{"id":"https://openalex.org/W4361237259","doi":"https://doi.org/10.1158/0008-5472.c.6508868.v1","title":"Data from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy","display_name":"Data from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361237259","doi":"https://doi.org/10.1158/0008-5472.c.6508868.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6508868.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508868.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6508868.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6508868.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Julia Reinhardt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Reinhardt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102705110","display_name":"Jennifer Landsberg","orcid":"https://orcid.org/0000-0003-2362-5831","observed_orcids":["https://orcid.org/0000-0003-2362-5831"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Landsberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032273611","display_name":"Jonathan Leo Schmid-Burgk","orcid":"https://orcid.org/0000-0003-0988-2487","observed_orcids":["https://orcid.org/0000-0003-0988-2487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan L. Schmid-Burgk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073940249","display_name":"Bartomeu Bibiloni Ramis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bartomeu Bibiloni Ramis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025785991","display_name":"Tobias Bald","orcid":"https://orcid.org/0000-0003-0061-235X","observed_orcids":["https://orcid.org/0000-0003-0061-235X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Bald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008698954","display_name":"Nicole Glodde","orcid":"https://orcid.org/0000-0002-7012-6034","observed_orcids":["https://orcid.org/0000-0002-7012-6034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Glodde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043373712","display_name":"Dorys Lopez-Ramos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dorys Lopez-Ramos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040207559","display_name":"Arabella Young","orcid":"https://orcid.org/0000-0002-6845-9753","observed_orcids":["https://orcid.org/0000-0002-6845-9753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arabella Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054642059","display_name":"Shin Foong Ngiow","orcid":"https://orcid.org/0000-0002-5738-2834","observed_orcids":["https://orcid.org/0000-0002-5738-2834"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shin Foong Ngiow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051141861","display_name":"Daniel Nettersheim","orcid":"https://orcid.org/0000-0002-4483-845X","observed_orcids":["https://orcid.org/0000-0002-4483-845X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Nettersheim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015796348","display_name":"Hubert Schorle","orcid":"https://orcid.org/0000-0001-8272-0076","observed_orcids":["https://orcid.org/0000-0001-8272-0076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hubert Schorle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044221013","display_name":"Thomas Quast","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Quast","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012137496","display_name":"Waldemar Kolanus","orcid":"https://orcid.org/0000-0003-1325-9444","observed_orcids":["https://orcid.org/0000-0003-1325-9444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waldemar Kolanus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034365278","display_name":"Dirk Schadendorf","orcid":"https://orcid.org/0000-0003-3524-7858","observed_orcids":["https://orcid.org/0000-0003-3524-7858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dirk Schadendorf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070576000","display_name":"Georgina Venetia Long","orcid":"https://orcid.org/0000-0001-8894-3545","observed_orcids":["https://orcid.org/0000-0001-8894-3545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgina V. Long","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030018577","display_name":"Jason Madore","orcid":"https://orcid.org/0000-0002-3499-474X","observed_orcids":["https://orcid.org/0000-0002-3499-474X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Madore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083653505","display_name":"Richard A. Scolyer","orcid":"https://orcid.org/0000-0002-8991-0013","observed_orcids":["https://orcid.org/0000-0002-8991-0013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard A. Scolyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083745558","display_name":"Antoni Ribas","orcid":"https://orcid.org/0000-0003-3669-8458","observed_orcids":["https://orcid.org/0000-0003-3669-8458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antoni Ribas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061575707","display_name":"Mark John Smyth","orcid":"https://orcid.org/0000-0001-7098-7240","observed_orcids":["https://orcid.org/0000-0001-7098-7240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J. Smyth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081677088","display_name":"Paul C. Tumeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul C. Tumeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078324938","display_name":"Thomas T\u00fcting","orcid":"https://orcid.org/0000-0001-7146-0934","observed_orcids":["https://orcid.org/0000-0001-7146-0934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas T\u00fcting","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010759010","display_name":"Michael H\u00f6lzel","orcid":"https://orcid.org/0000-0003-4048-8824","observed_orcids":["https://orcid.org/0000-0003-4048-8824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael H\u00f6lzel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.15039999783039093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08380000293254852,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd73","display_name":"CD73","score":0.8759999871253967},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.8700000047683716},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.921999990940094},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/intronic-enhancer","display_name":"intronic enhancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/t-cell-immunotherapy","display_name":"T cell therapy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9959999918937683},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7662355899810791},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6333147883415222},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6246719360351562},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6018074750900269},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5049110054969788},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5008549690246582},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49659115076065063},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45188745856285095},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4506318271160126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4481312036514282},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.4456421434879303},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4135599434375763},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40407174825668335},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34317338466644287},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2993239760398865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22518491744995117},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07345819473266602},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6508868.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508868.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6508868.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6508868.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508868.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6508868.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379052364","https://openalex.org/W2416795054","https://openalex.org/W2392126385","https://openalex.org/W1992848314","https://openalex.org/W2571013527","https://openalex.org/W3039146159","https://openalex.org/W3000805999","https://openalex.org/W3205845357","https://openalex.org/W2803061034","https://openalex.org/W3216620946"],"abstract_inverted_index":{"Abstract":[0],"Evolution":[1],"of":[2,16,46,81,137],"tumor":[3],"cell":[4,50],"phenotypes":[5],"promotes":[6],"heterogeneity":[7],"and":[8,33,43],"therapy":[9],"resistance.":[10],"Here":[11],"we":[12],"found":[13],"that":[14,20],"induction":[15],"CD73,":[17],"the":[18,62],"enzyme":[19],"generates":[21],"immunosuppressive":[22],"adenosine,":[23],"is":[24],"linked":[25],"to":[26,67,73,125,144],"melanoma":[27,49,101,146],"phenotype":[28],"switching.":[29],"Activating":[30],"MAPK":[31,59],"mutations":[32],"growth":[34],"factors":[35],"drove":[36],"CD73":[37,69,84,98,121,138],"expression,":[38],"which":[39,90],"marked":[40],"both":[41],"nascent":[42],"full":[44],"activation":[45],"a":[47,78,92,123,142],"mesenchymal-like":[48,93],"state":[51],"program.":[52],"Proinflammatory":[53],"cytokines":[54],"like":[55],"TNF\u03b1":[56],"cooperated":[57],"with":[58,127],"signaling":[60],"through":[61],"c-Jun/AP-1":[63],"transcription":[64,70],"factor":[65],"complex":[66],"activate":[68],"by":[71],"binding":[72],"an":[74,114],"intronic":[75],"enhancer.":[76],"In":[77],"mouse":[79],"model":[80],"T-cell":[82,106],"immunotherapy,":[83],"was":[85],"induced":[86],"in":[87,100],"relapse":[88],"melanomas,":[89],"acquired":[91],"phenotype.":[94],"We":[95],"also":[96],"detected":[97],"upregulation":[99],"patients":[102],"progressing":[103],"under":[104],"adoptive":[105],"transfer":[107],"or":[108],"immune":[109],"checkpoint":[110],"blockade,":[111],"arguing":[112],"for":[113],"adaptive":[115],"resistance":[116],"mechanism.":[117],"Our":[118],"work":[119],"substantiates":[120],"as":[122,141],"target":[124],"combine":[126],"current":[128],"immunotherapies,":[129],"but":[130],"its":[131],"dynamic":[132],"regulation":[133],"suggests":[134],"limited":[135],"value":[136],"pretreatment":[139],"expression":[140],"biomarker":[143],"stratify":[145],"patients.":[147],"Cancer":[148],"Res;":[149],"77(17);":[150],"4697\u2013709.":[151],"\u00a92017":[152],"AACR.":[153]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
