{"id":"https://openalex.org/W435811499","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.952.16","title":"Superoxide from uncoupled nitric oxide synthase reduces endothelium\u2010dependent arteriolar dilation in mice fed high salt","display_name":"Superoxide from uncoupled nitric oxide synthase reduces endothelium\u2010dependent arteriolar dilation in mice fed high salt","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W435811499","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.952.16","mag":"435811499"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.952.16","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.952.16","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.952.16","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070683975","display_name":"Matthew A. Boegehold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Boegehold","raw_affiliation_strings":["Center for Cardiovascular and Respiratory Sciences West Virginia University School of Medicine Morgantown WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular and Respiratory Sciences West Virginia University School of Medicine Morgantown WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046557083","display_name":"Timothy Robert Nurkiewicz","orcid":"https://orcid.org/0000-0001-9105-970X","observed_orcids":["https://orcid.org/0000-0001-9105-970X"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy R. Nurkiewicz","raw_affiliation_strings":["Center for Cardiovascular and Respiratory Sciences West Virginia University School of Medicine Morgantown WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular and Respiratory Sciences West Virginia University School of Medicine Morgantown WV","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05568095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uncoupled-nitric-oxide-synthase","display_name":"uncoupled nitric oxide synthase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nitric-oxide-oxidation","display_name":"NO oxidation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/endothelium-dependent-vasodilation","display_name":"endothelium-dependent vasodilation","score":0.871999979019165},{"id":"https://openalex.org/keywords/arteriolar-dilation","display_name":"arteriolar dilation","score":0.843999981880188},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/l-arginine-supplementation","display_name":"arginine supplementation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/l-nmma","display_name":"L-NMMA","score":0.7689999938011169},{"id":"https://openalex.org/keywords/acetylcholine-response","display_name":"acetylcholine response","score":0.8080000281333923},{"id":"https://openalex.org/keywords/arterial-pressure","display_name":"arterial pressure","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8408225774765015},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.7480752468109131},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7236467599868774},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6898049712181091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6710134744644165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.649795413017273},{"id":"https://openalex.org/C2777032099","wikidata":"https://www.wikidata.org/wiki/Q1225425","display_name":"Dilator","level":2,"score":0.5777119994163513},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5186630487442017},{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.5174915790557861},{"id":"https://openalex.org/C2776179834","wikidata":"https://www.wikidata.org/wiki/Q72158415","display_name":"Nitrite","level":3,"score":0.47741448879241943},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.47043487429618835},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.41800999641418457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2764151990413666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2098785638809204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20182368159294128},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13501617312431335},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776384668","wikidata":"https://www.wikidata.org/wiki/Q182168","display_name":"Nitrate","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.952.16","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.952.16","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.952.16","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3144351058","display_name":"Maternal Nanomaterial Exposures: Fetal Microvascular Endpoints and Programming","funder_award_id":"R01ES015022","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5418782337","display_name":null,"funder_award_id":"0755264B","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088740123","https://openalex.org/W2126525811","https://openalex.org/W1042412218","https://openalex.org/W1889649839","https://openalex.org/W2045264253","https://openalex.org/W2151726521","https://openalex.org/W4403020455","https://openalex.org/W1965491619","https://openalex.org/W2415290605","https://openalex.org/W2397912504"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"reported":[3],"that":[4,47,83,195],"the":[5,34,45,54,136,173,213],"impaired":[6],"endothelium\u2010dependent":[7],"dilation":[8,219],"of":[9,22,39,57,135,147,216],"arterioles":[10,100],"in":[11,33,65,84,101,119,151,175,179,189,220],"rodents":[12],"on":[13,186],"a":[14,69,87,115,223],"high":[15,70,224],"salt":[16,71,89,225],"diet":[17,74],"is":[18,53,204],"due":[19,198],"to":[20,43,95,122,161,199],"oxidation":[21],"nitric":[23,49],"oxide":[24,50],"(NO)":[25],"by":[26,111,132,144],"superoxide":[27],"anion":[28],"(O":[29],"2":[30,60,209],"\u2212":[31,61,210],")":[32,167],"arteriolar":[35,106,127,176,218],"wall.":[36],"The":[37],"aim":[38],"this":[40,58],"study":[41],"was":[42,78,130],"test":[44],"hypothesis":[46],"\"uncoupled\"":[48],"synthase":[51],"(NOS)":[52],"predominant":[55],"source":[56],"O":[59,208],".":[62],"Arterial":[63],"pressure":[64],"C57BL/6J":[66],"mice":[67,85,103,181,221],"fed":[68,86,222],"(4%,":[72],"HS)":[73],"for":[75,154,207],"4":[76,155,166,202],"weeks":[77],"not":[79],"significantly":[80],"different":[81],"from":[82],"normal":[88],"(0.45%,":[90],"NS)":[91],"diet.":[92,226],"However,":[93],"compared":[94],"NS":[96,190],"mice,":[97,126],"spinotrapezius":[98],"muscle":[99],"HS":[102,125,180],"had":[104,183],"elevated":[105],"wall":[107],"oxidant":[108,128],"activity":[109],"(assessed":[110],"hydroethidine":[112],"oxidation)":[113],"and":[114,143,212,231],"large":[116],"(75\u201080%)":[117],"reduction":[118,174],"dilator":[120],"responses":[121,178,188],"acetylcholine.":[123],"In":[124],"stress":[129],"abolished":[131],"acute":[133],"application":[134],"NOS":[137,196],"inhibitor":[138],"N":[139],"G":[140],"monomethyl":[141],"L\u2010arginine":[142,148,169],"long\u2010term":[145],"supplementation":[146,170],"intake":[149],"(1.51%":[150],"drinking":[152],"water":[153],"weeks),":[156],"which":[157],"has":[158],"been":[159],"shown":[160],"increase":[162],"vascular":[163],"tetrahydrobiopterin":[164],"(BH":[165],"levels.":[168],"also":[171],"prevented":[172],"ACh":[177],"but":[182],"no":[184],"effect":[185],"these":[187],"mice.":[191],"These":[192],"findings":[193],"suggest":[194],"uncoupling":[197],"reduced":[200],"BH":[201],"availability":[203],"primarily":[205],"responsible":[206],"accumulation":[211],"resultant":[214],"impairment":[215],"NO\u2010dependent":[217],"(Support":[227],"AHA":[228],"Grant\u2010in\u2010Aid":[229],"0755264B":[230],"NIH":[232],"ES\u2010015022)":[233]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}