{"id":"https://openalex.org/W4361239680","doi":"https://doi.org/10.1158/0008-5472.22397871","title":"Supplementary Figure 4 from Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells","display_name":"Supplementary Figure 4 from Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361239680","doi":"https://doi.org/10.1158/0008-5472.22397871"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22397871","doi":"https://doi.org/10.1158/0008-5472.22397871","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22397871","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Chk1_Targeting_Reactivates_PP2A_Tumor_Suppressor_Activity_in_Cancer_Cells/22397871/1/files/39843573.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Chk1_Targeting_Reactivates_PP2A_Tumor_Suppressor_Activity_in_Cancer_Cells/22397871/1/files/39843573.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059454613","display_name":"Anchit Khanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anchit Khanna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072167640","display_name":"Otto Kauko","orcid":"https://orcid.org/0000-0001-8948-9452","observed_orcids":["https://orcid.org/0000-0001-8948-9452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Otto Kauko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045989882","display_name":"Camilla B\u00f6ckelman","orcid":"https://orcid.org/0000-0002-1628-0305","observed_orcids":["https://orcid.org/0000-0002-1628-0305"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camilla B\u00f6ckelman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905616","display_name":"Anni Laine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anni Laine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027797713","display_name":"Ilona Schreck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilona Schreck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112137613","display_name":"Johanna I. Partanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johanna I. Partanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001104871","display_name":"Agnieszka Szwajda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnieszka Szwajda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072933416","display_name":"Stefanie Bormann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefanie Bormann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055026727","display_name":"T\u00fcrker Bilgen","orcid":"https://orcid.org/0000-0002-3015-0929","observed_orcids":["https://orcid.org/0000-0002-3015-0929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Turker Bilgen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109601698","display_name":"Merja Helenius","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merja Helenius","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002087247","display_name":"Yuba Raj Pokharel","orcid":"https://orcid.org/0000-0002-1202-5120","observed_orcids":["https://orcid.org/0000-0002-1202-5120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuba R. Pokharel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054479773","display_name":"John E. Pimanda","orcid":"https://orcid.org/0000-0002-0509-8962","observed_orcids":["https://orcid.org/0000-0002-0509-8962"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Pimanda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028199614","display_name":"Mike R. Russel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mike R. Russel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055369999","display_name":"Caj H. Haglund","orcid":"https://orcid.org/0000-0003-0456-4965","observed_orcids":["https://orcid.org/0000-0003-0456-4965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caj Haglund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005796905","display_name":"Kristina Ann Cole","orcid":"https://orcid.org/0000-0003-0064-2882","observed_orcids":["https://orcid.org/0000-0003-0064-2882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristina A. Cole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074241901","display_name":"Juha T. Klefstr\u00f6m","orcid":"https://orcid.org/0000-0001-7124-8431","observed_orcids":["https://orcid.org/0000-0001-7124-8431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juha Klefstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016681267","display_name":"Tero A. Aittokallio","orcid":"https://orcid.org/0000-0002-0886-9769","observed_orcids":["https://orcid.org/0000-0002-0886-9769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tero Aittokallio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037660240","display_name":"Carsten Wei\u00df","orcid":"https://orcid.org/0000-0002-5380-3208","observed_orcids":["https://orcid.org/0000-0002-5380-3208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carsten Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049950699","display_name":"Ari P. Ristimaki","orcid":"https://orcid.org/0000-0002-5373-9234","observed_orcids":["https://orcid.org/0000-0002-5373-9234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ari Ristim\u00e4ki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085775392","display_name":"Tapio Visakorpi","orcid":"https://orcid.org/0000-0002-5004-0364","observed_orcids":["https://orcid.org/0000-0002-5004-0364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tapio Visakorpi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008528112","display_name":"Jukka K. Westermarck","orcid":"https://orcid.org/0000-0001-7478-3018","observed_orcids":["https://orcid.org/0000-0001-7478-3018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jukka Westermarck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.12880000472068787,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cip2a","display_name":"CIP2A","score":0.878000020980835},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6579999923706055},{"id":"https://openalex.org/keywords/claspin","display_name":"Claspin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cancer-cell-viability","display_name":"tumor cell viability","score":0.9269999861717224},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5691816210746765},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5273388624191284},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49009382724761963},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4580196142196655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43596529960632324},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.4343518614768982},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41395068168640137},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40387243032455444},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37079060077667236},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21608275175094604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1670295000076294},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.16100680828094482},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.09860503673553467}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.22397871","doi":"https://doi.org/10.1158/0008-5472.22397871","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22397871","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Chk1_Targeting_Reactivates_PP2A_Tumor_Suppressor_Activity_in_Cancer_Cells/22397871/1/files/39843573.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22397871","doi":"https://doi.org/10.1158/0008-5472.22397871","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22397871","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Chk1_Targeting_Reactivates_PP2A_Tumor_Suppressor_Activity_in_Cancer_Cells/22397871/1/files/39843573.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361239680.pdf","grobid_xml":"https://content.openalex.org/works/W4361239680.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052113411","https://openalex.org/W4361239639","https://openalex.org/W2003309498","https://openalex.org/W2781683705","https://openalex.org/W2030371043","https://openalex.org/W2032332683","https://openalex.org/W2100008990","https://openalex.org/W2022037349","https://openalex.org/W4361240066","https://openalex.org/W2115255301"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"101K,":[3],"Figure":[4],"S4.":[5],"In":[6],"vitro":[7],"and":[8,18,24,31],"in":[9],"vivo":[10],"regulation":[11],"of":[12],"CIP2A":[13],"mRNA":[14],"expression":[15],"by":[16,28],"Chk1":[17],"effect":[19],"on":[20],"cancer":[21],"cell":[22],"viability":[23],"anchorage":[25],"independent":[26],"growth":[27],"Chk1,":[29],"Claspin":[30],"CIP2A.":[32]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-03-31T00:00:00"}
