{"id":"https://openalex.org/W4360600306","doi":null,"title":"Methotrexate Gel Either Alone or Combined with Narrow Band Ultraviolet B or Excimer Light for the Treatment of Vitiligo.","display_name":"Methotrexate Gel Either Alone or Combined with Narrow Band Ultraviolet B or Excimer Light for the Treatment of Vitiligo.","publication_year":2023,"publication_date":"2023-03-01","ids":{"openalex":"https://openalex.org/W4360600306","pmid":"https://pubmed.ncbi.nlm.nih.gov/36950044","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10027324"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10027324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10027324","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10027324/pdf/jcad_16_3_32.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10027324/pdf/jcad_16_3_32.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008225747","display_name":"Khaled Mohamed Gharib","orcid":"https://orcid.org/0000-0002-1752-0171","observed_orcids":["https://orcid.org/0000-0002-1752-0171"]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Khaled Gharib","raw_affiliation_strings":["All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018817072","display_name":"Al\u2010shimaa M. Ibrahim","orcid":"https://orcid.org/0000-0002-9674-4703","observed_orcids":["https://orcid.org/0000-0002-9674-4703"]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Alshimaa Ibrahim","raw_affiliation_strings":["All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023270993","display_name":"Yasmeen Ahmed Fahmi El Sharkawi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Yasmeen El Sharkawi","raw_affiliation_strings":["All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006690888","display_name":"Nagia Ahmed El-Megrab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nagia Elmegrab","raw_affiliation_strings":["All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"last","author":{"id":null,"display_name":"Mohamed Attia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed Attia","raw_affiliation_strings":["All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are with the Dermatology, Venereology and Andrology Department, Faculty of Medicine at Zagazig University in Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I192398990"],"apc_list":null,"apc_paid":null,"fwci":0.5909,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.53666539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"16","issue":"3","first_page":"32","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitiligo","display_name":"vitiligo","score":0.9309999942779541},{"id":"https://openalex.org/keywords/narrowband-uvb","display_name":"narrowband UVB","score":0.8450000286102295},{"id":"https://openalex.org/keywords/excimer-laser","display_name":"excimer laser","score":0.9670000076293945},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/repigmentation","display_name":"repigmentation","score":0.925000011920929},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.703000009059906},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9599999785423279},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.6050000190734863},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2779980618","wikidata":"https://www.wikidata.org/wiki/Q180152","display_name":"Vitiligo","level":2,"score":0.9283031225204468},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.9120377898216248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8903207778930664},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6319776773452759},{"id":"https://openalex.org/C3018555722","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet b","level":2,"score":0.5087102055549622},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.4753924608230591},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39263108372688293},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35626792907714844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31611543893814087}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10027324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10027324","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10027324/pdf/jcad_16_3_32.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},{"id":"pmid:36950044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36950044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical and aesthetic dermatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10027324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10027324","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10027324/pdf/jcad_16_3_32.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4360600306.pdf","grobid_xml":"https://content.openalex.org/works/W4360600306.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1534776554","https://openalex.org/W1975136759","https://openalex.org/W1987968975","https://openalex.org/W1994424350","https://openalex.org/W1996884483","https://openalex.org/W2014839119","https://openalex.org/W2040354092","https://openalex.org/W2083859038","https://openalex.org/W2123368313","https://openalex.org/W2137534469","https://openalex.org/W2146837153","https://openalex.org/W2160320787","https://openalex.org/W2193410163","https://openalex.org/W2234818171","https://openalex.org/W2237788291","https://openalex.org/W2287500835","https://openalex.org/W2512123286","https://openalex.org/W2626458389","https://openalex.org/W2946187537","https://openalex.org/W2954300430","https://openalex.org/W3012926994","https://openalex.org/W3024082105","https://openalex.org/W3024233105","https://openalex.org/W3092407459","https://openalex.org/W3136074032","https://openalex.org/W3209613318"],"related_works":["https://openalex.org/W4387799188","https://openalex.org/W4309518805","https://openalex.org/W7160243042","https://openalex.org/W4280564248","https://openalex.org/W7160279353","https://openalex.org/W2954300430","https://openalex.org/W2742199825","https://openalex.org/W4289593676","https://openalex.org/W4313451094","https://openalex.org/W2888731158"],"abstract_inverted_index":{"Background:":[0],"Methotrexate":[1,190],"has":[2],"been":[3],"used":[4,219],"successfully":[5],"in":[6,15,23,27,165,176,185],"the":[7,16,28,50,54,61,69,157,166,186,194,204],"treatment":[8,70,96,205],"of":[9,18,30,38,53,65,71,197,207],"vitiligo.":[10,208],"It":[11],"leads":[12],"to":[13,59,215],"decrease":[14],"number":[17,29],"TNF-\u03b1":[19],"secreting":[20],"T":[21,34],"cells":[22],"association":[24],"with":[25,77,84,90,102,111,124,130,169],"increase":[26,193],"interleukin":[31],"(IL)-10":[32],"producing":[33],"cells.":[35],"Topical":[36],"forms":[37,52],"methotrexate":[39,66,103,112,125,170],"do":[40],"not":[41,212],"have":[42],"significant":[43,152],"hematologic":[44],"or":[45,75,83,181],"hepatotoxic":[46],"side":[47],"effects":[48],"unlike":[49],"systemic":[51],"drug.":[55],"Objective:":[56],"We":[57],"sought":[58],"evaluate":[60],"efficacy":[62],"and":[63,172,199,202],"safety":[64],"gel":[67,104,113,126,171,191],"for":[68,138],"vitiligo,":[72],"either":[73],"alone":[74],"combined":[76,129],"narrowband":[78],"(NB)":[79],"ultraviolet":[80],"B":[81],"(UVB)":[82],"excimer":[85,131,200],"light.":[86],"Methods:":[87],"Forty-eight":[88],"patients":[89,175],"vitiligo":[91],"were":[92],"randomized":[93],"into":[94],"three":[95,139],"groups.":[97,188],"Group":[98,107,120,177],"I":[99],"was":[100,109,122,136,149,163,211],"treated":[101,110,123,168],"twice":[105,114,118,127,133],"daily.":[106],"II":[108,178],"daily":[115,128],"plus":[116],"NB-UVB":[117,198],"weekly.":[119,134],"III":[121],"light":[132],"Treatment":[135],"continued":[137],"months":[140],"followed":[141],"by":[142],"a":[143,150],"one-month":[144],"follow-up":[145],"period.":[146],"Results:":[147],"There":[148],"statistically":[151],"difference":[153],"between":[154],"groups":[155],"regarding":[156],"therapeutic":[158,195],"response.":[159],"The":[160],"highest":[161],"response":[162,183],"recorded":[164],"group":[167],"NB-UVB.":[173],"More":[174],"showed":[179],"good":[180],"excellent":[182],"than":[184],"other":[187],"Conclusion:":[189],"could":[192],"effect":[196],"laser":[201],"shorten":[203],"period":[206],"However,":[209],"it":[210],"effective":[213],"enough":[214],"induce":[216],"repigmentation":[217],"when":[218],"alone.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-03-24T00:00:00"}
