{"id":"https://openalex.org/W4361256757","doi":"https://doi.org/10.1158/0008-5472.22417127","title":"Supplemental Figures 5-8 from Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer","display_name":"Supplemental Figures 5-8 from Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361256757","doi":"https://doi.org/10.1158/0008-5472.22417127"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22417127","doi":"https://doi.org/10.1158/0008-5472.22417127","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22417127","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.22417127","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061034435","display_name":"Jason P.W. Carey","orcid":"https://orcid.org/0000-0002-9729-1742","observed_orcids":["https://orcid.org/0000-0002-9729-1742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason. P.W. Carey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011734599","display_name":"Cansu Karaka\u015f","orcid":"https://orcid.org/0000-0003-0357-5224","observed_orcids":["https://orcid.org/0000-0003-0357-5224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cansu Karakas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000113218","display_name":"Tuyen N. Bui","orcid":"https://orcid.org/0000-0001-8509-3653","observed_orcids":["https://orcid.org/0000-0001-8509-3653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tuyen Bui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422537","display_name":"Xian Chen","orcid":"https://orcid.org/0009-0000-5344-6012","observed_orcids":["https://orcid.org/0009-0000-5344-6012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xian Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006097717","display_name":"Smruthi Vijayaraghavan","orcid":"https://orcid.org/0000-0002-8131-0988","observed_orcids":["https://orcid.org/0000-0002-8131-0988"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Smruthi Vijayaraghavan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052526310","display_name":"Yang William Zhao","orcid":"https://orcid.org/0000-0002-6011-5948","observed_orcids":["https://orcid.org/0000-0002-6011-5948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378341","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-5398-0802","observed_orcids":["https://orcid.org/0000-0002-5398-0802","https://orcid.org/0009-0006-4171-5397","https://orcid.org/0000-0002-8911-9555","https://orcid.org/0009-0003-0661-5954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058106142","display_name":"Keith W. Mikule","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith Mikule","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014713051","display_name":"Jennifer Keating Litton","orcid":"https://orcid.org/0000-0001-8390-4985","observed_orcids":["https://orcid.org/0000-0001-8390-4985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer K. Litton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017411324","display_name":"Kelly K. Hunt","orcid":"https://orcid.org/0000-0001-9156-8723","observed_orcids":["https://orcid.org/0000-0001-9156-8723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly K. Hunt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042960706","display_name":"Khandan Keyomarsi","orcid":"https://orcid.org/0000-0002-5440-0849","observed_orcids":["https://orcid.org/0000-0002-5440-0849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khandan Keyomarsi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.9459999799728394},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.8529999852180481},{"id":"https://openalex.org/keywords/brca-status","display_name":"BRCA mutation status","score":0.7279999852180481},{"id":"https://openalex.org/keywords/dna-repair-pathways","display_name":"DNA repair pathways","score":0.9200000166893005},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.5450000166893005},{"id":"https://openalex.org/keywords/sum149-cells","display_name":"SUM149 cells","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7376832962036133},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.6511256694793701},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.609196126461029},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.575663685798645},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.567315399646759},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.556131899356842},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.5363377928733826},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5064679384231567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4883977770805359},{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.47055935859680176},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46325525641441345},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3736633062362671},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3571474552154541},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3389432728290558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30879753828048706},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.19717198610305786},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19707822799682617},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.18977391719818115},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09107699990272522},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.22417127","doi":"https://doi.org/10.1158/0008-5472.22417127","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22417127","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22417127","doi":"https://doi.org/10.1158/0008-5472.22417127","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22417127","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361257167","https://openalex.org/W2769003179","https://openalex.org/W2765145927","https://openalex.org/W4393086019","https://openalex.org/W4404968898","https://openalex.org/W4409631275","https://openalex.org/W4411291136","https://openalex.org/W3119481844","https://openalex.org/W4361945743","https://openalex.org/W2570352383"],"abstract_inverted_index":{"Supplementary":[0,11,22,36],"Figure":[1,12,23,37],"5":[2],"PARPi":[3],"sensitivity":[4],"of":[5,16,27,40],"BRCA1":[6],"short":[7],"hairpin":[8],"(shBRCA1)-knockdown":[9],"cells.":[10],"6":[13],"TCGA":[14],"analysis":[15,26],"MYC":[17,41],"and":[18,33,50],"DNA":[19],"repair":[20],"pathway.":[21],"7":[24],"Immunohistochemical":[25],"a":[28],"TNBC":[29,46],"patient":[30],"cohort":[31],"before":[32],"after":[34],"chemotherapy.":[35],"8":[38],"Inhibition":[39],"expression":[42],"(via":[43],"siMYC)":[44],"in":[45],"cell":[47],"lines":[48],"(MB231":[49],"SUM149).":[51]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-03-31T00:00:00"}
