{"id":"https://openalex.org/W4361237953","doi":"https://doi.org/10.1158/0008-5472.c.6508425.v1","title":"Data from Glucose Metabolism Reprogrammed by Overexpression of IKK\u03f5 Promotes Pancreatic Tumor Growth","display_name":"Data from Glucose Metabolism Reprogrammed by Overexpression of IKK\u03f5 Promotes Pancreatic Tumor Growth","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361237953","doi":"https://doi.org/10.1158/0008-5472.c.6508425.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6508425.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508425.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508425.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6508425.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064507141","display_name":"Haseeb Zubair","orcid":"https://orcid.org/0000-0002-2340-592X","observed_orcids":["https://orcid.org/0000-0002-2340-592X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haseeb Zubair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089187940","display_name":"Shafquat Azim","orcid":"https://orcid.org/0000-0002-2396-7738","observed_orcids":["https://orcid.org/0000-0002-2396-7738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shafquat Azim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sanjeev Kumar Srivastava","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjeev Kumar Srivastava","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072765154","display_name":"Aamir Ahmad","orcid":"https://orcid.org/0000-0003-1784-5723","observed_orcids":["https://orcid.org/0000-0003-1784-5723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aamir Ahmad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103685570","display_name":"Arun Bhardwaj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arun Bhardwaj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070123419","display_name":"Mohammad Aslam Khan","orcid":"https://orcid.org/0000-0003-1778-4086","observed_orcids":["https://orcid.org/0000-0003-1778-4086","https://orcid.org/0000-0002-1855-1279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Aslam Khan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031950018","display_name":"Girijesh Kumar Patel","orcid":"https://orcid.org/0000-0003-4660-5876","observed_orcids":["https://orcid.org/0000-0003-4660-5876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Girijesh Kumar Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045756","display_name":"Sumit Arora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sumit Arora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049219947","display_name":"James Elliot Carter","orcid":"https://orcid.org/0009-0002-4993-291X","observed_orcids":["https://orcid.org/0009-0002-4993-291X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Elliot Carter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115603189","display_name":"Seema Singh","orcid":"https://orcid.org/0000-0002-7188-3803","observed_orcids":["https://orcid.org/0000-0002-7188-3803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seema Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108140326","display_name":"Ajay Pratap Singh","orcid":"https://orcid.org/0009-0006-8446-5893","observed_orcids":["https://orcid.org/0009-0006-8446-5893","https://orcid.org/0009-0007-6852-6075"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ajay Pratap Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.42719998955726624,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ikkepsilon","display_name":"IKK\u03b5","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/glucose-metabolism-reprogramming","display_name":"glucose metabolism reprogramming","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6980000138282776},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9679999947547913},{"id":"https://openalex.org/keywords/akt-gsk-3beta-signaling","display_name":"Akt/GSK-3\u03b2 signaling","score":0.9279999732971191},{"id":"https://openalex.org/keywords/lactate-secretion","display_name":"lactate secretion","score":0.8339999914169312},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.781000018119812},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6666547060012817},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6448126435279846},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5908686518669128},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.5455335378646851},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.5151923298835754},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4863224923610687},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4859429597854614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44723302125930786},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4437863826751709},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.41914427280426025},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3898357152938843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3589504361152649},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3520253300666809},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34055328369140625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3157922327518463},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2638620138168335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24581801891326904},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24536636471748352},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23194974660873413},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1595204472541809},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.13410872220993042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13288277387619019},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09101659059524536}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6508425.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508425.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508425.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6508425.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508425.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508425.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/1"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2538604941","https://openalex.org/W4225160932","https://openalex.org/W2887296831","https://openalex.org/W4394869934","https://openalex.org/W2761562644","https://openalex.org/W4414004178","https://openalex.org/W7123575611","https://openalex.org/W2975346862","https://openalex.org/W2954469429","https://openalex.org/W4283820452"],"abstract_inverted_index":{"Abstract":[0],"Aberrant":[1],"expression":[2,60],"of":[3,61,129],"the":[4,69,126],"kinase":[5],"IKK\u03f5":[6,27,38,74,123],"in":[7,28,35,39,64,79,107,131],"pancreatic":[8],"ductal":[9],"adenocarcinoma":[10],"(PDAC)":[11],"has":[12],"been":[13],"associated":[14,82],"with":[15,83],"poor":[16],"prognosis.":[17],"In":[18,96],"this":[19],"study,":[20],"we":[21],"define":[22],"a":[23,80,104,117],"pathobiologic":[24],"function":[25],"for":[26],"reprogramming":[29],"glucose":[30,55,65,108],"metabolism":[31],"and":[32,59,111],"driving":[33],"progression":[34],"PDAC.":[36],"Silencing":[37],"PDAC":[40,102,130],"cells,":[41],"which":[42],"overexpressed":[43],"it":[44],"endogenously,":[45],"was":[46],"sufficient":[47],"to":[48,121,124],"reduce":[49],"malignant":[50],"cell":[51],"growth,":[52],"clonogenic":[53],"potential,":[54],"consumption,":[56],"lactate":[57],"secretion,":[58],"genes":[62],"involved":[63],"metabolism,":[66],"without":[67],"impacting":[68],"basal":[70],"oxygen":[71],"consumption":[72],"rate.":[73],"silencing":[75],"also":[76],"attenuated":[77],"c-Myc":[78],"manner":[81],"diminished":[84],"signaling":[85],"through":[86],"an":[87,97],"AKT/GSK3\u03b2/c-MYC":[88],"phosphorylation":[89],"cascade":[90],"that":[91],"promoted":[92],"MYC":[93],"nuclear":[94],"accumulation.":[95],"orthotopic":[98],"mouse":[99],"model,":[100],"IKK\u03f5-silenced":[101],"exhibited":[103],"relative":[105],"reduction":[106],"uptake,":[109],"tumorigenicity,":[110],"metastasis.":[112],"Overall,":[113],"our":[114],"findings":[115],"offer":[116],"preclinical":[118],"mechanistic":[119],"rationale":[120],"target":[122],"improve":[125],"therapeutic":[127],"management":[128],"patients.":[132],"Cancer":[133],"Res;":[134],"76(24);":[135],"7254\u201364.":[136],"\u00a92016":[137],"AACR.":[138]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-03-31T00:00:00"}
