{"id":"https://openalex.org/W435544313","doi":null,"title":"New diagnostic and therapeutic approaches in adrenocortical cancer.","display_name":"New diagnostic and therapeutic approaches in adrenocortical cancer.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W435544313","mag":"435544313"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-4243","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4243","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4243","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111970791","display_name":"Tanweera Shaheena Khan","orcid":"https://orcid.org/0000-0003-0679-9450","observed_orcids":["https://orcid.org/0000-0003-0679-9450"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tanweera Shaheena Khan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111970791"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenocortical-carcinoma","display_name":"adrenocortical carcinoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tumor-diagnosis","display_name":"tumor diagnosis","score":0.6000000238418579},{"id":"https://openalex.org/keywords/streptozotocin","display_name":"streptozotocin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mitotane","display_name":"mitotane","score":0.968999981880188},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.7699999809265137},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7580000162124634},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/c-kit-exon-11-mutation","display_name":"c-kit exon 11 mutation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/disease-free-interval","display_name":"disease-free interval","score":0.5080000162124634},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2781399356","wikidata":"https://www.wikidata.org/wiki/Q918285","display_name":"Adrenocortical carcinoma","level":2,"score":0.7406983375549316},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49625879526138306},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4696851074695587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4004853367805481},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24485695362091064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21020403504371643}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-4243","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4243","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:435544313","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/8155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-4243","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4243","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":145,"referenced_works":["https://openalex.org/W50763653","https://openalex.org/W104694997","https://openalex.org/W120544464","https://openalex.org/W156464271","https://openalex.org/W241085338","https://openalex.org/W291770033","https://openalex.org/W321050467","https://openalex.org/W1480603181","https://openalex.org/W1579641819","https://openalex.org/W1605353467","https://openalex.org/W1703816965","https://openalex.org/W1806278923","https://openalex.org/W1810594362","https://openalex.org/W1963496509","https://openalex.org/W1963846089","https://openalex.org/W1965260090","https://openalex.org/W1965293262","https://openalex.org/W1966376566","https://openalex.org/W1970226389","https://openalex.org/W1970737706","https://openalex.org/W1971083570","https://openalex.org/W1971984314","https://openalex.org/W1974079235","https://openalex.org/W1976265973","https://openalex.org/W1977296707","https://openalex.org/W1977651982","https://openalex.org/W1980482182","https://openalex.org/W1982560966","https://openalex.org/W1984022609","https://openalex.org/W1986232164","https://openalex.org/W1988821060","https://openalex.org/W1988892614","https://openalex.org/W1991690093","https://openalex.org/W1993119221","https://openalex.org/W1993316713","https://openalex.org/W1995049147","https://openalex.org/W1995930366","https://openalex.org/W1996160829","https://openalex.org/W2001990207","https://openalex.org/W2003238497","https://openalex.org/W2007799838","https://openalex.org/W2010743108","https://openalex.org/W2014346670","https://openalex.org/W2015015957","https://openalex.org/W2015330670","https://openalex.org/W2018171716","https://openalex.org/W2020252476","https://openalex.org/W2024425240","https://openalex.org/W2024510824","https://openalex.org/W2026435298","https://openalex.org/W2028265731","https://openalex.org/W2029987737","https://openalex.org/W2031348932","https://openalex.org/W2032359283","https://openalex.org/W2033246829","https://openalex.org/W2035853338","https://openalex.org/W2036938404","https://openalex.org/W2037695813","https://openalex.org/W2038596108","https://openalex.org/W2039037540","https://openalex.org/W2039694425","https://openalex.org/W2040476678","https://openalex.org/W2040572070","https://openalex.org/W2040642687","https://openalex.org/W2040842710","https://openalex.org/W2042262840","https://openalex.org/W2043488614","https://openalex.org/W2044004262","https://openalex.org/W2044828697","https://openalex.org/W2046154250","https://openalex.org/W2046829161","https://openalex.org/W2046866551","https://openalex.org/W2049509335","https://openalex.org/W2051723715","https://openalex.org/W2055763832","https://openalex.org/W2058054727","https://openalex.org/W2059783931","https://openalex.org/W2061938237","https://openalex.org/W2062637564","https://openalex.org/W2062685114","https://openalex.org/W2064062041","https://openalex.org/W2064698668","https://openalex.org/W2065554335","https://openalex.org/W2066809274","https://openalex.org/W2072799858","https://openalex.org/W2074216470","https://openalex.org/W2075270399","https://openalex.org/W2076710019","https://openalex.org/W2078720930","https://openalex.org/W2078986933","https://openalex.org/W2079420659","https://openalex.org/W2079874148","https://openalex.org/W2083374779","https://openalex.org/W2088746606","https://openalex.org/W2089304791","https://openalex.org/W2089542617","https://openalex.org/W2091317012","https://openalex.org/W2091394697","https://openalex.org/W2091480567","https://openalex.org/W2092732145","https://openalex.org/W2095171413","https://openalex.org/W2095974037","https://openalex.org/W2104662829","https://openalex.org/W2105214030","https://openalex.org/W2105268776","https://openalex.org/W2107542049","https://openalex.org/W2109134289","https://openalex.org/W2110561964","https://openalex.org/W2115425140","https://openalex.org/W2118857049","https://openalex.org/W2119455657","https://openalex.org/W2129288986","https://openalex.org/W2130937309","https://openalex.org/W2131607618","https://openalex.org/W2134170847","https://openalex.org/W2138045082","https://openalex.org/W2140596020","https://openalex.org/W2140814882","https://openalex.org/W2142673801","https://openalex.org/W2145251853","https://openalex.org/W2150099075","https://openalex.org/W2150110700","https://openalex.org/W2150501295","https://openalex.org/W2151527507","https://openalex.org/W2153339609","https://openalex.org/W2156216259","https://openalex.org/W2161607413","https://openalex.org/W2164470094","https://openalex.org/W2167918001","https://openalex.org/W2171620774","https://openalex.org/W2171675963","https://openalex.org/W2223265747","https://openalex.org/W2281555888","https://openalex.org/W2290326436","https://openalex.org/W2322851213","https://openalex.org/W2329648702","https://openalex.org/W2336089418","https://openalex.org/W2400255182","https://openalex.org/W2409985384","https://openalex.org/W2413232943","https://openalex.org/W2430030498","https://openalex.org/W2475190594","https://openalex.org/W3141275090","https://openalex.org/W4241946594","https://openalex.org/W4321317624"],"related_works":["https://openalex.org/W604836347","https://openalex.org/W2124262064","https://openalex.org/W2008345499","https://openalex.org/W1482664397","https://openalex.org/W2035178765","https://openalex.org/W6979745102","https://openalex.org/W4402122720","https://openalex.org/W2462084274","https://openalex.org/W4254472064","https://openalex.org/W2170729108"],"abstract_inverted_index":{"Adrenocortical":[0],"cancer":[1],"(ACC)":[2],"is":[3,8],"a":[4,96],"rare":[5],"disease":[6],"that":[7,70],"often":[9,15],"difficult":[10],"to":[11,73,115,206,225],"diagnose,":[12],"and":[13,35,87,101,157,166,210,233,263],"therefore":[14,41],"presents":[16],"at":[17],"an":[18],"advanced":[19,175],"stage.":[20],"Various":[21],"cytotoxic":[22],"treatments":[23],"have":[24,116],"been":[25],"tried":[26],"with":[27,63,83,99,152,162,174],"little":[28],"success.":[29],"Evaluation":[30],"of":[31,37,46,150,159,179,191,229,239,276,290],"new":[32],"diagnostic":[33,44],"methods":[34],"improvement":[36],"medical":[38],"therapies":[39],"are":[40],"crucial.":[42],"The":[43,110,155,182],"potential":[45,274],"11C-metomidate":[47],"positron":[48],"emission":[49],"tomography":[50],"(PET)":[51],"was":[52,113,146,185,196],"evaluated":[53,170],"in":[54,106,133,148,171,198,216,260,265,285],"eleven":[55,172],"ACC":[56,108,176,223,235,262],"patients.":[57,109,200],"PET":[58,80],"visualized":[59],"all":[60],"viable":[61],"tumors":[62,78,224],"high":[64],"tracer":[65,92],"uptake,":[66],"including":[67],"two":[68,199,218],"lesions":[69],"CT":[71],"failed":[72],"detect.":[74],"Necrotic":[75],"or":[76,143,256],"fibrotic":[77],"were":[79,169,203,214,283],"negative.":[81],"Medication":[82],"adrenal":[84],"steroid":[85],"inhibitors":[86],"chemotherapy":[88],"may":[89,297],"decrease":[90],"the":[91,119,189,227,273],"uptake.":[93],"We":[94,220],"performed":[95],"phase-II":[97],"study":[98],"streptozocin":[100],"o,p\u2019-DDD":[102],"(SO)":[103],"combination":[104,160],"therapy":[105,112,138,161],"40":[107],"SO":[111,180],"found":[114],"impact":[117],"on":[118,128],"disease-free":[120],"interval":[121],"(P":[122,130],"=":[123,131],"0.02)":[124],"as":[125,127,250],"well":[126],"survival":[129,184],"0.01)":[132],"patients":[134,151,173],"who":[135],"received":[136],"adjuvant":[137],"after":[139,177],"curative":[140],"resection.":[141],"Complete":[142],"partial":[144,194],"response":[145,195],"obtained":[147],"36.4%":[149],"measurable":[153],"disease.":[154],"efficacy":[156],"tolerability":[158],"vincristine,":[163],"cisplatin,":[164],"teniposide,":[165],"cyclophosphamide":[167],"(OPEC)":[168],"failure":[178],"therapy.":[181],"median":[183],"21":[186,222],"months":[187],"from":[188],"start":[190],"treatment.":[192],"A":[193],"achieved":[197],"Adverse":[201],"events":[202],"mainly":[204],"restricted":[205],"grade":[207,211],"1-2":[208],"toxicities,":[209],"3":[212],"toxicities":[213],"observed":[215],"only":[217],"cycles.":[219],"tested":[221],"analyze":[226],"expression":[228],"receptor":[230],"tyrosine":[231,277],"kinases":[232],"15":[234],"for":[236],"mutation":[237],"analysis":[238],"c-Kit":[240,259,281],"exon":[241,286],"11,":[242],"which":[243],"can":[244],"be":[245,298],"targeted":[246,293],"by":[247,294],"antagonists":[248],"such":[249],"imatinib.":[251],"All":[252],"ACCs":[253,269],"expressed":[254,270],"one":[255],"more":[257],"kinases:":[258],"19":[261],"phospho-c-Kit":[264],"three":[266],"while":[267],"14":[268],"PDGFR-beta,":[271],"suggesting":[272],"usefulness":[275],"kinase":[278],"inhibitors.":[279],"No":[280],"mutations":[282,292],"detected":[284],"11.":[287],"Further":[288],"evaluation":[289],"other":[291],"this":[295],"drug":[296],"needed.":[299]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}