{"id":"https://openalex.org/W4361015381","doi":"https://doi.org/10.7554/elife.83533.sa2","title":"Author response: Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling","display_name":"Author response: Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling","publication_year":2022,"publication_date":"2022-12-21","ids":{"openalex":"https://openalex.org/W4361015381","doi":"https://doi.org/10.7554/elife.83533.sa2"},"language":"en","primary_location":{"id":"doi:10.7554/elife.83533.sa2","doi":"https://doi.org/10.7554/elife.83533.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.83533.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.83533.sa2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107995564","display_name":"Xing Feng","orcid":"https://orcid.org/0000-0002-2253-4180","observed_orcids":["https://orcid.org/0000-0002-2253-4180"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Feng","raw_affiliation_strings":["Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-2253-4180","affiliations":[{"raw_affiliation_string":"Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108081400","display_name":"Ruifeng Sun","orcid":"https://orcid.org/0000-0003-2303-9998","observed_orcids":["https://orcid.org/0000-0003-2303-9998"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruifeng Sun","raw_affiliation_strings":["Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University","Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005896564","display_name":"Moon Young Lee","orcid":"https://orcid.org/0000-0003-4956-9241","observed_orcids":["https://orcid.org/0000-0003-4956-9241"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Moonyoung Lee","raw_affiliation_strings":["Department of Biomedical Sciences, Korea University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Korea University College of Medicine","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707817","display_name":"Xinyue Chen","orcid":"https://orcid.org/0000-0001-8288-7685","observed_orcids":["https://orcid.org/0000-0001-8288-7685","https://orcid.org/0000-0003-1188-9274","https://orcid.org/0009-0008-7346-0338","https://orcid.org/0000-0001-6987-5540"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyue Chen","raw_affiliation_strings":["Department of Cell Biology and Yale Stem Cell Center, Yale University"],"raw_orcid":"https://orcid.org/0000-0001-8288-7685","affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Yale Stem Cell Center, Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072320963","display_name":"Shangqin Guo","orcid":"https://orcid.org/0000-0003-1157-0423","observed_orcids":["https://orcid.org/0000-0003-1157-0423"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shangqin Guo","raw_affiliation_strings":["Department of Cell Biology and Yale Stem Cell Center, Yale University"],"raw_orcid":"https://orcid.org/0000-0003-1157-0423","affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Yale Stem Cell Center, Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020303646","display_name":"Huimin Geng","orcid":"https://orcid.org/0000-0001-5339-5446","observed_orcids":["https://orcid.org/0000-0001-5339-5446"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huimin Geng","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023176978","display_name":"Marcus M\u00fcschen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus M\u00fcschen","raw_affiliation_strings":["Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University","Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084355267","display_name":"Jungmin Choi","orcid":"https://orcid.org/0000-0002-8614-0973","observed_orcids":["https://orcid.org/0000-0002-8614-0973"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Jungmin Choi","raw_affiliation_strings":["Department of Biomedical Sciences, Korea University College of Medicine","Department of Genetics, School of Medicine, Yale University"],"raw_orcid":"https://orcid.org/0000-0002-8614-0973","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Korea University College of Medicine","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Genetics, School of Medicine, Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041693943","display_name":"Jo\u00e3o P. Pereira","orcid":"https://orcid.org/0000-0002-5694-4938","observed_orcids":["https://orcid.org/0000-0002-5694-4938"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joao Pedro Pereira","raw_affiliation_strings":["Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-5694-4938","affiliations":[{"raw_affiliation_string":"Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.18410000205039978,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.7950000166893005},{"id":"https://openalex.org/keywords/lymphopoiesis","display_name":"lymphocyte development","score":0.9229999780654907},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cxcr4-signaling","display_name":"CXCR4 signaling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-niche","display_name":"hematopoietic niche","score":0.7200000286102295},{"id":"https://openalex.org/keywords/competitive-advantage","display_name":"competitive advantage","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C61879462","wikidata":"https://www.wikidata.org/wiki/Q24774130","display_name":"Lymphotoxin","level":3,"score":0.8630384206771851},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6501467227935791},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6256585717201233},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6035651564598083},{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.5863401293754578},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.568389356136322},{"id":"https://openalex.org/C54500882","wikidata":"https://www.wikidata.org/wiki/Q14914431","display_name":"Lymphotoxin beta receptor","level":4,"score":0.5003955364227295},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.489847868680954},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.4689566493034363},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4636026620864868},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.44311630725860596},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43757516145706177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4338510036468506},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3584910035133362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34486156702041626},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.18405795097351074},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.16721469163894653},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.11708658933639526}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.83533.sa2","doi":"https://doi.org/10.7554/elife.83533.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.83533.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.83533.sa2","doi":"https://doi.org/10.7554/elife.83533.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.83533.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4324020438","https://openalex.org/W4318499636","https://openalex.org/W2585628954","https://openalex.org/W4409388200","https://openalex.org/W1984619334","https://openalex.org/W7132610645","https://openalex.org/W2931616080","https://openalex.org/W4395676636","https://openalex.org/W2834246098","https://openalex.org/W4392287346"],"abstract_inverted_index":{"Article":[0,18],"Figures":[1],"and":[2,19,26,30,41,60,71,80,86,103,115,143,159,224,234,256,313,318,322,333,343,349,369,373,390,401,415,448,458,501,505,533,547,553,557,566,571,586,600,618,621,632,639,655,691,695,808,818,829,862,895,898,908,925,928,943,950,962,1008,1060,1096,1103,1124,1144,1207,1231,1252,1275,1348,1360,1368,1394,1434,1469,1488,1511,1535,1541,1556,1585,1631,1644,1650,1697,1707,1737,1764,1775,1852,1879,1909,1973,2013,2024,2027,2035,2041,2100,2120,2148,2158,2186,2190,2194,2237,2246,2261,2314,2333,2369,2424,2447,2465,2505,2641,2670,2718,2725,2773,2796,2818,2859,2884,2924,2966,3016,3026,3192,3211,3237,3256,3329,3355,3373,3395,3466,3488,3500,3532,3573,3670,3695,3749,3777,3798,3816,3877,3957,3988,4024,4054,4058,4064,4123,4133,4168,4199,4211,4217,4256,4296,4320,4360],"data":[3,1720,3219,4110],"Abstract":[4,23],"Editor's":[5,182],"evaluation":[6,183],"Introduction":[7,273],"Results":[8,1034],"Discussion":[9],"Methods":[10],"Data":[11,1281,1318,1748,1826,2469,3090,4213,4229],"availability":[12],"References":[13],"Decision":[14,265],"letter":[15,266],"Author":[16],"response":[17,113,3485,3497,3537,3582],"author":[20],"information":[21],"Metrics":[22],"Acute":[24],"lymphoblastic":[25,552,1337,2491,3110,3993],"myeloblastic":[27,554],"leukemias":[28,168,555],"(ALL":[29,556],"AML)":[31,558],"have":[32,852,3591,3702,4249],"been":[33,799,853,1054],"known":[34,642],"to":[35,199,261,665,667,693,801,889,900,1030,1149,1155,1192,1366,1503,1573,2003,2075,2278,2406,2552,2656,2712,2719,2748,2829,2867,2886,3118,3261,3294,3473,3680,3787,4085,4104],"modify":[36],"the":[37,46,76,110,146,195,204,302,465,527,536,561,592,628,651,668,777,825,917,955,967,997,1078,1142,1193,1380,1389,1475,1549,1608,1880,1953,1965,1988,1998,2016,2083,2092,2134,2205,2213,2225,2251,2395,2553,2803,2868,2889,3156,3182,3222,3263,3334,3350,3399,3482,3494,3520,3620,3916,3955,4014,4069,4259,4303,4348,4368],"bone":[38,77,196,239,303,1286,1662,2869,4070],"marrow":[39,197,240,304,1287,1663,2870,4071],"microenvironment":[40,779,796],"disrupt":[42],"non-malignant":[43,105,931,1262,1386,1657,1674,1686,1728,1853,1961,2325,2370,2503,2721,2902,2994,4154],"hematopoiesis.":[44,208,1033,1255],"However,":[45,360,684,916,2291,4288],"molecular":[47,918,1021],"mechanisms":[48,171,851,919,1022,1954],"driving":[49],"these":[50,330,644,1045,1576,1601,2022,2293,2385,2799,3218,3278,3387,3568],"alterations":[51,2459],"remain":[52,933],"poorly":[53,934],"defined.":[54,935],"Using":[55],"mouse":[56,657,810,1568,1790,1885,1944,2506,2676,2742,2951,3006,3242,3971,4178],"models":[57,658,811],"of":[58,129,148,206,462,498,529,563,595,615,659,745,812,827,970,986,999,1011,1249,1261,1321,1383,1413,1451,1458,1477,1545,1634,1642,1665,1679,1692,1712,1719,1727,1789,1829,1883,1943,2019,2029,2068,2082,2115,2126,2143,2154,2215,2250,2292,2391,2402,2450,2477,2647,2791,2826,2847,2864,2901,2946,2975,2993,3004,3019,3058,3068,3078,3096,3158,3176,3189,3225,3245,3265,3352,3371,3393,3402,3416,3445,3481,3541,3551,3610,3622,3667,3803,3919,3959,4001,4021,4031,4073,4109,4153,4177,4207,4222,4232,4281,4314,4370],"ALL":[59,79,942,1035,1075,1111,1134,1211,1223,1339,1358,1384,1524,1546,1569,1594,1713,1785,1850,1859,1896,1925,1957,1971,1977,2036,2043,2051,2064,2101,2135,2157,2177,2267,2337,2347,2376,2392,2501,2510,2550,2558,2591,2664,2688,2698,2708,2729,2736,2753,2865,2942,2980,3000,3012,3126,3196,3234,3505,3587,3723,3769,3815,3872,3922,3949,4161,4227,4254],"AML,":[61],"here":[62,1082,2524],"we":[63,939,1069,1354,1428,1479,1855,1963,1991,2508,2696,2757,2808,3130,3312,3360,3389,3503,3659,3766,3869,4306],"show":[64,108,940,1285,1752,2387,2801],"that":[65,109,166,249,297,608,760,773,867,941,959,1017,1023,1176,1356,1430,1435,1491,1505,2227,2234,2529,2573,2673,2802,2807,3221,3288,3314,3333,3362,3512,3571,3593,3705,4251,4273,4308,4341],"leukemic":[66,123,140,192,222,262,625,661,913,1005,1018,1506],"cells":[67,82,96,193,223,226,233,288,311,315,375,662,686,722,740,751,766,859,887,945,964,1019,1076,1112,1123,1128,1201,1359,1364,1410,1507,1525,1538,1547,1563,1570,1595,1630,1649,1659,1676,1689,1706,1763,1860,1897,1958,2268,2348,2431,2511,2559,2592,2689,2699,2709,2730,2737,2965,3136,3287,3317,3365,3405,3410,3419,3448,3471,3506,3600,3618,3717,3724,3770,3802,3819,3873,3928,4006,4036,4067,4122,4149,4198,4210],"turn":[68,947,1003],"off":[69,100,948],"lymphopoiesis":[70,135,607,949,992,1230,1350,1899,2326,2621,2626,2722,2858,3116],"erythropoiesis":[72,951,995,1232,1919],"shortly":[73,952],"after":[74,953,1133,1210,1308,1792,2953,2971,3008,3034,3678,4180,4226],"colonizing":[75],"marrow.":[78],"AML":[81,806,858,944,963,4358,4365],"express":[83,965,1432,1508,1527,4310],"lymphotoxin":[84,88,119,229,971,1635,2827,2852,3557,3602,3629,3656,3710,3759,3790],"\u03b11\u03b22":[85,120,1626,3558,3603,3630,3657,3711,3760,3791],"activate":[87],"beta":[89,972,1636,2421,2853],"receptor":[90,236,973,1637,2422,2854,3596],"(LT\u03b2R)":[91,1638,2855],"signaling":[92,117,131,736,988,1342,1406,1437,1514,1848,1914,2196,2220,2363,2497,2545,2575,2649,2659,2693,2856,3585,3597,3652,3707,3726,3755,3987,4356],"in":[93,122,132,301,365,464,535,606,656,697,716,738,748,764,776,805,809,909,979,989,1002,1026,1115,1170,1185,1196,1229,1282,1343,1371,1385,1407,1411,1441,1455,1515,1517,1548,1582,1611,1628,1647,1651,1661,1677,1690,1703,1722,1733,1749,1937,1968,1974,2066,2124,2152,2183,2274,2281,2339,2355,2378,2394,2428,2460,2470,2498,2516,2518,2546,2548,2567,2576,2596,2604,2615,2622,2630,2639,2650,2660,2666,2694,2702,2716,2755,2760,2763,2784,2810,2857,2897,2920,2928,2979,2989,3022,3030,3042,3091,3128,3161,3181,3198,3205,3208,3232,3273,3284,3296,3322,3341,3439,3523,3560,3598,3632,3653,3662,3690,3713,3722,3762,3764,3796,3799,3814,3837,3846,3866,3905,3932,3940,3954,3997,4004,4017,4034,4045,4051,4062,4068,4087,4112,4146,4163,4171,4201,4214,4258,4284,4302,4316,4326,4347],"mesenchymal":[94,309,2429,2848,4147],"stem":[95,294,310,372,423,2430,2849,4148],"(MSCs),":[97],"which":[98,191,975,1001,1061,1377,1901,1935,2069,2116,2144,2740,3154,3203,3230,3437,3476,3626,3967],"turns":[99],"IL7":[101,157,437,977,1367,1393,1439,1580,2297,2319,2367,2594,2616,2714,2779,2805,3120,3139,3226,3737,3864,3913,4378],"production":[102,255,276,497,614,711,1029,1051,1106,1239,2617,3227,3461,3621],"prevents":[104,155,3513,3862],"lymphopoiesis.":[106,1387],"We":[107,957,2538],"DNA":[111,3268,3483,3495,3535,3580],"damage":[112,3484,3496,3536,3581],"pathway":[114,189,251,1610,2458,3272,3336,3486,3538],"CXCR4":[116,152,664,735,761,3584,3651,3754,3811,3859,3884,3910,3941,3963,3986,4059,4127,4189,4193,4252,4291,4315],"promote":[118,200,560,3709],"expression":[121,747,762,1440,1558,1627,1646,1985,2214,2353,2536,2582,2762,2780,2896,2978,2988,3041,3559,3575,3604,3631,3686,3712,3761,3792,3813,3914,4003,4023,4060,4145,4194,4283],"cells.":[124,242,263,1280,1300,1653,2909,2912,2916,2981,3194],"Genetic":[125,982],"or":[126,444,648,983,1768,1800,1810,1891,1920,2327,2361,2562,2880,2949,3010,3426,3782,3890,4044,4097,4188],"pharmacological":[127,984],"disruption":[128],"LT\u03b2R":[130,987,1341,1405,1433,1436,1509,1513,1609,1847,1877,1913,2076,2201,2228,2407,2496,2544,2574,2648,2658,2692,2830,2976,3335,3611,4355],"MSCs":[133,389,457,504,570,861,897,990,1372,1431,1516,1584,2125,2153,2275,2356,2499,2519,2547,2577,2651,2661,2717,3323],"restores":[134,991],"but":[136,512,993,1151,1940,1978,2602,3935,4278],"not":[137,636,688,994,1053,1553,1917,2317,2335,2365,2579,2603,3290,3458,3728],"erythropoiesis,":[138],"reduces":[139,1004,3228],"cell":[141,275,295,424,875,914,1006,1028,1050,1063,1105,1152,1198,1238,1265,1288,1731,2850,2905,2926,2997,3179,3275,3400,3521,3624,4157,4299,4334,4353],"growth,":[142,2502],"significantly":[144,515,821,1928,2264,2732,2744,3173,3201,3368,3555,3794,3930,3952,4311,4328],"extends":[145,1009],"survival":[147,1010,1490,1791,1945,2677,2743,2952,3007,3972,4179],"transplant":[149,1012],"recipients.":[150,1013],"Similarly,":[151,3925],"blocking":[153,2077,2202,2307,2359],"also":[154,559,798,1526,2052,2089,2530,2662,3319,3338,3366,3703,3861,4366],"leukemia-induced":[156],"downregulation":[158,528,562,594,634,744,978,1370,1396,1581,2298,2320,2368,2595,2715,2806,3432,3865,3904,4280,4369],"inhibits":[160,1036],"leukemia":[161,782,886,922,1040,1612,2286,3994],"growth.":[162,2861,3235],"These":[163,1014,1499,2271,2613,4338],"studies":[164,1015,1353,1400,1602,2571,2800,2812,3308,3569,3590,3701,4248,4271],"demonstrate":[165,216,958,1016,3220,3570],"acute":[167,551,1336,2284,2490,3109,3992],"exploit":[169,1020],"physiological":[170],"governing":[172],"hematopoietic":[173,293,334,362,371,417,452,499,531,816,906,1049,1062,2253,2294,4372],"output":[174],"as":[175,381,436,1085,2312,2527,2609,3822,4029],"a":[176,187,217,258,278,291,366,460,603,882,1166,1226,1402,1604,1870,1884,1938,2070,2170,2179,2230,2388,2399,2541,3142,3440,3478,3509,3637,3665,3834,4276,4323],"strategy":[177],"for":[178,283,339,344,383,438,441,446,611,650,743,855,923,929,1392,1404,1465,1607,1959,2543,2750,2891,3124,3730,3758,3774,3843,4008,4089],"gaining":[179],"competitive":[180,259],"advantage.":[181],"This":[184,1163],"study":[185,3262],"investigates":[186],"novel":[188],"by":[190,228,231,238,308,388,428,456,459,503,524,569,720,872,921,1067,1089,1147,1956,2039,2063,2176,2256,2266,2301,2434,2555,2678,2823,3579,3893,4375],"remodel":[194],"niche":[198,750],"their":[201,1234,3936],"expansion":[202,1224,2338,2393],"at":[203,996,1158,1173,1204,1216,1474,1930,3735,4013],"expense":[205],"normal":[207,253,1032,1156,3917,3939],"Feng":[209],"X,":[210],"Pereira":[211],"JP":[212],"et":[213,326,353,357,393,397,405,410,468,472,477,481,485,489,493,539,543,574,578,582,671,675,681,702,706,724,730,755,787,791,833,837,841,845,878,1374,1418,1422,1444,2288,2587,2814,3164,3299,3303,3325,3377,3381,3606,3641,3645,3719,3825,3829,3849,3853,3887,4262,4266,4380],"al.":[214],"convincingly":[215],"positive":[218],"feedback":[219],"loop":[220,3639],"between":[221,1141,1484,1876,1987,2098,2133,4294],"stromal":[225,241,1409,3617],"mediated":[227,871,2822],"produced":[230,387,455,568],"cancer":[232],"its":[235,1098,3989],"expressed":[237,2109,2255,2454,2831,3367,3612,4374],"The":[243,496,758,794,1543,2007,2654,3534],"authors":[244],"provide":[245],"compelling":[246],"evidence":[247,865],"suggesting":[248,3332],"this":[250,868,910,937,3310,3346],"disrupts":[252],"blood":[254,287,1027,1279,3210,4173],"provides":[257],"advantage":[260],"https://doi.org/10.7554/eLife.83533.sa0":[264],"Reviews":[267],"on":[268,377,422,1083,1100,1236,1254,1559,1772,1781,1997,2525,2832,2968,3398,3407,3519,3613,3991,4130,4140,4195],"Sciety":[269],"eLife's":[270],"review":[271],"process":[272,281],"Blood":[274],"is":[277,507,609,641,712,741,1240,2229,2821,3121,3756],"tightly":[279],"regulated":[280],"important":[282],"organismal":[284],"homeostasis.":[285],"All":[286],"develop":[289],"from":[290,1291,1710,1755,2001,2033,2046,2054,2475,2523,4220],"dedicated":[292],"(HSC)":[296],"colonizes":[298],"specialized":[299],"niches":[300,700,718,892],"(BM)":[305,1664,4072],"formed":[306],"predominantly":[307],"(MSCs)":[312,2432],"endothelial":[314],"(ECs)":[316],"(Morrison":[317],"Scadden,":[319],"2014;":[320,580,789,839,3851],"Pinho":[321],"Frenette,":[323],"2019;":[324,355,487,491,576,835],"Sugiyama":[325],"al.,":[327,354,358,394,398,406,411,469,473,478,482,486,490,494,540,544,575,579,583,672,676,682,703,707,725,731,756,788,792,834,838,842,846,879,1375,1419,1423,1445,2289,2588,2815,3165,3300,3304,3326,3378,3382,3607,3642,3646,3720,3826,3830,3850,3854,3888,4263,4267,4381],"2019).":[328,495,588,2290],"Within":[329],"niches,":[331,1043],"HSCs":[332,414],"progenitors":[335,418,431,4300],"receive":[336],"critical":[337],"signals":[338,3539],"long-term":[340,3844],"HSC":[341],"maintenance":[342],"differentiation":[345],"into":[346,1092,1861,1952,2512,2560,2877,2888,3036,3420,3771,3874,4183],"lymphoid,":[347,1101],"myeloid,":[348,1102],"erythroid":[350,1104,1200,2642,2925],"lineages":[351,1064,1416,2643],"(Sugiyama":[352],"Miao":[356],"2020).":[359,793],"most":[361,451,2086],"cytokines":[363,453,500,532,565,597,817,2191,2254,2464,4373],"act":[364],"short-range":[367],"manner,":[368],"thus":[370,2057,3635,3839],"progenitor":[374],"rely":[376],"localization":[378],"cues":[379],"such":[380,435,2311,2672],"CXCL12":[382,534,567,601,710,746,902,1369,1395,2581,3668,3681,3694,4012,4048,4282,4324],"accessing":[384],"growth":[385,1007,1251,1851,1926,2065,2377,2665,2754,3127,3996,4359],"factors":[386,2243],"ECs":[391,463,506,572,899],"(Noda":[392],"2011;":[395,399,474],"Tzeng":[396],"Ding":[400,480],"Morrison,":[402],"2013;":[403,407],"Greenbaum":[404],"Cordeiro":[408,475],"Gomes":[409,476],"2016).":[412,847,3305,3383],"While":[413,1388,3898],"uncommitted":[416],"are":[419,454,635,646,820,1065,1319,1827,3094,4219,4230,4343],"critically":[420],"dependent":[421],"factor":[425,2240],"(SCF,":[426],"encoded":[427],"Kitl),":[429],"committed":[430],"require":[432],"lineage-specific":[433],"signals,":[434],"lymphocytes,":[439],"IL15":[440],"NK":[442],"cells,":[443,3359,3634],"M-CSF":[445],"monocytes":[447,619],"macrophages.":[449],"Importantly,":[450,709,1566,1924,2249,2778],"subset":[461],"BM":[466,537,669,717,749,778,795,891,1042,1116,1408,1550,1583,1678,1691,1711,1753,2554,2833,2890,3031,3183,3199,3418,3867,3956,4164,4221,4260,4349],"(Miao":[467],"2020;":[470],"Noda":[471],"2016;":[479],"2012;":[483],"Baryawno":[484],"Comazzetto":[488],"Tikhonova":[492],"chemokines":[502,819],"relatively":[508],"stable":[509,1178],"during":[510,1970],"homeostasis":[511],"can":[513,3576,3708],"change":[514,1554],"under":[516,2583],"certain":[517,596,698],"perturbations.":[518],"For":[519],"example,":[520],"systemic":[521,590],"inflammation":[522],"caused":[523],"infections":[525],"enforces":[526,976],"multiple":[530,564,4371],"(Ueda":[538],"2004;":[541],"Ueda":[542],"2005;":[545,3827],"Manz":[546],"Boettcher,":[548,622],"2014).":[549,623,683,732,757,1424,3831],"Likewise,":[550],"(Baryawno":[573,832,2287,4379],"Hanoun":[577,836],"Fistonich":[581],"2018;":[584,2816,3327],"Zehentmeier":[585,2817,3328],"Pereira,":[587,2819,3330],"During":[589],"infection,":[591],"coordinated":[593],"(e.g.":[598],"IL7)":[599],"causes":[602,3477],"temporary":[604],"pause":[605],"necessary":[610],"an":[612,1481,2350,3240,3524,3881],"emergent":[613],"short-lived":[616],"neutrophils":[617],"(Manz":[620],"In":[624,653,936,1221,1301,1351,1425,1519,1911,2635,3277,3306,3384,3453,3947,4204],"states,":[626],"however,":[627],"mechanism(s)":[629,1390],"promoting":[630,2549],"cytokine":[631],"chemokine":[633,2466],"well":[637],"defined,":[638],"neither":[640],"if":[643,1059,1846,2495,2687,3114,3493,3650,3753,3858],"changes":[645,775,1046,2061,2273,2427,2614,2759],"protective":[647],"harmful":[649],"host.":[652],"humans":[654],"B-ALL,":[660],"use":[663],"home":[666,2887],"(Juarez":[670,4261],"2007;":[673,4264],"Colmone":[674],"2008;":[677,704,726,3301,3379],"van":[678,727],"den":[679,728,753,785],"Berk":[680,729,754,786],"B-ALL":[685,721,739,765,961,1250,1257,1299,1309,1459,1629,1648,1671,1746,1762,1793,2860,2918,2954,2964,3028,3135,4005,4035,4121,4169,4181],"do":[687],"distribute":[689],"randomly":[690],"seem":[692],"reside":[694],"proliferate":[696],"perivascular":[699],"(Colmone":[701,723],"Sipkins":[705,4265],"2005).":[708,4268],"measurably":[713],"reduced":[714,1140,1203,1898,1929,2212,2620,2751,3125,3556,3795,3931],"exclusively":[715],"colonized":[719],"Furthermore,":[733,1447,2306,2727,3684],"intact":[734],"presumably":[737],"required":[742,3757],"(van":[752,784],"fact":[759,2226],"levels":[763,1157,1450,4293],"inversely":[767],"correlate":[768],"with":[769,824,1165,1296,1471,1616,1670,1759,1766,1797,1808,1869,1892,1904,1976,1980,2103,2156,2160,2178,2218,2224,2283,2398,2411,2569,2619,2766,2787,2837,2961,3134,3137,3141,3170,3249,3257,3345,3386,3507,3545,3664,3693,3780,3880,3891,3909,3962,3969,3977,4011,4038,4047,4076,4095,4118,4126,4186],"patient":[770],"outcome":[771,1473],"suggests":[772,866],"B-ALL-induced":[774],"may":[780,869,3337],"favor":[781,912],"progression":[783],"Cancilla":[790],"has":[797,1052,3833],"reported":[800,1088,2809,3281],"be":[802,870,3339,3577],"severely":[803],"affected":[804,1066],"patients":[807],"AML.":[813],"Of":[814,2199],"note,":[815,2200],"downregulated":[822,2119,2151,2265],"along":[823],"re-programing":[826,927],"MSC":[828,924,1966,2396,2478],"EC":[830,926],"transcriptomes":[831],"Chandran":[840],"2015;":[843],"Geyh":[844],"Although":[848,1039,3699],"no":[849],"specific":[850],"identified":[854],"explaining":[856],"how":[857],"dysregulate":[860],"ECs,":[863],"some":[864,1414],"direct":[873,2824],"AML-niche":[874],"interactions":[876],"(H\u00e9rault":[877],"2017).":[880],"Thus,":[881],"model":[883,3243],"emerges":[884],"where":[885],"attracted":[888],"CXCL12-producing":[890],"physically":[893],"interact":[894],"re-program":[896],"reduce":[901,905,2375],"levels,":[903],"possibly":[904],"output,":[907],"way":[911],"expansion.":[915],"utilized":[920],"reducing":[930,1960],"hematopoiesis":[932,1038],"study,":[938],"preferentially":[946],"seeding":[954],"BM.":[956,1734,2921,2929,4202],"both":[960],"LT\u03b11\u03b22,":[966],"membrane-bound":[968],"ligand":[969,2977],"(LT\u03b2R),":[974],"LT\u03b2R-expressing":[980],"MSCs.":[981,2461,2834,2898,2990,3023,3043],"blockade":[985,1915],"onset":[998],"leukemia,":[1000,1068],"confer":[1024],"flexibility":[1025],"suppress":[1031],"non-leukemic":[1037,1120,1532,1560,3800,3817,4065,4297,4331,4351],"alters":[1041],"whether":[1044],"directly":[1047,2690,3122],"affect":[1048],"carefully":[1055],"studied.":[1056],"To":[1057,1844,1948,1982,2493,2684,3112,3491,3648,3751,3856],"determine":[1058],"transplanted":[1070,1295,1357,1669,1714,1758,1856,2509,2765,2786,2960,3133,3767,4075,4117],"3":[1071,1159,1180,1217,1857,2410,3032],"million":[1072,1858],"pre-B-cell":[1073],"precursor":[1074],"expressing":[1077,1522],"BCR-ABL1":[1079,1087,1521],"oncogene":[1080],"(from":[1081],"referred":[1084,2526],"ALL;":[1086],"YFP":[1090],"expression)":[1091],"non-irradiated":[1093],"C57Bl6/J":[1094],"mice":[1095,1294,1668,1681,1757,1778,1865,1975,2128,2155,2282,2513,2564,2598,2606,2624,2632,2764,2785,2883,3049,3056,3066,3076,3132,3168,3247,3254,3260,3425,3773,3805,3876,3900,3907,3920,3944,3960,4074,4137,4184,4223],"analyzed":[1097,1454,1780,1964,2967,4139],"impact":[1099,1235,1253,1382,2336,2390,3264,3459,3990],"over":[1107],"time.":[1108],"As":[1109,4362],"expected,":[1110],"expanded":[1113],"rapidly":[1114],"(Figure":[1117,1136,1161,1182,1219,1495,1539,1564,1596,1907,1922,1933,1946,2078,2095,2197,2221,2269,2304,2329,2341,2357,2380,2565,2607,2611,2633,2652,2668,2682,2704,2723,2738,2745,2794,3150,3184,3213,3411,3433,3449,3462,3528,3563,3682,3697,3745,3806,3820,3896,3923,3945,3965,3973,4286,4318,4336],"1A).":[1118,1498,3414],"Conversely,":[1119,3195,3808],"developing":[1121,1263,1704,1729,2903,2995,3177,3926,4155,4196,4208,4301,4332],"B":[1122,1127,1197,1264,1537,1705,1730,2904,2915,2996,3178,3274,3447,3623,3633,3927,4156,4197,4209,4298,4333,4352],"mature":[1125,1276,1536,1738],"recirculating":[1126],"declined":[1129],"sharply":[1130],"2":[1131,1174,1615,1931,3978,4132],"weeks":[1132,1146,1160,1175,1181,1218,1932,3033],"transplantation":[1135,1794,2955,3013,3035,4182],"1B).":[1137],"Monocyte":[1138],"numbers":[1139,1153,1172,1289,1754,2927,3029,3175,3197,3444,3937,3950],"first":[1143,2008],"second":[1145],"four-":[1148],"fivefold,":[1150],"recovered":[1154],"1C).":[1162,3216,3452],"contrasted":[1164],"moderate":[1167],"twofold":[1168],"decline":[1169,1228],"neutrophil":[1171],"remained":[1177,1397],"until":[1179,1817,4134],"1D).":[1183,2344],"Changes":[1184],"immature":[1186],"erythrocytes":[1187],"(Ter119+CD71+":[1188],"cells)":[1189,4033],"were":[1190,1453,1571,1586,1779,1806,2118,2122,2146,2150,2263,2276,2473,2644,2710,2875,2959,3200,3929,3938,3951,4083,4093,4116,4138],"similar":[1191,2277],"reductions":[1194,1215,2638,3207],"seen":[1195],"progenitors:":[1199],"progressively":[1202],"6,":[1205],"14,":[1206],"21":[1208],"days":[1209,1816],"transplantation,":[1212],"reaching":[1213],">10-fold":[1214],"1E).":[1220],"summary,":[1222],"induces":[1225,1340,4367],"strong":[1227,2171,2180],"while":[1233,2210],"myeloid":[1237,2285,2640],"modest.":[1241],"Figure":[1242,1614,2409,2835,3975],"1":[1243,1617,2412,2680,2838,3775,4041,4224],"Download":[1244,1621,2416,2842,3982],"asset":[1245,1247,1622,1624,2417,2419,2843,2845,3983,3985],"Open":[1246,1623,2418,2844,3984],"Kinetics":[1248],"(A)":[1256,1640,2436,2862,3999],"number.":[1258,1740,1747,2943,3001],"(B)":[1259,1695,2443,2894,4019],"Number":[1260,1726,2900,2992,4152],"subsets.":[1266,2906,2998,4158],"(C)":[1267,1716,2456,2907,4057],"Inflammatory":[1268],"monocytes.":[1269],"(D)":[1270,1725,2462,2910,4061],"Neutrophils.":[1271,1742,2931],"(E)":[1272,1735,2913,4106],"Immature":[1273,1736,2914,2935],"(Ter119+CD71+)":[1274],"(Ter119+CD71-)":[1277],"red":[1278,3072],"all":[1283,1302,1620,2415,2471,2841,3092,3981],"panels":[1284,1723,1750,2472,3093,4113,4215],"obtained":[1290],"wild-type":[1292,1666,2947],"(WT)":[1293,1667,2948],"3\u00d7106":[1297,1760,2557,2767,2770,2872,2962,3059,3069,3768,3871,4077,4119],"BCR-ABL-expressing":[1298,1761,2963,4120],"panels,":[1303],"X-axis":[1304],"indicates":[1305,3046,3064],"time":[1306,1476],"(days)":[1307],"transplantation.":[1310,1786,2972,4228],"Bars":[1311,1819,3083],"indicate":[1312,1820,3084],"mean,":[1313,1821,3085],"circles":[1314,1822,3086],"depict":[1315,1823,3074,3087],"individual":[1316,1824,3088],"mice.":[1317,1694,1715,1825,3038,3089],"representative":[1320,1828,3095,4231],"two":[1322,1830,2009,3097,4233],"independent":[1323,1831,2005,2646,3098,4234],"experiments.":[1324,1832,3099,4235],"**p<0.005;":[1325,1834,2483,3101,4237],"***p<0.0005":[1326,1835,3102,4238],"unpaired,":[1327,1836,2484,3103,4239],"two-sided,":[1328,1837,2485,3104,4240],"Student's":[1329,1838,2486,3105,4241],"t":[1330,1839,2487,3106,4242],"test.":[1331,1334,1840,1843,2488,3107,4243,4246],"###p<0.0005":[1332,1841],"Mann\u2013Whitney":[1333,1842,4245],"ALL,":[1335,2489,3108],"leukemia.":[1338,2492,3111],"MSCs,":[1344,2257,2695,3868,3906,4376],"downregulates":[1345],"Il7":[1346,2532,2761,3431],"expression,":[1347,3502,3658],"modulates":[1349],"previous":[1352,2811,3307],"noted":[1355,1480,3361,4307],"Artemis-deficient":[1361,3246,3315,3353,3363,3446],"(pre-leukemic)":[1362],"pre-B":[1363,1523,1562,1652,1658,1675,1688,3193,3286,3316,3358,3364,3404,3409,3801,3818,4066],"led":[1365,1501],"(Fistonich":[1373,2813,3324],"2018),":[1376],"could":[1378,3289,3318],"explain":[1379],"negative":[1381],"responsible":[1391,3123],"undefined,":[1398],"earlier":[1399],"suggested":[1401],"role":[1403,1606,2542],"development":[1412],"lymphoid":[1415,3615,3714],"(Wu":[1417],"2001;":[1420],"Kim":[1421],"recent":[1426],"studies,":[1427,3279],"found":[1429],"controls":[1438,3498],"vivo":[1442,2340,2379,2667,3162,3838,3847,4088,4285,4317],"(Zehentmeier":[1443,2586],"2022).":[1446,2589],"when":[1448,1567,3348,4289],"mRNA":[1449,2467],"LTB":[1452,1485],"pediatric":[1456],"samples":[1457,2045,2105],"(Children's":[1460],"Oncology":[1461],"Group":[1462],"Study":[1463],"9906":[1464],"High-Risk":[1466],"Pediatric":[1467],"ALL)":[1468],"associated":[1470,2217],"clinical":[1472],"diagnosis,":[1478],"inverse":[1482],"correlation":[1483],"transcript":[1486],"abundance":[1487],"relapse-free":[1489],"reached":[1492],"statistical":[1493,2181],"significance":[1494,2182],"2\u2014figure":[1496,1597],"supplement":[1497,1598,1618,2331,2343,2382,2413,2839,3152,3186,3215,3413,3435,3451,3464,3530,3565,3747],"observations":[1500,4339],"us":[1502],"hypothesize":[1504],"ligands":[1510,2828],"induce":[1512,2657,2691,2713,3320,4275],"vivo.":[1518,3998],"mice,":[1520,2522,3934],"higher":[1528,2789,3174,3369,3391,4312],"LT\u03b1/LT\u03b2":[1529],"amounts":[1530,3370,3392,4313],"than":[1531,1590,2734,3406,4330,4350],"pre-B,":[1533],"immature,":[1534],"2A":[1540,3748],"B).":[1542,3750],"presence":[1544],"environment":[1551],"did":[1552,1916,2316,2322,2334,2364,2373,3457],"LT\u03b1":[1555,1643,1696,3372,3394,3499,3518,3572,3677,3685,3733,4002,4022,4056],"LT\u03b2":[1557,1645,1698,3374,3396,3501,3574],"host":[1561],"2A).":[1565],"engineered":[1572],"over-express":[1574],"LT\u03b1/LT\u03b2,":[1575],"ALLs":[1577,1708,2776,2793,2874,3021,3081,3516,3562,3654,3661,3675,3691,3763,3797,4063,4082,4200,4274,4295,4309,4342],"induced":[1578,2062,2175,2433,2593],"stronger":[1579],"lethal":[1587],"more":[1588,4329,4345],"quickly":[1589],"empty":[1591],"vector":[1592],"transduced":[1593],"1B\u2013E).":[1599],"Combined,":[1600,2384,2798,3217,3567],"suggest":[1603,4340],"pathogenic":[1605],"progression.":[1613],"see":[1619,2414,2840,3980],"Lymphotoxin":[1625,2420],"therapeutic":[1632],"effect":[1633],"blocking.":[1639,2408],"Histograms":[1641,4000,4020],"Purple,":[1654],"B-ALL;":[1655],"green,":[1656],"(CD19+CD93+IgM-cKit-)":[1660],"cells;":[1672],"blue,":[1673],"WT":[1680,1756,1862,2623,3005,3772],"(no":[1682,3050],"B-ALL);":[1683],"filled":[1684],"gray,":[1685],"Ltb-deficient":[1687,2707,2728,2752,2792,3009],"Ltb-/-":[1693,2771,2775,3027,3070,3080],"mean":[1699,4026],"fluorescence":[1700],"intensity":[1701,4027],"(MFI)":[1702],"isolated":[1709],"Experimental":[1717,4107],"design":[1718,4108],"described":[1721,2280,4111],"D\u2013H.":[1724],"subsets":[1732,3180,4335],"erythrocyte":[1739],"(F)":[1741,2917,4143],"(G)":[1743,2930,4151],"Monocytes.":[1744,2933],"(H)":[1745,2932,4159],"D\u2013H":[1751],"treated":[1765,1807,1867,1979,2050,2102,2159,3131,3169,3504,3660,3692,3778,3878,3908,3943,3961,4007,4037,4094,4124,4185],"HEL-Ig":[1767,1799,1809],"LT\u03b2R-Ig":[1769,1801,1811,1872,1905,2047,2302],"(150":[1770,1812],"\u00b5g/mouse)":[1771,1813],"day":[1773,1776,1782,2969,4131,4135,4141],"0":[1774],"5;":[1777],"8":[1783,2970],"post":[1784],"(I)":[1787,2934,4175],"Frequency":[1788,3003,4176],"following":[1795],"pre-treatment":[1796],"either":[1798],"(n=5":[1802],"per":[1803],"group).":[1804],"Mice":[1805,2958,4092,4115],"every":[1814],"5":[1815,3976],"endpoint.":[1818],"*p<0.05;":[1833,2482,3100,4236],"test":[1845,2494,2686,3113,3492,3649,3752,3857],"impacts":[1849,2500],"hematopoiesis,":[1854,1962,2371,2504],"syngeneic":[1863],"recipient":[1864,3057,3067,3077],"(C57BL6/J)":[1866],"weekly":[1868],"soluble":[1871],"decoy":[1873],"(a":[1874,3547],"fusion":[1875],"ectodomain":[1878],"Fc":[1881],"domain":[1882],"IgG1":[1886],"recognizing":[1887],"Hen":[1888],"Egg":[1889],"Lysozyme)":[1890],"control":[1893,2034,2099,2127,2561,2580,2597,2878,3047,3427],"Hel-Ig.":[1894],"Transplanted":[1895,2590],"significantly,":[1900],"was":[1902,1927,2073,2299,2627,2781,3687,3727,3793],"reverted":[1903],"treatment":[1906,2303,3544,3845],"2C":[1908],"D).":[1910],"contrast,":[1912,2636,3454,3948],"restore":[1918],"myelopoiesis":[1921,2328],"2E\u2013G).":[1923],"2H),":[1934],"reflected":[1936,3204],"small":[1939,3548],"significant":[1941,2071,3206],"extension":[1942],"2I).":[1947],"gain":[1949],"further":[1950,2203,2685,3627,3688],"insight":[1951],"used":[1955,3239],"transcriptome":[1967,1999,3351],"homeostasis,":[1969],"expansion,":[1972],"LT\u03b2R-Ig.":[1981],"identify":[1983],"gene":[1984,2173,2208,2352],"differences":[1986],"three":[1989,2002,2093],"groups,":[1990],"performed":[1992],"principal":[1993,2010],"component":[1994,2438],"analyses":[1995,2168,2476],"(PCA)":[1996,2440],"datasets":[2000,2023],"four":[2004],"replicates.":[2006],"components":[2011],"(PC1":[2012],"PC2)":[2014],"represent":[2015],"main":[2017],"axes":[2018],"variation":[2020],"within":[2021,2042,3915],"explained":[2025],"46%":[2026],"17%":[2028],"variation,":[2030],"respectively.":[2031],"Samples":[2032],"groups":[2037,2094,2136],"separated":[2038],"PC1,":[2040],"cohorts,":[2044],"versus":[2048,2138],"Hel-Ig":[2049,2104,2161],"segregated":[2053,2091],"each":[2055],"other,":[2056],"indicating":[2058],"major":[2059,2389],"transcriptional":[2060,2272],"vivo,":[2067,2756,3129,3765],"fraction":[2072,2401],"sensitive":[2074,2405],"3A).":[2079],"Unsupervised":[2080,2444],"clustering":[2081,2446],"top":[2084,2451],"1000":[2085,2452],"variable":[2087],"genes":[2088,2110,2216],"independently":[2090],"3B).":[2096],"Comparisons":[2097,2132],"revealed":[2106,2140,2169,3429,4272],"322":[2107],"differentially":[2108,2453],"(DEGs;":[2111],"Padj":[2112],"<0.05,":[2113],"|log2FC|>1),":[2114],"74":[2117],"248":[2121],"upregulated":[2123,2147,3517,3676],"(Supplementary":[2129,2162],"file":[2130,2163],"1).":[2131],"(Hel-Ig":[2137],"LT\u03b2R-Ig)":[2139],"226":[2141],"DEGs":[2142,2403],"149":[2145],"77":[2149],"2).":[2164],"Gene":[2165],"set":[2166],"enrichment":[2167],"inflammatory":[2172],"signature":[2174,2354],"interferon":[2184,2206],"\u03b1-":[2185],"\u03b3-induced":[2187],"genes,":[2188],"complement,":[2189],"IL2,":[2192],"IL6,":[2193],"TNF\u03b1":[2195,2219,2313],"3C).":[2198],"increased":[2204,3115,3443,3689,3810],"stimulated":[2207],"signature,":[2209],"it":[2211,2323,2374,2674,3741,3841],"3C),":[2222,2358],"consistent":[2223],"TNF":[2231],"superfamily":[2232],"member":[2233],"activates":[2235],"canonical":[2236],"non-canonical":[2238],"nuclear":[2239],"kappa-binding":[2241],"transcription":[2242,2533],"(NF\u03baB)":[2244],"(Norris":[2245],"Ware,":[2247],"2007).":[2248],"several":[2252],"KITL,":[2258],"IL7,":[2259],"IGF1,":[2260],"CSF1":[2262],"3D).":[2270,2305,2612,4287],"those":[2279],"cytokines,":[2295,2310],"only":[2296],"blocked":[2300],"other":[2308],"NF\u03baB-inducing":[2309],"IL1\u03b2,":[2315],"prevent":[2318],"nor":[2321,2372],"rescue":[2324,2366],"3\u2014figure":[2330,2342,2381],"1A\u2013C)":[2332],"Even":[2345],"though":[2346,3740],"promoted":[2349,3742],"interferon-induced":[2351],"IFN\u03b1":[2360],"IFN\u03b3":[2362],"1E\u2013I).":[2383],"results":[2386,3231],"transcriptome,":[2397],"large":[2400],"being":[2404],"(LT\u03b2R)-dependent":[2423],"-independent":[2425],"transcriptomic":[2426],"B-ALL.":[2435],"Principal":[2437],"analysis":[2439],"distribution":[2441],"plot.":[2442],"hierarchical":[2445],"heatmap":[2448],"representation":[2449],"genes.":[2455],"GSEA-KEGG":[2457],"Hematopoietic":[2463],"expression.":[2468],"generated":[2474,2697],"bulk":[2479],"RNA":[2480],"sequencing.":[2481],"survival,":[2507],"conditionally":[2514],"deficient":[2515,2701],"Ltbr":[2517],"(Ltbrfl/fl;":[2520],"LeprCre/+":[2521],"LT\u03b2R\u2206)":[2528],"report":[2531],"via":[2534],"GFP":[2535],"(Il7GFP/+).":[2537],"ruled":[2539],"out":[2540],"homing":[2551,2866,4255],"transplanting":[2556],"LT\u03b2R\u2206":[2563,2605,2631,2881,2950,3424],"4A),":[2566],"agreement":[2568,3385],"prior":[2570,3700,3786,4103],"showing":[2572],"does":[2578],"homeostatic":[2584],"conditions":[2585],"(WT,":[2599],"Lepr+/+;":[2600],"Ltbrfl/fl)":[2601],"4B),":[2608],"expected":[2610,3823],"corresponded":[2618],"whereas":[2625],"largely":[2628,2645],"unaffected":[2629],"4C\u2013E).":[2634],"ALL-induced":[2637,2804,3863,3902],"4G\u2013J).":[2653],"inability":[2655],"impacted":[2663],"4F":[2669],"K)":[2671],"extended":[2675,2741,3970],"approximately":[2679],"week":[2681,3776,4225],"4L).":[2683],"genetically":[2700],"Ltb":[2703],"4M).":[2705],"Indeed,":[2706,3167,3674,3789],"unable":[2711,3472],"block":[2720],"4N":[2724],"O).":[2726],"proliferated":[2731],"less":[2733],"Ltb-sufficient":[2735,3011],"4P),":[2739],"4Q).":[2746],"Finally,":[2747],"account":[2749],"measured":[2758,3671],"Ltb+/+":[2768,3025,3060,4078],"ALLs,":[2769,2772],"9\u00d7106":[2774,3079],"(3\u00d7Ltb-/-).":[2777,3082],"unchanged":[2782],"even":[2783,3734,3739],"threefold":[2788],"number":[2790,4162],"4R":[2795],"S).":[2797],"2019)":[2820],"delivery":[2825],"4":[2836],"Effects":[2846,3018],"(MSC)-intrinsic":[2851],"Measurements":[2863],"(BM):":[2871],"BCR-ABL":[2873],"transferred":[2876,3870],"(red)":[2879],"(green)":[2882],"allowed":[2885,4084],"24":[2892],"hr.":[2893],"Il7-GFP":[2895,2987,3040,3903,4144],"(C\u2013E)":[2899],"ProB":[2908],"Pre-B":[2911],"frequency":[2919],"(G\u2013K)":[2922],"Myeloid":[2923],"RBCs.":[2936,2939],"(J)":[2937,4192],"Mature":[2938],"(K)":[2940,4203],"Total":[2941,4160],"(L)":[2944],"Probability":[2945],"(n=8":[2956],"mice/group).":[2957],"(M)":[2973],"Histogram":[2974],"Green,":[2982],"Ltb-sufficient;":[2983],"brown,":[2984],"Ltb-deficient.":[2985],"(N)":[2986],"(O)":[2991],"(P)":[2999],"(Q)":[3002],"(n=7/group).":[3014],"(R":[3015],"S)":[3017],"Ltb-expressing":[3020],"(R)":[3024],"Il7GFP/+":[3037,3048,3055,3065,3075,3423,3875],"(S)":[3039],"Gray":[3044],"bar":[3045,3053,3063],"ALL);":[3051],"green":[3052],"represents":[3054],"ALLs;":[3061,3071],"brown":[3062],"bars":[3073],"due":[3117,3293],"excess":[3119],"recombinant":[3138,3159],"complexed":[3140],"neutralizing":[3143],"anti-IL7":[3144],"(aIL7,":[3145],"clone":[3146],"M25)":[3147],"monoclonal":[3148],"antibody":[3149],"4\u2014figure":[3151,3185,3214],"1A),":[3153],"increases":[3155,3619,3628]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-03-30T00:00:00"}