{"id":"https://openalex.org/W4361246527","doi":"https://doi.org/10.1158/0008-5472.c.6497183","title":"Data from Glioma Pathogenesis-Related Protein 1 Exerts Tumor Suppressor Activities through Proapoptotic Reactive Oxygen Species\u2013c-Jun\u2013NH2 Kinase Signaling","display_name":"Data from Glioma Pathogenesis-Related Protein 1 Exerts Tumor Suppressor Activities through Proapoptotic Reactive Oxygen Species\u2013c-Jun\u2013NH2 Kinase Signaling","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361246527","doi":"https://doi.org/10.1158/0008-5472.c.6497183"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6497183","doi":"https://doi.org/10.1158/0008-5472.c.6497183","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6497183","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6497183","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103233838","display_name":"Likun Li","orcid":"https://orcid.org/0000-0002-1027-1352","observed_orcids":["https://orcid.org/0000-0002-1027-1352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Likun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110482","display_name":"Elmoataz Abdel Fattah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ElMoataz Abdel Fattah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072964389","display_name":"Guangwen Cao","orcid":"https://orcid.org/0000-0002-8094-1278","observed_orcids":["https://orcid.org/0000-0002-8094-1278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangwen Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905342","display_name":"Chengzhen Ren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chengzhen Ren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Guang Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guang Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103207936","display_name":"Alexei A. Goltsov","orcid":"https://orcid.org/0009-0000-1128-6372","observed_orcids":["https://orcid.org/0009-0000-1128-6372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexei A. Goltsov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111716329","display_name":"A. Craig Chinault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Craig Chinault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012970732","display_name":"Wei\u2010Wen Cai","orcid":"https://orcid.org/0009-0000-7756-4160","observed_orcids":["https://orcid.org/0009-0000-7756-4160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-Wen Cai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113538214","display_name":"Terry L. Timme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terry L. Timme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042000405","display_name":"Timothy C. Thompson","orcid":"https://orcid.org/0000-0003-1424-3831","observed_orcids":["https://orcid.org/0000-0003-1424-3831"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy C. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glipr1","display_name":"GLIPR1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7900000214576721},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9049999713897705},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/p53-target-genes","display_name":"p53 target genes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-free-survival","display_name":"tumor-free survival","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5195810794830322},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4662666916847229},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44507113099098206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40665948390960693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4049920439720154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3695703446865082},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29523807764053345},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.26687851548194885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10894957184791565}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6497183","doi":"https://doi.org/10.1158/0008-5472.c.6497183","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6497183","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6497183.v1","doi":"https://doi.org/10.1158/0008-5472.c.6497183.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6497183.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6497183","doi":"https://doi.org/10.1158/0008-5472.c.6497183","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6497183","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052233102","https://openalex.org/W2112075146","https://openalex.org/W1949969406","https://openalex.org/W2090303608","https://openalex.org/W7098273896","https://openalex.org/W4392726108","https://openalex.org/W3138915752","https://openalex.org/W2110560370","https://openalex.org/W6902437104","https://openalex.org/W2122907368"],"abstract_inverted_index":{"Abstract":[0],"Glioma":[1],"pathogenesis-related":[2],"protein":[3],"1":[4],"(GLIPR1),":[5],"a":[6,43,142,180],"novel":[7],"p53":[8],"target":[9],"gene,":[10],"is":[11,49,75],"down-regulated":[12],"by":[13],"methylation":[14],"in":[15,25,78,90,99,130],"prostate":[16,80,87],"cancer":[17,93,100],"and":[18,21,51,89,108,133,189],"has":[19,63],"p53-dependent":[20],"-independent":[22],"proapoptotic":[23,181],"activities":[24],"tumor":[26,33,44,60,81,182],"cells.":[27],"These":[28],"properties":[29],"suggest":[30],"an":[31,114],"important":[32],"suppressor":[34,45,61,183],"role":[35],"for":[36,47,194],"GLIPR1,":[37],"yet":[38],"direct":[39],"genetic":[40,135],"evidence":[41],"of":[42,73,97,105,110,141,145,157,167],"function":[46],"GLIPR1":[48,57,74,98,152,178],"lacking":[50],"the":[52,71,155,168,186,191],"molecular":[53],"mechanism(s),":[54],"through":[55,165,185],"which":[56],"exerts":[58],"its":[59],"functions,":[62],"not":[64],"been":[65],"shown.":[66],"Here,":[67],"we":[68],"report":[69],"that":[70,151],"expression":[72],"significantly":[76,119],"reduced":[77],"human":[79,92],"tissues":[82,88],"compared":[83],"with":[84,113],"adjacent":[85],"normal":[86],"multiple":[91],"cell":[94],"lines.":[95],"Overexpression":[96],"cells":[101],"leads":[102],"to":[103,138,163],"suppression":[104],"colony":[106],"growth":[107],"induction":[109],"apoptosis.":[111],"Mice":[112],"inactivated":[115],"Glipr1":[116],"gene":[117],"had":[118],"shorter":[120],"tumor-free":[121],"survival":[122],"times":[123],"than":[124],"either":[125],"Glipr1+/+":[126],"or":[127],"Glipr1+/\u2212":[128],"mice":[129],"both":[131],"p53+/+":[132],"p53+/\u2212":[134],"backgrounds,":[136],"owing":[137],"their":[139],"development":[140],"unique":[143],"array":[144],"malignant":[146],"tumors.":[147],"Mechanistic":[148],"analysis":[149],"indicated":[150],"up-regulation":[153],"increases":[154],"production":[156],"reactive":[158],"oxygen":[159],"species":[160],"(ROS)":[161],"leading":[162],"apoptosis":[164],"activation":[166],"c-Jun\u2013NH2":[169],"kinase":[170],"(JNK)":[171],"signaling":[172],"cascade.":[173],"Thus,":[174],"our":[175],"results":[176],"identify":[177],"as":[179],"acting":[184],"ROS-JNK":[187],"pathway":[188],"support":[190],"therapeutic":[192],"potential":[193],"this":[195],"protein.":[196],"[Cancer":[197],"Res":[198],"2008;68(2):434\u201343]":[199]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-03-31T00:00:00"}