{"id":"https://openalex.org/W4327596271","doi":"https://doi.org/10.52340/gbmn.2023.01.01.12.","title":"Comparison of Inflammatory and Oxidative Stress Markers Among Patients with Non-Obstructive vs. Obstructive Coronary Artery Disease","display_name":"Comparison of Inflammatory and Oxidative Stress Markers Among Patients with Non-Obstructive vs. Obstructive Coronary Artery Disease","publication_year":2023,"publication_date":"2023-03-16","ids":{"openalex":"https://openalex.org/W4327596271","doi":"https://doi.org/10.52340/gbmn.2023.01.01.12."},"language":"en","primary_location":{"id":"doi:10.52340/gbmn.2023.01.01.12.","doi":"https://doi.org/10.52340/gbmn.2023.01.01.12.","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gbmn.2023.01.01.12.","pdf_url":"https://doi.org/10.52340/gbmn.2023.01.01.12.","source":{"id":"https://openalex.org/S7407058177","display_name":"Georgian Biomedical News","issn_l":"2720-8796","issn":["2720-8796","2720-7994"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN BIOMEDICAL NEWS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.52340/gbmn.2023.01.01.12.","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022793605","display_name":"Ioseb Sikharulidze","orcid":"https://orcid.org/0009-0006-4985-4906","observed_orcids":["https://orcid.org/0009-0006-4985-4906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioseb Sikharulidze","raw_affiliation_strings":["Batumi Center for Cardiovascular Diseases and interventional Medicine , Clinic \"MedCenter\" LTD , Batumi , Georgia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Batumi Center for Cardiovascular Diseases and interventional Medicine , Clinic \"MedCenter\" LTD , Batumi , Georgia;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024994986","display_name":"Kakhaber Chelidze","orcid":"https://orcid.org/0000-0002-3906-9967","observed_orcids":["https://orcid.org/0000-0002-3906-9967"]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Kakhaber Chelidze","raw_affiliation_strings":["Department of Internal Medicine , Tbilisi State Medical University (TSMU) , Tbilisi , Georgia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine , Tbilisi State Medical University (TSMU) , Tbilisi , Georgia;","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025067655","display_name":"Levan Chelidze","orcid":"https://orcid.org/0000-0003-4200-300X","observed_orcids":["https://orcid.org/0000-0003-4200-300X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Levan Chelidze","raw_affiliation_strings":["Department of Interventional Cardiology & Cardio Surgery , LTD Tbilisi Heart Center , Tbilisi , Georgia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Cardiology & Cardio Surgery , LTD Tbilisi Heart Center , Tbilisi , Georgia;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000366087","display_name":"Tamar Kajaia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamar Kajaia","raw_affiliation_strings":["Angio-cardiology Clinic LTD \"Adapti\" LTD , Tbilisi , Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angio-cardiology Clinic LTD \"Adapti\" LTD , Tbilisi , Georgia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037651459","display_name":"Irma Bakhlishvili","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irma Bakhlishvili","raw_affiliation_strings":["Batumi Center for Cardiovascular Diseases and interventional Medicine , Clinic \"MedCenter\" LTD , Batumi , Georgia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Batumi Center for Cardiovascular Diseases and interventional Medicine , Clinic \"MedCenter\" LTD , Batumi , Georgia;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1763,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45151593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.2833999991416931,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.2833999991416931,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.1746000051498413,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.12849999964237213,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minoca","display_name":"MINOCA","score":0.8740000128746033},{"id":"https://openalex.org/keywords/non-st-elevation-acute-coronary-syndrome","display_name":"non-ST-elevation acute coronary syndrome","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9020000100135803},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.75},{"id":"https://openalex.org/keywords/free-radical-concentration","display_name":"radical concentration","score":0.4099999964237213},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9309999942779541},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9769999980926514},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7678862810134888},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.752301812171936},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7054522037506104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6826069951057434},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6824893951416016},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4911637008190155}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.52340/gbmn.2023.01.01.12.","doi":"https://doi.org/10.52340/gbmn.2023.01.01.12.","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gbmn.2023.01.01.12.","pdf_url":"https://doi.org/10.52340/gbmn.2023.01.01.12.","source":{"id":"https://openalex.org/S7407058177","display_name":"Georgian Biomedical News","issn_l":"2720-8796","issn":["2720-8796","2720-7994"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN BIOMEDICAL NEWS","raw_type":"journal-article"},{"id":"doi:10.52340/gbmn.2023.01.01.12","doi":"https://doi.org/10.52340/gbmn.2023.01.01.12","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gbmn.2023.01.01.12","pdf_url":"https://www.gbmn.org/_files/ugd/14893c_4f20485979e440188c7c31fb2140bc3e.pdf","source":{"id":"https://openalex.org/S7407058177","display_name":"Georgian Biomedical News","issn_l":"2720-8796","issn":["2720-8796","2720-7994"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN BIOMEDICAL NEWS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.52340/gbmn.2023.01.01.12.","doi":"https://doi.org/10.52340/gbmn.2023.01.01.12.","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gbmn.2023.01.01.12.","pdf_url":"https://doi.org/10.52340/gbmn.2023.01.01.12.","source":{"id":"https://openalex.org/S7407058177","display_name":"Georgian Biomedical News","issn_l":"2720-8796","issn":["2720-8796","2720-7994"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN BIOMEDICAL NEWS","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4327596271.pdf","grobid_xml":"https://content.openalex.org/works/W4327596271.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1503505289","https://openalex.org/W1964646781","https://openalex.org/W2012840031","https://openalex.org/W2027456987","https://openalex.org/W2112310038","https://openalex.org/W2317024394","https://openalex.org/W2343657979","https://openalex.org/W2586296716","https://openalex.org/W2621371007","https://openalex.org/W2755249976","https://openalex.org/W2791312292","https://openalex.org/W2901652829","https://openalex.org/W2911670512","https://openalex.org/W2915881405","https://openalex.org/W2915957789","https://openalex.org/W2966643712","https://openalex.org/W2995370080","https://openalex.org/W2999589863","https://openalex.org/W3011371150","https://openalex.org/W3022509442","https://openalex.org/W3094204418","https://openalex.org/W3117699317","https://openalex.org/W4210732323"],"related_works":["https://openalex.org/W4409293081","https://openalex.org/W4401505615","https://openalex.org/W4386660603","https://openalex.org/W2761096860","https://openalex.org/W2333304467","https://openalex.org/W4402228686","https://openalex.org/W2761451652","https://openalex.org/W4388595328","https://openalex.org/W4408725835","https://openalex.org/W2889017051"],"abstract_inverted_index":{"BACKGROUND.Myocardial":[0],"infarction":[1],"with":[2,48,53,59,104,115,176,179,215],"non-obstructive":[3],"coronary":[4,61,65,94,117],"artery":[5],"disease":[6,62,118],"(MINOCA)":[7],"accounts":[8],"for":[9],"5-20%":[10],"of":[11,14,22,32,57,70,79,82,88,92,145,157,169,187,194,219,226,234],"all":[12],"cases":[13],"myocardial":[15],"infarction.The":[16],"growing":[17],"evidence":[18],"indicates":[19],"the":[20,29,35,54,75,89,109,121,154,220,224,232],"importance":[21],"oxidative":[23,42,227],"stress":[24,125,228],"and":[25,43,50,112,126,201,229],"chronic":[26],"inflammation":[27,230],"in":[28,46,131,138,142,153,174,190,209,213,231],"heterogenous":[30],"pathophysiology":[31],"MINOCA.OBJECTIVES":[33],"In":[34],"present":[36,221],"study,":[37],"we":[38],"aimed":[39],"to":[40,74],"evaluate":[41],"inflammatory":[44,127,196,207],"statuses":[45],"patients":[47,58,72,103,114,175,211],"MINOCA":[49,105,177,191,210],"compare":[51],"them":[52],"same":[55],"indices":[56],"obstructive":[60,116],"non-ST-elevation":[63],"acute":[64,93],"syndrome":[66,95],"(NSTE-ACS).METHODS":[67],"Overall,":[68],"165":[69],"1018":[71],"admitted":[73],"Coronary":[76],"Care":[77],"Unit":[78],"Tsinamdzgvrishvili":[80],"Center":[81],"Cardiology":[83],"LTD":[84],"(Tbilisi,":[85],"Georgia)":[86],"because":[87],"first":[90],"episode":[91],"(ACS)":[96],"was":[97,150],"divided":[98],"into":[99,108,120],"two":[100],"groups:":[101],"115":[102],"were":[106,129],"distributed":[107],"group":[110,122],"1,":[111],"50":[113],"NSTE-ACS":[119,180],"2.":[123],"Oxidative":[124],"markers":[128],"evaluated":[130],"study":[132,146,222],"patients.":[133],"RESULTSWe":[134],"found":[135,163],"an":[136],"increase":[137],"free":[139],"radical":[140],"concentrations":[141],"both":[143],"groups":[144],"patients,":[147,181],"but":[148],"there":[149],"no":[151],"difference":[152],"mean":[155,167],"amount":[156],"overall":[158],"organic":[159],"radicals":[160],"(FORT)(p=0.412).We":[161],"also":[162],"a":[164,183],"significantly":[165,205],"lower":[166],"concentration":[168],"plasmatic":[170],"antioxidant":[171,188],"compounds":[172],"(FORD)":[173],"(p=0.036)compared":[178],"indicating":[182],"more":[184],"pronounced":[185],"depletion":[186],"potential":[189],"patients.The":[192],"results":[193,218],"admission":[195],"markers,":[197],"such":[198],"as":[199],"hs-CRP":[200],"hemogram-derived":[202],"NLR,":[203],"suggest":[204],"higher":[206],"status":[208],"than":[212],"those":[214],"NSTE-ACS.":[216],"CONCLUSIONSThe":[217],"emphasize":[223],"significance":[225],"pathogenesis":[233],"MINOCA.":[235]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-03-17T00:00:00"}