{"id":"https://openalex.org/W4361263264","doi":"https://doi.org/10.1158/0008-5472.c.6498170.v1","title":"Data from Interleukin-15/Interleukin-15R\u03b1 Complexes Promote Destruction of Established Tumors by Reviving Tumor-Resident CD8+ T Cells","display_name":"Data from Interleukin-15/Interleukin-15R\u03b1 Complexes Promote Destruction of Established Tumors by Reviving Tumor-Resident CD8+ T Cells","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361263264","doi":"https://doi.org/10.1158/0008-5472.c.6498170.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6498170.v1","doi":"https://doi.org/10.1158/0008-5472.c.6498170.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6498170.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6498170.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048357847","display_name":"Mathieu Epardaud","orcid":"https://orcid.org/0000-0001-9878-4488","observed_orcids":["https://orcid.org/0000-0001-9878-4488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mathieu Epardaud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068499852","display_name":"Kutlu G. Elpek","orcid":"https://orcid.org/0009-0004-3085-096X","observed_orcids":["https://orcid.org/0009-0004-3085-096X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kutlu G. Elpek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046739998","display_name":"Mark P. Rubinstein","orcid":"https://orcid.org/0000-0003-4748-0286","observed_orcids":["https://orcid.org/0000-0003-4748-0286","https://orcid.org/0000-0002-9942-7519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark P. Rubinstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067875114","display_name":"Ai-ris Yonekura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ai-ris Yonekura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035899830","display_name":"Ang\u00e9lique Bellemare\u2010Pelletier","orcid":"https://orcid.org/0000-0001-7671-0103","observed_orcids":["https://orcid.org/0000-0001-7671-0103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelique Bellemare-Pelletier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054412365","display_name":"Roderick Terry Bronson","orcid":"https://orcid.org/0000-0003-3725-2511","observed_orcids":["https://orcid.org/0000-0003-3725-2511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roderick Bronson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021144595","display_name":"Jessica A. Hamerman","orcid":"https://orcid.org/0000-0001-5864-5299","observed_orcids":["https://orcid.org/0000-0001-5864-5299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica A. Hamerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055310419","display_name":"Ananda W. Goldrath","orcid":"https://orcid.org/0000-0002-5900-508X","observed_orcids":["https://orcid.org/0000-0002-5900-508X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ananda W. Goldrath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011465411","display_name":"Shannon J. Turley","orcid":"https://orcid.org/0000-0002-0444-3031","observed_orcids":["https://orcid.org/0000-0002-0444-3031","https://orcid.org/0000-0002-0307-908X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shannon J. Turley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4004000127315521,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4004000127315521,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.34279999136924744,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.21549999713897705,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.574999988079071},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8579999804496765},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.7329999804496765},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.5879999995231628},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.550000011920929},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5922882556915283},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5888240337371826},{"id":"https://openalex.org/C98119934","wikidata":"https://www.wikidata.org/wiki/Q14907167","display_name":"Interleukin 15","level":4,"score":0.5598437786102295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5375769734382629},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5241665840148926},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4976096451282501},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4922241270542145},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4860246777534485},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.47669050097465515},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4626961350440979},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.4202345311641693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41240304708480835},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.3509686589241028},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3469269275665283},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17388251423835754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08635920286178589}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6498170.v1","doi":"https://doi.org/10.1158/0008-5472.c.6498170.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6498170.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6498170.v1","doi":"https://doi.org/10.1158/0008-5472.c.6498170.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6498170.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2166365836","https://openalex.org/W3000091084","https://openalex.org/W3127740761","https://openalex.org/W3098107622","https://openalex.org/W2995191565","https://openalex.org/W2119312822","https://openalex.org/W3138680754","https://openalex.org/W4413956558","https://openalex.org/W2484211124","https://openalex.org/W7117973112"],"abstract_inverted_index":{"Abstract":[0],"Tumors":[1],"often":[2],"escape":[3],"immune-mediated":[4],"destruction":[5,127],"by":[6,76,133,161],"suppressing":[7],"lymphocyte":[8],"infiltration":[9],"or":[10],"effector":[11,37],"function.":[12],"New":[13],"approaches":[14],"are":[15,59],"needed":[16,60],"that":[17,88],"overcome":[18],"this":[19,78],"suppression":[20,160],"and":[21,36,47,56,97,118,165,172],"thereby":[22],"augment":[23],"the":[24,126,148,162],"tumoricidal":[25],"capacity":[26,38],"of":[27,39,70,92,100,112,128,150,174],"tumor-reactive":[28],"lymphocytes.":[29],"The":[30,67],"cytokine":[31,79],"interleukin-15":[32],"(IL-15)":[33],"promotes":[34],"proliferation":[35],"CD8+":[40,139],"T":[41,140,156],"cells,":[42,46],"natural":[43],"killer":[44],"(NK)":[45],"NKT":[48],"cells;":[49],"however,":[50],"it":[51],"has":[52],"a":[53,109],"short":[54],"half-life":[55],"high":[57],"doses":[58],"to":[61,80,153],"achieve":[62],"functional":[63,159],"responses":[64],"in":[65,89,104,115],"vivo.":[66],"biological":[68],"activity":[69],"IL-15":[71],"can":[72],"be":[73],"dramatically":[74],"increased":[75],"complexing":[77],"its":[81],"soluble":[82],"receptor,":[83],"IL-15R\u03b1.":[84],"Here,":[85],"we":[86],"report":[87],"vivo":[90],"delivery":[91],"IL-15/IL-15R\u03b1":[93,124,151],"complexes":[94,152],"triggers":[95],"rapid":[96],"significant":[98,167],"regression":[99],"established":[101],"solid":[102,129],"tumors":[103,130],"two":[105],"murine":[106],"models.":[107],"Despite":[108],"marked":[110],"expansion":[111],"IL-2/IL-15R\u03b2+":[113],"cells":[114,157],"lymphoid":[116],"organs":[117],"peripheral":[119],"blood":[120],"following":[121],"treatment":[122,173],"with":[123],"complexes,":[125],"was":[131],"orchestrated":[132],"tumor-resident":[134,155],"rather":[135],"than":[136],"newly":[137],"infiltrating":[138],"cells.":[141],"Our":[142],"data":[143],"provide":[144],"novel":[145],"insights":[146],"into":[147],"use":[149],"relieve":[154],"from":[158],"tumor":[163],"microenvironment":[164],"have":[166],"implications":[168],"for":[169],"cancer":[170],"immunotherapy":[171],"chronic":[175],"infections.":[176],"[Cancer":[177],"Res":[178],"2008;68(8):2972\u201383]":[179]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2023-03-31T00:00:00"}
