{"id":"https://openalex.org/W4361001237","doi":"https://doi.org/10.1021/jacs.2c12809","title":"Ligation to Scavenging Strategy Enables On-Demand Termination of Targeted Protein Degradation","display_name":"Ligation to Scavenging Strategy Enables On-Demand Termination of Targeted Protein Degradation","publication_year":2023,"publication_date":"2023-03-27","ids":{"openalex":"https://openalex.org/W4361001237","doi":"https://doi.org/10.1021/jacs.2c12809","pmid":"https://pubmed.ncbi.nlm.nih.gov/36971523"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.2c12809","doi":"https://doi.org/10.1021/jacs.2c12809","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.2c12809","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101711417","display_name":"Yuhui Jin","orcid":"https://orcid.org/0000-0003-4493-8204","observed_orcids":["https://orcid.org/0000-0003-4493-8204"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhui Jin","raw_affiliation_strings":["Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]},{"raw_affiliation_string":"Nanjing 210009, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112237171","display_name":"Jing Fan","orcid":"https://orcid.org/0000-0002-1981-1052","observed_orcids":["https://orcid.org/0000-0002-1981-1052"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Fan","raw_affiliation_strings":["Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]},{"raw_affiliation_string":"Nanjing 210009, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015476236","display_name":"Ruyan Wang","orcid":"https://orcid.org/0000-0003-3109-4807","observed_orcids":["https://orcid.org/0000-0003-3109-4807"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruyan Wang","raw_affiliation_strings":["Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]},{"raw_affiliation_string":"Nanjing 210009, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101528693","display_name":"Xuanyu Wang","orcid":"https://orcid.org/0009-0002-8350-2577","observed_orcids":["https://orcid.org/0009-0002-8350-2577","https://orcid.org/0009-0007-9223-6166"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuanyu Wang","raw_affiliation_strings":["Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]},{"raw_affiliation_string":"Nanjing 210009, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100369026","display_name":"Ning Li","orcid":"https://orcid.org/0000-0002-4485-998X","observed_orcids":["https://orcid.org/0000-0002-4485-998X"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ning Li","raw_affiliation_strings":["Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000372945","display_name":"Qidong You","orcid":"https://orcid.org/0000-0002-8587-0122","observed_orcids":["https://orcid.org/0000-0002-8587-0122"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qidong You","raw_affiliation_strings":["Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","Nanjing 210009, China"],"raw_orcid":"https://orcid.org/0000-0002-8587-0122","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]},{"raw_affiliation_string":"Nanjing 210009, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081678793","display_name":"Zhengyu Jiang","orcid":"https://orcid.org/0000-0002-1671-1582","observed_orcids":["https://orcid.org/0000-0002-1671-1582"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhengyu Jiang","raw_affiliation_strings":["Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","Nanjing 210009, China"],"raw_orcid":"https://orcid.org/0000-0002-1671-1582","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]},{"raw_affiliation_string":"Nanjing 210009, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000372945","https://openalex.org/A5081678793","https://openalex.org/A5100369026"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I161716053","https://openalex.org/I4391767909"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.1819,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.93911367,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"145","issue":"13","first_page":"7218","last_page":"7229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.7829999923706055},{"id":"https://openalex.org/keywords/targeted-protein-degradation","display_name":"targeted protein degradation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pamam-dendrimers","display_name":"PAMAM dendrimers","score":0.8980000019073486},{"id":"https://openalex.org/keywords/inverse-electron-demand-diels-alder-reaction","display_name":"inverse electron demand Diels-Alder reaction","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bifunctional-molecules","display_name":"bifunctional molecules","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9808204174041748},{"id":"https://openalex.org/C2777807096","wikidata":"https://www.wikidata.org/wiki/Q1285257","display_name":"Scavenging","level":3,"score":0.739528238773346},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.68647700548172},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.5592705011367798},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2472037672996521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12875142693519592},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.06946337223052979},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jacs.2c12809","doi":"https://doi.org/10.1021/jacs.2c12809","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.2c12809","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:36971523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36971523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1753799057","display_name":null,"funder_award_id":"81773581","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2445077267","display_name":null,"funder_award_id":"BK20221037","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G3797499583","display_name":null,"funder_award_id":"82173680","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5567352959","display_name":null,"funder_award_id":"2022M723509","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G6069643383","display_name":null,"funder_award_id":"YESS20180146","funder_id":"https://openalex.org/F4320311778","funder_display_name":"China Association for Science and Technology"},{"id":"https://openalex.org/G6789531494","display_name":null,"funder_award_id":"BK20220087","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G7329734242","display_name":null,"funder_award_id":"81930100","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320311778","display_name":"China Association for Science and Technology","ror":"https://ror.org/035vmht26"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1565539350","https://openalex.org/W1963598974","https://openalex.org/W1980232662","https://openalex.org/W1992620470","https://openalex.org/W2007736465","https://openalex.org/W2030286106","https://openalex.org/W2062524026","https://openalex.org/W2069977295","https://openalex.org/W2072952339","https://openalex.org/W2077605453","https://openalex.org/W2149148789","https://openalex.org/W2149888617","https://openalex.org/W2395546188","https://openalex.org/W2460068665","https://openalex.org/W2561707298","https://openalex.org/W2602684234","https://openalex.org/W2787623985","https://openalex.org/W2803024865","https://openalex.org/W2803256145","https://openalex.org/W2898638931","https://openalex.org/W2913905783","https://openalex.org/W2938832260","https://openalex.org/W2974217727","https://openalex.org/W2976419981","https://openalex.org/W2978960573","https://openalex.org/W2987291349","https://openalex.org/W2994869094","https://openalex.org/W2996021589","https://openalex.org/W3000297762","https://openalex.org/W3000673710","https://openalex.org/W3008203358","https://openalex.org/W3008322752","https://openalex.org/W3011240628","https://openalex.org/W3014659512","https://openalex.org/W3019413018","https://openalex.org/W3072592197","https://openalex.org/W3086905229","https://openalex.org/W3087167818","https://openalex.org/W3109429946","https://openalex.org/W3130648111","https://openalex.org/W3135017708","https://openalex.org/W3146169114","https://openalex.org/W3153520238","https://openalex.org/W3160345061","https://openalex.org/W3161698207","https://openalex.org/W3163700030","https://openalex.org/W3166285126","https://openalex.org/W3166304202","https://openalex.org/W3172495168","https://openalex.org/W3178147999","https://openalex.org/W3188341649","https://openalex.org/W3192878968","https://openalex.org/W3214405229","https://openalex.org/W4200271893","https://openalex.org/W4205379795","https://openalex.org/W4206984956","https://openalex.org/W4213138084","https://openalex.org/W4220723941","https://openalex.org/W4221063109","https://openalex.org/W4224436834","https://openalex.org/W4228998294","https://openalex.org/W4281715620","https://openalex.org/W4282935215","https://openalex.org/W4289450662","https://openalex.org/W4298088893","https://openalex.org/W4307155509"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W2062208111","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"Event-driven":[0],"bifunctional":[1],"molecules,":[2],"typified":[3],"by":[4],"proteolysis":[5],"targeting":[6],"chimera":[7],"(PROTAC)":[8],"technology,":[9],"have":[10],"been":[11],"successfully":[12],"applied":[13],"in":[14,94,113],"degrading":[15],"many":[16],"proteins":[17,93],"of":[18,32,37,64,91,110],"interest":[19],"(POI).":[20],"Due":[21],"to":[22,47,50,59,106],"the":[23,35,38,55,60,89,108,118],"unique":[24],"catalytic":[25],"mechanism,":[26],"PROTACs":[27,71,79],"will":[28],"induce":[29],"multiple":[30],"cycles":[31],"degradation":[33,53,90],"until":[34],"elimination":[36],"target":[39,122],"protein.":[40],"Here,":[41],"we":[42],"propose":[43],"a":[44,65,101],"versatile":[45],"\"Ligation":[46],"scavenging\"":[48],"approach":[49,105],"terminate":[51,88],"event-driven":[52],"for":[54,120],"first":[56],"time.":[57],"Ligation":[58],"scavenging":[61],"system":[62],"consists":[63],"TCO-modified":[66],"dendrimer":[67],"(PAMAM-G5-TCO)":[68],"and":[69,87],"tetrazine-modified":[70],"(Tz-PROTACs).":[72],"PAMAM-G5-TCO":[73],"can":[74],"rapidly":[75],"scavenge":[76],"intracellular":[77],"free":[78],"via":[80],"an":[81],"inverse":[82],"electron":[83],"demand":[84],"Diels-Alder":[85],"reaction":[86],"certain":[92],"living":[95,114],"cells.":[96],"Thus,":[97],"this":[98],"work":[99],"proposes":[100],"flexible":[102],"chemical":[103],"knockdown":[104],"adjust":[107],"levels":[109],"POI":[111],"on-demand":[112],"cells,":[115],"which":[116],"paves":[117],"way":[119],"controlled":[121],"protein":[123],"degradation.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8}],"updated_date":"2026-10-23T09:35:12.469056","created_date":"2025-10-10T00:00:00"}
