{"id":"https://openalex.org/W4360844217","doi":"https://doi.org/10.21203/rs.3.rs-2424056/v1","title":"Long noncoding RNA MALAT1 promotes angiogenesis through the caveolin-1/VEGF pathway after cerebral ischemic injury.","display_name":"Long noncoding RNA MALAT1 promotes angiogenesis through the caveolin-1/VEGF pathway after cerebral ischemic injury.","publication_year":2023,"publication_date":"2023-03-24","ids":{"openalex":"https://openalex.org/W4360844217","doi":"https://doi.org/10.21203/rs.3.rs-2424056/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-2424056/v1","doi":"https://doi.org/10.21203/rs.3.rs-2424056/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2424056/v1","pdf_url":"https://www.researchsquare.com/article/rs-2424056/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2424056/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110930469","display_name":"Yao Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Lin","raw_affiliation_strings":["Yuying Children\u2019s Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University Fengxia Tu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University Fengxia Tu","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003034555","display_name":"Qiongyi Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiongyi Pang","raw_affiliation_strings":["Yuying Children\u2019s Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University Fengxia Tu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University Fengxia Tu","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048208148","display_name":"Yuanxi Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanxi Shi","raw_affiliation_strings":["Yuying Children\u2019s Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University Fengxia Tu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University Fengxia Tu","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011475400","display_name":"Xuanbo Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuanbo Hu","raw_affiliation_strings":["Yuying Children\u2019s Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University Fengxia Tu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University Fengxia Tu","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101676031","display_name":"Anqi Zhu","orcid":"https://orcid.org/0000-0003-3659-9097","observed_orcids":["https://orcid.org/0000-0003-3659-9097"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anqi Zhu","raw_affiliation_strings":["Yuying Children\u2019s Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University Fengxia Tu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University Fengxia Tu","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Changjun Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changjun Ge","raw_affiliation_strings":["Yuying Children\u2019s Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University Fengxia Tu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University Fengxia Tu","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102147939","display_name":"Kecheng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kecheng Wu","raw_affiliation_strings":["Yuying Children\u2019s Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University Fengxia Tu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University Fengxia Tu","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441917","display_name":"Xiang 'Anthony' Chen","orcid":"https://orcid.org/0000-0002-2499-8261","observed_orcids":["https://orcid.org/0000-0002-2499-8261"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Chen","raw_affiliation_strings":["Yuying Children\u2019s Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University","Children's Hospital of Wenzhou Medical University Fengxia Tu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Children's Hospital of Wenzhou Medical University Fengxia Tu","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065124661","display_name":"Fengxia Tu","orcid":"https://orcid.org/0000-0002-6469-3219","observed_orcids":["https://orcid.org/0000-0002-6469-3219"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengxia Tu","raw_affiliation_strings":["Yuying Children\u2019s Hospital of Wenzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.6718999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.6718999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.20399999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malat1","display_name":"MALAT1","score":1.0},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.996999979019165},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.7870000004768372},{"id":"https://openalex.org/keywords/ischemic-brain-injury","display_name":"ischemic brain injury","score":0.8740000128746033},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9190000295639038},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion-reperfusion","display_name":"middle cerebral artery occlusion/reperfusion","score":0.8840000033378601},{"id":"https://openalex.org/keywords/oxygen-glucose-deprivation-reoxygenation","display_name":"oxygen-glucose deprivation/reoxygenation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7642629742622375},{"id":"https://openalex.org/C2779134362","wikidata":"https://www.wikidata.org/wiki/Q18056223","display_name":"MALAT1","level":5,"score":0.7097738981246948},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5515459179878235},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.5175756216049194},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49222126603126526},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4273017346858978},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.4272609055042267},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.39576664566993713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39350655674934387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3296734690666199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3221479058265686},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.28328099846839905},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24045345187187195},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13039252161979675},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0687762200832367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-2424056/v1","doi":"https://doi.org/10.21203/rs.3.rs-2424056/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2424056/v1","pdf_url":"https://www.researchsquare.com/article/rs-2424056/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2424056/v1","doi":"https://doi.org/10.21203/rs.3.rs-2424056/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2424056/v1","pdf_url":"https://www.researchsquare.com/article/rs-2424056/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7508603009","display_name":null,"funder_award_id":"LY20H170001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4360844217.pdf","grobid_xml":"https://content.openalex.org/works/W4360844217.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1988929385","https://openalex.org/W2021715667","https://openalex.org/W2040288680","https://openalex.org/W2054278625","https://openalex.org/W2087356761","https://openalex.org/W2114044413","https://openalex.org/W2121158877","https://openalex.org/W2124820756","https://openalex.org/W2128070064","https://openalex.org/W2129282529","https://openalex.org/W2146302616","https://openalex.org/W2153628517","https://openalex.org/W2223839359","https://openalex.org/W2412228438","https://openalex.org/W2415128986","https://openalex.org/W2511206720","https://openalex.org/W2523566149","https://openalex.org/W2529899971","https://openalex.org/W2572173857","https://openalex.org/W2584210640","https://openalex.org/W2587631001","https://openalex.org/W2594524236","https://openalex.org/W2747089052","https://openalex.org/W2752796394","https://openalex.org/W2789760542","https://openalex.org/W2904040737","https://openalex.org/W2921434986","https://openalex.org/W2982647838","https://openalex.org/W2995195054","https://openalex.org/W3013898987","https://openalex.org/W3123138257","https://openalex.org/W3154494316","https://openalex.org/W3159024074","https://openalex.org/W3197233575","https://openalex.org/W3202228446","https://openalex.org/W4240678085"],"related_works":["https://openalex.org/W2572870642","https://openalex.org/W2917518561","https://openalex.org/W2765388136","https://openalex.org/W7215098496","https://openalex.org/W3013898987","https://openalex.org/W2806087917","https://openalex.org/W3043000008","https://openalex.org/W4389606481","https://openalex.org/W2583753777","https://openalex.org/W3120667140"],"abstract_inverted_index":{"Abstract":[0],"Metastasis-associated":[1],"lung":[2],"adenocarcinoma":[3],"transcript":[4],"1":[5],"(MALAT1),":[6],"a":[7,44,143,175],"long":[8],"noncoding":[9],"RNA":[10],"(lncRNA),":[11],"has":[12],"been":[13],"reported":[14],"to":[15,83,109],"potentially":[16],"protect":[17],"against":[18],"cerebral":[19,39,130,163],"ischemic":[20,32,131,164,179],"injury.":[21],"We":[22],"investigated":[23],"the":[24,120,146,167],"role":[25],"and":[26,43,79,100,113,142],"underlying":[27],"mechanism":[28],"of":[29,37,52,124,140,148],"MALAT1":[30,101,106,125,158,173],"in":[31,95,103,116,127,145],"stroke.":[33,180],"A":[34],"mouse":[35],"model":[36,51],"middle":[38],"artery":[40],"occlusion/reperfusion":[41],"(MCAO/R)":[42],"human":[45],"brain":[46],"microvascular":[47],"endothelial":[48,87,150],"cell":[49,69,88,91,93,98,111],"(HBMEC)":[50],"oxygen-glucose":[53],"deprivation/reoxygenation":[54],"(OGD/R)":[55],"were":[56,81],"established.":[57],"The":[58],"Zea":[59],"Longa":[60],"5-point":[61],"scale,":[62],"VEGFR2/CD34":[63],"double":[64],"immunofluorescence":[65],"(IF),":[66],"TUNEL":[67],"staining,":[68],"counting":[70],"kit-8":[71],"(CCK-8)":[72],"assay,":[73,76,78],"tube":[74,114],"formation":[75,115],"Transwell":[77],"qRT\u2013PCR":[80],"used":[82],"evaluate":[84],"neurological":[85,137],"deficits,":[86,138],"(EC)":[89],"proliferation,":[90],"apoptosis,":[92,141],"viability,":[94],"vitro":[96,117],"angiogenesis,":[97],"migration,":[99],"levels":[102],"mice,":[104],"respectively.":[105],"was":[107],"found":[108],"promote":[110,160],"migration":[112],"by":[118,135],"affecting":[119],"caveolin-1/VEGF":[121,168],"pathway.":[122],"Downregulation":[123],"expression":[126],"vivo":[128],"exacerbated":[129],"injury":[132,165],"as":[133],"manifested":[134],"severe":[136],"elevation":[139],"decrease":[144],"number":[147],"VEGFR2+/CD34+":[149],"progenitor":[151],"cells":[152],"(EPCs).":[153],"These":[154],"findings":[155],"indicated":[156],"that":[157,172],"may":[159],"angiogenesis":[161],"after":[162],"via":[166],"pathway,":[169],"thereby":[170],"suggesting":[171],"is":[174],"therapeutic":[176],"target":[177],"for":[178]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-03-25T00:00:00"}