{"id":"https://openalex.org/W4353072289","doi":"https://doi.org/10.1038/s41598-023-31790-7","title":"NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein","display_name":"NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein","publication_year":2023,"publication_date":"2023-03-22","ids":{"openalex":"https://openalex.org/W4353072289","doi":"https://doi.org/10.1038/s41598-023-31790-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/36949141","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10033925"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-31790-7","doi":"https://doi.org/10.1038/s41598-023-31790-7","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41598-023-31790-7","pdf_url":"https://www.nature.com/articles/s41598-023-31790-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-31790-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032282253","display_name":"Fotine Libanje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fotine Libanje","raw_affiliation_strings":["Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France. Fotine.libanje@gmail.com","Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France. Fotine.libanje@gmail.com","institution_ids":["https://openalex.org/I183367347"]},{"raw_affiliation_string":"Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068954983","display_name":"Raphael Delille","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raphael Delille","raw_affiliation_strings":["Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047900519","display_name":"Pamela A Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pamela A Young","raw_affiliation_strings":["Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039063177","display_name":"Sylvie Rolland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Rolland","raw_affiliation_strings":["Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019295463","display_name":"Florence Meyer-Losic","orcid":"https://orcid.org/0000-0003-0245-2855","observed_orcids":["https://orcid.org/0000-0003-0245-2855"]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florence Meyer-Losic","raw_affiliation_strings":["Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040964251","display_name":"Elodie Lewkowicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elodie Lewkowicz","raw_affiliation_strings":["Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Biomarkers and Pharmacology, IPSEN Innovation, Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054166052","display_name":"Stephan G. Klinz","orcid":"https://orcid.org/0000-0001-7354-3346","observed_orcids":["https://orcid.org/0000-0001-7354-3346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephan Klinz","raw_affiliation_strings":["Early Development and Translational Sciences, IPSEN Bioscience, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Development and Translational Sciences, IPSEN Bioscience, Cambridge, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032282253"],"corresponding_institution_ids":["https://openalex.org/I183367347"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.3648,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.48422973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"13","issue":"1","first_page":"4663","last_page":"4663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.4372999966144562,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.4372999966144562,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.19760000705718994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotensin-receptor-1","display_name":"neurotensin receptor 1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/protein-glycosylation","display_name":"protein glycosylation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-cleavage","display_name":"matrix metalloproteinase cleavage","score":0.8149999976158142},{"id":"https://openalex.org/keywords/n-terminal-cleavage","display_name":"N-terminal cleavage","score":0.703000009059906},{"id":"https://openalex.org/keywords/protein-isoforms","display_name":"protein isoforms","score":0.7459999918937683},{"id":"https://openalex.org/keywords/neurotensin","display_name":"neurotensin","score":0.8429999947547913},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9380000233650208},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4760192036628723},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.46789443492889404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4263855218887329}],"mesh":[{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009496","descriptor_name":"Neurotensin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018028","descriptor_name":"Receptors, Neurotensin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-023-31790-7","doi":"https://doi.org/10.1038/s41598-023-31790-7","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41598-023-31790-7","pdf_url":"https://www.nature.com/articles/s41598-023-31790-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10033925","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10033925","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10033925/pdf/41598_2023_Article_31790.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:36949141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36949141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:be382bd032474f35b6aa1e1fa79c16c2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/be382bd032474f35b6aa1e1fa79c16c2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-31790-7","doi":"https://doi.org/10.1038/s41598-023-31790-7","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41598-023-31790-7","pdf_url":"https://www.nature.com/articles/s41598-023-31790-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328455","display_name":"Ipsen","ror":"https://ror.org/00d801g55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4353072289.pdf","grobid_xml":"https://content.openalex.org/works/W4353072289.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1561980913","https://openalex.org/W1898941951","https://openalex.org/W1964694538","https://openalex.org/W1969833092","https://openalex.org/W1972500822","https://openalex.org/W1979710105","https://openalex.org/W1980383847","https://openalex.org/W1988848774","https://openalex.org/W1995079656","https://openalex.org/W2015551880","https://openalex.org/W2017576671","https://openalex.org/W2018879686","https://openalex.org/W2020470717","https://openalex.org/W2020509469","https://openalex.org/W2024858596","https://openalex.org/W2028645925","https://openalex.org/W2029187954","https://openalex.org/W2041324213","https://openalex.org/W2042082129","https://openalex.org/W2046833185","https://openalex.org/W2057148477","https://openalex.org/W2058130105","https://openalex.org/W2062034250","https://openalex.org/W2070258464","https://openalex.org/W2079800856","https://openalex.org/W2096905866","https://openalex.org/W2136714025","https://openalex.org/W2144885450","https://openalex.org/W2152582764","https://openalex.org/W2166132430","https://openalex.org/W2279743762","https://openalex.org/W2301572477","https://openalex.org/W2593147010","https://openalex.org/W2593366386","https://openalex.org/W2614012013","https://openalex.org/W2618376239","https://openalex.org/W2763089507","https://openalex.org/W2803349860","https://openalex.org/W2810515339","https://openalex.org/W2917117437","https://openalex.org/W2962699792","https://openalex.org/W3010996038","https://openalex.org/W3011107589","https://openalex.org/W3019246390","https://openalex.org/W3092379981","https://openalex.org/W3103992827","https://openalex.org/W3106991016","https://openalex.org/W3109752137","https://openalex.org/W3119259526","https://openalex.org/W3121001695","https://openalex.org/W3131279123","https://openalex.org/W3164281787","https://openalex.org/W3167689908"],"related_works":["https://openalex.org/W2277389606","https://openalex.org/W2465559315","https://openalex.org/W2734335972","https://openalex.org/W4308367956","https://openalex.org/W7221612420","https://openalex.org/W2087366156","https://openalex.org/W2080563198","https://openalex.org/W2905109453","https://openalex.org/W39188065","https://openalex.org/W4302024319"],"abstract_inverted_index":{"NTSR1":[0,19,35,49,62,97,136,186,196],"abnormal":[1],"expression":[2],"by":[3,95,109,121],"cancer":[4],"cells":[5,159],"makes":[6],"it":[7],"a":[8,74,80,116],"strategic":[9],"target":[10],"for":[11],"antitumoral":[12],"therapies,":[13],"such":[14],"as":[15,66,179,181],"compounds":[16],"that":[17,103,118,189],"use":[18],"binding":[20],"probes":[21],"to":[22,26,63,111,150,192],"deliver":[23],"cytotoxic":[24],"agents":[25],"tumor":[27],"cells.":[28,59],"Success":[29],"of":[30,132,139],"these":[31],"therapies":[32],"relies":[33],"on":[34],"protein":[36,50,69,89,187],"availability":[37],"and":[38,53,57,83,86,137,160,176],"accessibility;":[39],"therefore,":[40],"understanding":[41],"the":[42,71,77,87,91,104,113,122,130,143,152,157],"protein's":[43],"biology":[44,188],"is":[45,107,119],"crucial.":[46],"We":[47,60,101],"studied":[48],"in":[51,156,161],"exogenously":[52],"endogenously":[54],"expressing":[55],"non-tumoral":[56],"tumoral":[58,158],"found":[61,147],"be":[64,151],"expressed":[65],"three":[67],"distinct":[68],"forms:":[70],"NTSR1-high":[72,105],"form,":[73,79,115],"glycosylated":[75],"protein;":[76,85],"NTSR1-low":[78,114,140,148],"N-terminally":[81],"cleaved":[82,108],"de-glycosylated":[84],"NTSR1-LP":[88],"with":[90],"MW":[92],"size":[93],"predicted":[94],"its":[96,167],"amino":[98],"acid":[99],"sequence.":[100],"show":[102],"form":[106,141,149,155],"MMPs":[110],"generate":[112],"process":[117],"promoted":[120],"Neurotensin":[123],"(NTS)":[124],"ligand.":[125],"In":[126],"addition,":[127],"NTS":[128],"induced":[129],"internalization":[131],"plasma":[133],"membrane":[134],"localized":[135],"degradation":[138],"via":[142],"proteasome.":[144],"Importantly,":[145],"we":[146],"most":[153],"abundant":[154],"PDAC":[162],"Patient":[163],"Derived":[164],"Xenograft,":[165],"demonstrating":[166],"physiopathological":[168],"relevance.":[169],"Altogether,":[170],"our":[171],"work":[172],"provides":[173],"important":[174],"technical":[175],"experimental":[177],"tools":[178],"well":[180],"new":[182],"crucial":[183],"insights":[184],"into":[185],"are":[190],"required":[191],"develop":[193],"clinically":[194],"relevant":[195],"targeting":[197],"anti-tumoral":[198],"therapies.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-03-23T00:00:00"}