{"id":"https://openalex.org/W4361254595","doi":"https://doi.org/10.1158/0008-5472.c.6494129","title":"Data from Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasion","display_name":"Data from Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasion","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361254595","doi":"https://doi.org/10.1158/0008-5472.c.6494129"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6494129","doi":"https://doi.org/10.1158/0008-5472.c.6494129","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6494129","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6494129","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028477575","display_name":"Arnold H. Zea","orcid":"https://orcid.org/0000-0002-1272-0027","observed_orcids":["https://orcid.org/0000-0002-1272-0027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnold H. Zea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032410036","display_name":"Paulo C. Rodr\u0131\u0301guez","orcid":"https://orcid.org/0000-0001-7480-6566","observed_orcids":["https://orcid.org/0000-0001-7480-6566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paulo C. Rodriguez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052526230","display_name":"Michael B. Atkins","orcid":"https://orcid.org/0000-0003-3901-9924","observed_orcids":["https://orcid.org/0000-0003-3901-9924"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael B. Atkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110875","display_name":"Claudia M. Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-4607-0536","observed_orcids":["https://orcid.org/0000-0002-4607-0536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Hernandez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046795494","display_name":"Sabina Signoretti","orcid":"https://orcid.org/0000-0002-5000-9105","observed_orcids":["https://orcid.org/0000-0002-5000-9105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabina Signoretti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030449403","display_name":"Jovanny Zabaleta","orcid":"https://orcid.org/0000-0002-5961-6761","observed_orcids":["https://orcid.org/0000-0002-5961-6761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jovanny Zabaleta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007052233","display_name":"David F. McDermott","orcid":"https://orcid.org/0000-0002-2675-5095","observed_orcids":["https://orcid.org/0000-0002-2675-5095","https://orcid.org/0000-0001-6978-0867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David McDermott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062311446","display_name":"David G. Quiceno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Quiceno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025859134","display_name":"Amanda Youmans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Youmans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045549","display_name":"Anne O\u2019Neill","orcid":"https://orcid.org/0009-0002-7334-4560","observed_orcids":["https://orcid.org/0009-0002-7334-4560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne O'Neill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108518835","display_name":"James Walter Mier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Mier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004037751","display_name":"Augusto C. Ochoa","orcid":"https://orcid.org/0000-0001-6457-8029","observed_orcids":["https://orcid.org/0000-0001-6457-8029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Augusto C. Ochoa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arginase","display_name":"arginase","score":0.921999990940094},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7879999876022339},{"id":"https://openalex.org/keywords/arginine-deprivation","display_name":"arginine deprivation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ornithine","display_name":"ornithine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.9675454497337341},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.7295653223991394},{"id":"https://openalex.org/C2776796294","wikidata":"https://www.wikidata.org/wiki/Q410198","display_name":"Ornithine","level":4,"score":0.6125892400741577},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5945268869400024},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5558536648750305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4827679693698883},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.4161491096019745},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3576001524925232},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3343221843242645},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.31835806369781494},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2912256717681885},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.27392423152923584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2179381549358368},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13918370008468628},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.1317075788974762},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6494129","doi":"https://doi.org/10.1158/0008-5472.c.6494129","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6494129","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6494129","doi":"https://doi.org/10.1158/0008-5472.c.6494129","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6494129","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134401635","https://openalex.org/W2138654133","https://openalex.org/W4361822473","https://openalex.org/W2054246680","https://openalex.org/W2321069046","https://openalex.org/W2548879187","https://openalex.org/W3190076594","https://openalex.org/W2920895864","https://openalex.org/W2171506577","https://openalex.org/W3024126283"],"abstract_inverted_index":{"Abstract":[0],"Myeloid":[1],"suppressor":[2,77,188,208],"cells":[3,56,78,91,149,162,189,210],"with":[4,16,95,150],"high":[5,80,176],"arginase":[6,41,81,110,137,212,225],"activity":[7,42,138],"are":[8],"found":[9,104],"in":[10,46,83,164,180,213,231],"tumors":[11],"and":[12,18,32,37,120,155,175,194],"spleen":[13],"of":[14,69,124,145,158,173,178,183,207,234],"mice":[15],"colon":[17],"lung":[19],"cancer.":[20],"These":[21,112,198],"cells,":[22,29],"described":[23,45,163],"as":[24],"macrophages":[25,159],"or":[26,160],"immature":[27],"dendritic":[28,161],"deplete":[30],"arginine":[31,58,174],"impair":[33],"T":[34,125,191],"cell":[35,65,85,98,126,192],"proliferation":[36,193],"cytokine":[38,118],"production.":[39],"Although":[40],"has":[43],"been":[44],"cancer":[47,215],"patients,":[48],"it":[49,219],"is":[50],"thought":[51],"to":[52,59,62,73,101,105,141],"originate":[53],"from":[54,92],"tumor":[55],"metabolizing":[57],"ornithine":[60,179],"needed":[61],"sustain":[63],"rapid":[64],"proliferation.":[66],"The":[67],"goal":[68],"this":[70],"study":[71],"was":[72,139],"determine":[74],"whether":[75],"myeloid":[76,187,209],"producing":[79,211],"existed":[82],"renal":[84,97],"carcinoma":[86],"patients.":[87,216],"Peripheral":[88],"blood":[89],"mononuclear":[90],"123":[93],"patients":[94,113,169],"metastatic":[96],"carcinoma,":[99],"prior":[100],"treatment,":[102],"were":[103],"have":[106],"a":[107,115,142,151],"significantly":[108],"increased":[109,136],"activity.":[111],"had":[114,170],"markedly":[116],"decreased":[117],"production":[119],"expressed":[121],"low":[122,171],"levels":[123,172,177],"receptor":[127],"CD3\u03b6":[128,195],"chain.":[129],"Cell":[130],"separation":[131],"studies":[132],"showed":[133],"that":[134,223],"the":[135,184,202,205,221,232],"limited":[140],"specific":[143],"subset":[144],"CD11b+,":[146,185],"CD14\u2212,":[147],"CD15+":[148],"polymorphonuclear":[152],"granulocyte":[153],"morphology":[154],"markers,":[156],"instead":[157],"mouse":[165],"models.":[166],"Furthermore,":[167],"these":[168],"plasma.":[181],"Depletion":[182],"CD14\u2212":[186],"reestablished":[190],"chain":[196],"expression.":[197],"results":[199],"showed,":[200],"for":[201],"first":[203],"time,":[204],"existence":[206],"human":[214],"In":[217],"addition,":[218],"supports":[220],"concept":[222],"blocking":[224],"may":[226],"be":[227],"an":[228],"important":[229],"step":[230],"success":[233],"immunotherapy.":[235]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-03-31T00:00:00"}