{"id":"https://openalex.org/W4361235582","doi":"https://doi.org/10.1158/0008-5472.22417373.v1","title":"Figures S1-S7, Tables S1-S6, Supplementary Materials and Methods, Supplementary References from Tissue Tranglutaminase Regulates Interactions between Ovarian Cancer Stem Cells and the Tumor Niche","display_name":"Figures S1-S7, Tables S1-S6, Supplementary Materials and Methods, Supplementary References from Tissue Tranglutaminase Regulates Interactions between Ovarian Cancer Stem Cells and the Tumor Niche","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361235582","doi":"https://doi.org/10.1158/0008-5472.22417373.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22417373.v1","doi":"https://doi.org/10.1158/0008-5472.22417373.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22417373.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39863480","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/ndownloader/files/39863480","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076427573","display_name":"Salvatore Condello","orcid":"https://orcid.org/0000-0003-4979-3681","observed_orcids":["https://orcid.org/0000-0003-4979-3681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvatore Condello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082803202","display_name":"Livia Elena Sima","orcid":"https://orcid.org/0000-0002-3404-4162","observed_orcids":["https://orcid.org/0000-0002-3404-4162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Livia Sima","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3404-4162","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082498438","display_name":"Cristina Ivan","orcid":"https://orcid.org/0000-0002-4848-0168","observed_orcids":["https://orcid.org/0000-0002-4848-0168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Ivan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074942227","display_name":"Horacio C\u00e1rdenas","orcid":"https://orcid.org/0000-0002-2129-6766","observed_orcids":["https://orcid.org/0000-0002-2129-6766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Horacio Cardenas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079762031","display_name":"Gary E. Schiltz","orcid":"https://orcid.org/0000-0003-4180-5051","observed_orcids":["https://orcid.org/0000-0003-4180-5051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Schiltz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4180-5051","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059724338","display_name":"Rama K. Mishra","orcid":"https://orcid.org/0000-0003-3608-2602","observed_orcids":["https://orcid.org/0000-0003-3608-2602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rama K. Mishra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067743297","display_name":"Daniela Elena Matei","orcid":"https://orcid.org/0000-0003-2169-5035","observed_orcids":["https://orcid.org/0000-0003-2169-5035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Matei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-transglutaminase","display_name":"tissue transglutaminase","score":0.7490000128746033},{"id":"https://openalex.org/keywords/ovarian-cancer-stem-cells","display_name":"ovarian cancer stem cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.6439999938011169},{"id":"https://openalex.org/keywords/aldh1a1","display_name":"ALDH1A1","score":0.7429999709129333},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.7639999985694885},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/spheroids","display_name":"spheroids","score":0.6159999966621399},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.6809999942779541},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8019999861717224},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.652999997138977},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5389999747276306},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.6129999756813049},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.5099999904632568},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.6119999885559082},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.8216490745544434},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.820122480392456},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.6025659441947937},{"id":"https://openalex.org/C2778265714","wikidata":"https://www.wikidata.org/wiki/Q18033993","display_name":"KLF4","level":5,"score":0.5555407404899597},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5356283783912659},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5152580738067627},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5140525102615356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4873102903366089},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.4736795723438263},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4444938898086548},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3963412642478943},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31387120485305786},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2426186203956604},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.199745774269104},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1716577112674713},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.168779194355011},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11413738131523132},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0714118480682373},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22417373.v1","doi":"https://doi.org/10.1158/0008-5472.22417373.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22417373.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39863480","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22417373","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Figures_S1-S7_Tables_S1-S6_Supplementary_Materials_and_Methods_Supplementary_References_from_Tissue_Tranglutaminase_Regulates_Interactions_between_Ovarian_Cancer_Stem_Cells_and_the_Tumor_Niche/22417373","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22417373.v1","doi":"https://doi.org/10.1158/0008-5472.22417373.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22417373.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39863480","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361235582.pdf","grobid_xml":"https://content.openalex.org/works/W4361235582.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3081536093","https://openalex.org/W2887780345","https://openalex.org/W2792582780","https://openalex.org/W4361235111","https://openalex.org/W7148995434","https://openalex.org/W2009213090","https://openalex.org/W2410338679","https://openalex.org/W4284976869","https://openalex.org/W2050946558","https://openalex.org/W2048349559"],"abstract_inverted_index":{"Supplementary":[0,122,184,232,272,335,379,473,486,499,508,521,534,542,546],"Figure":[1,123,185,233,273,336,380],"S1.":[2,475],"ALDH1A1,":[3,16,59,244],"Sox2,":[4,17,60,245],"Nanog,":[5,18,61,246],"Oct-4":[6,20,63,248],"and":[7,12,19,31,41,47,62,78,93,113,115,118,131,159,169,199,209,219,240,247,264,281,290,327,343,366,368,377,419,431,439,544],"TG2":[8,85,102,158,168,456],"expression":[9,86,252,435,458],"in":[10,24,43,48,67,79,88,109,136,175,192,222,249,254,267,283,292,302,315,329,386,393,437,449,463,482],"OCSCs":[11],"ovarian":[13,143,484],"spheroids.":[14,258,271,309,388],"A-B.":[15],"mRNA":[21,64,125,251,434,457],"levels":[22,65,87,156,166,253,436],"measured":[23,66],"ALDH+/CD133+":[25],"vs.":[26,70,162,172],"ALDH-/CD133-":[27],"isolated":[28],"from":[29,73,318,360,369],"OVCAR5":[30,438],"COV362":[32,204,257,270,293,305],"cells.":[33,81,285],"C-D.":[34],"Expression":[35,496],"of":[36,84,157,160,167,170,188,201,276,354,383,408],"TG2,":[37,129,217],"integrin":[38,132,220,324],"\u03b21":[39,133,221,236,279,477],"(ITGB1),":[40],"FN1":[42,130],"primary":[44,75,223,370],"OC":[45,76,89,224,284,332,340,361,371,387,465],"cells":[46,50,77,111,205,225,306,355,372,395,410,441],"SKOV3":[49,80,110,394,409,440],"grown":[51,206,226],"as":[52,207,227,308,357],"monolayers":[53,68],"(mono)":[54,69],"or":[55,99,400,415,421,425,446,452],"spheroids":[56,71,208,228,341,358],"(sphere).":[57],"E-F.":[58],"(sphere)":[72],"human":[74,483],"G.":[82],"W.B.":[83],"cell":[90,120,333,362],"lines":[91,363],"(SKOV3":[92],"HEY)":[94],"stably":[95,396,411,442],"transduced":[96,397,412,443],"with":[97,211,375,398,413,423,444,461],"AS-TG2":[98],"ShRNA":[100,417,448],"targeting":[101],"(Sh-TG2).":[103],"H.":[104],"Flow":[105,195],"cytometry":[106,196],"measures":[107,197,351,406,429],"ALDEFLUOR-FITC+/CD133-APC+":[108],"(pcDNA3.1":[112],"AS-TG2)":[114],"HEY":[116],"(Sh-Ctr":[117],"Sh-TG2)":[119],"lines.":[121,334],"S2.":[124,488],"microarray":[126],"comparison":[127],"between":[128],"(ITGB1)":[134],"(A-B)":[135],"the":[137,176,277,352,464],"Affymetrix":[138,177,466,515,528],"Human":[139,178,467,516,529],"Exon":[140,179,468,517,530],"1.0":[141,180,469,518,531],"ST":[142,181,470,519,532],"cancer":[144],"TCGA":[145,182,471],"database.":[146,183,472],"C.":[147,310],"Estimated":[148],"overall":[149,491,504,513,526],"survival":[150,492,505,514,527],"curves":[151],"for":[152,216,261,288,313,323,391,539],"tumors":[153,316],"expressing":[154,164],"high":[155],"ITGB1":[161,171],"those":[163],"low":[165],"all":[173],"others":[174],"S3.":[186,501],"Effects":[187],"anti-TG2":[189],"(4G3)":[190],"treatment":[191,374],"OCSCs.":[193],"A.":[194,243,286,389],"apoptosis":[198],"necrosis":[200],"OVCAR5,":[202],"SKOV3,":[203],"treated":[210,256,269,304,331,420],"4G3.":[212],"B-C.":[213,403],"IF":[214,321],"staining":[215,312,322],"FN,":[218,326],"after":[229,373,453],"4G3":[230,250,255,268,303,330,376],"treatment.":[231],"S4.":[234,510],"TG2/FN/Integrin":[235,278],"complex":[237,280],"regulates":[238],"stemness":[239],"\u03b2-catenin":[241,314],"activation.":[242],"B.":[259,298],"Q-RT-PCR":[260,287,390,428],"\u03b2-catenin,":[262],"c-Myc,":[263],"cyclin":[265,432],"D1":[266,433],"S5.":[274,523],"Functions":[275],"Fzd7":[282,291,328,392,462],"Fzd1":[289],"CSCs":[294],"compared":[295],"to":[296,345],"non-CSCs.":[297],"TCF/LEF":[299],"luciferase":[300],"reporter":[301],"plated":[307],"IHC":[311],"derived":[317,359],"xenografts.":[319],"D-E.":[320],"\u03b21,":[325],"S6.":[337],"TG2-targeting":[338],"disrupts":[339],"proliferation":[342,407],"response":[344],"Wnt":[346,384],"ligand.":[347],"A-D.":[348],"Proliferation":[349],"assay":[350,405],"number":[353],"growing":[356],"(OVCAR5,":[364],"COV362,":[365],"SKOV3)":[367],"Wnt7A.":[378,426],"S7.":[381],"Activation":[382],"pathway":[385],"scrambled-":[399,414,445],"Fzd7-targeting":[401,416,447],"ShRNA.":[402],"CCK8":[404],"clones":[418],"not":[422],"Wnt3A":[424],"D-I.":[427],"c-Myc":[430],"basal":[450],"conditions":[451],"Wnt3A/7A.":[454],"J.":[455],"level":[459],"correlates":[460],"Table":[474,487,500,509,522,535],"TG2/integrin":[476],"co-localization":[478],"detected":[479],"by":[480],"PLA":[481],"tumors.":[485],"Univariate":[489,511],"analysis":[490,503,512,525],"Agilent":[493,506],"244K":[494],"Gene":[495],"G4502A-07":[497],"data.":[498,507,520,533],"Multivariate":[502,524],"S6:":[536],"Primers":[537],"used":[538],"Quantitative":[540],"RT-PCR.":[541],"Materials":[543],"Methods.":[545],"References.":[547]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2023-03-31T00:00:00"}