{"id":"https://openalex.org/W4353083348","doi":"https://doi.org/10.2174/1570180820666230321090227","title":"Pyridazinone-substituted Benzenesulfonamides Demonstrate Inhibition of Monoamine Oxidase","display_name":"Pyridazinone-substituted Benzenesulfonamides Demonstrate Inhibition of Monoamine Oxidase","publication_year":2023,"publication_date":"2023-03-22","ids":{"openalex":"https://openalex.org/W4353083348","doi":"https://doi.org/10.2174/1570180820666230321090227"},"language":"en","primary_location":{"id":"doi:10.2174/1570180820666230321090227","doi":"https://doi.org/10.2174/1570180820666230321090227","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570180820666230321090227","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design &amp; Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079529603","display_name":"An\u00e9l Petzer","orcid":"https://orcid.org/0000-0001-8114-8223","observed_orcids":["https://orcid.org/0000-0001-8114-8223"]},"institutions":[{"id":"https://openalex.org/I27765905","display_name":"North-West University","ror":"https://ror.org/010f1sq29","country_code":"ZA","type":"education","lineage":["https://openalex.org/I27765905"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"An\u00e9l Petzer","raw_affiliation_strings":["Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, North-West University,\nPotchefstroom, 2520, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, North-West University,\nPotchefstroom, 2520, South Africa","institution_ids":["https://openalex.org/I27765905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044473159","display_name":"\u0410\u043d\u0442\u043e\u043d \u0410. \u0428\u0435\u0442\u043d\u0435\u0432","orcid":"https://orcid.org/0000-0002-4389-461X","observed_orcids":["https://orcid.org/0000-0002-4389-461X"]},"institutions":[{"id":"https://openalex.org/I4210121576","display_name":"Yaroslavl State Pedagogical University","ror":"https://ror.org/02n3d5p55","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210121576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anton Shetnev","raw_affiliation_strings":["Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University\nnamed after K.D. Ushinsky, St., Yaroslavl, 150000, Russian Federation","Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University named after K.D. Ushinsky, 108 Respublikanskaya St., Yaroslavl, 150000, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University\nnamed after K.D. Ushinsky, St., Yaroslavl, 150000, Russian Federation","institution_ids":["https://openalex.org/I4210121576"]},{"raw_affiliation_string":"Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University named after K.D. Ushinsky, 108 Respublikanskaya St., Yaroslavl, 150000, Russian Federation","institution_ids":["https://openalex.org/I4210121576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067079807","display_name":"Julia A. Efimova","orcid":"https://orcid.org/0000-0003-3027-0223","observed_orcids":["https://orcid.org/0000-0003-3027-0223"]},"institutions":[{"id":"https://openalex.org/I4210121576","display_name":"Yaroslavl State Pedagogical University","ror":"https://ror.org/02n3d5p55","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210121576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Julia Efimova","raw_affiliation_strings":["Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University\nnamed after K.D. Ushinsky, St., Yaroslavl, 150000, Russian Federation","Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University named after K.D. Ushinsky, 108 Respublikanskaya St., Yaroslavl, 150000, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University\nnamed after K.D. Ushinsky, St., Yaroslavl, 150000, Russian Federation","institution_ids":["https://openalex.org/I4210121576"]},{"raw_affiliation_string":"Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University named after K.D. Ushinsky, 108 Respublikanskaya St., Yaroslavl, 150000, Russian Federation","institution_ids":["https://openalex.org/I4210121576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050245122","display_name":"Mikhail K. Korsakov","orcid":"https://orcid.org/0000-0003-0913-2571","observed_orcids":["https://orcid.org/0000-0003-0913-2571"]},"institutions":[{"id":"https://openalex.org/I4210121576","display_name":"Yaroslavl State Pedagogical University","ror":"https://ror.org/02n3d5p55","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210121576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mikhail Korsakov","raw_affiliation_strings":["Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University\nnamed after K.D. Ushinsky, St., Yaroslavl, 150000, Russian Federation","Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University named after K.D. Ushinsky, 108 Respublikanskaya St., Yaroslavl, 150000, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University\nnamed after K.D. Ushinsky, St., Yaroslavl, 150000, Russian Federation","institution_ids":["https://openalex.org/I4210121576"]},{"raw_affiliation_string":"Pharmaceutical Technology Transfer Center, Yaroslavl State Pedagogical University named after K.D. Ushinsky, 108 Respublikanskaya St., Yaroslavl, 150000, Russian Federation","institution_ids":["https://openalex.org/I4210121576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001004911","display_name":"\u0421. \u0418. \u0424\u0438\u043b\u0438\u043c\u043e\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0001-9903-4099","observed_orcids":["https://orcid.org/0000-0001-9903-4099"]},"institutions":[{"id":"https://openalex.org/I4210112073","display_name":"Yaroslavl State Technical University","ror":"https://ror.org/022wdak15","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210112073"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergei Filimonov","raw_affiliation_strings":["Department of General and Physical\nChemistry, Yaroslavl State Technical University, 150023, 88 Moskovsky Pr. Yaroslavl, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Physical\nChemistry, Yaroslavl State Technical University, 150023, 88 Moskovsky Pr. Yaroslavl, Russian Federation","institution_ids":["https://openalex.org/I4210112073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030450621","display_name":"Jacobus Petrus Petzer","orcid":"https://orcid.org/0000-0002-7114-8120","observed_orcids":["https://orcid.org/0000-0002-7114-8120"]},"institutions":[{"id":"https://openalex.org/I27765905","display_name":"North-West University","ror":"https://ror.org/010f1sq29","country_code":"ZA","type":"education","lineage":["https://openalex.org/I27765905"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Jacobus P. Petzer","raw_affiliation_strings":["Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, North-West University,\nPotchefstroom, 2520, South Africa"],"raw_orcid":"https://orcid.org/0000-0002-7114-8120","affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, North-West University,\nPotchefstroom, 2520, South Africa","institution_ids":["https://openalex.org/I27765905"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030450621"],"corresponding_institution_ids":["https://openalex.org/I27765905"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":null,"fwci":0.6724,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62723067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"8","first_page":"1429","last_page":"1436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.08500000089406967,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoamine-oxidase-b","display_name":"monoamine oxidase B","score":0.843999981880188},{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":0.8700000047683716},{"id":"https://openalex.org/keywords/benzenesulfonamide","display_name":"benzenesulfonamide","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pyridazinone-derivatives","display_name":"pyridazinone derivatives","score":0.8740000128746033},{"id":"https://openalex.org/keywords/sulfonamide-inhibitors","display_name":"sulfonamide inhibitors","score":0.6700000166893005},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7760000228881836},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.8383904099464417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7349340319633484},{"id":"https://openalex.org/C39398028","wikidata":"https://www.wikidata.org/wiki/Q18028862","display_name":"Monoamine oxidase B","level":4,"score":0.7242408394813538},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.6273859739303589},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5731017589569092},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5199357867240906},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5066088438034058},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4952365458011627},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.4512825906276703},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4299491345882416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36192837357521057},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.272605299949646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17482632398605347},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16315963864326477},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.14586517214775085}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1570180820666230321090227","doi":"https://doi.org/10.2174/1570180820666230321090227","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570180820666230321090227","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design &amp; Discovery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1551887052","display_name":null,"funder_award_id":"22-13-20085","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G3481946727","display_name":null,"funder_award_id":"119001","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G6124681649","display_name":null,"funder_award_id":"132168","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W969268145","https://openalex.org/W1549819404","https://openalex.org/W1970684497","https://openalex.org/W1972365640","https://openalex.org/W1973116161","https://openalex.org/W1977535429","https://openalex.org/W1998408883","https://openalex.org/W2012516949","https://openalex.org/W2024770800","https://openalex.org/W2042386533","https://openalex.org/W2046592449","https://openalex.org/W2051176914","https://openalex.org/W2051536119","https://openalex.org/W2054253103","https://openalex.org/W2057440913","https://openalex.org/W2069885091","https://openalex.org/W2069885465","https://openalex.org/W2071537273","https://openalex.org/W2149472336","https://openalex.org/W2564665275","https://openalex.org/W2616318791","https://openalex.org/W2783421922","https://openalex.org/W2914570013","https://openalex.org/W2973017604"],"related_works":["https://openalex.org/W2973017604","https://openalex.org/W4404229532","https://openalex.org/W4388910303","https://openalex.org/W4400203209","https://openalex.org/W4410246427","https://openalex.org/W4392508850","https://openalex.org/W2041249353","https://openalex.org/W3010244847","https://openalex.org/W4307583332","https://openalex.org/W4224218747"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-03-23T00:00:00"}
