{"id":"https://openalex.org/W4361243264","doi":"https://doi.org/10.1158/0008-5472.c.6500670","title":"Data from Serum microRNA Profiles Serve as Novel Biomarkers for HBV Infection and Diagnosis of HBV-Positive Hepatocarcinoma","display_name":"Data from Serum microRNA Profiles Serve as Novel Biomarkers for HBV Infection and Diagnosis of HBV-Positive Hepatocarcinoma","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361243264","doi":"https://doi.org/10.1158/0008-5472.c.6500670"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6500670","doi":"https://doi.org/10.1158/0008-5472.c.6500670","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6500670","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6500670","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100388521","display_name":"Limin Li","orcid":"https://orcid.org/0000-0001-8310-8313","observed_orcids":["https://orcid.org/0000-0001-8310-8313"]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Min Li","raw_affiliation_strings":["Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084213516","display_name":"Zhibin Hu","orcid":"https://orcid.org/0000-0002-8277-5234","observed_orcids":["https://orcid.org/0000-0002-8277-5234"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Bin Hu","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, and","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100841278","display_name":"Zhen-Xian Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150549","display_name":"Nanjing Second Hospital","ror":"https://ror.org/04rhtf097","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150549"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-Xian Zhou","raw_affiliation_strings":["Clinical Laboratory, Nanjing Second Hospital, Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, Nanjing Second Hospital, Nanjing, China;","institution_ids":["https://openalex.org/I4210150549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033289523","display_name":"Xi Chen","orcid":"https://orcid.org/0000-0002-5807-4219","observed_orcids":["https://orcid.org/0000-0002-5807-4219","https://orcid.org/0000-0001-6756-7130"]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Chen","raw_affiliation_strings":["Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015982206","display_name":"Fen-Yong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fen-Yong Liu","raw_affiliation_strings":["Department of Virology, University of California School of Public Health, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, University of California School of Public Health, Berkeley, California","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028199089","display_name":"Junfeng Jim Zhang","orcid":"https://orcid.org/0000-0003-3759-6672","observed_orcids":["https://orcid.org/0000-0003-3759-6672","https://orcid.org/0000-0002-3003-803X"]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Feng Zhang","raw_affiliation_strings":["Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001453048","display_name":"Hongbing Shen","orcid":"https://orcid.org/0000-0002-2581-5906","observed_orcids":["https://orcid.org/0000-0002-2581-5906"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Bing Shen","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, and","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112212826","display_name":"Chen\u2010Yu Zhang","orcid":"https://orcid.org/0000-0002-7329-7162","observed_orcids":["https://orcid.org/0000-0002-7329-7162"]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen-Yu Zhang","raw_affiliation_strings":["Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082076770","display_name":"Ke Zen","orcid":"https://orcid.org/0000-0002-5166-2974","observed_orcids":["https://orcid.org/0000-0002-5166-2974"]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Zen","raw_affiliation_strings":["Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univer-sity,","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/serum-mirna","display_name":"serum microRNA","score":0.9160000085830688},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7480000257492065},{"id":"https://openalex.org/keywords/mir-375","display_name":"miR-375","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mir-92a","display_name":"miR-92a","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mir-25","display_name":"miR-25","score":0.9729999899864197},{"id":"https://openalex.org/keywords/let-7f","display_name":"let-7f","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.8379999995231628},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8507673740386963},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7300912737846375},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.7002316117286682},{"id":"https://openalex.org/C143660080","wikidata":"https://www.wikidata.org/wiki/Q7684883","display_name":"TaqMan","level":4,"score":0.6679716110229492},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6445456743240356},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6126012206077576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5611995458602905},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.46569713950157166},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4167843461036682},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4079475998878479},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40210914611816406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39861929416656494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23920753598213196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1542942225933075},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6500670","doi":"https://doi.org/10.1158/0008-5472.c.6500670","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6500670","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6500670","doi":"https://doi.org/10.1158/0008-5472.c.6500670","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6500670","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322195","display_name":"Huo Yingdong Education Foundation","ror":"https://ror.org/05w1m1q56"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1966566182","https://openalex.org/W1974650935","https://openalex.org/W2000093333","https://openalex.org/W2005894707","https://openalex.org/W2014946489","https://openalex.org/W2015018301","https://openalex.org/W2030607381","https://openalex.org/W2030701238","https://openalex.org/W2034440827","https://openalex.org/W2038634134","https://openalex.org/W2042748226","https://openalex.org/W2043090634","https://openalex.org/W2051936739","https://openalex.org/W2056353125","https://openalex.org/W2061663571","https://openalex.org/W2066442082","https://openalex.org/W2071813506","https://openalex.org/W2087438476","https://openalex.org/W2096528675","https://openalex.org/W2097233439","https://openalex.org/W2097331409","https://openalex.org/W2100084607","https://openalex.org/W2103454678","https://openalex.org/W2109261002","https://openalex.org/W2110605071","https://openalex.org/W2111583453","https://openalex.org/W2114776578","https://openalex.org/W2115093090","https://openalex.org/W2127550752","https://openalex.org/W2131456432","https://openalex.org/W2138583492","https://openalex.org/W2139344413","https://openalex.org/W2144212871","https://openalex.org/W2150203365","https://openalex.org/W2159183335","https://openalex.org/W2159807040","https://openalex.org/W2163482204","https://openalex.org/W2163486683","https://openalex.org/W4253812894","https://openalex.org/W4255483444"],"related_works":["https://openalex.org/W2162769953","https://openalex.org/W1969188594","https://openalex.org/W2569705407","https://openalex.org/W2012522143","https://openalex.org/W2981375153","https://openalex.org/W2049047145","https://openalex.org/W1992985213","https://openalex.org/W1154407209","https://openalex.org/W4385981443","https://openalex.org/W2607754672"],"abstract_inverted_index":{"Abstract":[0],"Diagnosis":[1],"of":[2,13,21,24,34,45,73,91,176,196,219],"hepatitis":[3,61,97],"B":[4,98],"virus":[5,63],"(HBV)-positive":[6],"hepatocellular":[7],"carcinoma":[8],"(HCC),":[9],"particularly":[10],"HCC":[11,143,157,172,209,226,253],"independent":[12],"cirrhosis":[14],"etiology,":[15],"presents":[16],"a":[17,22,71,92],"great":[18],"challenge":[19],"because":[20,90],"lack":[23],"biomarkers.":[25],"Here":[26],"we":[27,101,151,193,205],"test":[28],"the":[29,234],"hypothesis":[30],"that":[31,110,119,167,237],"expression":[32,104],"profiles":[33,105,240],"microRNAs":[35],"(miRNAs)":[36],"in":[37,106,111,123,156,161,171,225],"serum":[38,108,113,158,238],"can":[39,241],"serve":[40,242],"as":[41,189,203,243],"biomarkers":[42,247],"for":[43,233,248],"diagnosis":[44],"HBV":[46,107,124,133,148,190,249],"infection":[47,250],"and":[48,57,65,69,99,114,137,147,163,180,201,213,245,251],"HBV-positive":[49,142,252],"HCC.":[50],"We":[51],"recruited":[52],"513":[53],"subjects":[54],"(210":[55],"controls":[56,136,162],"135":[58],"HBV-,":[59],"48":[60],"C":[62],"(HCV)-,":[64],"120":[66],"HCC-affected":[67],"individuals)":[68],"employed":[70,194],"strategy":[72],"initial":[74],"screening":[75],"by":[76,80,185],"Solexa":[77],"sequencing":[78],"followed":[79],"validation":[81],"with":[82,109,159],"TaqMan":[83],"probe-based":[84],"quantitative":[85],"reverse":[86],"transcription-PCR":[87],"assay.":[88],"First,":[89],"close":[93],"link":[94],"between":[95],"chronic":[96],"HCC,":[100],"compared":[102,153],"miRNA":[103,154,239],"control":[112,146],"successfully":[115],"obtained":[116],"13":[117],"miRNAs":[118,166,198],"were":[120,168,182],"differentially":[121],"expressed":[122],"serum.":[125],"This":[126],"13-miRNA\u2013based":[127],"biomarker":[128],"accurately":[129],"discriminated":[130],"not":[131],"only":[132],"cases":[134,144,210],"from":[135,145,211],"HCV":[138],"cases,":[139],"but":[140],"also":[141,183],"cases.":[149],"Second,":[150],"directly":[152],"expressions":[155],"those":[160],"identified":[164,184],"6":[165],"significantly":[169],"upregulated":[170],"samples.":[173],"Interestingly,":[174],"2":[175],"these":[177,197],"miRNAs,":[178],"miR-375":[179,214],"miR-92a,":[181],"our":[186,230],"first":[187,235],"approach":[188],"specific.":[191],"When":[192],"3":[195],"(miR-25,":[199],"miR-375,":[200],"let-7f)":[202],"biomarkers,":[204],"could":[206],"clearly":[207],"separate":[208],"controls,":[212],"alone":[215],"had":[216],"an":[217],"ROC":[218],"0.96":[220],"(specificity:":[221],"96%;":[222],"sensitivity:":[223],"100%)":[224],"prediction.":[227],"In":[228],"conclusion,":[229],"study":[231],"demonstrates":[232],"time":[236],"novel":[244],"noninvasive":[246],"diagnosis.":[254],"Cancer":[255],"Res;":[256],"70(23);":[257],"9798\u2013807.":[258],"\u00a92010":[259],"AACR.":[260]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-03-31T00:00:00"}
