{"id":"https://openalex.org/W4361246650","doi":"https://doi.org/10.1158/0008-5472.c.6496457.v1","title":"Data from Automated, Quantitative Screening Assay for Antiangiogenic Compounds Using Transgenic Zebrafish","display_name":"Data from Automated, Quantitative Screening Assay for Antiangiogenic Compounds Using Transgenic Zebrafish","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361246650","doi":"https://doi.org/10.1158/0008-5472.c.6496457.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6496457.v1","doi":"https://doi.org/10.1158/0008-5472.c.6496457.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6496457.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6496457.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111660526","display_name":"T. Cameron Tran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Cameron Tran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061379685","display_name":"Blossom Sneed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Blossom Sneed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033905706","display_name":"Jamil Haider","orcid":"https://orcid.org/0009-0004-9675-8613","observed_orcids":["https://orcid.org/0009-0004-9675-8613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamil Haider","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050331335","display_name":"Delali Blavo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delali Blavo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Audrey White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Audrey White","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083969723","display_name":"Temitope Aiyejorun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Temitope Aiyejorun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038661202","display_name":"Timothy C. Baranowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy C. Baranowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113699665","display_name":"Amy L. Rubinstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy L. Rubinstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024811779","display_name":"Thanh N. Doan","orcid":"https://orcid.org/0000-0001-9079-9087","observed_orcids":["https://orcid.org/0000-0001-9079-9087"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thanh N. Doan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041248710","display_name":"Raymond J Dingledine","orcid":"https://orcid.org/0000-0001-7128-4520","observed_orcids":["https://orcid.org/0000-0001-7128-4520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond Dingledine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046059762","display_name":"Eric M. Sandberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric M. Sandberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-angiogenic-compounds","display_name":"anti-angiogenic compounds","score":0.972000002861023},{"id":"https://openalex.org/keywords/transgenic-zebrafish","display_name":"transgenic zebrafish","score":0.8989999890327454},{"id":"https://openalex.org/keywords/automated-high-throughput-screening","display_name":"automated high-throughput screening","score":0.8309999704360962},{"id":"https://openalex.org/keywords/angiogenesis-assay","display_name":"angiogenesis assay","score":0.5820000171661377},{"id":"https://openalex.org/keywords/indirubin-3-monoxime","display_name":"indirubin-3'-monoxime","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ag1478","display_name":"AG1478","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.847000002861023},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9508945941925049},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7269676923751831},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5339585542678833},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4629875421524048},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42349761724472046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4037016034126282},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3871806263923645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23722580075263977},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18941855430603027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0707787573337555}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6496457.v1","doi":"https://doi.org/10.1158/0008-5472.c.6496457.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6496457.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6496457.v1","doi":"https://doi.org/10.1158/0008-5472.c.6496457.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6496457.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2016046902","https://openalex.org/W2989451149","https://openalex.org/W6995949344","https://openalex.org/W1533466347","https://openalex.org/W4293047621","https://openalex.org/W2227848099","https://openalex.org/W1562759933","https://openalex.org/W2063299186","https://openalex.org/W2949942700","https://openalex.org/W4390047540"],"abstract_inverted_index":{"Abstract":[0],"Pathologic":[1],"angiogenesis":[2,143,202],"has":[3,195],"emerged":[4],"as":[5,104],"an":[6],"important":[7],"therapeutic":[8],"target":[9],"in":[10,22,64,80,131,140,189,198],"several":[11],"major":[12],"diseases.":[13],"Zebrafish":[14],"offer":[15],"the":[16,29,74,88,124,141,154,158,183],"potential":[17],"for":[18,34,57,92],"high-throughput":[19],"drug":[20],"discovery":[21],"a":[23,69,190],"whole":[24],"vertebrate":[25],"system.":[26],"We":[27,54,119],"developed":[28,55,68],"first":[30,184],"quantitative,":[31],"automated":[32,58],"assay":[33,42,83,144,192],"antiangiogenic":[35,93,97,113,129,185],"compound":[36,90,108,186],"identification":[37],"using":[38],"zebrafish":[39,45,63,142,191],"embryos.":[40],"This":[41],"uses":[43],"transgenic":[44],"with":[46,109],"fluorescent":[47],"blood":[48,78],"vessels":[49,79],"to":[50,72,86],"facilitate":[51],"image":[52],"analysis.":[53],"methods":[56],"drugging":[59],"and":[60,67,100,138,148,171,176],"imaging":[61],"of":[62,76,123,135,157,174],"384-well":[65],"plates":[66],"custom":[70],"algorithm":[71],"quantify":[73],"number":[75],"angiogenic":[77],"zebrafish.":[81,132],"The":[82,133],"was":[84,117,145],"used":[85],"screen":[87],"LOPAC1280":[89],"library":[91],"compounds.":[94,160],"Two":[95],"known":[96,112],"compounds,":[98],"SU4312":[99],"AG1478,":[101,137],"were":[102],"identified":[103],"hits.":[105],"Additionally,":[106],"one":[107],"no":[110],"previously":[111],"activity,":[114],"indirubin-3\u2032-monoxime":[115],"(IRO),":[116],"identified.":[118],"showed":[120],"that":[121,193],"each":[122],"hit":[125,159],"compounds":[126],"had":[127,153],"dose-dependent":[128],"activity":[130,197],"IC50":[134],"SU4312,":[136],"IRO":[139,152,162],"1.8,":[146],"8.5,":[147],"0.31":[149],"\u03bcmol/L,":[150,178],"respectively.":[151],"highest":[155],"potency":[156],"Moreover,":[161],"inhibited":[163],"human":[164,199],"umbilical":[165],"vein":[166],"endothelial":[167,200],"cell":[168],"tube":[169],"formation":[170],"proliferation":[172],"(IC50":[173],"6.5":[175],"0.36":[177],"respectively).":[179],"It":[180],"is":[181],"therefore":[182],"discovered":[187],"initially":[188],"also":[194],"demonstrable":[196],"cell-based":[201],"assays.":[203],"[Cancer":[204],"Res":[205],"2007;67(23):11386\u201392]":[206]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-03-31T00:00:00"}
