{"id":"https://openalex.org/W4361259770","doi":"https://doi.org/10.1158/0008-5472.c.6504389","title":"Data from Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma","display_name":"Data from Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361259770","doi":"https://doi.org/10.1158/0008-5472.c.6504389"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6504389","doi":"https://doi.org/10.1158/0008-5472.c.6504389","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6504389","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6504389","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103581339","display_name":"Kelly R. Ostler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly R. Ostler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Qiwei Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiwei Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042832211","display_name":"Timothy J. Looney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy J. Looney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425501","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-0698-0754","observed_orcids":["https://orcid.org/0000-0002-0698-0754","https://orcid.org/0009-0001-1086-4924"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102788564","display_name":"Aparna Vasanthakumar","orcid":"https://orcid.org/0000-0003-3857-8812","observed_orcids":["https://orcid.org/0000-0003-3857-8812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aparna Vasanthakumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100526542","display_name":"Yufeng Tian","orcid":"https://orcid.org/0000-0003-2564-0816","observed_orcids":["https://orcid.org/0000-0003-2564-0816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yufeng Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110546707","display_name":"Masha Kocherginsky","orcid":"https://orcid.org/0000-0002-3510-9562","observed_orcids":["https://orcid.org/0000-0002-3510-9562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masha Kocherginsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029649755","display_name":"Stacey L. Raimondi","orcid":"https://orcid.org/0000-0001-7667-6814","observed_orcids":["https://orcid.org/0000-0001-7667-6814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stacey L. Raimondi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038975181","display_name":"Jessica G. DeMaio","orcid":"https://orcid.org/0000-0001-9062-1422","observed_orcids":["https://orcid.org/0000-0001-9062-1422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica G. DeMaio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010357258","display_name":"Helen R. Salwen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen R. Salwen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060189952","display_name":"Song Gu","orcid":"https://orcid.org/0000-0002-6568-1623","observed_orcids":["https://orcid.org/0000-0002-6568-1623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Song Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003692438","display_name":"Alexandre Chlenski","orcid":"https://orcid.org/0000-0002-9885-4017","observed_orcids":["https://orcid.org/0000-0002-9885-4017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandre Chlenski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000459362","display_name":"Arlene H. Naranjo","orcid":"https://orcid.org/0000-0001-7737-4324","observed_orcids":["https://orcid.org/0000-0001-7737-4324"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arlene Naranjo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043627815","display_name":"Amy Gill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Gill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068817584","display_name":"Radhika Peddinti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radhika Peddinti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081946675","display_name":"Bruce T. Lahn","orcid":"https://orcid.org/0000-0002-6145-2217","observed_orcids":["https://orcid.org/0000-0002-6145-2217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce T. Lahn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035030496","display_name":"Susan Lerner Cohn","orcid":"https://orcid.org/0000-0001-5749-7650","observed_orcids":["https://orcid.org/0000-0001-5749-7650"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan L. Cohn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065240782","display_name":"Lucy A. Godley","orcid":"https://orcid.org/0000-0003-1914-9158","observed_orcids":["https://orcid.org/0000-0003-1914-9158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucy A. Godley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dnmt3b","display_name":"DNMT3B","score":0.925000011920929},{"id":"https://openalex.org/keywords/truncated-isoform","display_name":"truncated protein isoform","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7540000081062317},{"id":"https://openalex.org/keywords/ganglioneuroblastoma","display_name":"ganglioneuroblastoma","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.7549999952316284},{"id":"https://openalex.org/keywords/fos","display_name":"FOS","score":0.8130000233650208},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.996999979019165},{"id":"https://openalex.org/keywords/retinoic-acid-receptor","display_name":"retinoic acid receptor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2777142704","wikidata":"https://www.wikidata.org/wiki/Q15313456","display_name":"DNMT3B","level":5,"score":0.8325707316398621},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6940710544586182},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.681909441947937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6517547369003296},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.6020805239677429},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5415781140327454},{"id":"https://openalex.org/C102280478","wikidata":"https://www.wikidata.org/wiki/Q3270441","display_name":"AP-1 transcription factor","level":4,"score":0.540521502494812},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4736964702606201},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4582267701625824},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.42027518153190613},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39222338795661926},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35879766941070557},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.24942171573638916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2061256468296051},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16773125529289246}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6504389","doi":"https://doi.org/10.1158/0008-5472.c.6504389","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6504389","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6504389.v1","doi":"https://doi.org/10.1158/0008-5472.c.6504389.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6504389.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6504389","doi":"https://doi.org/10.1158/0008-5472.c.6504389","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6504389","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2117990418","https://openalex.org/W2023636140","https://openalex.org/W4245789673","https://openalex.org/W7159606697","https://openalex.org/W4361825103","https://openalex.org/W2996650680","https://openalex.org/W2565111727","https://openalex.org/W1980194279","https://openalex.org/W2045239093","https://openalex.org/W2800931272"],"abstract_inverted_index":{"Abstract":[0],"Epigenetic":[1],"changes":[2,201],"in":[3,37,47,63,69,78,109,119,126,141,173,196,202],"pediatric":[4],"neuroblastoma":[5,110,176,197],"may":[6,90],"contribute":[7],"to":[8,82,186,199,211],"the":[9,20,33,39,103,144,174,194],"aggressive":[10,94],"pathophysiology":[11],"of":[12,74,88,105,116,133,143],"this":[13,26,99],"disease,":[14],"but":[15],"little":[16],"is":[17,44],"known":[18],"about":[19],"basis":[21],"for":[22,32],"such":[23],"changes.":[24],"In":[25],"study,":[27],"we":[28,65,101],"examined":[29],"a":[30,92,113,138],"role":[31],"DNA":[34,56],"methyltransferase":[35],"DNMT3B,":[36],"particular,":[38],"truncated":[40],"isoform":[41],"DNMT3B7,":[42],"which":[43],"generated":[45],"frequently":[46],"cancer.":[48],"To":[49,97],"investigate":[50],"if":[51],"aberrant":[52],"DNMT3B":[53,67],"transcripts":[54],"alter":[55],"methylation,":[57],"gene":[58,203],"expression,":[59,204],"and":[60,121,123,137,146,164,208],"phenotypic":[61],"character":[62],"neuroblastoma,":[64],"measured":[66],"expression":[68,87,108,142,163],"primary":[70],"tumors.":[71],"Higher":[72],"levels":[73,132],"DNMT3B7":[75,89,107,192],"were":[76],"detected":[77],"differentiated":[79],"ganglioneuroblastomas":[80],"compared":[81,185],"undifferentiated":[83],"neuroblastomas,":[84],"suggesting":[85],"that":[86,150,191],"induce":[91,200],"less":[93],"clinical":[95],"phenotype.":[96],"test":[98],"hypothesis,":[100],"investigated":[102],"effects":[104],"enforced":[106],"cells,":[111],"finding":[112],"significant":[114],"inhibition":[115],"cell":[117],"proliferation":[118],"vitro":[120],"angiogenesis":[122],"tumor":[124,206],"growth":[125],"vivo.":[127],"DNMT3B7-positive":[128],"cells":[129,177,198],"had":[130],"higher":[131],"total":[134],"genomic":[135],"methylation":[136],"dramatic":[139],"decrease":[140],"FOS":[145],"JUN":[147],"family":[148],"members":[149],"comprise":[151],"AP1":[152,162],"transcription":[153],"factors.":[154],"Consistent":[155],"with":[156,180],"an":[157],"established":[158],"antagonistic":[159],"relationship":[160],"between":[161],"retinoic":[165,182],"acid":[166,183],"receptor":[167],"activity,":[168],"increased":[169],"differentiation":[170],"was":[171],"seen":[172],"DNMT3B7-expressing":[175],"following":[178],"treatment":[179],"all-trans":[181],"(ATRA)":[184],"controls.":[187],"Our":[188],"results":[189],"indicate":[190],"modifies":[193],"epigenome":[195],"inhibit":[205],"growth,":[207],"increase":[209],"sensitivity":[210],"ATRA.":[212],"Cancer":[213],"Res;":[214],"72(18);":[215],"4714\u201323.":[216],"\u00a92012":[217],"AACR.":[218]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-03-31T00:00:00"}
