{"id":"https://openalex.org/W4361237800","doi":"https://doi.org/10.1158/0008-5472.c.6507359","title":"Data from Obesity Contributes to Ovarian Cancer Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages","display_name":"Data from Obesity Contributes to Ovarian Cancer Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361237800","doi":"https://doi.org/10.1158/0008-5472.c.6507359"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507359","doi":"https://doi.org/10.1158/0008-5472.c.6507359","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507359","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6507359","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101845944","display_name":"Yueying Liu","orcid":"https://orcid.org/0000-0001-7608-0164","observed_orcids":["https://orcid.org/0000-0001-7608-0164"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yueying Liu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040213651","display_name":"Matthew N. Metzinger","orcid":"https://orcid.org/0009-0001-4942-5646","observed_orcids":["https://orcid.org/0009-0001-4942-5646"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew N. Metzinger","raw_affiliation_strings":["Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012839132","display_name":"Kyle A. Lewellen","orcid":"https://orcid.org/0009-0004-1711-1476","observed_orcids":["https://orcid.org/0009-0004-1711-1476"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle A. Lewellen","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050557396","display_name":"Stephanie N. Cripps","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie N. Cripps","raw_affiliation_strings":["University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo College of Medicine and Life Sciences, Toledo, Ohio","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020404261","display_name":"Kyle D. Carey","orcid":"https://orcid.org/0000-0001-8130-859X","observed_orcids":["https://orcid.org/0000-0001-8130-859X"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle D. Carey","raw_affiliation_strings":["Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091108869","display_name":"Elizabeth I. Harper","orcid":"https://orcid.org/0000-0002-3547-1692","observed_orcids":["https://orcid.org/0000-0002-3547-1692"]},"institutions":[{"id":"https://openalex.org/I130712669","display_name":"Earlham College","ror":"https://ror.org/0566sj483","country_code":"US","type":"education","lineage":["https://openalex.org/I130712669"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth I. Harper","raw_affiliation_strings":["Earlham College, Richmond, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Earlham College, Richmond, Indiana","institution_ids":["https://openalex.org/I130712669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032803774","display_name":"Zonggao Shi","orcid":"https://orcid.org/0000-0001-7503-2953","observed_orcids":["https://orcid.org/0000-0001-7503-2953"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zonggao Shi","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061594032","display_name":"Laura Tarwater","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Tarwater","raw_affiliation_strings":["Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112512148","display_name":"Anne Grisoli","orcid":"https://orcid.org/0000-0001-9081-4814","observed_orcids":["https://orcid.org/0000-0001-9081-4814"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annie Grisoli","raw_affiliation_strings":["Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073691963","display_name":"Eric Boya Lee","orcid":"https://orcid.org/0000-0002-3659-1020","observed_orcids":["https://orcid.org/0000-0002-3659-1020"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Lee","raw_affiliation_strings":["Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024500343","display_name":"Ania Slusarz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ania Slusarz","raw_affiliation_strings":["Department of Medical Physiology and Pharmacology, University of Missouri School of Medicine, Columbia, Missouri","Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology and Pharmacology, University of Missouri School of Medicine, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459993","display_name":"Jing Han Yang","orcid":"https://orcid.org/0009-0008-3542-5347","observed_orcids":["https://orcid.org/0009-0008-3542-5347","https://orcid.org/0000-0003-0164-9699","https://orcid.org/0000-0002-7973-5717"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045272571","display_name":"Elizabeth A. Loughran","orcid":"https://orcid.org/0000-0002-7940-3157","observed_orcids":["https://orcid.org/0000-0002-7940-3157"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Loughran","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001864673","display_name":"Kaitlyn B. Conley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlyn Conley","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007403831","display_name":"Jeff J. Johnson","orcid":"https://orcid.org/0000-0003-0473-2869","observed_orcids":["https://orcid.org/0000-0003-0473-2869"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff J. Johnson","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029483139","display_name":"Yuliya Klymenko","orcid":"https://orcid.org/0000-0001-7324-8427","observed_orcids":["https://orcid.org/0000-0001-7324-8427"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuliya Klymenko","raw_affiliation_strings":["Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070863249","display_name":"Lana Bruney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lana Bruney","raw_affiliation_strings":["Department of Medical Physiology and Pharmacology, University of Missouri School of Medicine, Columbia, Missouri","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology and Pharmacology, University of Missouri School of Medicine, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376847","display_name":"Liang Zhong","orcid":"https://orcid.org/0000-0002-4514-9074","observed_orcids":["https://orcid.org/0000-0002-4514-9074"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhong Liang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086220920","display_name":"Norman J. Dovic\u0300hi","orcid":"https://orcid.org/0000-0002-1331-3191","observed_orcids":["https://orcid.org/0000-0002-1331-3191"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman J. Dovichi","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074360177","display_name":"Bentley Cheatham","orcid":"https://orcid.org/0000-0001-9201-5602","observed_orcids":["https://orcid.org/0000-0001-9201-5602"]},"institutions":[{"id":"https://openalex.org/I4210137063","display_name":"Zen Bio (United States)","ror":"https://ror.org/03m5rvq73","country_code":"US","type":"company","lineage":["https://openalex.org/I4210137063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bentley Cheatham","raw_affiliation_strings":["Zen-Bio Inc., Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zen-Bio Inc., Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I4210137063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001102675","display_name":"W. Matthew Leevy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Matthew Leevy","raw_affiliation_strings":["Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034090671","display_name":"Mary Sharon Stack","orcid":"https://orcid.org/0000-0003-4563-7390","observed_orcids":["https://orcid.org/0000-0003-4563-7390"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I4394709205","display_name":"Mike and Josie Harper Cancer Research Institute","ror":"https://ror.org/030jvtg87","country_code":null,"type":"facility","lineage":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Sharon Stack","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5034090671"],"corresponding_institution_ids":["https://openalex.org/I107639228","https://openalex.org/I4394709205"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.43479999899864197,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.43479999899864197,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.2549000084400177,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.25049999356269836,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/peritoneal-metastases","display_name":"peritoneal carcinomatosis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mesothelium","display_name":"mesothelium","score":0.6629999876022339},{"id":"https://openalex.org/keywords/microvilli","display_name":"microvilli","score":0.6309999823570251},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.9120000004768372},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/tumor-vascularity","display_name":"tumor vascularity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.9480000138282776},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.735237717628479},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5576575994491577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5279784798622131},{"id":"https://openalex.org/C2779747549","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelium","level":3,"score":0.5268462896347046},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5106549859046936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49119970202445984},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.46413323283195496},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4386952519416809},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43416327238082886},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42278459668159485},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37955915927886963},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.3279929757118225},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32091379165649414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30931252241134644},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30511265993118286},{"id":"https://openalex.org/C2909640154","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelial Cell","level":2,"score":0.2991809844970703},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6507359","doi":"https://doi.org/10.1158/0008-5472.c.6507359","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507359","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507359","doi":"https://doi.org/10.1158/0008-5472.c.6507359","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507359","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W73154690","https://openalex.org/W142304055","https://openalex.org/W1490315563","https://openalex.org/W1494623524","https://openalex.org/W1563140450","https://openalex.org/W1577597369","https://openalex.org/W1966870353","https://openalex.org/W1971297175","https://openalex.org/W1978281808","https://openalex.org/W1979051608","https://openalex.org/W1980968791","https://openalex.org/W1987540540","https://openalex.org/W1987713254","https://openalex.org/W2000269194","https://openalex.org/W2016835842","https://openalex.org/W2031047219","https://openalex.org/W2033899321","https://openalex.org/W2041237929","https://openalex.org/W2042633087","https://openalex.org/W2045072263","https://openalex.org/W2068226850","https://openalex.org/W2072339349","https://openalex.org/W2076197452","https://openalex.org/W2081275953","https://openalex.org/W2083894759","https://openalex.org/W2091936574","https://openalex.org/W2102310375","https://openalex.org/W2106787323","https://openalex.org/W2108965452","https://openalex.org/W2121857344","https://openalex.org/W2122874141","https://openalex.org/W2142296587","https://openalex.org/W2151172917","https://openalex.org/W2156194356","https://openalex.org/W2157314109","https://openalex.org/W2158294624","https://openalex.org/W2159575833","https://openalex.org/W2168361516","https://openalex.org/W2169862066","https://openalex.org/W2171249989","https://openalex.org/W2171640413","https://openalex.org/W2326356596","https://openalex.org/W4200291501"],"related_works":["https://openalex.org/W2463944296","https://openalex.org/W2021441858","https://openalex.org/W2070104648","https://openalex.org/W1979194948","https://openalex.org/W2416798274","https://openalex.org/W4237484236","https://openalex.org/W1970404696","https://openalex.org/W4389020874","https://openalex.org/W1987902940","https://openalex.org/W1972133041"],"abstract_inverted_index":{"Abstract":[0],"Epithelial":[1],"ovarian":[2,29,33,75,102,191,205],"cancer":[3,30,34,76,103,192,206],"(EOC)":[4],"is":[5],"the":[6,37,69,92,135,180,199],"leading":[7],"cause":[8],"of":[9,39,49,127,137],"death":[10],"from":[11,112],"gynecologic":[12],"malignancy,":[13],"with":[14],"high":[15],"mortality":[16],"attributable":[17],"to":[18,53,67,74,91,108,198],"widespread":[19],"intraperitoneal":[20,144],"metastases.":[21],"Recent":[22],"meta-analyses":[23],"report":[24],"an":[25,55,97],"association":[26],"between":[27,202],"obesity,":[28],"incidence,":[31],"and":[32,63,172,204],"survival,":[35],"but":[36],"effect":[38],"obesity":[40,72,116,188,203],"on":[41],"metastasis":[42],"has":[43],"not":[44],"been":[45],"evaluated.":[46],"The":[47],"objective":[48],"this":[50],"study":[51],"was":[52,147],"use":[54],"integrative":[56],"approach":[57],"combining":[58],"in":[59,64,80,96,118,134,139,149,154,157,166],"vitro,":[60],"ex":[61,98],"vivo,":[62],"vivo":[65,99,158],"studies":[66,82],"test":[68],"hypothesis":[70],"that":[71,164,187],"contributes":[73,197],"metastatic":[77,193],"success.":[78],"Initial":[79],"vitro":[81],"using":[83],"three-dimensional":[84],"mesomimetic":[85],"cultures":[86],"showed":[87],"enhanced":[88,143,170,181],"cell\u2013cell":[89],"adhesion":[90,107],"lipid-loaded":[93],"mesothelium.":[94],"Furthermore,":[95],"colonization":[100],"assay,":[101],"cells":[104],"exhibited":[105],"increased":[106],"mesothelial":[109,128],"explants":[110],"excised":[111],"mice":[113],"modeling":[114],"diet-induced":[115],"(DIO),":[117],"which":[119,195],"they":[120],"were":[121],"fed":[122],"a":[123,131],"\u201cWestern\u201d":[124],"diet.":[125],"Examination":[126],"ultrastructure":[129],"revealed":[130],"substantial":[132],"increase":[133],"density":[136],"microvilli":[138],"DIO":[140],"mice.":[141],"Moreover,":[142],"tumor":[145],"burden":[146],"observed":[148],"overweight":[150],"or":[151],"obese":[152],"animals":[153],"three":[155],"distinct":[156],"models.":[159],"Further":[160],"histologic":[161],"analyses":[162],"suggested":[163],"alterations":[165],"lipid":[167],"regulatory":[168],"factors,":[169],"vascularity,":[171],"decreased":[173],"M1/M2":[174],"macrophage":[175],"ratios":[176],"may":[177],"account":[178],"for":[179],"tumorigenicity.":[182],"Together,":[183],"these":[184],"findings":[185],"show":[186],"potently":[189],"affects":[190],"success,":[194],"likely":[196],"negative":[200],"correlation":[201],"survival.":[207],"Cancer":[208],"Res;":[209],"75(23);":[210],"5046\u201357.":[211],"\u00a92015":[212],"AACR.":[213]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}