{"id":"https://openalex.org/W4361244136","doi":"https://doi.org/10.1158/0008-5472.c.6500219","title":"Data from Phosphomimetic Mutants of Pigment Epithelium-Derived Factor with Enhanced Antiangiogenic Activity as Potent Anticancer Agents","display_name":"Data from Phosphomimetic Mutants of Pigment Epithelium-Derived Factor with Enhanced Antiangiogenic Activity as Potent Anticancer Agents","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361244136","doi":"https://doi.org/10.1158/0008-5472.c.6500219"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6500219","doi":"https://doi.org/10.1158/0008-5472.c.6500219","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6500219","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6500219","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069920831","display_name":"Alexander Konson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Konson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043392987","display_name":"Sunila Pradeep","orcid":"https://orcid.org/0000-0003-2441-7727","observed_orcids":["https://orcid.org/0000-0003-2441-7727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunila Pradeep","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079331236","display_name":"Rony Seger","orcid":"https://orcid.org/0000-0001-9363-8852","observed_orcids":["https://orcid.org/0000-0001-9363-8852"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rony Seger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pigment-epithelium-derived-factor","display_name":"pigment epithelium-derived factor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/phosphomimetic-mutant","display_name":"phosphomimetic mutant","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.828000009059906},{"id":"https://openalex.org/keywords/endothelial-cell-apoptosis","display_name":"endothelial cell apoptosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/vegf-independent-angiogenesis","display_name":"VEGF-independent angiogenesis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/vegf-receptor-2","display_name":"VEGF receptor 2","score":0.8050000071525574},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8159999847412109},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.7559999823570251},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C52237779","wikidata":"https://www.wikidata.org/wiki/Q18030441","display_name":"PEDF","level":3,"score":0.9903464317321777},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7297008037567139},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.601975679397583},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5891520977020264},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.520915687084198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4998204708099365},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4972279369831085},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4966610074043274},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42270174622535706},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3540951609611511},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2490113079547882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1904798150062561},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.10181298851966858}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6500219","doi":"https://doi.org/10.1158/0008-5472.c.6500219","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6500219","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6500219","doi":"https://doi.org/10.1158/0008-5472.c.6500219","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6500219","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981182292","https://openalex.org/W2319632197","https://openalex.org/W2889423514","https://openalex.org/W2077753445","https://openalex.org/W2157266866","https://openalex.org/W1998718523","https://openalex.org/W2096478643","https://openalex.org/W2134168653","https://openalex.org/W3016349393","https://openalex.org/W2132063659"],"abstract_inverted_index":{"Abstract":[0],"Pigment":[1],"epithelium-derived":[2],"factor":[3,42,116],"(PEDF)":[4],"is":[5,95,180,224,245],"an":[6,177],"endogenous":[7],"inhibitor":[8],"of":[9,17,40,54,91,99,126,150,168,186,212,221,228,242,254],"angiogenesis":[10],"and":[11,35,73,82,129,146,193,205,250],"a":[12,112],"promising":[13],"anticancer":[14,260],"agent":[15,103],"capable":[16],"suppressing":[18],"solid":[19],"tumor":[20],"growth":[21,72,115,191],"in":[22,70,75,111,171,183,247],"animal":[23],"cancer":[24,214],"models.":[25,86],"We":[26],"have":[27,235],"previously":[28],"shown":[29],"that":[30,36,51,98,138,163,179,217],"PEDF":[31,69,139,164,204,255],"can":[32],"be":[33],"phosphorylated":[34],"distinct":[37],"phosphorylation":[38],"states":[39],"this":[41],"differentially":[43],"regulate":[44],"its":[45,206],"physiologic":[46],"function.":[47],"Here,":[48],"we":[49],"report":[50],"phosphomimetic":[52,93],"mutants":[53,94,140,165,207,256],"PEDF,":[55],"which":[56,244],"possess":[57],"significantly":[58],"increased":[59],"antiangiogenic":[60,102,219],"activity,":[61],"are":[62],"much":[63,173,195],"more":[64],"efficient":[65],"than":[66,175],"wild-type":[67],"(WT)":[68],"inhibiting":[71],"neovascularization":[74],"MDA-MB-231":[76],"(breast":[77],"cancer),":[78,81],"HCT116":[79],"(colon":[80],"U87-MG":[83],"(glioblastoma)":[84],"xenograft":[85],"Importantly,":[87],"the":[88,92,100,124,148,184,201,218,225,229,240,252],"antitumor":[89,231],"activity":[90,220],"comparable":[96],"with":[97],"established":[101],"bevacizumab.":[104],"However,":[105],"unlike":[106],"bevacizumab,":[107],"these":[108,222],"compounds":[109],"act":[110],"vascular":[113,152],"endothelial":[114,144,156,169,197],"(VEGF)\u2013independent":[117],"manner,":[118],"as":[119,257],"they":[120],"do":[121],"not":[122,209],"affect":[123,141,210],"levels":[125],"VEGF-A":[127],"mRNA":[128],"VEGF":[130,187],"receptor":[131],"2":[132],"phosphorylation.":[133],"Further":[134],"immunohistochemical":[135],"analysis":[136],"revealed":[137],"mainly":[142],"tumor-residing":[143],"cells":[145,170],"prevent":[147],"formation":[149],"intratumoral":[151],"network":[153],"by":[154],"facilitating":[155],"cell":[157,198],"apoptosis.":[158,199],"It":[159],"was":[160],"also":[161],"found":[162],"reduce":[166],"survival":[167,211],"culture":[172],"better":[174],"WT-PEDF,":[176,243],"effect":[178],"apparent":[181],"even":[182],"presence":[185],"or":[188],"basic":[189],"fibroblast":[190],"factor,":[192],"promote":[194],"stronger":[196],"On":[200],"other":[202],"hand,":[203],"did":[208],"cultured":[213],"cells,":[215],"indicating":[216],"agents":[223],"foremost":[226],"element":[227],"observed":[230],"effect.":[232],"These":[233],"findings":[234],"specific":[236],"implications":[237],"on":[238],"improving":[239],"properties":[241],"currently":[246],"preclinical":[248],"development,":[249],"encourage":[251],"development":[253],"specific,":[258],"neovascularization-targeting":[259],"agents.":[261],"Cancer":[262],"Res;":[263],"70(15);":[264],"6247\u201357.":[265],"\u00a92010":[266],"AACR.":[267]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2023-03-31T00:00:00"}