{"id":"https://openalex.org/W4352998034","doi":"https://doi.org/10.1039/d3an00086a","title":"Multifunctional Exo III-assisted scalability strategy for constructing DNA molecular logic circuits","display_name":"Multifunctional Exo III-assisted scalability strategy for constructing DNA molecular logic circuits","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4352998034","doi":"https://doi.org/10.1039/d3an00086a","pmid":"https://pubmed.ncbi.nlm.nih.gov/36994799"},"language":"en","primary_location":{"id":"doi:10.1039/d3an00086a","doi":"https://doi.org/10.1039/d3an00086a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d3an00086a","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031989091","display_name":"Chenyi Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyi Zeng","raw_affiliation_strings":["Key Laboratory of Advanced Design and Intelligent Computing, School of Software Engineering, Dalian University, Dalian 116622, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Advanced Design and Intelligent Computing, School of Software Engineering, Dalian University, Dalian 116622, China","institution_ids":["https://openalex.org/I4210092944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352358","display_name":"Xin Liu","orcid":"https://orcid.org/0009-0004-9774-5064","observed_orcids":["https://orcid.org/0009-0004-9774-5064"]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Liu","raw_affiliation_strings":["School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China"],"raw_orcid":"https://orcid.org/0009-0004-9774-5064","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100733648","display_name":"Bin Wang","orcid":"https://orcid.org/0000-0003-4903-2161","observed_orcids":["https://orcid.org/0000-0003-4903-2161"]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Wang","raw_affiliation_strings":["Key Laboratory of Advanced Design and Intelligent Computing, School of Software Engineering, Dalian University, Dalian 116622, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Advanced Design and Intelligent Computing, School of Software Engineering, Dalian University, Dalian 116622, China","institution_ids":["https://openalex.org/I4210092944"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Qin","raw_affiliation_strings":["Key Laboratory of Advanced Design and Intelligent Computing, School of Software Engineering, Dalian University, Dalian 116622, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Advanced Design and Intelligent Computing, School of Software Engineering, Dalian University, Dalian 116622, China","institution_ids":["https://openalex.org/I4210092944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100381999","display_name":"Qiang Zhang","orcid":"https://orcid.org/0000-0003-3776-9799","observed_orcids":["https://orcid.org/0000-0003-3776-9799","https://orcid.org/0000-0003-0609-0337","https://orcid.org/0000-0002-7071-9884","https://orcid.org/0000-0001-8901-1395","https://orcid.org/0009-0006-9721-3441"]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiang Zhang","raw_affiliation_strings":["Key Laboratory of Advanced Design and Intelligent Computing, School of Software Engineering, Dalian University, Dalian 116622, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Advanced Design and Intelligent Computing, School of Software Engineering, Dalian University, Dalian 116622, China","institution_ids":["https://openalex.org/I4210092944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100381999"],"corresponding_institution_ids":["https://openalex.org/I4210092944"],"apc_list":null,"apc_paid":null,"fwci":0.4449,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.48929901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"148","issue":"9","first_page":"1954","last_page":"1960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.361299991607666,"subfield":{"id":"https://openalex.org/subfields/2614","display_name":"Theoretical Computer Science"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exonuclease-iii","display_name":"exonuclease III","score":0.9259999990463257},{"id":"https://openalex.org/keywords/toehold-mediated-strand-displacement","display_name":"toehold-mediated strand displacement","score":0.9279999732971191},{"id":"https://openalex.org/keywords/endonuclease-activity","display_name":"endonuclease activity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/scalability","display_name":"scalability","score":0.49000000953674316},{"id":"https://openalex.org/keywords/dna-computing","display_name":"DNA computing","score":0.7799999713897705},{"id":"https://openalex.org/keywords/biosensing","display_name":"biosensing","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.600520133972168},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.5757359266281128},{"id":"https://openalex.org/C131017901","wikidata":"https://www.wikidata.org/wiki/Q170451","display_name":"Logic gate","level":2,"score":0.5577834248542786},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.5362216234207153},{"id":"https://openalex.org/C187075797","wikidata":"https://www.wikidata.org/wiki/Q173245","display_name":"Sequential logic","level":3,"score":0.460053414106369},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.346744567155838},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.23503604531288147},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2151922583580017},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1728479266166687},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.12101855874061584},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005090","descriptor_name":"Exodeoxyribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/d3an00086a","doi":"https://doi.org/10.1039/d3an00086a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d3an00086a","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},{"id":"pmid:36994799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36994799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G27255293","display_name":null,"funder_award_id":"2021\u2010MS\u2010344","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G4031126346","display_name":null,"funder_award_id":"2021\u2010KF\u201011\u201003","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G4085202548","display_name":null,"funder_award_id":"2022RJ08","funder_id":"https://openalex.org/F4320336812","funder_display_name":"Science Fund for Distinguished Young Scholars of Dalian Province"},{"id":"https://openalex.org/G7168018679","display_name":null,"funder_award_id":"61802040","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7571448297","display_name":null,"funder_award_id":"2022-KF-12-14","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G7772559714","display_name":"DNA\u6838\u9176\u7f6e\u6362\u9a71\u52a8\u7684DNA\u8ba1\u7b97\u6a21\u578b\u7814\u7a76","funder_award_id":"61972266","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8292714235","display_name":null,"funder_award_id":"XLYC2008017","funder_id":"https://openalex.org/F4320329895","funder_display_name":"Liaoning Revitalization Talents Program"},{"id":"https://openalex.org/G8610243087","display_name":null,"funder_award_id":"62272079","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null},{"id":"https://openalex.org/F4320329895","display_name":"Liaoning Revitalization Talents Program","ror":null},{"id":"https://openalex.org/F4320336812","display_name":"Science Fund for Distinguished Young Scholars of Dalian Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1617520624","https://openalex.org/W1991453437","https://openalex.org/W2075031385","https://openalex.org/W2546365378","https://openalex.org/W2801699617","https://openalex.org/W2810268565","https://openalex.org/W2896828834","https://openalex.org/W2944304173","https://openalex.org/W2967685063","https://openalex.org/W2969212135","https://openalex.org/W2976321815","https://openalex.org/W2982615775","https://openalex.org/W2989620465","https://openalex.org/W2990086523","https://openalex.org/W3002005338","https://openalex.org/W3011948626","https://openalex.org/W3025742727","https://openalex.org/W3035564435","https://openalex.org/W3037289547","https://openalex.org/W3092127308","https://openalex.org/W3094867625","https://openalex.org/W3113151662","https://openalex.org/W3119682241","https://openalex.org/W3122836537","https://openalex.org/W3181047251","https://openalex.org/W3183081917","https://openalex.org/W3200131276","https://openalex.org/W3202571872","https://openalex.org/W3203450872","https://openalex.org/W3211380197","https://openalex.org/W3214854734","https://openalex.org/W3214904222","https://openalex.org/W4206052256","https://openalex.org/W4210912594","https://openalex.org/W4224059379","https://openalex.org/W4226292531","https://openalex.org/W4281290505","https://openalex.org/W4283793854","https://openalex.org/W4285387016","https://openalex.org/W4285404465","https://openalex.org/W4285796420","https://openalex.org/W4288698980","https://openalex.org/W4296014257","https://openalex.org/W4306841621","https://openalex.org/W4307339730","https://openalex.org/W4307995536","https://openalex.org/W4309508836","https://openalex.org/W4311114767","https://openalex.org/W4313278772","https://openalex.org/W4319758801"],"related_works":["https://openalex.org/W4383187614","https://openalex.org/W4393443493","https://openalex.org/W2976321815","https://openalex.org/W2895286645","https://openalex.org/W4391140382","https://openalex.org/W4200227141","https://openalex.org/W2894941103","https://openalex.org/W3158602568","https://openalex.org/W2075031385","https://openalex.org/W4281290505"],"abstract_inverted_index":{"The":[0,43,116],"construction":[1,39],"of":[2,19,40,107,124],"logic":[3,27,126,130,141,145,165],"circuits":[4,153],"is":[5,55],"critical":[6],"to":[7,25,36,87],"DNA":[8,68],"computing.":[9],"Simple":[10],"and":[11,157,168],"effective":[12,122],"scalability":[13,123],"methods":[14],"have":[15],"been":[16],"the":[17,38,80,92,96,104,121,155],"focus":[18],"attention":[20],"in":[21,85,138,154,164],"various":[22],"fields":[23],"related":[24],"constructing":[26,139],"circuits.":[28,42],"We":[29],"propose":[30],"a":[31,56,140,159],"double-stranded":[32,93],"separation":[33],"(DSS)":[34],"strategy":[35,44,118],"facilitate":[37],"complex":[41,152],"combines":[45],"toehold-mediated":[46],"strand":[47,81,89,97],"displacement":[48,82,90,98],"with":[49,70,143],"exonuclease":[50],"III":[51,60],"(Exo":[52],"III),":[53],"which":[54],"multifunctional":[57],"nuclease.":[58],"Exo":[59,108],"can":[61,74,99],"quickly":[62],"recognize":[63],"an":[64,71,76,112],"apurinic/apyrimidinic":[65],"(AP)":[66],"site.":[67],"oligos":[69],"AP":[72],"site":[73],"generate":[75],"output":[77,114],"signal":[78],"by":[79,103],"reaction.":[83],"However,":[84],"contrast":[86],"traditional":[88],"reactions,":[91],"waste":[94],"from":[95],"be":[100],"further":[101],"hydrolysed":[102],"endonuclease":[105],"function":[106],"III,":[109],"thus":[110],"generating":[111],"additional":[113],"signal.":[115],"DSS":[117],"allows":[119],"for":[120,150,162],"molecular":[125],"circuits,":[127],"enabling":[128],"multiple":[129],"computing":[131],"capabilities":[132],"simultaneously.":[133],"In":[134],"addition,":[135],"we":[136],"succeeded":[137],"circuit":[142],"dual":[144],"functions":[146],"that":[147],"provides":[148],"foundations":[149],"more":[151],"future":[156],"has":[158],"broad":[160],"scope":[161],"development":[163],"computing,":[166],"biosensing,":[167],"nanomachines.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-03-23T00:00:00"}