{"id":"https://openalex.org/W4361237255","doi":"https://doi.org/10.1158/0008-5472.c.6508452.v1","title":"Data from CIC-DUX4 Induces Small Round Cell Sarcomas Distinct from Ewing Sarcoma","display_name":"Data from CIC-DUX4 Induces Small Round Cell Sarcomas Distinct from Ewing Sarcoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361237255","doi":"https://doi.org/10.1158/0008-5472.c.6508452.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6508452.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508452.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508452.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6508452.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007358330","display_name":"Toyoki Yoshimoto","orcid":"https://orcid.org/0009-0003-1676-7257","observed_orcids":["https://orcid.org/0009-0003-1676-7257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toyoki Yoshimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023730666","display_name":"Miwa Tanaka","orcid":"https://orcid.org/0000-0003-4934-3787","observed_orcids":["https://orcid.org/0000-0003-4934-3787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miwa Tanaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001807716","display_name":"Mizuki Homme","orcid":"https://orcid.org/0009-0006-1747-4028","observed_orcids":["https://orcid.org/0009-0006-1747-4028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mizuki Homme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036671946","display_name":"Yukari Yamazaki","orcid":"https://orcid.org/0000-0001-9373-8618","observed_orcids":["https://orcid.org/0000-0001-9373-8618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukari Yamazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061851582","display_name":"Yutaka Takazawa","orcid":"https://orcid.org/0009-0007-0119-0212","observed_orcids":["https://orcid.org/0009-0007-0119-0212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutaka Takazawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086786876","display_name":"Cristina R. Antonescu","orcid":"https://orcid.org/0000-0002-9717-8205","observed_orcids":["https://orcid.org/0000-0002-9717-8205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina R. Antonescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110966437","display_name":"Takuro Nakamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takuro Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-round-cell-sarcoma","display_name":"small round cell sarcoma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/muc5ac","display_name":"MUC5AC","score":0.9890000224113464},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ret","display_name":"RET","score":0.6269999742507935},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.8600000143051147},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/trabectedin","display_name":"trabectedin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.655850887298584},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5811786651611328},{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.5164132714271545},{"id":"https://openalex.org/C2780752271","wikidata":"https://www.wikidata.org/wiki/Q2637746","display_name":"Trabectedin","level":4,"score":0.4835641086101532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45766571164131165},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.41887983679771423},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38642218708992004},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31955486536026},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.2717147767543793},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.258770614862442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19464167952537537},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1491813361644745},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.09432974457740784},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09407559037208557},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6508452.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508452.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508452.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6508452.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508452.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508452.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2084739604","https://openalex.org/W2164801867","https://openalex.org/W2059874848","https://openalex.org/W4380667482","https://openalex.org/W2048514585","https://openalex.org/W2233738120","https://openalex.org/W4235783898","https://openalex.org/W4302425178","https://openalex.org/W2179832015","https://openalex.org/W2908434774"],"abstract_inverted_index":{"Abstract":[0],"CIC-DUX4":[1,83,90,114,150],"sarcoma":[2,6,14,21,96,173],"(CDS)":[3],"or":[4],"CIC-rearranged":[5],"is":[7,33],"a":[8,196],"subcategory":[9],"of":[10,19,50,67,98,107,113,149,180],"small":[11,99],"round":[12,100],"cell":[13],"resembling":[15],"the":[16,47,65,170,178],"morphological":[17],"phenotypes":[18],"Ewing":[20],"(ES).":[22],"However,":[23],"recent":[24],"clinicopathologic":[25],"and":[26,52,109,124,131,137,156,169,194,202],"molecular":[27],"genetic":[28],"analyses":[29,127],"indicate":[30],"that":[31,135],"CDS":[32,74,108,144,160,193],"an":[34,68,93],"independent":[35],"disease":[36],"entity":[37],"from":[38,145],"ES.":[39,146],"Few":[40],"ancillary":[41],"markers":[42],"have":[43],"been":[44],"used":[45],"in":[46,163],"differential":[48],"diagnosis":[49],"CDS,":[51],"additional":[53],"CDS-specific":[54],"biomarkers":[55,141,201],"are":[56,139],"needed":[57],"for":[58,73,128,205],"more":[59],"definitive":[60],"classification.":[61],"Here,":[62],"we":[63],"report":[64],"generation":[66],"ex":[69],"vivo":[70],"mouse":[71,130,181,186],"model":[72,187],"by":[75],"transducing":[76],"embryonic":[77],"mesenchymal":[78],"cells":[79],"(eMC)":[80],"with":[81,88],"human":[82,132],"cDNA.":[84],"Recipient":[85],"mice":[86],"transplanted":[87],"eMC-expressing":[89],"rapidly":[91],"developed":[92],"aggressive,":[94],"undifferentiated":[95],"composed":[97],"to":[101,142,199],"short":[102],"spindle":[103],"cells.":[104],"Gene-expression":[105],"profiles":[106],"eMC":[110],"revealed":[111],"upregulation":[112],"downstream":[115],"genes":[116],"such":[117],"as":[118,151,153],"PEA3":[119],"family":[120],"genes,":[121],"Ccnd2,":[122,154],"Crh,":[123],"Zic1.":[125],"IHC":[126],"both":[129],"tumors":[133],"showed":[134],"CCND2":[136],"MUC5AC":[138],"reliable":[140],"distinguish":[143],"Gene":[147],"silencing":[148],"well":[152],"Ret,":[155],"Bcl2":[157],"effectively":[158],"inhibited":[159],"tumor":[161],"growth":[162,179],"vitro.":[164],"The":[165],"CDK4/6":[166],"inhibitor":[167],"palbociclib":[168],"soft":[171],"tissue":[172],"drug":[174],"trabectedin":[175],"also":[176],"blocked":[177],"CDS.":[182,206],"In":[183],"summary,":[184],"our":[185],"provides":[188,195],"important":[189],"biological":[190],"information":[191],"about":[192],"useful":[197],"platform":[198],"explore":[200],"therapeutic":[203],"agents":[204],"Cancer":[207],"Res;":[208],"77(11);":[209],"2927\u201337.":[210],"\u00a92017":[211],"AACR.":[212]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}