{"id":"https://openalex.org/W43315102","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.615.1","title":"Neutrophil activation during reperfusion after ischemic stroke in mice","display_name":"Neutrophil activation during reperfusion after ischemic stroke in mice","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W43315102","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.615.1","mag":"43315102"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.615.1","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.615.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.615.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065766833","display_name":"Helena Willington Morrison","orcid":"https://orcid.org/0000-0003-3791-0190","observed_orcids":["https://orcid.org/0000-0003-3791-0190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helena Willington Morrison","raw_affiliation_strings":["College of Nursing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Nursing","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013587071","display_name":"Grace Davis\u2010Gorman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grace Davis\u2010Gorman","raw_affiliation_strings":["Department of Surgery","Sarver Heart Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery","institution_ids":[]},{"raw_affiliation_string":"Sarver Heart Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113864554","display_name":"Jennifer Beischel Frye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Frye","raw_affiliation_strings":["Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109530795","display_name":"Paul F. McDonagh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul McDonagh","raw_affiliation_strings":["Department of Surgery","Sarver Heart Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery","institution_ids":[]},{"raw_affiliation_string":"Sarver Heart Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051357897","display_name":"Janet L. Funk","orcid":"https://orcid.org/0000-0002-9826-5407","observed_orcids":["https://orcid.org/0000-0002-9826-5407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet Funk","raw_affiliation_strings":["College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109809712","display_name":"Leslie S. Ritter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Ritter","raw_affiliation_strings":["College of Nursing","Department of Neurology University of Arizona Tucson AZ","Department of Neurology, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Nursing","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology University of Arizona Tucson AZ","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Neurology, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00433353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.31200000643730164,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd11b-expression","display_name":"CD11b expression","score":0.8460000157356262},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8209999799728394},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.656000018119812},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7734900116920471},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6267508268356323},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5840545892715454},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5581322312355042},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5383085012435913},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.5031313300132751},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5000102519989014},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.49610719084739685},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4717726707458496},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.46867117285728455},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.4236762225627899},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3384101390838623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31174373626708984},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27898848056793213},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.615.1","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.615.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.615.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000261620","display_name":null,"funder_award_id":"HL58859","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031696048","https://openalex.org/W2167915117","https://openalex.org/W2368044908","https://openalex.org/W3032724398","https://openalex.org/W2945452503","https://openalex.org/W615257400","https://openalex.org/W2187027320","https://openalex.org/W2751949016","https://openalex.org/W2156076525","https://openalex.org/W2387031406"],"abstract_inverted_index":{"Experimental":[0],"evidence":[1],"in":[2,13,48,77,118,134,193],"non\u2010murine":[3],"models":[4],"suggests":[5],"that":[6,192],"activated":[7,47,203],"neutrophils":[8,45,200],"play":[9],"a":[10,108,131,148,194],"pivotal":[11],"role":[12],"cerebral":[14,67],"reperfusion":[15,58,73,98,230],"injury.":[16],"Neutrophils":[17],"release":[18],"toxic":[19],"mediators":[20],"as":[21],"they":[22],"initially":[23],"adhere":[24],"to":[25,35,104,126,222],"the":[26,32,51,86,127,207,224],"microcirculation":[27],"and":[28,54,72,102,147,165,180,204,210,216],"migrate":[29],"out":[30],"of":[31,65,97,168,187,197,214,226,248],"circulation":[33],"into":[34],"brain":[36],"tissue.":[37],"In":[38],"this":[39],"study":[40],"we":[41],"investigated":[42],"whether":[43],"systemic":[44,199],"are":[46,202],"mice":[49,80],"during":[50,206],"first":[52,208],"minutes":[53,90,209],"24":[55,95,154,181,212],"hours":[56,96,155,182,213],"after":[57,88,211,232],"following":[59,138,151],"ischemic":[60],"stroke.":[61,233],"The":[62],"filament":[63],"method":[64],"middle":[66],"artery":[68],"occlusion":[69],"(60":[70],"min)":[71],"(MCAOR)":[74],"was":[75,83,116,130,161],"performed":[76],"male":[78],"C57Bl/6J":[79],"(22\u201025g).":[81],"Blood":[82],"drawn":[84],"from":[85,107],"aorta":[87],"15":[89,141,174],"(MCAOR":[91,99],"15min,":[92],"n=6)":[93],"or":[94],"24hr,":[100],"n=2)":[101],"compared":[103],"blood":[105,120],"obtained":[106],"sham":[109],"surgery":[110],"(Sham,":[111],"n=4).":[112],"Neutrophil":[113],"CD11b":[114,136,171],"expression":[115,137,172],"measured":[117],"whole":[119],"using":[121],"flow":[122],"cytometry":[123],"methods.":[124],"Compared":[125],"shams,":[128],"there":[129],"70%":[132],"increase":[133,150,167],"neutrophil":[135,170],"MCAOR":[139,152],"at":[140,153,173],"min":[142,175],"(":[143,156,176,183],"p":[144,157,177,184],"=":[145,158,178,185],"0.06)":[146],"108%":[149],"0.03).":[159],"There":[160],"also":[162],"an":[163],"83%":[164],"94%":[166],"LPS\u2010stimulated":[169],"0.08)":[179],"0.13)":[186],"reperfusion.":[188],"These":[189],"results":[190],"indicate":[191],"mouse":[195],"model":[196],"MCAOR,":[198],"1)":[201],"primed":[205],"reperfusion,":[215],"2)":[217],"can":[218],"be":[219],"easily":[220],"monitored":[221],"assess":[223],"effects":[225],"new":[227],"treatments":[228],"for":[229],"injury":[231],"Supported":[234],"by":[235],"NIH":[236,243],"NRSA":[237],"1":[238],"F31":[239],"NR010658":[240],"\u201001":[241],"(Morrison)":[242],"HL":[244],"58859":[245],"(McDonagh)":[246],"University":[247],"Arizona":[249],"Emmons":[250],"(Ritter)":[251]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}