{"id":"https://openalex.org/W4361235722","doi":"https://doi.org/10.1158/0008-5472.c.6509709","title":"Data from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8+ T Cells","display_name":"Data from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8+ T Cells","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361235722","doi":"https://doi.org/10.1158/0008-5472.c.6509709"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6509709","doi":"https://doi.org/10.1158/0008-5472.c.6509709","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6509709","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6509709","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006274128","display_name":"Christopher Bryce Johnson","orcid":"https://orcid.org/0000-0003-1255-8207","observed_orcids":["https://orcid.org/0000-0003-1255-8207","https://orcid.org/0000-0003-0730-0877"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Bryce Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088171834","display_name":"Bennett R. May","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bennett R. May","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076371763","display_name":"Brian Riesenberg","orcid":"https://orcid.org/0000-0001-7358-3479","observed_orcids":["https://orcid.org/0000-0001-7358-3479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian P. Riesenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010067171","display_name":"Samantha Suriano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samantha Suriano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041139369","display_name":"Shikhar Mehrotra","orcid":"https://orcid.org/0000-0002-5411-9504","observed_orcids":["https://orcid.org/0000-0002-5411-9504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shikhar Mehrotra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029296725","display_name":"Elizabeth S. Garrett-Mayer","orcid":"https://orcid.org/0000-0003-4709-0333","observed_orcids":["https://orcid.org/0000-0003-4709-0333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Garrett-Mayer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018009812","display_name":"Mohamed Labib Salem","orcid":"https://orcid.org/0000-0003-0840-5291","observed_orcids":["https://orcid.org/0000-0003-0840-5291"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed L. Salem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066424143","display_name":"Emily K. Jeng","orcid":"https://orcid.org/0000-0002-9896-0645","observed_orcids":["https://orcid.org/0000-0002-9896-0645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily K. Jeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069160791","display_name":"Hing C. Wong","orcid":"https://orcid.org/0000-0002-6865-4313","observed_orcids":["https://orcid.org/0000-0002-6865-4313"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hing C. Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044271217","display_name":"Chrystal Mary Paulos","orcid":"https://orcid.org/0000-0002-0784-2601","observed_orcids":["https://orcid.org/0000-0002-0784-2601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chrystal M. Paulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089431719","display_name":"John M. Wrangle","orcid":"https://orcid.org/0000-0001-8998-4509","observed_orcids":["https://orcid.org/0000-0001-8998-4509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Wrangle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011910232","display_name":"David J. Cole","orcid":"https://orcid.org/0000-0003-3162-701X","observed_orcids":["https://orcid.org/0000-0003-3162-701X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Cole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046739998","display_name":"Mark P. Rubinstein","orcid":"https://orcid.org/0000-0003-4748-0286","observed_orcids":["https://orcid.org/0000-0003-4748-0286","https://orcid.org/0000-0002-9942-7519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark P. Rubinstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.3725999891757965,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.3725999891757965,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.31130000948905945,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2485000044107437,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphodepletion","display_name":"lymphocyte depletion","score":0.8899999856948853},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.7490000128746033},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.8740000128746033},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.7689999938011169},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-engraftment","display_name":"T cell engraftment","score":0.8489999771118164},{"id":"https://openalex.org/keywords/t-cell-persistence","display_name":"T cell persistence","score":0.8889999985694885},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cytokine-supplementation","display_name":"cytokine supplementation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.6362612843513489},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5811315178871155},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5761693716049194},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5541099905967712},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.49966955184936523},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.47385433316230774},{"id":"https://openalex.org/C2777371436","wikidata":"https://www.wikidata.org/wiki/Q3237071","display_name":"Leukapheresis","level":4,"score":0.43336382508277893},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4277379810810089},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.42206865549087524},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4185892343521118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30219340324401855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2100841999053955},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.19053536653518677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18547788262367249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17092260718345642},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11323648691177368},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.095582515001297},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09238016605377197},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0778479278087616},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6509709","doi":"https://doi.org/10.1158/0008-5472.c.6509709","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6509709","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6509709","doi":"https://doi.org/10.1158/0008-5472.c.6509709","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6509709","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966007516","https://openalex.org/W2988581130","https://openalex.org/W4385351029","https://openalex.org/W2066283134","https://openalex.org/W2100716781","https://openalex.org/W1860916193","https://openalex.org/W2349603434","https://openalex.org/W4385685231","https://openalex.org/W3025611346","https://openalex.org/W2022215519"],"abstract_inverted_index":{"Abstract":[0],"Effector":[1],"CD8+":[2,55],"T":[3,56,99,128,143,167,194],"cells":[4,45,100,129,144],"conditioned":[5],"with":[6,115,131,210],"IL12":[7],"during":[8],"activation":[9],"mediate":[10],"enhanced":[11,79],"antitumor":[12,51,124,150,162,190,232],"efficacy":[13,125,163,199],"after":[14,107,137,179],"adoptive":[15],"transfer":[16,140],"into":[17],"lymphodepleted":[18],"hosts;":[19],"this":[20],"is":[21,183],"due":[22],"in":[23,71,82,112,226],"part":[24],"to":[25,89,103,146,185],"improved":[26,205],"IL7":[27,135,177],"responsiveness.":[28],"Therefore,":[29],"we":[30,73],"hypothesized":[31],"that":[32,75,172,197],"increasing":[33],"the":[34,48,90,110,123,159,173,187,198],"intensity":[35],"or":[36,70,149,154,212],"type":[37],"of":[38,53,92,97,126,141,164,175,192,200],"lymphodepletion":[39,77,119,182,218],"would":[40],"deplete":[41],"more":[42],"IL7-consuming":[43],"host":[44,104,176],"and":[46,50,61,139,161,189,196,219,231],"improve":[47,147],"persistence":[49,148,160],"activity":[52,191],"IL12-conditioned":[54],"cells.":[57,168],"Using":[58],"cyclophosphamide,":[59],"fludarabine,":[60],"total":[62],"body":[63],"irradiation":[64],"(TBI,":[65],"6":[66],"Gy)":[67],"either":[68],"individually":[69],"combination,":[72],"found":[74],"combined":[76],"best":[78],"T-cell":[80,229],"engraftment":[81,113,230],"mice.":[83],"This":[84],"improvement":[85,111],"was":[86],"strongly":[87],"related":[88],"extent":[91],"leukopenia,":[93],"as":[94],"posttransfer":[95,208],"levels":[96],"donor":[98,127,165,193,228],"inversely":[101],"correlated":[102],"cell":[105],"counts":[106],"lymphodepletion.":[108],"Despite":[109],"seen":[114],"combination":[116],"lymphodepletion,":[117],"dual-agent":[118],"did":[120],"not":[121],"augment":[122],"compared":[130],"TBI":[132,138],"alone.":[133],"Similarly,":[134],"supplementation":[136,156],"tumor-reactive":[142,166],"failed":[145],"immunity.":[151],"However,":[152],"IL15":[153],"IL2":[155,211],"greatly":[157],"augmented":[158],"Our":[169],"results":[170],"indicate":[171],"amount":[174],"induced":[178],"single":[180],"agent":[181],"sufficient":[184],"potentiate":[186],"expansion":[188],"cells,":[195],"future":[201],"regimens":[202],"may":[203],"be":[204],"by":[206],"providing":[207],"support":[209,221],"IL15.":[213],"Significance:":[214],"The":[215],"relationship":[216],"between":[217],"cytokine":[220],"plays":[222],"a":[223],"critical":[224],"role":[225],"determining":[227],"efficacy.":[233],"Cancer":[234],"Res;":[235],"78(11);":[236],"3067\u201374.":[237],"\u00a92018":[238],"AACR.":[239]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}
