{"id":"https://openalex.org/W4361237657","doi":"https://doi.org/10.1158/0008-5472.22410434","title":"Supplementary Materials and Methods and Supplementary Figure Legends from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer","display_name":"Supplementary Materials and Methods and Supplementary Figure Legends from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361237657","doi":"https://doi.org/10.1158/0008-5472.22410434"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22410434","doi":"https://doi.org/10.1158/0008-5472.22410434","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22410434","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22410434","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038157289","display_name":"No\u00ebl J.\u2010M. Raynal","orcid":"https://orcid.org/0000-0002-4241-6800","observed_orcids":["https://orcid.org/0000-0002-4241-6800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"No\u00ebl J.-M. Raynal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Justin T. Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin T. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004339250","display_name":"Youjun Wang","orcid":"https://orcid.org/0000-0003-0961-1716","observed_orcids":["https://orcid.org/0000-0003-0961-1716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youjun Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108638375","display_name":"Annie Beaudry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annie Beaudry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060535489","display_name":"Priyanka Madireddi","orcid":"https://orcid.org/0009-0006-9524-3620","observed_orcids":["https://orcid.org/0009-0006-9524-3620","https://orcid.org/0000-0002-5702-1262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Priyanka Madireddi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043562849","display_name":"Judith Garriga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judith Garriga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064378838","display_name":"Gabriel G. Malouf","orcid":"https://orcid.org/0000-0003-3527-0417","observed_orcids":["https://orcid.org/0000-0003-3527-0417","https://orcid.org/0000-0001-9524-9885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel G. Malouf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086705074","display_name":"Sarah Dumont","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Dumont","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048618968","display_name":"Elisha J. Dettman","orcid":"https://orcid.org/0000-0002-0059-836X","observed_orcids":["https://orcid.org/0000-0002-0059-836X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisha J. Dettman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007622652","display_name":"Vazganush Gharibyan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vazganush Gharibyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058607368","display_name":"Saira Ahmed","orcid":"https://orcid.org/0009-0007-0520-1089","observed_orcids":["https://orcid.org/0009-0007-0520-1089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saira Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079853830","display_name":"Woonbok Chung","orcid":"https://orcid.org/0000-0002-3663-8554","observed_orcids":["https://orcid.org/0000-0002-3663-8554"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Woonbok Chung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032459319","display_name":"Wayne E. Childers","orcid":"https://orcid.org/0000-0003-0527-3684","observed_orcids":["https://orcid.org/0000-0003-0527-3684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wayne E. Childers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006147441","display_name":"Magid A. Abou-Gharbia","orcid":"https://orcid.org/0000-0001-7524-6011","observed_orcids":["https://orcid.org/0000-0001-7524-6011"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magid Abou-Gharbia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083713804","display_name":"Ryan A. Henry","orcid":"https://orcid.org/0000-0002-4240-8878","observed_orcids":["https://orcid.org/0000-0002-4240-8878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan A. Henry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009582417","display_name":"Andrew J. Andrews","orcid":"https://orcid.org/0000-0002-2529-3714","observed_orcids":["https://orcid.org/0000-0002-2529-3714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew J. Andrews","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027336256","display_name":"Jaroslav Jel\u0131\u0301nek","orcid":"https://orcid.org/0000-0002-2533-0220","observed_orcids":["https://orcid.org/0000-0002-2533-0220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaroslav Jelinek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694792","display_name":"Ying Cui","orcid":"https://orcid.org/0000-0002-1454-4389","observed_orcids":["https://orcid.org/0000-0002-1454-4389","https://orcid.org/0000-0002-7072-689X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Cui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058612163","display_name":"Stephen B. Baylin","orcid":"https://orcid.org/0000-0003-3697-3798","observed_orcids":["https://orcid.org/0000-0003-3697-3798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen B. Baylin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013483031","display_name":"Donald L. Gill","orcid":"https://orcid.org/0000-0003-0587-2548","observed_orcids":["https://orcid.org/0000-0003-0587-2548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald L. Gill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062330946","display_name":"Jean\u2010Pierre J. Issa","orcid":"https://orcid.org/0000-0003-2258-5030","observed_orcids":["https://orcid.org/0000-0003-2258-5030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Pierre J. Issa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epigenetic-reactivation","display_name":"epigenetic reactivation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":1.0},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7542515993118286},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.7183594703674316},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5800317525863647},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4911958873271942},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47432252764701843},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4282997250556946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42233502864837646},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.4158504605293274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35045915842056274},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28476786613464355},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.1444835066795349}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.22410434","doi":"https://doi.org/10.1158/0008-5472.22410434","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22410434","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22410434","doi":"https://doi.org/10.1158/0008-5472.22410434","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22410434","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361238105","https://openalex.org/W2282228815","https://openalex.org/W4361850590","https://openalex.org/W4361238024","https://openalex.org/W3082050978","https://openalex.org/W2567496810","https://openalex.org/W2042915813","https://openalex.org/W1493596136","https://openalex.org/W2018281189","https://openalex.org/W2415304630"],"abstract_inverted_index":{"Supplementary":[0,5],"Materials":[1],"and":[2,4],"Methods":[3],"Figure":[6],"Legends":[7]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-03-31T00:00:00"}