{"id":"https://openalex.org/W4353083363","doi":"https://doi.org/10.2174/1570180820666230321121939","title":"Neuroprotective Cognitive Effects of Nose-to-brain Delivered Linagliptin Loaded Polymeric Nanosuspension in Animal Model","display_name":"Neuroprotective Cognitive Effects of Nose-to-brain Delivered Linagliptin Loaded Polymeric Nanosuspension in Animal Model","publication_year":2023,"publication_date":"2023-03-22","ids":{"openalex":"https://openalex.org/W4353083363","doi":"https://doi.org/10.2174/1570180820666230321121939"},"language":"en","primary_location":{"id":"doi:10.2174/1570180820666230321121939","doi":"https://doi.org/10.2174/1570180820666230321121939","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570180820666230321121939","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design & Discovery","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4353083363"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102816584","display_name":"Deepika Joshi","orcid":"https://orcid.org/0000-0002-8893-0370","observed_orcids":["https://orcid.org/0000-0002-8893-0370"]},"institutions":[{"id":"https://openalex.org/I1281160679","display_name":"Graphic Era Hill University","ror":"https://ror.org/01bb4h160","country_code":"IN","type":"education","lineage":["https://openalex.org/I1281160679"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Deepika Joshi","raw_affiliation_strings":["School of Pharmacy, Graphic Era Hill University, Dehradun, 248001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Graphic Era Hill University, Dehradun, 248001, India","institution_ids":["https://openalex.org/I1281160679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023945917","display_name":"Bhavna Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I933318745","display_name":"Dehradun Institute of Technology University","ror":"https://ror.org/01v5k4d73","country_code":"IN","type":"education","lineage":["https://openalex.org/I933318745"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhavna Kumar","raw_affiliation_strings":["Faculty of Pharmacy, DIT University,\nDehradun, 248009, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, DIT University,\nDehradun, 248009, India","institution_ids":["https://openalex.org/I933318745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031571414","display_name":"Manmohan Singhal","orcid":"https://orcid.org/0000-0002-1674-259X","observed_orcids":["https://orcid.org/0000-0002-1674-259X"]},"institutions":[{"id":"https://openalex.org/I933318745","display_name":"Dehradun Institute of Technology University","ror":"https://ror.org/01v5k4d73","country_code":"IN","type":"education","lineage":["https://openalex.org/I933318745"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manmohan Singhal","raw_affiliation_strings":["Faculty of Pharmacy, DIT University,\nDehradun, 248009, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, DIT University,\nDehradun, 248009, India","institution_ids":["https://openalex.org/I933318745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055513484","display_name":"Samir Bhargava","orcid":"https://orcid.org/0000-0002-9694-4617","observed_orcids":["https://orcid.org/0000-0002-9694-4617"]},"institutions":[{"id":"https://openalex.org/I933318745","display_name":"Dehradun Institute of Technology University","ror":"https://ror.org/01v5k4d73","country_code":"IN","type":"education","lineage":["https://openalex.org/I933318745"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Samir Bhargava","raw_affiliation_strings":["Faculty of Pharmacy, DIT University,\nDehradun, 248009, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, DIT University,\nDehradun, 248009, India","institution_ids":["https://openalex.org/I933318745"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kaul Ankur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114989","display_name":"Institute of Nuclear Medicine & Allied Sciences","ror":"https://ror.org/029g42942","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I4210114989","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kaul Ankur","raw_affiliation_strings":["Division of Cyclotron & Radiopharmaceutical Sciences, Institute of Nuclear Medicine & Allied Sciences, Brig. SK Majumdar Marg, Timarpur, Delhi, 110054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cyclotron & Radiopharmaceutical Sciences, Institute of Nuclear Medicine & Allied Sciences, Brig. SK Majumdar Marg, Timarpur, Delhi, 110054, India","institution_ids":["https://openalex.org/I4210114989"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102816584"],"corresponding_institution_ids":["https://openalex.org/I1281160679"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":null,"fwci":0.2019,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.34966979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"1","first_page":"152","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linagliptin","display_name":"linagliptin","score":1.0},{"id":"https://openalex.org/keywords/nose-to-brain-drug-delivery","display_name":"nose-to-brain delivery","score":0.9810000061988831},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.7490000128746033},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9750000238418579},{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.847000002861023},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6869999766349792},{"id":"https://openalex.org/keywords/radionuclide-imaging","display_name":"scintigraphy","score":0.75},{"id":"https://openalex.org/keywords/nanoprecipitation","display_name":"nanoprecipitation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2780031085","wikidata":"https://www.wikidata.org/wiki/Q909745","display_name":"Linagliptin","level":4,"score":0.8695249557495117},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8104887008666992},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6804696321487427},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6649127006530762},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6149794459342957},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49109554290771484},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4587434232234955},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3547285795211792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33721014857292175},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2813071012496948},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.24216660857200623},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.1617308259010315},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10425418615341187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07268336415290833},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1570180820666230321121939","doi":"https://doi.org/10.2174/1570180820666230321121939","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570180820666230321121939","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design & Discovery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W911598418","https://openalex.org/W1488734028","https://openalex.org/W1529056475","https://openalex.org/W1546941007","https://openalex.org/W1578359906","https://openalex.org/W1968953073","https://openalex.org/W1974503082","https://openalex.org/W1992535564","https://openalex.org/W1999864520","https://openalex.org/W2007787335","https://openalex.org/W2015041432","https://openalex.org/W2018121350","https://openalex.org/W2022407523","https://openalex.org/W2028109362","https://openalex.org/W2035873080","https://openalex.org/W2037471099","https://openalex.org/W2045846363","https://openalex.org/W2048811481","https://openalex.org/W2050875709","https://openalex.org/W2059774217","https://openalex.org/W2071791968","https://openalex.org/W2078846888","https://openalex.org/W2079878023","https://openalex.org/W2082682251","https://openalex.org/W2086691171","https://openalex.org/W2088551872","https://openalex.org/W2106833597","https://openalex.org/W2115932722","https://openalex.org/W2124386285","https://openalex.org/W2150321503","https://openalex.org/W2150601513","https://openalex.org/W2155326661","https://openalex.org/W2156946852","https://openalex.org/W2300093480","https://openalex.org/W2380988490","https://openalex.org/W2741769732","https://openalex.org/W2756746367","https://openalex.org/W2789907019","https://openalex.org/W2992634898","https://openalex.org/W3022781719","https://openalex.org/W4232663087","https://openalex.org/W4240190488"],"related_works":["https://openalex.org/W4410176501","https://openalex.org/W7133550538","https://openalex.org/W2577491046","https://openalex.org/W4221018372","https://openalex.org/W2771410961","https://openalex.org/W4417032289","https://openalex.org/W4380883201","https://openalex.org/W2757922890","https://openalex.org/W4384945164","https://openalex.org/W2280653124"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-03-23T00:00:00"}