{"id":"https://openalex.org/W4361247346","doi":"https://doi.org/10.1158/0008-5472.c.6497165.v1","title":"Data from A Small-Molecule E2F Inhibitor Blocks Growth in a Melanoma Culture Model","display_name":"Data from A Small-Molecule E2F Inhibitor Blocks Growth in a Melanoma Culture Model","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361247346","doi":"https://doi.org/10.1158/0008-5472.c.6497165.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6497165.v1","doi":"https://doi.org/10.1158/0008-5472.c.6497165.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6497165.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6497165.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088825137","display_name":"Yihong Ma","orcid":"https://orcid.org/0000-0001-8710-4707","observed_orcids":["https://orcid.org/0000-0001-8710-4707","https://orcid.org/0000-0003-4729-5953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yihong Ma","raw_affiliation_strings":["Molecular Oncology Program and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Program and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021459182","display_name":"Courtney A. Kurtyka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Courtney A. Kurtyka","raw_affiliation_strings":["Molecular Oncology Program and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Program and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002494985","display_name":"Sandhya Boyapalle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandhya Boyapalle","raw_affiliation_strings":["Molecular Oncology Program and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Program and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108216537","display_name":"Shen\u2010Shu Sung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shen-Shu Sung","raw_affiliation_strings":["High Throughput Screening and Chemistry Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Throughput Screening and Chemistry Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057921101","display_name":"Harshani R. Lawrence","orcid":"https://orcid.org/0000-0002-9263-7775","observed_orcids":["https://orcid.org/0000-0002-9263-7775"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harshani Lawrence","raw_affiliation_strings":["High Throughput Screening and Chemistry Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Throughput Screening and Chemistry Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061379138","display_name":"Wayne C. Guida","orcid":"https://orcid.org/0000-0003-3353-4853","observed_orcids":["https://orcid.org/0000-0003-3353-4853"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne Guida","raw_affiliation_strings":["High Throughput Screening and Chemistry Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Throughput Screening and Chemistry Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053258201","display_name":"William Douglas Cress","orcid":"https://orcid.org/0000-0002-9119-3658","observed_orcids":["https://orcid.org/0000-0002-9119-3658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Douglas Cress","raw_affiliation_strings":["Molecular Oncology Program and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Program and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7789999842643738},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/e2f-target-genes","display_name":"E2F target genes","score":0.734000027179718},{"id":"https://openalex.org/keywords/a375-cells","display_name":"A375 cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mouse-embryonic-fibroblasts","display_name":"mouse embryonic fibroblasts","score":0.8399999737739563},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"virtual screening","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6852381825447083},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.555957019329071},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5419526696205139},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5323050022125244},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.5182366371154785},{"id":"https://openalex.org/C83258922","wikidata":"https://www.wikidata.org/wiki/Q24771933","display_name":"E2F","level":4,"score":0.49893856048583984},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4611281752586365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45076924562454224},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4311944842338562},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4114798903465271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3909074068069458},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.28979629278182983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18834906816482544},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13269531726837158},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08692583441734314}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6497165.v1","doi":"https://doi.org/10.1158/0008-5472.c.6497165.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6497165.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6497165.v1","doi":"https://doi.org/10.1158/0008-5472.c.6497165.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6497165.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1481014355","https://openalex.org/W1609607086","https://openalex.org/W1950559180","https://openalex.org/W1952139389","https://openalex.org/W1957295278","https://openalex.org/W1976817291","https://openalex.org/W1985588649","https://openalex.org/W1999656457","https://openalex.org/W2001070862","https://openalex.org/W2004355167","https://openalex.org/W2007840001","https://openalex.org/W2026226318","https://openalex.org/W2032643249","https://openalex.org/W2035822469","https://openalex.org/W2043999454","https://openalex.org/W2064200041","https://openalex.org/W2074920283","https://openalex.org/W2086602499","https://openalex.org/W2089271371","https://openalex.org/W2095073038","https://openalex.org/W2101297848","https://openalex.org/W2125072003","https://openalex.org/W2152264745","https://openalex.org/W2169238577","https://openalex.org/W2181336523","https://openalex.org/W2332826805","https://openalex.org/W2335175983","https://openalex.org/W2791873134"],"related_works":["https://openalex.org/W2150366724","https://openalex.org/W7043279244","https://openalex.org/W2801356018","https://openalex.org/W2326491256","https://openalex.org/W1500939379","https://openalex.org/W2119271276","https://openalex.org/W2107252213","https://openalex.org/W2968291860","https://openalex.org/W4361822736","https://openalex.org/W2790402681"],"abstract_inverted_index":{"Abstract":[0],"HLM006474":[1,25,47,64,83,131],"was":[2,132],"identified":[3],"using":[4,158],"a":[5,73,87,133,143],"computer-based":[6],"virtual":[7],"screen":[8],"and":[9,78,92,130,139],"the":[10,15,28,105,109,121,125],"known":[11,58],"crystal":[12],"structure":[13],"of":[14,20,30,51,63,108,124,136],"DNA-bound":[16],"E2F4/DP2":[17],"heterodimer.":[18],"Treatment":[19],"multiple":[21],"cell":[22,68,76],"lines":[23,69],"with":[24,155],"resulted":[26,48],"in":[27,49,75,81,86,127,142,165],"loss":[29],"intracellular":[31],"E2F4":[32,53],"DNA-binding":[33],"activity":[34,107,123,157],"as":[35,55,57],"measured":[36],"by":[37],"electrophoretic":[38],"mobility":[39],"shift":[40],"assay":[41],"within":[42],"hours.":[43],"Overnight":[44],"exposure":[45],"to":[46,104,120],"down-regulation":[50],"total":[52],"protein":[54],"well":[56],"E2F":[59,156],"targets.":[60],"The":[61],"effects":[62],"treatment":[65],"on":[66],"different":[67],"varied":[70],"but":[71],"included":[72],"reduction":[74],"proliferation":[77,138],"an":[79],"increase":[80],"apoptosis.":[82],"induced":[84],"apoptosis":[85],"manner":[88],"distinct":[89],"from":[90],"cisplatin":[91],"doxorubicin.":[93],"E2F4-null":[94],"mouse":[95],"embryonic":[96],"fibroblasts":[97],"were":[98,117],"less":[99],"sensitive":[100,119],"than":[101],"wild-type":[102],"counterparts":[103],"apoptosis-inducing":[106,122],"compound,":[110],"revealing":[111],"its":[112],"biological":[113],"specificity.":[114],"A375":[115],"cells":[116],"extremely":[118],"compound":[126],"two-dimensional":[128],"culture,":[129],"potent":[134],"inhibitor":[135],"melanocytes":[137],"subsequent":[140],"invasion":[141],"three-dimensional":[144],"tissue":[145],"culture":[146],"model":[147],"system.":[148],"Together,":[149],"these":[150],"results":[151],"suggest":[152],"that":[153],"interference":[154],"small":[159],"molecules":[160],"may":[161],"have":[162],"clinical":[163],"application":[164],"cancer":[166],"therapy.":[167],"[Cancer":[168],"Res":[169],"2008;68(15):6292\u20139]":[170]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-03-31T00:00:00"}
