{"id":"https://openalex.org/W4328119005","doi":"https://doi.org/10.3389/fcell.2023.1186367","title":"Editorial: Signaling by primary cilia in development and disease","display_name":"Editorial: Signaling by primary cilia in development and disease","publication_year":2023,"publication_date":"2023-03-21","ids":{"openalex":"https://openalex.org/W4328119005","doi":"https://doi.org/10.3389/fcell.2023.1186367","pmid":"https://pubmed.ncbi.nlm.nih.gov/37025179","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10070995"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2023.1186367","doi":"https://doi.org/10.3389/fcell.2023.1186367","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2023.1186367","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2023.1186367/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2023.1186367/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051869793","display_name":"Sung\u2010Eun Kim","orcid":"https://orcid.org/0000-0001-8667-3887","observed_orcids":["https://orcid.org/0000-0001-8667-3887"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sung-Eun Kim","raw_affiliation_strings":["Department of Pediatrics, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068160677","display_name":"Inna V. Nechipurenko","orcid":"https://orcid.org/0000-0003-0249-6620","observed_orcids":["https://orcid.org/0000-0003-0249-6620"]},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inna Nechipurenko","raw_affiliation_strings":["Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, United States","institution_ids":["https://openalex.org/I107077323"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044711408","display_name":"S\u00f8ren T. Christensen","orcid":"https://orcid.org/0000-0001-5004-304X","observed_orcids":["https://orcid.org/0000-0001-5004-304X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren Tvorup Christensen","raw_affiliation_strings":["Department of Biology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051869793"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":null,"first_page":"1186367","last_page":"1186367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-cilia","display_name":"primary cilia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ciliary-signaling","display_name":"ciliary signaling","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ciliopathy","display_name":"ciliopathies","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ciliogenesis","display_name":"ciliogenesis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/transition-zone","display_name":"transition zone","score":0.7429999709129333},{"id":"https://openalex.org/keywords/ttbk2","display_name":"TTBK2","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cp110","display_name":"CP110","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.7630000114440918},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.765999972820282},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.628000020980835},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.5730000138282776},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-signaling","display_name":"receptor tyrosine kinase signaling","score":0.8130000233650208},{"id":"https://openalex.org/keywords/extracellular-matrix-signaling","display_name":"extracellular matrix signaling","score":0.8560000061988831},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hindlimb-development","display_name":"hindlimb development","score":0.6650000214576721},{"id":"https://openalex.org/keywords/forelimb-development","display_name":"forelimb development","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.780556321144104},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45048144459724426},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4231157898902893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38666823506355286},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33760204911231995}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fcell.2023.1186367","doi":"https://doi.org/10.3389/fcell.2023.1186367","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2023.1186367","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2023.1186367/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10070995","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10070995","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10070995/pdf/fcell-11-1186367.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:37025179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37025179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Editorial"},{"id":"pmh:oai:pure.atira.dk:openaire/7d1fe5fc-0d59-4867-9b1d-020f6cd2e386","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/7d1fe5fc-0d59-4867-9b1d-020f6cd2e386","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kim, S E, Nechipurenko, I & Christensen, S T 2023, 'Editorial : Signaling by primary cilia in development and disease', Frontiers in Cell and Developmental Biology, vol. 11, 1186367. https://doi.org/10.3389/fcell.2023.1186367","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:b4cdc621925643ba9475fc9c7503fb96","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4cdc621925643ba9475fc9c7503fb96","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 11 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2023.1186367","doi":"https://doi.org/10.3389/fcell.2023.1186367","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2023.1186367","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2023.1186367/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.5299999713897705}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2257799055","display_name":"The Role of GPR161 in the Etiology of Neural Tube Defects","funder_award_id":"R01HD093758","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4328119005.pdf","grobid_xml":"https://content.openalex.org/works/W4328119005.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1809267070","https://openalex.org/W2023743240","https://openalex.org/W2077802746","https://openalex.org/W2144833749","https://openalex.org/W2156632504","https://openalex.org/W2207941023","https://openalex.org/W2734540391","https://openalex.org/W2785279167","https://openalex.org/W2913985590","https://openalex.org/W4312067083"],"related_works":["https://openalex.org/W4415652331","https://openalex.org/W2785279167","https://openalex.org/W7213944142","https://openalex.org/W2010748058","https://openalex.org/W2789965744","https://openalex.org/W2023021322","https://openalex.org/W2913985590","https://openalex.org/W2006545529","https://openalex.org/W2901588773","https://openalex.org/W2379332906"],"abstract_inverted_index":{"Editorial":[0],"on":[1,59],"the":[2,25,120,130,134,195,202,253,257,260,275,281,285,289,298,302,340,355],"Research":[3,192],"Topic":[4,193],"Signaling":[5],"by":[6,105,330],"primary":[7,47,135,247],"cilia":[8,13,48,102,116,218],"in":[9,20,138,217,230,263,311,318,325],"development":[10,317],"and":[11,41,51,67,90,122,128,150,163,177,181,184,189,197,208,220,226,243,306,335],"diseasePrimary":[12],"are":[14,103,169,239],"antenna-like":[15],"cell":[16,30,261],"structures":[17],"that":[18,36,118,140,146,168,200],"protrude":[19],"a":[21,106,110,155,347],"single":[22],"copy":[23],"from":[24,280,293,339],"surface":[26],"of":[27,46,63,124,133,157,204,222,246,274,284,301,333,337],"most":[28],"vertebrate":[29],"types":[31],"to":[32,49,259,349],"detect":[33,50],"extracellular":[34,91],"cues":[35],"regulate":[37,147],"embryonic":[38,212,314,361],"patterning,":[39],"organogenesis,":[40],"adult":[42],"tissue/organ":[43],"homeostasis.The":[44],"capacity":[45],"transduce":[52],"signaling":[53,94,131,209,224],"information":[54],"into":[55,235],"cellular":[56],"processes":[57,153],"relies":[58],"their":[60],"unique":[61],"complement":[62],"receptors,":[64,127],"ion":[65],"channels,":[66],"associated":[68,171,345],"signal":[69],"transduction":[70],"modules,":[71],"e.g.,":[72],"G":[73],"protein-coupled":[74],"receptor":[75,77],"(GPCR),":[76],"tyrosine":[78],"kinase":[79],"(RTK),":[80],"Hedgehog,":[81],"Wnt,":[82],"transforming":[83],"growth":[84],"factor-beta":[85],"(TGFB)/bone":[86],"morphogenetic":[87],"protein":[88,237,277],"(BMP),":[89],"matrix":[92],"(ECM)":[93],"(Wheway":[95],"et":[96,99,271,295],"al.,":[97,100,272],"2018;Anvarian":[98],"2019).All":[101],"compartmentalized":[104],"transition":[107],"zone":[108],"(TZ),":[109],"specialized":[111],"gating":[112],"structure":[113],"found":[114],"at":[115],"base,":[117],"controls":[119],"entry":[121],"exit":[123],"proteins,":[125,225],"including":[126],"thereby":[129],"properties":[132,245],"cilium.Consequently,":[136],"mutations":[137],"genes":[139,207],"encode":[141],"TZ":[142],"components":[143],"or":[144],"proteins":[145,268],"ciliary":[148,206,223,232,290],"assembly":[149,219,242,358],"intraciliary":[151],"trafficking":[152],"cause":[154],"spectrum":[156],"more":[158],"than":[159],"35":[160],"human":[161],"diseases":[162],"syndromes,":[164],"collectively":[165],"called":[166,252],"ciliopathies,":[167],"commonly":[170],"with":[172,346],"obesity,":[173],"renal":[174],"anomalies,":[175],"neurodevelopmental":[176],"psychiatric":[178],"impairment,":[179],"craniofacial":[180],"skeletal":[182],"defects":[183,229],"congenital":[185],"heart":[186],"disease":[187],"(Reiter":[188],"Leroux,":[190],"2017).Our":[191],"comprises":[194],"reviews":[196],"research":[198],"articles":[199],"examine":[201],"function":[203],"select":[205],"systems":[210,233],"during":[211,313,360],"development,":[213],"highlight":[214],"tissue-specific":[215,356],"mechanisms":[216],"localization":[221],"discuss":[227],"how":[228],"these":[231],"translate":[234],"ciliopathies.Multiple":[236],"complexes":[238],"required":[240],"for":[241],"sensory":[244],"cilia.A":[248],"modified":[249],"mother":[250,286,341],"centriole":[251,287],"basal":[254],"body":[255],"anchors":[256],"cilium":[258],"membrane":[262],"part":[264],"via":[265],"distal":[266,282],"appendage":[267],"(DAPs)":[269],"(Tanos":[270],"2013).Removal":[273],"centrosomal":[276],"110":[278],"(CP110)":[279],"end":[283],"initiates":[288],"assembly.The":[291],"work":[292],"Lee":[294],"al.":[296],"demonstrated":[297],"differential":[299],"role":[300],"DAP,":[303],"sodium":[304],"channel":[305],"clathrin":[307],"linker":[308],"1":[309],"(Sclt1)":[310],"ciliogenesis":[312,324],"fore-and":[315],"hindlimb":[316,327],"novel":[319],"Sclt1":[320],"mutant":[321],"mice.Sclt1":[322],"regulates":[323],"developing":[326],"mesenchymal":[328],"cells":[329],"facilitating":[331],"recruitment":[332],"Ttbk2":[334],"removal":[336],"Cp110":[338],"centriole,":[342],"which":[343],"is":[344],"response":[348],"Sonic":[350],"hedgehog":[351],"signaling.The":[352],"authors":[353],"provide":[354],"DAP":[357],"programs":[359],"limb":[362]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-03-22T00:00:00"}