{"id":"https://openalex.org/W4328115579","doi":"https://doi.org/10.1002/adsc.202300024","title":"Continuous\u2010Flow Enantioselective 1,4\u2010Addition Reactions of Malonates with Nitroolefins on Ni\u2010Supported Mesoporous Silica Materials with Co\u2010feeding of a Chiral Ligand","display_name":"Continuous\u2010Flow Enantioselective 1,4\u2010Addition Reactions of Malonates with Nitroolefins on Ni\u2010Supported Mesoporous Silica Materials with Co\u2010feeding of a Chiral Ligand","publication_year":2023,"publication_date":"2023-03-20","ids":{"openalex":"https://openalex.org/W4328115579","doi":"https://doi.org/10.1002/adsc.202300024"},"language":"en","primary_location":{"id":"doi:10.1002/adsc.202300024","doi":"https://doi.org/10.1002/adsc.202300024","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adsc.202300024","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adsc.202300024","source":{"id":"https://openalex.org/S36069537","display_name":"Advanced Synthesis & Catalysis","issn_l":"1615-4150","issn":["1615-4150","1615-4169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Synthesis &amp; Catalysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adsc.202300024","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110469472","display_name":"Haruro Ishitani","orcid":"https://orcid.org/0009-0004-7155-0947","observed_orcids":["https://orcid.org/0009-0004-7155-0947"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Haruro Ishitani","raw_affiliation_strings":["Green &amp; Sustainable Chemistry Cooperation Laboratory Graduate School of Science The University of Tokyo, Hongo  Bunkyo-ku, Tokyo 133-0033 Japan","Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 133-0033 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Green &amp; Sustainable Chemistry Cooperation Laboratory Graduate School of Science The University of Tokyo, Hongo  Bunkyo-ku, Tokyo 133-0033 Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 133-0033 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113213405","display_name":"Kan Kanai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kan Kanai","raw_affiliation_strings":["Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049553063","display_name":"Sh\u016b Kobayashi","orcid":"https://orcid.org/0000-0002-8235-4368","observed_orcids":["https://orcid.org/0000-0002-8235-4368"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Sh\u016b Kobayashi","raw_affiliation_strings":["Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan","Green &amp; Sustainable Chemistry Cooperation Laboratory Graduate School of Science The University of Tokyo, Hongo  Bunkyo-ku, Tokyo 133-0033 Japan"],"raw_orcid":"https://orcid.org/0000-0002-8235-4368","affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Green &amp; Sustainable Chemistry Cooperation Laboratory Graduate School of Science The University of Tokyo, Hongo  Bunkyo-ku, Tokyo 133-0033 Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049553063","https://openalex.org/A5110469472"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":{"value":4220,"currency":"USD","value_usd":4220},"fwci":0.3948,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.41116678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"365","issue":"9","first_page":"1526","last_page":"1530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enantioselective-1-4-addition","display_name":"enantioselective 1,4-addition","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dimethyl-malonate","display_name":"dimethyl malonate","score":0.8529999852180481},{"id":"https://openalex.org/keywords/nitroalkenes","display_name":"nitroalkenes","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nickel-based-catalysts","display_name":"nickel catalysts","score":0.7519999742507935},{"id":"https://openalex.org/keywords/mesoporous-silica-support","display_name":"mesoporous silica support","score":0.7390000224113464},{"id":"https://openalex.org/keywords/chiral-diamine-ligands","display_name":"chiral diamine ligands","score":0.7689999938011169},{"id":"https://openalex.org/keywords/continuous-flow-catalysis","display_name":"continuous flow catalysis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/fixed-bed-reactor","display_name":"fixed-bed reactor","score":0.6809999942779541},{"id":"https://openalex.org/keywords/immobilized-catalysts","display_name":"immobilized catalysts","score":0.6309999823570251},{"id":"https://openalex.org/keywords/asymmetric-catalysis","display_name":"asymmetric catalysis","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.9242435097694397},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8899658918380737},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6917393803596497},{"id":"https://openalex.org/C2777496208","wikidata":"https://www.wikidata.org/wiki/Q17156473","display_name":"Mesoporous silica","level":4,"score":0.6227734684944153},{"id":"https://openalex.org/C82776694","wikidata":"https://www.wikidata.org/wiki/Q380049","display_name":"Mesoporous material","level":3,"score":0.5975285172462463},{"id":"https://openalex.org/C2985264121","wikidata":"https://www.wikidata.org/wiki/Q216320","display_name":"Continuous flow","level":2,"score":0.5357033610343933},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.46325573325157166},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4452313184738159},{"id":"https://openalex.org/C132482357","wikidata":"https://www.wikidata.org/wiki/Q5462089","display_name":"Flow chemistry","level":3,"score":0.4309021234512329},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.4061813950538635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07485988736152649},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06730937957763672},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/adsc.202300024","doi":"https://doi.org/10.1002/adsc.202300024","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adsc.202300024","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adsc.202300024","source":{"id":"https://openalex.org/S36069537","display_name":"Advanced Synthesis & Catalysis","issn_l":"1615-4150","issn":["1615-4150","1615-4169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Synthesis &amp; Catalysis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/adsc.202300024","doi":"https://doi.org/10.1002/adsc.202300024","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adsc.202300024","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adsc.202300024","source":{"id":"https://openalex.org/S36069537","display_name":"Advanced Synthesis & Catalysis","issn_l":"1615-4150","issn":["1615-4150","1615-4169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Synthesis &amp; Catalysis","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4328115579.pdf","grobid_xml":"https://content.openalex.org/works/W4328115579.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1937018166","https://openalex.org/W1954905398","https://openalex.org/W2021517220","https://openalex.org/W2034484631","https://openalex.org/W2055816746","https://openalex.org/W2125978211","https://openalex.org/W2206546104","https://openalex.org/W2291845424","https://openalex.org/W2330090921","https://openalex.org/W2552822738","https://openalex.org/W2607248489","https://openalex.org/W2621108245","https://openalex.org/W2753023124","https://openalex.org/W2793801613","https://openalex.org/W2891682108","https://openalex.org/W2901670787","https://openalex.org/W2937525844","https://openalex.org/W2966549609","https://openalex.org/W3000449988","https://openalex.org/W3007926432","https://openalex.org/W3043745674","https://openalex.org/W4231060169","https://openalex.org/W4232317406"],"related_works":["https://openalex.org/W7144099124","https://openalex.org/W1986303410","https://openalex.org/W2138202154","https://openalex.org/W2036254616","https://openalex.org/W4231060169","https://openalex.org/W1558392344","https://openalex.org/W2336243034","https://openalex.org/W2138685310","https://openalex.org/W3092058682","https://openalex.org/W4317538900"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"catalytic":[2],"system":[3],"is":[4,10],"described":[5],"in":[6,54],"which":[7],"achiral":[8],"Ni":[9],"immobilized":[11],"on":[12,73],"mesoporous":[13],"silica":[14],"material":[15],"with":[16,27,38,41,57,65],"external":[17],"addition":[18],"of":[19,35,43,69],"a":[20,44,66],"chiral":[21,45],"modifier":[22],"enabling":[23],"continuous\u2010flow":[24],"enantioselective":[25,32],"reactions":[26,34],"catalyst\u2010packed":[28],"bed":[29],"reactors.":[30],"Continuous\u2010flow":[31],"1,4\u2010addition":[33],"dimethyl":[36],"malonate":[37],"nitroalkenes":[39],"proceeded":[40],"co\u2010feeding":[42],"diamine":[46],"ligand,":[47],"and":[48],"the":[49],"corresponding":[50],"products":[51],"were":[52],"obtained":[53],"high":[55,58],"yields":[56],"enantioselectivities":[59],"for":[60],"more":[61],"than":[62],"80":[63],"h":[64],"turnover":[67],"frequency":[68],"3.1":[70],"h\u22121":[71],"based":[72],"[Ni].":[74]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-03-22T00:00:00"}
