{"id":"https://openalex.org/W4360874199","doi":"https://doi.org/10.32596/ejcm.galenos.2023.2022-12-054","title":"Analysis of Associated Genes and Biological Pathways Between Inflammatory Dilated Cardiomyopathy and Ischemic Cardiomyopathy by Bioinformatics","display_name":"Analysis of Associated Genes and Biological Pathways Between Inflammatory Dilated Cardiomyopathy and Ischemic Cardiomyopathy by Bioinformatics","publication_year":2023,"publication_date":"2023-03-01","ids":{"openalex":"https://openalex.org/W4360874199","doi":"https://doi.org/10.32596/ejcm.galenos.2023.2022-12-054"},"language":"en","primary_location":{"id":"doi:10.32596/ejcm.galenos.2023.2022-12-054","doi":"https://doi.org/10.32596/ejcm.galenos.2023.2022-12-054","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32596/ejcm.galenos.2023.2022-12-054","pdf_url":"https://doi.org/10.32596/ejcm.galenos.2023.2022-12-054","source":{"id":"https://openalex.org/S4210240025","display_name":"e-Journal of Cardiovascular Medicine","issn_l":"2147-1924","issn":["2147-1924"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"e-Journal of Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.32596/ejcm.galenos.2023.2022-12-054","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017635835","display_name":"Weichen Si","orcid":"https://orcid.org/0000-0002-8036-9427","observed_orcids":["https://orcid.org/0000-0002-8036-9427"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weichen Si","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine, Shanghai City, China"],"raw_orcid":"https://orcid.org/0000-0002-8036-9427","affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine, Shanghai City, China","institution_ids":["https://openalex.org/I4210098460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017635835"],"corresponding_institution_ids":["https://openalex.org/I4210098460"],"apc_list":null,"apc_paid":null,"fwci":0.3614,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58215158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"1","first_page":"31","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.3109999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.09719999879598618,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-dilated-cardiomyopathy","display_name":"inflammatory dilated cardiomyopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ischemic-cardiomyopathy","display_name":"ischemic cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ppar-signaling-pathway","display_name":"PPAR signaling","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ecm-receptor-interaction","display_name":"ECM-receptor interaction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.36399999260902405},{"id":"https://openalex.org/keywords/myocarditis","display_name":"myocarditis","score":0.75},{"id":"https://openalex.org/keywords/myh6","display_name":"MYH6","score":0.9559999704360962},{"id":"https://openalex.org/keywords/col1a1","display_name":"COL1A1","score":0.7519999742507935},{"id":"https://openalex.org/keywords/col3a1","display_name":"COL3A1","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.8140413761138916},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7833430767059326},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.6048300266265869},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.603925883769989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.558115541934967},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.497639924287796},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4950651228427887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4800913631916046},{"id":"https://openalex.org/C2776383484","wikidata":"https://www.wikidata.org/wiki/Q283656","display_name":"Dilated cardiomyopathy","level":3,"score":0.43057170510292053},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39818042516708374},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.363044410943985},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.326190322637558},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31717342138290405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27927878499031067},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.23363754153251648},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12093448638916016}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32596/ejcm.galenos.2023.2022-12-054","doi":"https://doi.org/10.32596/ejcm.galenos.2023.2022-12-054","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32596/ejcm.galenos.2023.2022-12-054","pdf_url":"https://doi.org/10.32596/ejcm.galenos.2023.2022-12-054","source":{"id":"https://openalex.org/S4210240025","display_name":"e-Journal of Cardiovascular Medicine","issn_l":"2147-1924","issn":["2147-1924"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"e-Journal of Cardiovascular Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.32596/ejcm.galenos.2023.2022-12-054","doi":"https://doi.org/10.32596/ejcm.galenos.2023.2022-12-054","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32596/ejcm.galenos.2023.2022-12-054","pdf_url":"https://doi.org/10.32596/ejcm.galenos.2023.2022-12-054","source":{"id":"https://openalex.org/S4210240025","display_name":"e-Journal of Cardiovascular Medicine","issn_l":"2147-1924","issn":["2147-1924"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"e-Journal of Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4360874199.pdf","grobid_xml":"https://content.openalex.org/works/W4360874199.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1515354795","https://openalex.org/W1531779637","https://openalex.org/W1965797641","https://openalex.org/W2038189352","https://openalex.org/W2075822314","https://openalex.org/W2159420561","https://openalex.org/W2165568633","https://openalex.org/W2464496825","https://openalex.org/W2605530586","https://openalex.org/W2890374197","https://openalex.org/W2890916368","https://openalex.org/W3010559190","https://openalex.org/W3022047361","https://openalex.org/W3047238919","https://openalex.org/W3089265392","https://openalex.org/W3095461179","https://openalex.org/W3165474371","https://openalex.org/W3177232349","https://openalex.org/W3196819690","https://openalex.org/W3202571733","https://openalex.org/W3216852659","https://openalex.org/W4200134816","https://openalex.org/W4211001885","https://openalex.org/W4283264522","https://openalex.org/W4291972524","https://openalex.org/W4296372849"],"related_works":["https://openalex.org/W2562759069","https://openalex.org/W2317330882","https://openalex.org/W3199054880","https://openalex.org/W4280594707","https://openalex.org/W4318776787","https://openalex.org/W4389071313","https://openalex.org/W4365517680","https://openalex.org/W4388714079","https://openalex.org/W3112998640","https://openalex.org/W2741162426"],"abstract_inverted_index":{"Objectives:":[0],"To":[1],"screen":[2],"the":[3,31,39,45,58,86,95,122,130,145,159,162,180,188,199,202],"associated":[4],"genes":[5,26,52,63,147],"and":[6,14,23,36,48,57,68,77,81,97,101,115,148,153,155,170,194],"biological":[7,59,83,109,149],"pathways":[8,150],"of":[9,34,61,75,89,99,151,161,183,191,201],"inflammatory":[10],"dilated":[11],"cardiomyopathy":[12,16],"(DCMi)":[13],"ischemic":[15],"(ICM)":[17],"a":[18],"transcriptome":[19,32],"data":[20,33],"method.":[21],"Materials":[22],"Methods:The":[24],"differential":[25],"(DEGs)":[27],"were":[28,53,79,126],"analyzed":[29],"by":[30,55,66,186],"DCMi":[35,76,90,125,152],"ICM":[37,78,104],"in":[38,85,124,129,138],"comprehensive":[40],"gene":[41,50],"expression":[42],"database,":[43],"then":[44],"cluster":[46],"analysis":[47,88],"Hub":[49],"candidate":[51,62],"identified":[54],"Cytoscape,":[56],"pathway":[60,133,165,182],"was":[64],"studied":[65],"GO":[67,87],"KEGG":[69,117],"enrichment":[70],"analysis.":[71],"Results:The":[72],"common":[73],"DEGs":[74,123],"RPS4Y1":[80],"MYH6.The":[82],"processes":[84,110],"are":[91],"mainly":[92,106,127,136],"related":[93,107,146],"to":[94,108,168,178],"development":[96],"regulation":[98],"muscle":[100],"cardiomyocytes,":[102],"while":[103],"is":[105,166,176],"such":[111],"as":[112],"extracellular":[113],"matrix":[114],"collagen.Through":[116],"analysis,":[118],"we":[119,156],"found":[120],"that":[121,158],"enriched":[128,137],"PPAR":[131,163],"signaling":[132,164],"(inhibition).In":[134],"ICM,":[135,154,174],"ECM-receptor":[139,184],"interaction":[140,185],"(activation).":[141],"Conclusion:Our":[142],"results":[143],"reveal":[144],"believe":[157],"activation":[160],"expected":[167],"alleviate":[169],"improve":[171],"myocardial":[172],"inflammation.In":[173],"it":[175],"possible":[177],"regulate":[179],"signal":[181],"increasing":[187],"transcriptional":[189],"levels":[190],"COL3A1,":[192],"COL1A1,":[193],"COL1A2,":[195],"thus":[196],"further":[197],"promoting":[198],"progression":[200],"disease.":[203]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-03-25T00:00:00"}