{"id":"https://openalex.org/W4328126390","doi":"https://doi.org/10.1038/s41598-023-31347-8","title":"Human memory T cell dynamics after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccination","display_name":"Human memory T cell dynamics after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccination","publication_year":2023,"publication_date":"2023-03-21","ids":{"openalex":"https://openalex.org/W4328126390","doi":"https://doi.org/10.1038/s41598-023-31347-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/36944716","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10028771"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-31347-8","doi":"https://doi.org/10.1038/s41598-023-31347-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-31347-8","pdf_url":"https://www.nature.com/articles/s41598-023-31347-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-31347-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070157777","display_name":"Ece Tavuk\u00e7uo\u011flu","orcid":"https://orcid.org/0000-0003-3344-468X","observed_orcids":["https://orcid.org/0000-0003-3344-468X"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ece Tavukcuoglu","raw_affiliation_strings":["Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey","Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061452698","display_name":"Hamdullah Yan\u0131k","orcid":"https://orcid.org/0000-0002-1066-552X","observed_orcids":["https://orcid.org/0000-0002-1066-552X"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hamdullah Yanik","raw_affiliation_strings":["Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey","Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056397368","display_name":"Mubaida Parveen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mubaida Parveen","raw_affiliation_strings":["Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey","Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075913544","display_name":"S\u0131la Ulut\u00fcrk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sila Uluturk","raw_affiliation_strings":["Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey","Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085293984","display_name":"Mine Durusu Tanr\u0131\u00f6ver","orcid":"https://orcid.org/0000-0001-9565-4389","observed_orcids":["https://orcid.org/0000-0001-9565-4389"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mine Durusu-Tanriover","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052400916","display_name":"Ahmet \u00c7a\u011fkan \u0130nkaya","orcid":"https://orcid.org/0000-0001-7943-8715","observed_orcids":["https://orcid.org/0000-0001-7943-8715"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet Cagkan Inkaya","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054863331","display_name":"Murat Akova","orcid":"https://orcid.org/0000-0002-6904-9473","observed_orcids":["https://orcid.org/0000-0002-6904-9473"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Murat Akova","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090594476","display_name":"Serhat \u00dcnal","orcid":"https://orcid.org/0000-0003-1184-4711","observed_orcids":["https://orcid.org/0000-0003-1184-4711"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serhat Unal","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041355015","display_name":"G\u00fcne\u015f Esenda\u011fl\u0131","orcid":"https://orcid.org/0000-0003-4865-2377","observed_orcids":["https://orcid.org/0000-0003-4865-2377"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Gunes Esendagli","raw_affiliation_strings":["Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey. gunese@hacettepe.edu.tr","Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, 06100, Sihhiye, Ankara, Turkey. gunese@hacettepe.edu.tr","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041355015"],"corresponding_institution_ids":["https://openalex.org/I66514158"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.9445,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.7021603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"1","first_page":"4610","last_page":"4610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.8090000152587891},{"id":"https://openalex.org/keywords/inactivated-whole-virion-vaccine","display_name":"inactivated whole-virion vaccine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/coronavac","display_name":"CoronaVac","score":0.9570000171661377},{"id":"https://openalex.org/keywords/aluminium-adjuvants","display_name":"alum adjuvant","score":0.9760000109672546},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/central-memory-t-cells","display_name":"central memory T cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/effector-memory-t-cells","display_name":"effector memory T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/temra-cells","display_name":"TEMRA cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/ifn-gamma-secretion","display_name":"IFN-gamma secretion","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lamp1","display_name":"LAMP1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2777367678","wikidata":"https://www.wikidata.org/wiki/Q2304808","display_name":"Memory T cell","level":4,"score":0.726224422454834},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6400880813598633},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.602636992931366},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5172625184059143},{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.5064090490341187},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.49496883153915405},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.48904213309288025},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4874696731567383},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4734061658382416},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44111502170562744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3853434920310974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3603712320327759},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10435721278190613},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.08717867732048035},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000091246","descriptor_name":"Memory T Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015164","descriptor_name":"Vaccines, Inactivated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-023-31347-8","doi":"https://doi.org/10.1038/s41598-023-31347-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-31347-8","pdf_url":"https://www.nature.com/articles/s41598-023-31347-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10028771","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10028771","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10028771/pdf/41598_2023_Article_31347.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:36944716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36944716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:doaj.org/article:483c49ed6f914b609c58f1b562184fb6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/483c49ed6f914b609c58f1b562184fb6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-31347-8","doi":"https://doi.org/10.1038/s41598-023-31347-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-31347-8","pdf_url":"https://www.nature.com/articles/s41598-023-31347-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319756","display_name":"T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131","ror":"https://ror.org/01d6ka036"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4328126390.pdf","grobid_xml":"https://content.openalex.org/works/W4328126390.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1639400191","https://openalex.org/W1968806769","https://openalex.org/W1974433492","https://openalex.org/W2000495010","https://openalex.org/W2013887826","https://openalex.org/W2056489903","https://openalex.org/W2113847305","https://openalex.org/W2147635993","https://openalex.org/W2496085280","https://openalex.org/W2788070661","https://openalex.org/W2791401412","https://openalex.org/W2895634023","https://openalex.org/W2905477444","https://openalex.org/W2954635041","https://openalex.org/W3014004967","https://openalex.org/W3016288338","https://openalex.org/W3022917947","https://openalex.org/W3023770076","https://openalex.org/W3023991776","https://openalex.org/W3032533580","https://openalex.org/W3034173374","https://openalex.org/W3037544553","https://openalex.org/W3041494167","https://openalex.org/W3045734160","https://openalex.org/W3045971896","https://openalex.org/W3046194290","https://openalex.org/W3046448610","https://openalex.org/W3048827124","https://openalex.org/W3082102108","https://openalex.org/W3083217488","https://openalex.org/W3083750089","https://openalex.org/W3108666979","https://openalex.org/W3117730334","https://openalex.org/W3117773316","https://openalex.org/W3119669780","https://openalex.org/W3121008609","https://openalex.org/W3135734644","https://openalex.org/W3136423686","https://openalex.org/W3145075207","https://openalex.org/W3145164461","https://openalex.org/W3152827077","https://openalex.org/W3157764873","https://openalex.org/W3158062106","https://openalex.org/W3176141337","https://openalex.org/W3178010802","https://openalex.org/W3179152893","https://openalex.org/W3180160398","https://openalex.org/W3190606158","https://openalex.org/W3200692126","https://openalex.org/W3204989207","https://openalex.org/W3214613814","https://openalex.org/W4210298817","https://openalex.org/W4213426117","https://openalex.org/W4214861685","https://openalex.org/W4226441364","https://openalex.org/W4281732387","https://openalex.org/W4282969244","https://openalex.org/W4283577520","https://openalex.org/W4283659749"],"related_works":["https://openalex.org/W4298009427","https://openalex.org/W3209607274","https://openalex.org/W4312190944","https://openalex.org/W4291021066","https://openalex.org/W3209892380","https://openalex.org/W4200576652","https://openalex.org/W4306968936","https://openalex.org/W4307140630","https://openalex.org/W4214735163","https://openalex.org/W3152827077"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"study":[2],"evaluates":[3],"the":[4,24,45,60,64,66,89,96,120,136,165,203],"functional":[5,216],"capacity":[6],"of":[7,47,63,119,135,154,205],"CD4+":[8,106,178],"and":[9,17,56,73,107,117,130,159,180,182,186,191],"CD8+":[10,108,184],"terminally-differentiated":[11],"effector":[12,18],"(TEMRA),":[13],"central":[14],"memory":[15,19,67,92,109,166],"(TCM),":[16],"(TEM)":[20],"cells":[21,79,94,143],"obtained":[22],"from":[23,95],"volunteers":[25,36],"vaccinated":[26,97,121,137],"with":[27,82,209],"an":[28,133],"aluminum-adjuvanted":[29],"inactivated":[30,206],"whole-virion":[31,207],"SARS-CoV-2":[32,83],"vaccine":[33],"(CoronaVac).":[34],"The":[35,152],"were":[37,71],"followed":[38],"for":[39],"T":[40,68,93,110,167,217],"cell":[41,69,111,168,218],"immune":[42],"responses":[43],"following":[44],"termination":[46],"a":[48,128,162],"randomized":[49],"phase":[50],"III":[51],"clinical":[52],"trial.":[53],"Seven":[54],"days":[55],"four":[57],"months":[58],"after":[59,198],"second":[61],"dose":[62],"vaccine,":[65],"subsets":[70],"collected":[72],"stimulated":[74],"by":[75,149],"autologous":[76],"monocyte-derived":[77],"dendritic":[78],"(mDCs)":[80],"loaded":[81],"spike":[84],"glycoprotein":[85],"S1.":[86],"Compared":[87],"to":[88,103,146,196,214],"placebo":[90],"group,":[91],"individuals":[98,138],"significantly":[99],"proliferated":[100],"in":[101,115,164],"response":[102],"S1-loaded":[104,147],"mDCs.":[105],"proliferation":[112,190],"was":[113,175],"detected":[114],"86%":[116],"78%":[118],"individuals,":[122],"respectively.":[123],"More":[124],"than":[125],"73%":[126],"(after":[127,132],"short-term)":[129],"62%":[131],"intermediate-term)":[134],"harbored":[139],"TCM":[140,187],"and/or":[141],"TEM":[142,185],"that":[144],"responded":[145],"mDCs":[148],"secreting":[150],"IFN-\u03b3.":[151],"expression":[153],"CD25,":[155],"CD38,":[156],"4-1BB,":[157],"PD-1,":[158],"CD107a":[160],"indicated":[161],"modulation":[163],"subsets.":[169],"Especially":[170],"on":[171,177,183],"day":[172],"120,":[173],"PD-1":[174],"upregulated":[176],"TEMRA":[179],"TCM,":[181],"cells;":[188],"accordingly,":[189],"IFN-\u03b3":[192],"secretion":[193],"capacities":[194,213],"tended":[195],"decline":[197],"4":[199],"months.":[200],"In":[201],"conclusion,":[202],"combination":[204],"particles":[208],"aluminum":[210],"adjuvants":[211],"possesses":[212],"induce":[215],"responses.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-03-22T00:00:00"}