{"id":"https://openalex.org/W4361265865","doi":"https://doi.org/10.1158/0008-5472.c.6495119","title":"Data from Cell Adhesion Molecule L1 Disrupts E-Cadherin-Containing Adherens Junctions and Increases Scattering and Motility of MCF7 Breast Carcinoma Cells","display_name":"Data from Cell Adhesion Molecule L1 Disrupts E-Cadherin-Containing Adherens Junctions and Increases Scattering and Motility of MCF7 Breast Carcinoma Cells","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361265865","doi":"https://doi.org/10.1158/0008-5472.c.6495119"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6495119","doi":"https://doi.org/10.1158/0008-5472.c.6495119","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6495119","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6495119","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016479290","display_name":"Michael S. Shtutman","orcid":"https://orcid.org/0000-0002-2458-3226","observed_orcids":["https://orcid.org/0000-0002-2458-3226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Shtutman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084495365","display_name":"Elina M. Levina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elina Levina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080445359","display_name":"Patrice Y. Ohouo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrice Ohouo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112384860","display_name":"Mirza Baig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mirza Baig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006208805","display_name":"Igor B. Roninson","orcid":"https://orcid.org/0000-0002-9211-1327","observed_orcids":["https://orcid.org/0000-0002-9211-1327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor B. Roninson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.45730000734329224,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l1cam","display_name":"L1CAM","score":0.9959999918937683},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.996999979019165},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-scattering","display_name":"cell scattering","score":0.8659999966621399},{"id":"https://openalex.org/keywords/beta-catenin-transcriptional-activity","display_name":"\u03b2-catenin transcriptional activity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tumor-invasion-and-metastasis","display_name":"tumor invasion and metastasis","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cell-density","display_name":"cell density","score":0.492000013589859},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.9665117263793945},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.6092930436134338},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.608813464641571},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5893238186836243},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4605078101158142},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4552454352378845},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.44019946455955505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4363996684551239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.435380756855011},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4132077395915985},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.4108516275882721},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3403121829032898},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32912319898605347},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.32140928506851196},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2764190137386322},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19309744238853455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08442500233650208},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6495119","doi":"https://doi.org/10.1158/0008-5472.c.6495119","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6495119","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6495119","doi":"https://doi.org/10.1158/0008-5472.c.6495119","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6495119","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8704000115394592,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2164704968","https://openalex.org/W2011751087","https://openalex.org/W2151549305","https://openalex.org/W7218205734","https://openalex.org/W6954787722","https://openalex.org/W2109789850","https://openalex.org/W4401371880","https://openalex.org/W2054531472","https://openalex.org/W2102411854","https://openalex.org/W2061876396"],"abstract_inverted_index":{"Abstract":[0],"The":[1,28],"first":[2],"steps":[3],"of":[4,11,17,50,76,81,90,110,117,129,145,152,159,167,190,204,209],"invasion":[5],"and":[6,14,52,132,183],"metastasis":[7],"include":[8],"the":[9,15,39,73,127,143,153,165,168,188,191,202],"dissociation":[10],"adherens":[12,101,130],"junctions":[13,131],"induction":[16],"migratory":[18],"phenotype,":[19],"through":[20],"a":[21,138,173,199,207],"program":[22],"that":[23,60,122],"resembles":[24],"epithelial-mesenchymal":[25],"transition":[26],"(EMT).":[27],"L1":[29,61,92,119,123,140,155,178,205],"cell":[30,84,107],"adhesion":[31],"molecule,":[32],"which":[33,98,177],"is":[34,103,180],"normally":[35],"found":[36],"primarily":[37],"in":[38,47,65,95,172,176,185,212],"brain,":[40],"was":[41],"recently":[42],"shown":[43],"to":[44,53,106,126],"be":[45],"expressed":[46],"different":[48,88],"types":[49,89],"cancer":[51],"have":[54],"tumor-promoting":[55],"activity.":[56,136],"We":[57],"now":[58],"find":[59],"mediates":[62],"EMT-like":[63,210],"events":[64,211],"MCF7":[66,70,96,111,169],"breast":[67],"carcinoma":[68],"cells.":[69,215],"predominantly":[71],"expresses":[72],"nonneuronal":[74,118],"isoform":[75,120],"L1,":[77],"as":[78,206],"do":[79],"16":[80],"17":[82],"other":[83],"lines":[85],"derived":[86],"from":[87,148],"cancer.":[91],"protein":[93],"expression":[94,124,141,179],"cells,":[97],"form":[99],"E-cadherin-containing":[100],"junctions,":[102],"inversely":[104],"related":[105],"density.":[108],"Analysis":[109],"cells":[112,147,186],"with":[113],"overexpression":[114],"or":[115],"knockdown":[116],"revealed":[121],"leads":[125],"disruption":[128],"increases":[133,164],"\u03b2-catenin":[134],"transcriptional":[135],"As":[137],"result,":[139],"promotes":[142],"scattering":[144],"epithelial":[146,170,214],"compact":[149],"colonies.":[150],"Expression":[151],"full-length":[154],"protein,":[156],"but":[157],"not":[158],"its":[160],"soluble":[161],"extracellular":[162],"moiety,":[163],"motility":[166],"monolayer":[171],"wound-healing":[174],"assay,":[175],"preferentially":[181],"observed":[182],"required":[184],"leading":[187],"movement":[189],"monolayer.":[192],"Based":[193],"on":[194],"these":[195],"results,":[196],"we":[197],"propose":[198],"model":[200],"for":[201],"role":[203],"trigger":[208],"transformed":[213],"(Cancer":[216],"Res":[217],"2006;":[218],"66(23):":[219],"11370-80)":[220]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-03-31T00:00:00"}
