{"id":"https://openalex.org/W4327698223","doi":"https://doi.org/10.21203/rs.3.rs-2692091/v1","title":"Efficacy and adverse effects of different immunotherapy in the elderly","display_name":"Efficacy and adverse effects of different immunotherapy in the elderly","publication_year":2023,"publication_date":"2023-03-17","ids":{"openalex":"https://openalex.org/W4327698223","doi":"https://doi.org/10.21203/rs.3.rs-2692091/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-2692091/v1","doi":"https://doi.org/10.21203/rs.3.rs-2692091/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2692091/v1","pdf_url":"https://www.researchsquare.com/article/rs-2692091/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2692091/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091417108","display_name":"yunxin yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"yunxin yang","raw_affiliation_strings":["Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100867226","display_name":"Song Mi","orcid":"https://orcid.org/0000-0002-4520-8687","observed_orcids":["https://orcid.org/0000-0002-4520-8687"]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Mi","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009258719","display_name":"Li Liu","orcid":"https://orcid.org/0000-0002-9731-6145","observed_orcids":["https://orcid.org/0000-0002-9731-6145"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"li Liu","raw_affiliation_strings":["Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006458345","display_name":"Meng Yuan","orcid":"https://orcid.org/0000-0001-7704-8633","observed_orcids":["https://orcid.org/0000-0001-7704-8633"]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Yuan","raw_affiliation_strings":["Weifang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weifang Medical University","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459495","display_name":"Hang Wang","orcid":"https://orcid.org/0000-0001-6021-739X","observed_orcids":["https://orcid.org/0000-0001-6021-739X"]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]},{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang Wang","raw_affiliation_strings":["The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University",". Department of Oncology, The First A liated Hospital of Shandong First Medical University &",". Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University,",". Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, 250000, China. ",". School of Clinical Medicine, Weifang Medical University, Weifang, China","Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","Shandong University of Traditional Chinese Medicine, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]},{"raw_affiliation_string":". Department of Oncology, The First A liated Hospital of Shandong First Medical University &","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":". Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University,","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]},{"raw_affiliation_string":". Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, 250000, China. ","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":". School of Clinical Medicine, Weifang Medical University, Weifang, China","institution_ids":["https://openalex.org/I117331123"]},{"raw_affiliation_string":"Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","institution_ids":["https://openalex.org/I4210153274"]},{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine, Jinan, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087037240","display_name":"Chenlin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenlin Wang","raw_affiliation_strings":["Weifang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weifang Medical University","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115591813","display_name":"Yanfei Chen","orcid":"https://orcid.org/0000-0002-2185-9303","observed_orcids":["https://orcid.org/0000-0002-2185-9303"]},"institutions":[{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanfei Chen","raw_affiliation_strings":["The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065621331","display_name":"Ning Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Liang","raw_affiliation_strings":["Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112073474","display_name":"Guodong Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guodong Deng","raw_affiliation_strings":["Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103018223","display_name":"Pingping Hu","orcid":"https://orcid.org/0000-0001-9925-0939","observed_orcids":["https://orcid.org/0000-0001-9925-0939"]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]},{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pingping Hu","raw_affiliation_strings":["Shandong University",". Department of Oncology, The First A liated Hospital of Shandong First Medical University &",". Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University,",". Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, 250000, China. ",". School of Clinical Medicine, Weifang Medical University, Weifang, China","Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, 250000, China","Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","Shandong University of Traditional Chinese Medicine, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":". Department of Oncology, The First A liated Hospital of Shandong First Medical University &","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":". Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University,","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]},{"raw_affiliation_string":". Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, 250000, China. ","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":". School of Clinical Medicine, Weifang Medical University, Weifang, China","institution_ids":["https://openalex.org/I117331123"]},{"raw_affiliation_string":"Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, 250000, China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","institution_ids":["https://openalex.org/I4210153274"]},{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine, Jinan, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100366278","display_name":"Jiandong Zhang","orcid":"https://orcid.org/0000-0002-0635-3419","observed_orcids":["https://orcid.org/0000-0002-0635-3419"]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]},{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiandong Zhang","raw_affiliation_strings":["Shandong University",". Department of Oncology, The First A liated Hospital of Shandong First Medical University &",". Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University,",". Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, 250000, China. ",". School of Clinical Medicine, Weifang Medical University, Weifang, China","Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, 250000, China","Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","Shandong University of Traditional Chinese Medicine, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":". Department of Oncology, The First A liated Hospital of Shandong First Medical University &","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":". Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University,","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]},{"raw_affiliation_string":". Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, 250000, China. ","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":". School of Clinical Medicine, Weifang Medical University, Weifang, China","institution_ids":["https://openalex.org/I117331123"]},{"raw_affiliation_string":"Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, 250000, China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute","institution_ids":["https://openalex.org/I4210153274"]},{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine, Jinan, China","institution_ids":["https://openalex.org/I134738993"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103018223"],"corresponding_institution_ids":["https://openalex.org/I117331123","https://openalex.org/I134738993","https://openalex.org/I154099455","https://openalex.org/I4210153274","https://openalex.org/I4210163399"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.4235999882221222,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.4235999882221222,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.29980000853538513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9179999828338623},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9710000157356262},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6980000138282776},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.8140000104904175},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8370000123977661},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5609999895095825},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6769999861717224},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8949999809265137},{"id":"https://openalex.org/keywords/fda-adverse-event-reporting-system","display_name":"FDA Adverse Event Reporting System","score":0.5130000114440918},{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8421573638916016},{"id":"https://openalex.org/C199475168","wikidata":"https://www.wikidata.org/wiki/Q1539689","display_name":"MedDRA","level":4,"score":0.7511024475097656},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7021145224571228},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.613064169883728},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6082828044891357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5955368876457214},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.510562539100647},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.48405522108078003},{"id":"https://openalex.org/C2777105317","wikidata":"https://www.wikidata.org/wiki/Q4686710","display_name":"Adverse Event Reporting System","level":3,"score":0.4456920921802521},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42300665378570557},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3533658981323242},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3264670968055725},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.32138824462890625},{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.2232920229434967},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-2692091/v1","doi":"https://doi.org/10.21203/rs.3.rs-2692091/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2692091/v1","pdf_url":"https://www.researchsquare.com/article/rs-2692091/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2692091/v1","doi":"https://doi.org/10.21203/rs.3.rs-2692091/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2692091/v1","pdf_url":"https://www.researchsquare.com/article/rs-2692091/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311026","display_name":"Shandong University","ror":"https://ror.org/0207yh398"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4327698223.pdf","grobid_xml":"https://content.openalex.org/works/W4327698223.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1982481909","https://openalex.org/W2100398274","https://openalex.org/W2109653150","https://openalex.org/W2110110495","https://openalex.org/W2126856198","https://openalex.org/W2127828695","https://openalex.org/W2144670268","https://openalex.org/W2151595445","https://openalex.org/W2338494814","https://openalex.org/W2398917392","https://openalex.org/W2538232731","https://openalex.org/W2581283430","https://openalex.org/W2735397724","https://openalex.org/W2745874962","https://openalex.org/W2782863308","https://openalex.org/W2791133407","https://openalex.org/W2803642760","https://openalex.org/W2979129241","https://openalex.org/W2999905840","https://openalex.org/W3009099064","https://openalex.org/W3013347515","https://openalex.org/W3015840715","https://openalex.org/W3044620903","https://openalex.org/W3130538187","https://openalex.org/W3160711784","https://openalex.org/W4281646247"],"related_works":["https://openalex.org/W7133183786","https://openalex.org/W4387826338","https://openalex.org/W4281691679","https://openalex.org/W4283446297","https://openalex.org/W2891179139","https://openalex.org/W4362458778","https://openalex.org/W4389936322","https://openalex.org/W4399757996","https://openalex.org/W2972829090","https://openalex.org/W2890894484"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"rely":[2],"on":[3,70],"the":[4,16,22,25,54,71,109,117,199,202,228,238],"Food":[5],"and":[6,24,27,37,82,100,114,129,137,150],"Drug":[7],"Adverse":[8],"Event":[9],"Reporting":[10],"System":[11],"(FAERS)":[12],"database":[13,56],"to":[14,60],"evaluate":[15],"medication":[17],"status":[18],"of":[19,29,49,65,122,144,164,217],"immunotherapy":[20,31],"in":[21,53,108,116,140,160,176,182,187],"elderly,":[23],"efficacy":[26,128],"safety":[28],"different":[30],"strategies":[32],"by":[33],"mining":[34],"large":[35],"samples":[36],"real-world":[38],"data.":[39],"The":[40,63,93,196],"present":[41],"study":[42],"included":[43],"19,446":[44],"patients":[45],"over":[46,210,214],"65":[47],"years":[48,113,121,143,163,216],"age":[50,95,123,145,165,218,230],"with":[51,86,180,184,201],"NSCLC":[52],"FAERS":[55],"from":[57],"January":[58],"2015":[59],"December":[61],"2022.":[62],"definition":[64],"adverse":[66,130],"events":[67],"(AEs)":[68],"relied":[69],"Medical":[72],"Dictionary":[73],"for":[74,126,198,232],"Regulatory":[75],"Activities":[76],"(MedDRA).":[77],"Statistical":[78],"analysis":[79],"was":[80,172],"performed,":[81],"odds":[83],"ratios":[84],"(ORs)":[85],"95%":[87],"confidence":[88],"intervals":[89],"(CIs)":[90],"were":[91,146,166],"calculated.":[92],"65\u201374":[94],"group":[96],"comprised":[97],"12,878(66.2%)":[98],"individuals":[99,102],"6,566(33.8%)":[101],"\u2265":[103,111,119,141,161],"75":[104,112,142,211],"years.":[105],"Combined":[106,132,155],"chemotherapy":[107,133],"elderly":[110,118,189],"Bevacizumab":[115,156],"80":[120,162,215],"are":[124],"optimal":[125],"both":[127],"effects.":[131],"delayed":[134,157],"disease":[135,158],"progression":[136,159],"reduced":[138],"mortality":[139],"OR,0.68":[147],"(95%":[148,152,168],"CI,0.56\u20130.89)":[149],"OR,0.75":[151],"CI,0.57\u20130.99)":[153],"respectively.":[154],"OR,0.24":[167],"CI,0.08\u20130.67)":[169],"although":[170],"there":[171],"no":[173],"statistical":[174],"significance":[175],"reducing":[177],"mortality.":[178],"Treatment":[179],"ICIs":[181],"combination":[183],"other":[185],"agents":[186],"very":[188],"populations":[190],"has":[191],"demonstrated":[192],"improved":[193],"survival":[194],"benefits.":[195],"reason":[197],"discrepancy":[200],"clinical":[203],"studies":[204],"may":[205],"be":[206],"that":[207,227],"older":[208],"adults":[209],"or":[212],"even":[213],"do":[219],"not":[220],"meet":[221],"enrollment":[222,233],"requirements.":[223],"It":[224],"is":[225],"expected":[226],"upper":[229],"limit":[231],"will":[234],"also":[235],"increase":[236],"as":[237],"aging":[239],"era":[240],"advances":[241],"further.":[242]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-03-18T00:00:00"}
