{"id":"https://openalex.org/W4361237797","doi":"https://doi.org/10.1158/0008-5472.c.6507344.v1","title":"Data from Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210","display_name":"Data from Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361237797","doi":"https://doi.org/10.1158/0008-5472.c.6507344.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507344.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507344.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507344.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6507344.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003314533","display_name":"Muhammad Zaeem Noman","orcid":"https://orcid.org/0000-0002-1837-3097","observed_orcids":["https://orcid.org/0000-0002-1837-3097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Zaeem Noman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091343254","display_name":"Bassam Janji","orcid":"https://orcid.org/0000-0002-9763-0943","observed_orcids":["https://orcid.org/0000-0002-9763-0943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bassam Janji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035131138","display_name":"Shijun Hu","orcid":"https://orcid.org/0000-0002-0068-8429","observed_orcids":["https://orcid.org/0000-0002-0068-8429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shijun Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047561254","display_name":"Joseph C. Wu","orcid":"https://orcid.org/0000-0002-6068-8041","observed_orcids":["https://orcid.org/0000-0002-6068-8041","https://orcid.org/0000-0003-4274-0413"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph C. Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075376877","display_name":"Fabio Martelli","orcid":"https://orcid.org/0000-0002-8624-7738","observed_orcids":["https://orcid.org/0000-0002-8624-7738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabio Martelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052489243","display_name":"Vincenzo Bronte","orcid":"https://orcid.org/0000-0002-3741-5141","observed_orcids":["https://orcid.org/0000-0002-3741-5141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincenzo Bronte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045530749","display_name":"Salem Choua\u0131\u0308b","orcid":"https://orcid.org/0009-0007-3228-6882","observed_orcids":["https://orcid.org/0009-0007-3228-6882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salem Chouaib","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mir-210","display_name":"miR-210","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.878000020980835},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.824999988079071},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6620000004768372},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.9359999895095825},{"id":"https://openalex.org/keywords/arginase","display_name":"arginase","score":0.6660000085830688},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interleukin-16","display_name":"interleukin-16","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mirna-inhibitors","display_name":"miRNA inhibitors","score":0.5139999985694885},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6374189853668213},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6192688941955566},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6142480373382568},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.549629271030426},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5271560549736023},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4716048836708069},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.459416002035141},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4453512132167816},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4254003167152405},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.3733149766921997},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3324323296546936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23040327429771423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1786453127861023},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.17780810594558716},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.1757047176361084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1627798080444336},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08040934801101685},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6507344.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507344.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507344.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507344.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507344.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507344.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2117700636","https://openalex.org/W1636810713","https://openalex.org/W2109424201","https://openalex.org/W2138312235","https://openalex.org/W4396955185","https://openalex.org/W4380422804","https://openalex.org/W4392686739","https://openalex.org/W3092856616","https://openalex.org/W2142816685","https://openalex.org/W1491861997"],"abstract_inverted_index":{"Abstract":[0],"Myeloid-derived":[1],"suppressor":[2],"cells":[3],"(MDSC)":[4],"contribute":[5],"significantly":[6],"to":[7,45,64,79,93,188,195],"the":[8,71,139,146,168],"malignant":[9],"characters":[10],"conferred":[11],"by":[12,38,108],"hypoxic":[13],"tumor":[14,55,178],"microenvironments.":[15],"However,":[16],"selective":[17],"biomarkers":[18],"of":[19,127,141,148,171],"MDSC":[20,43,50,95,106,172],"function":[21,96,107],"in":[22,42,70,173,176,199],"this":[23],"critical":[24],"setting":[25],"have":[26],"not":[27],"been":[28],"defined.":[29],"Here,":[30],"we":[31,57],"report":[32],"that":[33,59,103],"miR-210":[34,72,75,90,104,132,160,190],"expression":[35,126],"is":[36],"elevated":[37],"hypoxia-inducible":[39],"factor-1\u03b1":[40],"(HIF1\u03b1)":[41],"localized":[44],"tumors,":[46],"compared":[47],"with":[48],"splenic":[49,130],"from":[51],"tumor-bearing":[52],"mice.":[53],"In":[54,129],"MDSC,":[56,131],"determined":[58],"HIF1\u03b1":[60],"was":[61,77,91],"bound":[62],"directly":[63],"a":[65,185],"transcriptionally":[66],"active":[67],"hypoxia-response":[68],"element":[69],"proximal":[73],"promoter.":[74],"overexpression":[76,161],"sufficient":[78,92],"enhance":[80],"MDSC-mediated":[81],"T-cell":[82],"suppression":[83],"under":[84,150],"normoxic":[85,151],"conditions,":[86],"while":[87],"targeting":[88,163],"hypoxia-induced":[89],"decrease":[94],"against":[97],"T":[98],"cells.":[99],"Mechanistic":[100],"investigations":[101],"revealed":[102],"modulated":[105],"increasing":[109],"arginase":[110],"activity":[111,170],"and":[112,136,144,156],"nitric":[113],"oxide":[114],"production,":[115],"without":[116],"affecting":[117],"reactive":[118],"oxygen":[119],"species,":[120],"IL6,":[121],"or":[122,125,162,165],"IL10":[123],"production":[124],"PD-L1.":[128],"regulated":[133],"Arg1,":[134],"Cxcl12,":[135],"IL16":[137,164],"at":[138],"levels":[140],"both":[142],"mRNA":[143],"protein,":[145],"reversal":[147],"which":[149],"conditions":[152],"decreased":[153],"T-cell\u2013suppressive":[154],"effects":[155],"IFN\u03b3":[157],"production.":[158],"Interestingly,":[159],"CXCL12":[166],"enhanced":[167],"immunosuppressive":[169],"vivo,":[174],"resulting":[175],"increased":[177],"growth.":[179],"Taken":[180],"together,":[181],"these":[182],"results":[183],"provide":[184],"preclinical":[186],"rationale":[187],"explore":[189],"inhibitory":[191],"oligonucleotides":[192],"as":[193],"adjuvants":[194],"boost":[196],"immunotherapeutic":[197],"responses":[198],"cancer":[200],"patients.":[201],"Cancer":[202],"Res;":[203],"75(18);":[204],"3771\u201387.":[205],"\u00a92015":[206],"AACR.":[207]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-03-31T00:00:00"}