{"id":"https://openalex.org/W4361237458","doi":"https://doi.org/10.1158/0008-5472.c.6508016","title":"Data from Genomic Landscape of Somatic Alterations in Esophageal Squamous Cell Carcinoma and Gastric Cancer","display_name":"Data from Genomic Landscape of Somatic Alterations in Esophageal Squamous Cell Carcinoma and Gastric Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361237458","doi":"https://doi.org/10.1158/0008-5472.c.6508016"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6508016","doi":"https://doi.org/10.1158/0008-5472.c.6508016","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6508016","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6508016","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101603422","display_name":"Nan Hu","orcid":"https://orcid.org/0009-0009-0845-6532","observed_orcids":["https://orcid.org/0009-0009-0845-6532","https://orcid.org/0000-0002-0516-0738","https://orcid.org/0000-0001-8356-8571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076336316","display_name":"Mitsutaka Kadota","orcid":"https://orcid.org/0000-0002-1674-6697","observed_orcids":["https://orcid.org/0000-0002-1674-6697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsutaka Kadota","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115588460","display_name":"Huaitian Liu","orcid":"https://orcid.org/0000-0002-7791-1502","observed_orcids":["https://orcid.org/0000-0002-7791-1502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huaitian Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012823292","display_name":"Christian C. Abnet","orcid":"https://orcid.org/0000-0002-3008-7843","observed_orcids":["https://orcid.org/0000-0002-3008-7843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian C. Abnet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hua Su","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Su","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013054784","display_name":"Hai\u2010Long Wu","orcid":"https://orcid.org/0000-0003-4483-2557","observed_orcids":["https://orcid.org/0000-0003-4483-2557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hailong Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089976309","display_name":"Neal D. Freedman","orcid":"https://orcid.org/0000-0003-0074-1098","observed_orcids":["https://orcid.org/0000-0003-0074-1098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neal D. Freedman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008522290","display_name":"Howard Hua Yang","orcid":"https://orcid.org/0000-0002-9291-631X","observed_orcids":["https://orcid.org/0000-0002-9291-631X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard H. Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100765527","display_name":"Chaoyu Wang","orcid":"https://orcid.org/0000-0002-5849-8943","observed_orcids":["https://orcid.org/0000-0002-5849-8943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaoyu Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104294656","display_name":"Chunhua Yan","orcid":"https://orcid.org/0000-0001-5474-7431","observed_orcids":["https://orcid.org/0000-0001-5474-7431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunhua Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054393035","display_name":"Lemin Wang","orcid":"https://orcid.org/0009-0002-9526-7471","observed_orcids":["https://orcid.org/0009-0002-9526-7471","https://orcid.org/0000-0001-5887-2299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lemin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073755562","display_name":"Sheryl Gere","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheryl Gere","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088697436","display_name":"Amy A Hutchinson","orcid":"https://orcid.org/0000-0002-4962-2711","observed_orcids":["https://orcid.org/0000-0002-4962-2711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Hutchinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102202679","display_name":"Guohong Song","orcid":"https://orcid.org/0000-0002-8696-1149","observed_orcids":["https://orcid.org/0000-0002-8696-1149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guohong Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yuan Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014333073","display_name":"Ti Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ti Ding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023533442","display_name":"You\u2010Lin Qiao","orcid":"https://orcid.org/0000-0001-6380-0871","observed_orcids":["https://orcid.org/0000-0001-6380-0871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"You-Lin Qiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082507553","display_name":"Jill E. Koshiol","orcid":"https://orcid.org/0000-0002-3832-6204","observed_orcids":["https://orcid.org/0000-0002-3832-6204"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill Koshiol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072634086","display_name":"Sanford M. Dawsey","orcid":"https://orcid.org/0000-0003-2185-0533","observed_orcids":["https://orcid.org/0000-0003-2185-0533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanford M. Dawsey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037413259","display_name":"Carol A. Giffen","orcid":"https://orcid.org/0000-0001-5302-6771","observed_orcids":["https://orcid.org/0000-0001-5302-6771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carol Giffen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063007431","display_name":"Alisa M. Goldstein","orcid":"https://orcid.org/0000-0002-7538-3582","observed_orcids":["https://orcid.org/0000-0002-7538-3582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alisa M. Goldstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080559639","display_name":"Philip R. Taylor","orcid":"https://orcid.org/0000-0003-0163-1421","observed_orcids":["https://orcid.org/0000-0003-0163-1421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip R. Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055646675","display_name":"Maxwell P. Lee","orcid":"https://orcid.org/0000-0003-3738-1292","observed_orcids":["https://orcid.org/0000-0003-3738-1292"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maxwell P. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.04619999974966049,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/gastric-cardia-cancer","display_name":"gastric cardia cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9490000009536743},{"id":"https://openalex.org/keywords/guanine-oxidation","display_name":"guanine oxidation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mutational-signatures","display_name":"mutational signatures","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.7820000052452087},{"id":"https://openalex.org/keywords/jak3","display_name":"JAK3","score":0.875},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/fbxw7","display_name":"FBXW7","score":0.7609999775886536},{"id":"https://openalex.org/keywords/macrod2","display_name":"MACROD2","score":0.7910000085830688},{"id":"https://openalex.org/keywords/fhit","display_name":"FHIT","score":0.8880000114440918},{"id":"https://openalex.org/keywords/park2","display_name":"PARK2","score":0.9440000057220459},{"id":"https://openalex.org/keywords/intragenic-deletion","display_name":"intragenic deletion","score":0.8809999823570251},{"id":"https://openalex.org/keywords/chromosome-alterations","display_name":"chromosome alterations","score":0.7649999856948853},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cancer-genes","display_name":"cancer genes","score":0.6110000014305115},{"id":"https://openalex.org/keywords/kiss1r","display_name":"KISS1R","score":0.746999979019165},{"id":"https://openalex.org/keywords/anti-mullerian-hormone","display_name":"anti-M\u00fcllerian hormone","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mnx1","display_name":"MNX1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/wnk2","display_name":"WNK2","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6629085540771484},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6290496587753296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5900797247886658},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.45343297719955444},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.44700267910957336},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44696614146232605},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4440406560897827},{"id":"https://openalex.org/C37846818","wikidata":"https://www.wikidata.org/wiki/Q18032813","display_name":"BAP1","level":3,"score":0.4424774646759033},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4184775948524475}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6508016","doi":"https://doi.org/10.1158/0008-5472.c.6508016","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6508016","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6508016","doi":"https://doi.org/10.1158/0008-5472.c.6508016","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6508016","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2310029373","https://openalex.org/W3143892279","https://openalex.org/W2415494861","https://openalex.org/W3000359363","https://openalex.org/W1696610950","https://openalex.org/W2144333719","https://openalex.org/W3112479683","https://openalex.org/W6889667756","https://openalex.org/W2805193692","https://openalex.org/W3121677731"],"abstract_inverted_index":{"Abstract":[0],"Gastric":[1],"cancer":[2,5,22,140,150,155,232],"and":[3,9,23,40,60,77,93,151,166,168,177,196,227,233],"esophageal":[4,24],"are":[6],"the":[7,33,50,97,107,120,209,222],"second":[8],"sixth":[10],"leading":[11],"causes":[12],"of":[13,36,52,55,66,101,117,132,189],"cancer-related":[14],"death":[15],"worldwide.":[16],"Multiple":[17],"genomic":[18,37,223],"alterations":[19,184,205],"underlying":[20,139,230],"gastric":[21,73,80,149,231],"squamous":[25],"cell":[26],"carcinoma":[27],"(ESCC)":[28],"have":[29,42],"been":[30],"identified,":[31],"but":[32],"full":[34],"spectrum":[35],"structural":[38,204],"variations":[39],"mutations":[41,126,147],"yet":[43],"to":[44,96,106],"be":[45,135],"uncovered.":[46],"Here,":[47],"we":[48,114,143,180],"report":[49],"results":[51],"whole-genome":[53],"sequencing":[54],"30":[56],"samples":[57],"comprising":[58],"tumor":[59],"blood":[61],"from":[62],"15":[63],"patients,":[64],"four":[65,78],"whom":[67],"presented":[68],"with":[69,72,79,146],"ESCC,":[70,152],"seven":[71],"cardia":[74],"adenocarcinoma":[75],"(GCA),":[76],"noncardia":[81],"adenocarcinoma.":[82],"Analyses":[83],"revealed":[84],"that":[85,130,198],"an":[86],"A>C":[87,125],"mutation":[88,108,228],"was":[89],"common":[90],"in":[91,94,111,119,127,148,185,191],"GCA,":[92],"addition":[95],"preferential":[98],"nucleotide":[99],"sequence":[100],"A":[102],"located":[103],"5":[104,121],"prime":[105,122],"as":[109],"noted":[110],"previous":[112],"studies,":[113],"found":[115],"enrichment":[116],"T":[118],"base.":[123],"The":[124,210],"GCA":[128],"suggested":[129],"oxidation":[131],"guanine":[133],"may":[134],"a":[136],"potential":[137],"mechanism":[138],"mutagenesis.":[141],"Furthermore,":[142],"identified":[144,181],"genes":[145],"including":[153,193],"well-known":[154],"genes,":[156,172,192],"TP53,":[157],"JAK3,":[158],"BRCA2,":[159],"FGF2,":[160],"FBXW7,":[161],"MSH3,":[162],"PTCH,":[163],"NF1,":[164],"ERBB2,":[165],"CHEK2,":[167],"potentially":[169],"novel":[170],"cancer-associated":[171],"KISS1R,":[173],"AMH,":[174],"MNX1,":[175],"WNK2,":[176],"PRKRIR.":[178],"Finally,":[179],"recurrent":[182],"chromosome":[183],"at":[186],"least":[187],"30%":[188],"tumors":[190],"MACROD2,":[194],"FHIT,":[195],"PARK2":[197],"were":[199,206],"often":[200],"intragenic":[201],"deletions.":[202],"These":[203],"validated":[207],"using":[208],"Cancer":[211,236],"Genome":[212],"Atlas":[213],"dataset.":[214],"Our":[215],"studies":[216],"provide":[217],"new":[218],"insights":[219],"into":[220],"understanding":[221],"landscape,":[224],"genome":[225],"instability,":[226],"profile":[229],"ESCC":[234],"development.":[235],"Res;":[237],"76(7);":[238],"1714\u201323.":[239],"\u00a92016":[240],"AACR.":[241]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-03-31T00:00:00"}