{"id":"https://openalex.org/W4353052182","doi":"https://doi.org/10.1016/j.canlet.2023.216146","title":"Extracellular vesicle-derived LINC00482 induces microglial M2 polarization to facilitate brain metastasis of NSCLC","display_name":"Extracellular vesicle-derived LINC00482 induces microglial M2 polarization to facilitate brain metastasis of NSCLC","publication_year":2023,"publication_date":"2023-03-22","ids":{"openalex":"https://openalex.org/W4353052182","doi":"https://doi.org/10.1016/j.canlet.2023.216146","pmid":"https://pubmed.ncbi.nlm.nih.gov/36963460"},"language":"en","primary_location":{"id":"doi:10.1016/j.canlet.2023.216146","doi":"https://doi.org/10.1016/j.canlet.2023.216146","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2023.216146","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4353052182"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102018254","display_name":"Wenwen Xu","orcid":"https://orcid.org/0000-0003-2756-3498","observed_orcids":["https://orcid.org/0000-0003-2756-3498"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwen Xu","raw_affiliation_strings":["Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101614274","display_name":"Nishant D. Patel","orcid":"https://orcid.org/0000-0002-2573-7469","observed_orcids":["https://orcid.org/0000-0002-2573-7469"]},"institutions":[{"id":"https://openalex.org/I4210138078","display_name":"Second Affiliated Hospital of Nanjing Medical University","ror":"https://ror.org/04pge2a40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138078"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nishant Patel","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, PR China","institution_ids":["https://openalex.org/I4210138078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071666031","display_name":"Yuxia Deng","orcid":"https://orcid.org/0000-0002-6294-2111","observed_orcids":["https://orcid.org/0000-0002-6294-2111"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxia Deng","raw_affiliation_strings":["Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102904624","display_name":"Shuang Ding","orcid":"https://orcid.org/0000-0003-0041-3879","observed_orcids":["https://orcid.org/0000-0003-0041-3879"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Ding","raw_affiliation_strings":["Department of Oncology, Nanjing First Hospital, Nanjing, 210001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Nanjing First Hospital, Nanjing, 210001, PR China","institution_ids":["https://openalex.org/I4405277390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086475017","display_name":"Tingya Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingya Wang","raw_affiliation_strings":["Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100458460","display_name":"Haijun Zhang","orcid":"https://orcid.org/0000-0002-4313-3001","observed_orcids":["https://orcid.org/0000-0002-4313-3001"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haijun Zhang","raw_affiliation_strings":["Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China. Electronic address: haijunzhang@seu.edu.cn","Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China. Electronic address: haijunzhang@seu.edu.cn","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]},{"raw_affiliation_string":"Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100458460"],"corresponding_institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":3.7079,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.95481009,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"561","issue":null,"first_page":"216146","last_page":"216146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.902999997138977},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7940000295639038},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microglial-m2-polarization","display_name":"microglial M2 polarization","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mir-142-3p","display_name":"miR-142-3p","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pre-metastatic-niche","display_name":"pre-metastatic niche","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6384379863739014},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6230738759040833},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5849918723106384},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.5687980651855469},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5109826326370239},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.4622070789337158},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44349944591522217},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43885964155197144},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4320027828216553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40422698855400085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31760483980178833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.308100163936615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18253079056739807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.160169780254364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13900521397590637},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.08762946724891663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.canlet.2023.216146","doi":"https://doi.org/10.1016/j.canlet.2023.216146","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2023.216146","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:36963460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36963460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6200600180","display_name":null,"funder_award_id":"BE2019716","funder_id":"https://openalex.org/F4320334925","funder_display_name":"Science and Technology Support Program of Jiangsu Province"},{"id":"https://openalex.org/G8329467864","display_name":null,"funder_award_id":"BE2019738","funder_id":"https://openalex.org/F4320334925","funder_display_name":"Science and Technology Support Program of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320334925","display_name":"Science and Technology Support Program of Jiangsu Province","ror":"https://ror.org/02mkqta53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1774700235","https://openalex.org/W2001717792","https://openalex.org/W2075086965","https://openalex.org/W2341537876","https://openalex.org/W2480295405","https://openalex.org/W2557222435","https://openalex.org/W2589491783","https://openalex.org/W2596133050","https://openalex.org/W2612537388","https://openalex.org/W2747254185","https://openalex.org/W2786514708","https://openalex.org/W2792177655","https://openalex.org/W2803151969","https://openalex.org/W2803949946","https://openalex.org/W2883027795","https://openalex.org/W2893457968","https://openalex.org/W2905827542","https://openalex.org/W2910026377","https://openalex.org/W2936985008","https://openalex.org/W2969934413","https://openalex.org/W2981385303","https://openalex.org/W2986494140","https://openalex.org/W2987834130","https://openalex.org/W2991216234","https://openalex.org/W3005104290","https://openalex.org/W3007511370","https://openalex.org/W3011514672","https://openalex.org/W3013635688","https://openalex.org/W3013961155","https://openalex.org/W3017034037","https://openalex.org/W3033428106","https://openalex.org/W3044582075","https://openalex.org/W3093157159","https://openalex.org/W3128646645","https://openalex.org/W3156773835","https://openalex.org/W3157745490","https://openalex.org/W3183256386","https://openalex.org/W3201325011","https://openalex.org/W4206769360","https://openalex.org/W4213366250","https://openalex.org/W4213452602","https://openalex.org/W4281847391","https://openalex.org/W6638025115","https://openalex.org/W6794477506"],"related_works":["https://openalex.org/W4394952712","https://openalex.org/W7132819005","https://openalex.org/W4311431206","https://openalex.org/W4410748625","https://openalex.org/W7222816121","https://openalex.org/W3005597885","https://openalex.org/W4313650555","https://openalex.org/W4402059977","https://openalex.org/W7164479625","https://openalex.org/W4213447223"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-03-23T00:00:00"}