{"id":"https://openalex.org/W43512720","doi":null,"title":"[Effects of taurine on brain development and learning ability in filial mice fed with high iodine].","display_name":"[Effects of taurine on brain development and learning ability in filial mice fed with high iodine].","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W43512720","mag":"43512720","pmid":"https://pubmed.ncbi.nlm.nih.gov/11413683"},"language":"zh","primary_location":{"id":"pmid:11413683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11413683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022349030","display_name":"Lei Xu","orcid":"https://orcid.org/0000-0003-1297-1210","observed_orcids":["https://orcid.org/0000-0003-1297-1210"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L Xu","raw_affiliation_strings":["Department of Biochemistry, Hebei Medical University, Shijiazhuang 050017, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hebei Medical University, Shijiazhuang 050017, China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G Yin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Yin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102956474","display_name":"Hui Zhu","orcid":"https://orcid.org/0000-0003-0852-6894","observed_orcids":["https://orcid.org/0000-0003-0852-6894"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00499792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"2","first_page":"114","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":1.0},{"id":"https://openalex.org/keywords/iodine-toxicity","display_name":"iodine toxicity","score":0.5709999799728394},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.8399999737739563},{"id":"https://openalex.org/keywords/learning-ability","display_name":"learning ability","score":0.9300000071525574},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.9120000004768372},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.8809999823570251},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/offspring","display_name":"offspring","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.9370099902153015},{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.7925843596458435},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.6846634149551392},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6492218375205994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6277076601982117},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.624254584312439},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.5941330194473267},{"id":"https://openalex.org/C2778660577","wikidata":"https://www.wikidata.org/wiki/Q18377123","display_name":"Iodine deficiency","level":3,"score":0.4131563901901245},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.3696388006210327},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3616718649864197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34107500314712524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1600034534931183},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13389509916305542},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.056154727935791016},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007455","descriptor_name":"Iodine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007455","descriptor_name":"Iodine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11413683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11413683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]","raw_type":"English Abstract"},{"id":"mag:3151865415","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHYF200102014.htm","pdf_url":null,"source":{"id":"https://openalex.org/S3012613651","display_name":"Zhonghua yufang yixue zazhi","issn_l":"0253-9624","issn":["0253-9624"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua yufang yixue zazhi","raw_type":null},{"id":"mag:43512720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11413683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W174548348","https://openalex.org/W2000575345","https://openalex.org/W2386352172","https://openalex.org/W2389937186","https://openalex.org/W2356452483","https://openalex.org/W2360551550","https://openalex.org/W2394137822","https://openalex.org/W3081413709","https://openalex.org/W3030760949","https://openalex.org/W2388156355"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"observe":[2],"the":[3,27,36,42,51,66,85,97,133,151],"effects":[4],"of":[5,34,91,122,129,135,140,147,180],"taurine":[6,112,158],"on":[7],"brain":[8,67,181],"development":[9,182],"and":[10,41,53,69,72,93,101,113,127],"learning":[11,73],"ability":[12,74],"in":[13,65,84,96,107,132,150,171,183],"filial":[14,136,152,184],"mice":[15,55,137,153,185],"fed":[16,30],"with":[17,31,38,44,80,111,143,154,161],"high":[18],"iodine.":[19,145,189],"METHODS:":[20],"Mice":[21],"were":[22,56,75],"divided":[23],"into":[24],"three":[25,58,86],"groups,":[26],"first":[28],"one":[29],"adequate":[32],"dose":[33],"iodine,":[35,40,163],"second":[37],"high-dose":[39,45,98,144,155,188],"third":[43],"iodine":[46,99,115,156],"plus":[47,157],"0.6%":[48],"taurine.":[49],"All":[50],"male":[52],"female":[54],"mated":[57],"months":[59],"after":[60,118],"treatment.":[61],"Relevant":[62],"biochemical":[63],"indicators":[64],"tissues":[68],"their":[70,78,119],"memory":[71],"measured":[76],"for":[77],"offsprings":[79],"30":[81,116,141],"days":[82,117,142],"old":[83],"groups.":[87],"RESULTS:":[88],"Brain":[89],"contents":[90],"protein":[92],"DNA":[94],"reduced":[95],"group,":[100],"there":[102,165],"was":[103,166],"no":[104,167],"significant":[105,169],"difference":[106,170],"them":[108],"between":[109,173],"groups":[110],"adequate-dose":[114,162],"birth.":[120],"Activity":[121],"acetylcholine":[123,130,148],"esterase":[124],"(ACHE)":[125],"increased":[126,149],"content":[128],"decreased":[131],"hippocampus":[134],"at":[138],"age":[139],"Content":[146],"than":[159],"that":[160],"but":[164],"statistically":[168],"ACHE":[172],"them.":[174],"CONCLUSION:":[175],"Taurine":[176],"could":[177],"antagonize":[178],"disturbance":[179],"caused":[186],"by":[187]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}