{"id":"https://openalex.org/W4361297029","doi":"https://doi.org/10.1111/jre.13102","title":"The association between Aggregatibacter actinomycetemcomitans JP2 clone and periodontitis: A systematic review and meta\u2010analysis","display_name":"The association between Aggregatibacter actinomycetemcomitans JP2 clone and periodontitis: A systematic review and meta\u2010analysis","publication_year":2023,"publication_date":"2023-03-28","ids":{"openalex":"https://openalex.org/W4361297029","doi":"https://doi.org/10.1111/jre.13102","pmid":"https://pubmed.ncbi.nlm.nih.gov/36987541"},"language":"en","primary_location":{"id":"doi:10.1111/jre.13102","doi":"https://doi.org/10.1111/jre.13102","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jre.13102","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1111/jre.13102","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083822885","display_name":"Jaimini Mehta","orcid":"https://orcid.org/0000-0003-2804-7356","observed_orcids":["https://orcid.org/0000-0003-2804-7356"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jaimini Mehta","raw_affiliation_strings":["Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-2804-7356","affiliations":[{"raw_affiliation_string":"Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036718367","display_name":"Carolyn Eaton","orcid":"https://orcid.org/0000-0002-6082-6045","observed_orcids":["https://orcid.org/0000-0002-6082-6045"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carolyn Eaton","raw_affiliation_strings":["Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-6082-6045","affiliations":[{"raw_affiliation_string":"Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019150637","display_name":"Meaad Mohammed Alamri","orcid":"https://orcid.org/0009-0008-7430-8864","observed_orcids":["https://orcid.org/0009-0008-7430-8864"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Meaad AlAmri","raw_affiliation_strings":["Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040001021","display_name":"Guo\u2010Hao Lin","orcid":"https://orcid.org/0000-0003-1290-9994","observed_orcids":["https://orcid.org/0000-0003-1290-9994"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guo\u2010Hao Lin","raw_affiliation_strings":["Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":"https://orcid.org/0000-0003-1290-9994","affiliations":[{"raw_affiliation_string":"Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091632184","display_name":"Luigi Nibali","orcid":"https://orcid.org/0000-0002-7750-5010","observed_orcids":["https://orcid.org/0000-0002-7750-5010","https://orcid.org/0000-0002-1744-3487"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Luigi Nibali","raw_affiliation_strings":["Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-7750-5010","affiliations":[{"raw_affiliation_string":"Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091632184"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":{"value":4430,"currency":"USD","value_usd":4430},"fwci":0.5594,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.4665826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"58","issue":"3","first_page":"465","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aggregatibacter-actinomycetemcomitans","display_name":"Aggregatibacter actinomycetemcomitans","score":0.9980000257492065},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.984000027179718},{"id":"https://openalex.org/keywords/subgingival-plaque","display_name":"subgingival plaque","score":0.8669999837875366},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.9269999861717224},{"id":"https://openalex.org/keywords/early-onset-periodontitis","display_name":"early-onset periodontitis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/bacterial-detection","display_name":"bacterial detection","score":0.546999990940094},{"id":"https://openalex.org/keywords/disease-onset-prediction","display_name":"disease onset prediction","score":0.75},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C2778714489","wikidata":"https://www.wikidata.org/wiki/Q2174895","display_name":"Aggregatibacter actinomycetemcomitans","level":4,"score":0.8505133390426636},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.8244614601135254},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7988781332969666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7032372951507568},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5722127556800842},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5358710289001465},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.5290564298629761},{"id":"https://openalex.org/C2778883934","wikidata":"https://www.wikidata.org/wiki/Q4692285","display_name":"Aggressive periodontitis","level":3,"score":0.45551955699920654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44501954317092896},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.42791467905044556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16800490021705627},{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.11333954334259033},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003773","descriptor_name":"Dental Plaque","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010520","descriptor_name":"Aggressive Periodontitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016976","descriptor_name":"Aggregatibacter actinomycetemcomitans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jre.13102","doi":"https://doi.org/10.1111/jre.13102","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jre.13102","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},{"id":"pmid:36987541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36987541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontal research","raw_type":"Meta-Analysis"}],"best_oa_location":{"id":"doi:10.1111/jre.13102","doi":"https://doi.org/10.1111/jre.13102","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jre.13102","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1483251018","https://openalex.org/W1500213558","https://openalex.org/W1666655813","https://openalex.org/W1844472299","https://openalex.org/W1852618725","https://openalex.org/W1857905357","https://openalex.org/W1872855314","https://openalex.org/W1964178334","https://openalex.org/W1971460368","https://openalex.org/W1975050592","https://openalex.org/W1979933738","https://openalex.org/W1980808682","https://openalex.org/W1992698498","https://openalex.org/W1994080141","https://openalex.org/W1999292038","https://openalex.org/W2002230907","https://openalex.org/W2002973505","https://openalex.org/W2008294135","https://openalex.org/W2010710109","https://openalex.org/W2024969319","https://openalex.org/W2030711174","https://openalex.org/W2035476973","https://openalex.org/W2046802279","https://openalex.org/W2048624291","https://openalex.org/W2057364477","https://openalex.org/W2065623087","https://openalex.org/W2073848123","https://openalex.org/W2077790572","https://openalex.org/W2089617789","https://openalex.org/W2094750411","https://openalex.org/W2098923148","https://openalex.org/W2100134709","https://openalex.org/W2100616628","https://openalex.org/W2104256467","https://openalex.org/W2104341725","https://openalex.org/W2105356824","https://openalex.org/W2109590304","https://openalex.org/W2112929690","https://openalex.org/W2122556206","https://openalex.org/W2125399267","https://openalex.org/W2127311345","https://openalex.org/W2127672404","https://openalex.org/W2129529802","https://openalex.org/W2129624735","https://openalex.org/W2131684681","https://openalex.org/W2136201977","https://openalex.org/W2137864481","https://openalex.org/W2137878745","https://openalex.org/W2141232322","https://openalex.org/W2141865470","https://openalex.org/W2143765214","https://openalex.org/W2144504410","https://openalex.org/W2145966983","https://openalex.org/W2147913608","https://openalex.org/W2151220059","https://openalex.org/W2151444835","https://openalex.org/W2165105035","https://openalex.org/W2174784305","https://openalex.org/W2178195071","https://openalex.org/W2180433170","https://openalex.org/W2288896350","https://openalex.org/W2586459956","https://openalex.org/W2593487359","https://openalex.org/W2660159430","https://openalex.org/W2724612321","https://openalex.org/W2745333932","https://openalex.org/W2809048536","https://openalex.org/W2902033246","https://openalex.org/W2914149058","https://openalex.org/W2954371950","https://openalex.org/W3014529666","https://openalex.org/W3021868853","https://openalex.org/W3092561793","https://openalex.org/W3111319789","https://openalex.org/W3118615836","https://openalex.org/W3148962211","https://openalex.org/W4230233764","https://openalex.org/W4248478067","https://openalex.org/W6649067274"],"related_works":["https://openalex.org/W2105356824","https://openalex.org/W2104256467","https://openalex.org/W2122556206","https://openalex.org/W2137878745","https://openalex.org/W4281719835","https://openalex.org/W1857905357","https://openalex.org/W4207080230","https://openalex.org/W2072549138","https://openalex.org/W2574286557","https://openalex.org/W2143765214"],"abstract_inverted_index":{"Abstract":[0],"To":[1],"appraise":[2],"the":[3,6,9,33,50,63,92,101,119,159,186,202,219,258],"literature":[4,34],"on":[5,17,47],"prevalence":[7],"of":[8,12,24,32,49,53,57,69,82,91,118,124,158,164,189,199,215,218,222,235,237,246,261,270,277],"JP2":[10,51,102,120,160,220,259],"clone":[11,52,103,121,161,221,260],"Aggregatibacter":[13],"actinomycetemcomitans":[14],"(A.a.)":[15],"and":[16,22,40,109,112,122,133,148,151,162,227,239],"its":[18],"association":[19,115,154],"with":[20,78,135,176,232,265],"presence":[21],"progression":[23],"periodontitis":[25,125,165,238],"in":[26,37,62,76,224,255],"different":[27],"populations.":[28],"A":[29,55],"systematic":[30,249],"search":[31,68],"was":[35],"conducted":[36],"Medline,":[38],"Embase":[39],"Cochrane":[41],"Library":[42],"for":[43],"studies":[44,108,147],"reporting":[45],"data":[46],"detection":[48,117,157,269],"A.a.":[54,223,262],"total":[56],"56":[58],"papers":[59,193,204],"were":[60,73,194,205],"included":[61,106,145],"review,":[64],"from":[65,131],"an":[66,114,153,209],"initial":[67],"685":[70],"titles.":[71],"Studies":[72],"carried":[74],"out":[75],"populations":[77],"a":[79],"mean":[80],"age":[81],"26.34":[83],"years":[84,170],"(range":[85],"6.24\u201353.85":[86],"years).":[87],"Just":[88],"over":[89,166],"16%":[90],"overall":[93,187,210],"population":[94],"assessed":[95],"(n":[96],"=":[97,127,139,172,180],"13":[98],"751)":[99],"had":[100],"detected.":[104],"Meta\u2010analyses":[105,144],"16":[107],"1775":[110],"patients,":[111,150],"revealed":[113,152],"between":[116,155],"diagnosis":[123,236],"(RR":[126,171],"1.86,":[128],"95%":[129,174],"1.43\u20132.42)":[130],"saliva":[132,228],"plaque,":[134],"high":[136,177,213],"heterogeneity":[137,178],"(I2":[138,179],"85%,":[140],"p":[141,182],"<":[142,183],".00001).":[143],"5":[146,169],"616":[149],"baseline":[156],"onset":[163,245],"2":[167],"to":[168,207,243,274],"4.12,":[173],"2.42\u20137.00),":[175],"81%,":[181],".0003).":[184],"From":[185],"risk":[188,198,214],"bias":[190],"score,":[191],"29":[192],"judged":[195,206],"as":[196],"low":[197],"bias,":[200],"whilst":[201],"remaining":[203],"have":[208],"medium":[211],"or":[212],"bias.":[216],"Detection":[217],"subgingival":[225],"plaque":[226],"samples":[229],"is":[230,263],"associated":[231,264],"increased":[233],"odds":[234],"may":[240],"be":[241,275],"able":[242],"predict":[244],"periodontitis.":[247,267],"This":[248],"review":[250],"provides":[251],"clear":[252],"evidence":[253],"that":[254],"certain":[256],"populations,":[257],"early\u2010onset":[266],"Furthermore,":[268],"this":[271],"bacterium":[272],"seems":[273],"predictive":[276],"disease":[278],"onset.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-03-31T00:00:00"}
