{"id":"https://openalex.org/W4361259797","doi":"https://doi.org/10.1158/0008-5472.22395765","title":"Supplementary Table 2 from RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer","display_name":"Supplementary Table 2 from RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361259797","doi":"https://doi.org/10.1158/0008-5472.22395765"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22395765","doi":"https://doi.org/10.1158/0008-5472.22395765","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22395765","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.22395765","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023344713","display_name":"Ronil A. Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronil A. Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074682099","display_name":"Kara D. Forinash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kara D. Forinash","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000278449","display_name":"Roberta Pireddu","orcid":"https://orcid.org/0000-0003-2322-2346","observed_orcids":["https://orcid.org/0000-0003-2322-2346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberta Pireddu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355567","display_name":"Ying Sun","orcid":"https://orcid.org/0000-0003-1984-007X","observed_orcids":["https://orcid.org/0000-0003-1984-007X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406405","display_name":"Nan Sun","orcid":"https://orcid.org/0000-0001-7583-9802","observed_orcids":["https://orcid.org/0000-0001-7583-9802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060153880","display_name":"Mathew P. Martin","orcid":"https://orcid.org/0000-0003-4810-3351","observed_orcids":["https://orcid.org/0000-0003-4810-3351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mathew P. Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024223427","display_name":"E. Sch\u00f6nbrunn","orcid":"https://orcid.org/0000-0002-3589-3510","observed_orcids":["https://orcid.org/0000-0002-3589-3510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernst Sch\u00f6nbrunn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027503793","display_name":"Nicholas J. Lawrence","orcid":"https://orcid.org/0000-0003-1129-2558","observed_orcids":["https://orcid.org/0000-0003-1129-2558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas J. Lawrence","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103060677","display_name":"Sa\u0131\u0308d M. Sebti","orcid":"https://orcid.org/0000-0001-5163-1038","observed_orcids":["https://orcid.org/0000-0001-5163-1038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sa\u00efd M. Sebti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rho-kinase-inhibitor","display_name":"ROCK inhibitor","score":0.7450000047683716},{"id":"https://openalex.org/keywords/rock-kinase","display_name":"ROCK kinase","score":0.6230000257492065},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-volume","display_name":"tumor volume","score":0.6259999871253967},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.8709999918937683},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.875},{"id":"https://openalex.org/keywords/anti-invasive-activity","display_name":"anti-invasive activity","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.566415548324585},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5411978363990784},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.5378913283348083},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5307676196098328},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.48400256037712097},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.458662211894989},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.4575549364089966},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.45164936780929565},{"id":"https://openalex.org/C2986637895","wikidata":"https://www.wikidata.org/wiki/Q953865","display_name":"Breast tumor","level":4,"score":0.4349886178970337},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3844931721687317},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3613482713699341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35023754835128784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34747201204299927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3161212205886841},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11318451166152954},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09309205412864685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07695499062538147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07149633765220642},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22395765","doi":"https://doi.org/10.1158/0008-5472.22395765","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22395765","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22395765.v1","doi":"https://doi.org/10.1158/0008-5472.22395765.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22395765.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_2_from_RKI-1447_Is_a_Potent_Inhibitor_of_the_Rho-Associated_ROCK_Kinases_with_Anti-Invasive_and_Antitumor_Activities_in_Breast_Cancer/22395765/1/files/39841392.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22395765","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Table_2_from_RKI-1447_Is_a_Potent_Inhibitor_of_the_Rho-Associated_ROCK_Kinases_with_Anti-Invasive_and_Antitumor_Activities_in_Breast_Cancer/22395765","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22395765","doi":"https://doi.org/10.1158/0008-5472.22395765","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22395765","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361259797.pdf","grobid_xml":"https://content.openalex.org/works/W4361259797.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361259799","https://openalex.org/W2139655719","https://openalex.org/W2041452091","https://openalex.org/W4210596121","https://openalex.org/W2335594606","https://openalex.org/W2258884648","https://openalex.org/W3179659298","https://openalex.org/W2017890252","https://openalex.org/W1662889716","https://openalex.org/W7100646632"],"abstract_inverted_index":{"PDF":[0],"file,":[1],"58K,":[2],"Percent":[3,29],"tumor":[4,14,32,38],"volume":[5,33,47,56],"change":[6,30],"after":[7],"mouse":[8],"treatment":[9],"with":[10,19],"vehicle.":[11],"ErbB2":[12],"mammary":[13],"transgenic":[15],"mice":[16],"were":[17],"treated":[18],"Vehicle":[20],"(20%":[21],"HPCD)":[22],"as":[23],"described":[24],"under":[25],"Materials":[26],"and":[27,53],"Methods.":[28],"in":[31],"was":[34],"calculated":[35],"for":[36],"each":[37],"using":[39],"the":[40,49,58],"following":[41],"formula;":[42],"(Vf-V0)/V0*100;":[43],"where":[44],"V0=":[45],"Initial":[46],"(at":[48,57],"beginning":[50],"of":[51,60],"treatment)":[52],"Vf=":[54],"Final":[55],"end":[59],"treatment).":[61]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-03-31T00:00:00"}