{"id":"https://openalex.org/W4361243873","doi":"https://doi.org/10.1158/0008-5472.c.6495660","title":"Data from Combined Natural Killer T-Cell\u2013Based Immunotherapy Eradicates Established Tumors in Mice","display_name":"Data from Combined Natural Killer T-Cell\u2013Based Immunotherapy Eradicates Established Tumors in Mice","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361243873","doi":"https://doi.org/10.1158/0008-5472.c.6495660"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6495660","doi":"https://doi.org/10.1158/0008-5472.c.6495660","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6495660","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6495660","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007330428","display_name":"Michele W.L. Teng","orcid":"https://orcid.org/0000-0003-1886-9145","observed_orcids":["https://orcid.org/0000-0003-1886-9145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michele W.L. Teng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036088140","display_name":"Jennifer A. Westwood","orcid":"https://orcid.org/0000-0003-2957-5767","observed_orcids":["https://orcid.org/0000-0003-2957-5767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer A. Westwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055053148","display_name":"Phillip Kevin Darcy","orcid":"https://orcid.org/0000-0002-5303-9561","observed_orcids":["https://orcid.org/0000-0002-5303-9561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillip K. Darcy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069017947","display_name":"Janelle Sharkey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janelle Sharkey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070087777","display_name":"Moriya Tsuji","orcid":"https://orcid.org/0000-0001-8587-277X","observed_orcids":["https://orcid.org/0000-0001-8587-277X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moriya Tsuji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110471080","display_name":"Richard W. Franck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard W. Franck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016158429","display_name":"Steven Anthony Porcelli","orcid":"https://orcid.org/0000-0002-4441-9888","observed_orcids":["https://orcid.org/0000-0002-4441-9888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven A. Porcelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016293777","display_name":"Gurdyal Singh Besra","orcid":"https://orcid.org/0000-0002-5605-0395","observed_orcids":["https://orcid.org/0000-0002-5605-0395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gurdyal S. Besra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074513079","display_name":"Kazuyoshi Takeda","orcid":"https://orcid.org/0000-0002-5539-310X","observed_orcids":["https://orcid.org/0000-0002-5539-310X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuyoshi Takeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070494006","display_name":"Hideo Yagita\u2225","orcid":"https://orcid.org/0000-0003-4279-9343","observed_orcids":["https://orcid.org/0000-0003-4279-9343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideo Yagita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026944433","display_name":"Michael H. Kershaw","orcid":"https://orcid.org/0000-0002-2697-487X","observed_orcids":["https://orcid.org/0000-0002-2697-487X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael H. Kershaw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061575707","display_name":"Mark John Smyth","orcid":"https://orcid.org/0000-0001-7098-7240","observed_orcids":["https://orcid.org/0000-0001-7098-7240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J. Smyth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/glycolipid-ligands","display_name":"glycolipid ligands","score":0.9259999990463257},{"id":"https://openalex.org/keywords/alpha-galactosylceramide","display_name":"alpha-galactosylceramide","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cd1d","display_name":"CD1d","score":0.7139999866485596},{"id":"https://openalex.org/keywords/anti-cd40-antibody","display_name":"anti-CD40 antibody","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-related-apoptosis-inducing-ligand","display_name":"tumor necrosis factor-related apoptosis-inducing ligand","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tumor-rejection","display_name":"tumor rejection","score":0.5799999833106995},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7609999775886536},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.6690000295639038},{"id":"https://openalex.org/keywords/monoclonal-antibody-therapy","display_name":"monoclonal antibody therapy","score":0.703000009059906},{"id":"https://openalex.org/keywords/therapeutic-index","display_name":"therapeutic index","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5629514455795288},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.5379247665405273},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5135717391967773},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5046664476394653},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4623618721961975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4396926164627075},{"id":"https://openalex.org/C22222904","wikidata":"https://www.wikidata.org/wiki/Q422882","display_name":"Glycolipid","level":2,"score":0.4329681098461151},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3925546705722809},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38633695244789124},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38087138533592224},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3465149700641632},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34432029724121094},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.30631017684936523},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20683583617210388},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17825382947921753},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12554338574409485}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6495660","doi":"https://doi.org/10.1158/0008-5472.c.6495660","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6495660","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6495660","doi":"https://doi.org/10.1158/0008-5472.c.6495660","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6495660","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2111506773","https://openalex.org/W1947552363","https://openalex.org/W1978354618","https://openalex.org/W2618250791","https://openalex.org/W1972884449","https://openalex.org/W3022575231","https://openalex.org/W2811357073","https://openalex.org/W2766991138","https://openalex.org/W3030619918","https://openalex.org/W2104578054"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"rational":[2],"monoclonal":[3],"antibody":[4],"(mAb)-based":[5],"antitumor":[6,200],"therapy":[7,27,151],"approach":[8,238],"has":[9],"previously":[10],"been":[11,68],"shown":[12],"to":[13,49,58],"eradicate":[14],"various":[15],"established":[16,113],"experimental":[17,114],"and":[18,53,111,117,126,140,146,208,223,236],"carcinogen-induced":[19],"tumors":[20,119],"in":[21,70,75,122,168,204],"a":[22,212],"majority":[23],"of":[24,65,165,178,185,194,225],"mice.":[25],"This":[26],"comprised":[28],"an":[29,45,54,234],"agonistic":[30,46,55],"mAb":[31,48,57,78,110],"reactive":[32],"with":[33,79,124,206],"tumor":[34,43,134,166,220],"necrosis":[35],"factor\u2013related":[36],"apoptosis-inducing":[37],"ligand":[38],"receptor":[39],"(DR5),":[40],"expressed":[41],"by":[42,89,229],"cells,":[44,52,143,145],"anti-CD40":[47,77,109],"mature":[50],"dendritic":[51,81,226],"anti-4-1BB":[56,127],"costimulate":[59],"CD8+":[60,141],"T":[61,93,142],"cells.":[62,95],"Because":[63],"agonists":[64,232],"CD40":[66],"have":[67],"toxic":[69],"patients,":[71],"we":[72,97],"were":[73],"interested":[74],"substituting":[76],"other":[80],"cell\u2013maturing":[82],"agents,":[83],"such":[84],"as":[85],"glycolipid":[86,101],"ligands":[87,102],"recognized":[88],"invariant":[90],"natural":[91],"killer":[92],"(iNKT)":[94],"Here,":[96],"show":[98],"that":[99],"CD1d-restricted":[100],"for":[103,108,239],"iNKT":[104],"cells":[105],"effectively":[106],"substitute":[107],"reject":[112],"mouse":[115],"breast":[116],"renal":[118],"when":[120,202],"used":[121,203],"combination":[123,205],"anti-DR5":[125],"mAbs":[128],"(termed":[129],"\u201cNKTMab\u201d":[130],"therapy).":[131],"NKTMab":[132,150],"therapy\u2013induced":[133],"rejection":[135,167],"was":[136,172],"dependent":[137],"on":[138],"CD4+":[139],"NKT":[144,230],"the":[147,175,183],"cytokine":[148],"IFN-\u03b3.":[149],"containing":[152],"either":[153],"\u03b1-galactosylceramide":[154],"(\u03b1-GC)":[155],"or":[156],"\u03b1-C-galactosylceramide":[157],"(\u03b1-c-GC)":[158],"at":[159,174],"high":[160],"concentrations":[161],"induced":[162],"similar":[163],"rates":[164],"mice;":[169],"however,":[170],"toxicity":[171],"observed":[173],"highest":[176],"doses":[177,193],"\u03b1-GC":[179],"(>250":[180],"ng/injection),":[181],"limiting":[182],"use":[184],"this":[186],"glycolipid.":[187],"By":[188],"contrast,":[189],"even":[190],"very":[191],"low":[192],"\u03b1-c-GC":[195,210],"(25":[196],"ng/injection)":[197],"retained":[198],"considerable":[199],"activity":[201],"anti-DR5/anti-4-1BB,":[207],"thus,":[209],"showed":[211],"considerably":[213],"greater":[214],"therapeutic":[215],"index.":[216],"In":[217],"summary,":[218],"sequential":[219],"cell":[221,227,231],"apoptosis":[222],"amplification":[224],"function":[228],"represents":[233],"exciting":[235],"novel":[237],"cancer":[240],"treatment.":[241],"[Cancer":[242],"Res":[243],"2007;67(15):7495\u2013504]":[244]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-03-31T00:00:00"}