{"id":"https://openalex.org/W4361237697","doi":"https://doi.org/10.1158/0008-5472.c.6507134.v1","title":"Data from Acute Tissue Injury Activates Satellite Cells and Promotes Sarcoma Formation via the HGF/c-MET Signaling Pathway","display_name":"Data from Acute Tissue Injury Activates Satellite Cells and Promotes Sarcoma Formation via the HGF/c-MET Signaling Pathway","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361237697","doi":"https://doi.org/10.1158/0008-5472.c.6507134.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507134.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507134.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507134.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6507134.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000984171","display_name":"David Van Mater","orcid":"https://orcid.org/0000-0002-1573-589X","observed_orcids":["https://orcid.org/0000-0002-1573-589X","https://orcid.org/0000-0002-2458-8457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Van Mater","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085911135","display_name":"Leonor A\u00f1\u00f3","orcid":"https://orcid.org/0000-0002-9590-025X","observed_orcids":["https://orcid.org/0000-0002-9590-025X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonor A\u00f1\u00f3","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114031672","display_name":"Jordan M. Blum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan M. Blum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053311946","display_name":"Micah T. Webster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Micah T. Webster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015077522","display_name":"WeiQiao Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"WeiQiao Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066234500","display_name":"Nerissa T. Williams","orcid":"https://orcid.org/0000-0003-0554-9222","observed_orcids":["https://orcid.org/0000-0003-0554-9222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nerissa Williams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443226","display_name":"Yan Ma","orcid":"https://orcid.org/0000-0001-6897-5064","observed_orcids":["https://orcid.org/0000-0001-6897-5064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081989505","display_name":"Diana Marcella Cardona","orcid":"https://orcid.org/0000-0002-6877-2280","observed_orcids":["https://orcid.org/0000-0002-6877-2280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana M. Cardona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051566104","display_name":"Chen\u2010Ming Fan","orcid":"https://orcid.org/0000-0003-3211-6617","observed_orcids":["https://orcid.org/0000-0003-3211-6617","https://orcid.org/0000-0001-8806-2166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen-Ming Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070216920","display_name":"David G. Kirsch","orcid":"https://orcid.org/0000-0002-2086-205X","observed_orcids":["https://orcid.org/0000-0002-2086-205X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G. Kirsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.824999988079071},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/met-signaling","display_name":"C-MET signaling","score":0.9169999957084656},{"id":"https://openalex.org/keywords/p53-deletion","display_name":"p53 deletion","score":0.8059999942779541},{"id":"https://openalex.org/keywords/oncogenic-kras","display_name":"oncogenic KRAS","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pax7","display_name":"Pax7","score":0.6710000038146973},{"id":"https://openalex.org/keywords/tumor-formation","display_name":"tumor formation","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.6554481983184814},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.603437602519989},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5670251250267029},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.4881342351436615},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.44342106580734253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3886021673679352},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.376883327960968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31855493783950806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31745457649230957},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31299471855163574},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21309176087379456},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20994511246681213},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.16402864456176758},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6507134.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507134.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507134.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507134.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507134.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507134.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3030972949","https://openalex.org/W4306404900","https://openalex.org/W4229832877","https://openalex.org/W3111812619","https://openalex.org/W4248366929","https://openalex.org/W2590035663","https://openalex.org/W2914997899","https://openalex.org/W1686926070","https://openalex.org/W4367603427","https://openalex.org/W3093086801"],"abstract_inverted_index":{"Abstract":[0],"Some":[1],"patients":[2,202],"with":[3,69],"soft-tissue":[4],"sarcoma":[5,39,112,149],"(STS)":[6],"report":[7,73],"a":[8,44,63,177,190,204],"history":[9],"of":[10,15,36,47,78,83,90,96,111,143,148,154,168,193,209],"injury":[11,37,170,188],"at":[12,151,206],"the":[13,34,80,146,152,165,207],"site":[14,153,208],"their":[16],"tumor.":[17],"Although":[18],"this":[19],"phenomenon":[20],"is":[21,51,56,100,157],"widely":[22],"reported,":[23],"there":[24],"are":[25],"relatively":[26],"few":[27],"experimental":[28],"systems":[29],"that":[30,74,135],"have":[31],"directly":[32],"assessed":[33],"role":[35],"in":[38,58,126,189],"formation.":[40,113],"We":[41,133],"recently":[42],"described":[43],"mouse":[45,191],"model":[46,192],"STS":[48,205],"whereby":[49],"p53":[50,91],"deleted":[52],"and":[53,92,196],"oncogenic":[54],"Kras":[55],"activated":[57],"muscle":[59,98],"satellite":[60,118,137],"cells":[61,85,119],"via":[62,140],"Pax7CreER":[64],"driver":[65],"following":[66],"intraperitoneal":[67],"injection":[68,77,142],"tamoxifen.":[70],"Here,":[71],"we":[72],"after":[75,186],"systemic":[76],"tamoxifen,":[79],"vast":[81],"majority":[82],"Pax7-expressing":[84],"remain":[86],"quiescent":[87,117],"despite":[88],"mutation":[89],"Kras.":[93],"The":[94],"fate":[95],"these":[97],"progenitors":[99],"dramatically":[101],"altered":[102],"by":[103,179],"tissue":[104,169,187],"injury,":[105],"which":[106,156,180],"leads":[107],"to":[108,128],"faster":[109],"kinetics":[110],"In":[114],"adult":[115],"muscle,":[116],"will":[120],"transition":[121],"into":[122],"an":[123],"active":[124],"state":[125],"response":[127],"hepatocyte":[129],"growth":[130],"factor":[131],"(HGF).":[132],"show":[134],"modulating":[136],"cell":[138],"quiescence":[139],"intramuscular":[141],"HGF":[144],"increases":[145],"penetrance":[147],"formation":[150,185],"injection,":[155],"dependent":[158],"on":[159],"its":[160],"cognate":[161],"receptor":[162],"c-MET.":[163],"Unexpectedly,":[164],"tumor-promoting":[166],"effect":[167],"also":[171],"requires":[172],"c-Met.":[173],"These":[174],"results":[175],"reveal":[176],"mechanism":[178],"HGF/c-MET":[181],"signaling":[182],"promotes":[183],"tumor":[184],"primary":[194],"STS,":[195],"they":[197],"may":[198],"explain":[199],"why":[200],"some":[201],"develop":[203],"injury.":[210],"Cancer":[211],"Res;":[212],"75(3);":[213],"605\u201314.":[214],"\u00a92014":[215],"AACR.":[216]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}