[59],"on":[60,161],"redox":[62,93,129],"status":[63],"of":[64,87,120,135,239,293,321,327,347,356,366],"primary":[65],"enhance":[69],"their":[70,128,236],"ability":[71,225,246],"sustain":[73],"oxidative":[74],"stress":[75,157],"treatment.":[78],"Fresh":[79],"isolated":[82],"from":[83,208,303],"peripheral":[85],"blood":[86],"patients":[89],"exhibited":[90],"two":[91],"alterations":[94],"when":[95,115],"they":[96],"were":[97,153],"cultured":[98,116],"alone:":[99],"significant":[101],"decrease":[102,138],"cellular":[104,328],"glutathione":[105],"(GSH)":[106],"an":[108,132,143],"increase":[109],"basal":[111],"ROS":[112,156],"levels.":[113],"However,":[114],"presence":[119,292,355],"cells,":[124],"restored":[127],"balance":[130],"with":[131],"increased":[133],"synthesis":[134,174,190,233],"GSH,":[136],"spontaneous":[140],"apoptosis,":[141,305],"improved":[144],"survival.":[146],"Further":[147],"study":[148,360],"showed":[149,219],"that":[150,166,220],"under":[154],"intrinsic":[155],"highly":[159],"dependent":[160],"GSH":[162,173,189,232,282,286,329],"for":[163,188,231,268,281],"survival,":[164],"promoted":[172],"through":[178],"mechanism.":[182],"Cysteine":[183],"limiting":[186],"substrate":[187],"chemically":[193],"unstable.":[194],"Cells":[195],"normally":[196],"obtain":[197],"cysteine":[198,216,267],"uptaking":[200],"more":[202],"stable":[203],"abundant":[205],"precursor":[206],"cystine":[207,230,262],"tissue":[210,272],"convert":[213],"it":[214,265],"intracellularly.":[217],"I":[218],"had":[223,244],"limited":[224],"take":[227],"up":[228,261,277],"extracellular":[229],"due":[234],"low":[237],"expression":[238],"transporter":[241],"Xc-,":[242],"but":[243],"normal":[245],"uptake":[248],"cysteine.":[249],"In":[250],"co-culture":[252],"system,":[253],"effectively":[259,342],"took":[260],"reduced":[264],"secretion":[269],"into":[270],"microenvironment":[273],"be":[275],"taken":[276],"synthesis.":[283],"elevated":[285],"significantly":[298],"protected":[299],"stress-induced":[304],"rendered":[307],"them":[308],"resistant":[309],"standard":[311],"therapeutic":[312,374],"agents":[313],"such":[314],"as":[315],"fludarabine":[316,348],"oxaliplatin.":[318],"Importantly,":[319],"disabling":[320],"this":[322],"protective":[323],"depletion":[326],"using":[330],"pharmacological":[332],"approach":[333],"potently":[334],"sensitized":[335],"treatment,":[340],"enhanced":[343],"cytotoxic":[345],"action":[346],"oxaliplatin":[350],"against":[351],"cells.":[358],"This":[359],"reveals":[361],"key":[363],"leukemia-stromal":[367],"interaction,":[369],"identifies":[371],"new":[373],"strategy":[375],"overcome":[377],"resistance":[379],"vivo.":[381]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}