{"id":"https://openalex.org/W4324329595","doi":"https://doi.org/10.1002/adma.202300232","title":"Pyroptosis\u2010Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor\u2010Membrane\u2010Targeted Photosensitive Dimer","display_name":"Pyroptosis\u2010Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor\u2010Membrane\u2010Targeted Photosensitive Dimer","publication_year":2023,"publication_date":"2023-03-15","ids":{"openalex":"https://openalex.org/W4324329595","doi":"https://doi.org/10.1002/adma.202300232","pmid":"https://pubmed.ncbi.nlm.nih.gov/36921347"},"language":"en","primary_location":{"id":"doi:10.1002/adma.202300232","doi":"https://doi.org/10.1002/adma.202300232","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adma.202300232","pdf_url":null,"source":{"id":"https://openalex.org/S99352657","display_name":"Advanced Materials","issn_l":"0935-9648","issn":["0935-9648","1521-4095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041141498","display_name":"Yuqi Tang","orcid":"https://orcid.org/0009-0001-5851-7657","observed_orcids":["https://orcid.org/0009-0001-5851-7657","https://orcid.org/0009-0004-0529-4666"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Tang","raw_affiliation_strings":["Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027603567","display_name":"Hari Krishna Bisoyi","orcid":"https://orcid.org/0000-0002-9775-6757","observed_orcids":["https://orcid.org/0000-0002-9775-6757"]},"institutions":[{"id":"https://openalex.org/I149910238","display_name":"Kent State University","ror":"https://ror.org/049pfb863","country_code":"US","type":"education","lineage":["https://openalex.org/I149910238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hari Krishna Bisoyi","raw_affiliation_strings":["Advanced Materials and Liquid Crystal Institute and Materials Science Graduate Program, Kent State University, Kent, OH, 44242 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Materials and Liquid Crystal Institute and Materials Science Graduate Program, Kent State University, Kent, OH, 44242 USA","institution_ids":["https://openalex.org/I149910238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017421065","display_name":"Xu\u2010Man Chen","orcid":"https://orcid.org/0000-0002-3077-5806","observed_orcids":["https://orcid.org/0000-0002-3077-5806"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xu\u2010Man Chen","raw_affiliation_strings":["Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670652","display_name":"Zhiyang Liu","orcid":"https://orcid.org/0000-0003-1213-7533","observed_orcids":["https://orcid.org/0000-0003-1213-7533","https://orcid.org/0000-0002-5522-2853"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiyang Liu","raw_affiliation_strings":["Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Chen","raw_affiliation_strings":["Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Zhang","raw_affiliation_strings":["Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100447154","display_name":"Quan Li","orcid":"https://orcid.org/0000-0002-9042-360X","observed_orcids":["https://orcid.org/0000-0002-9042-360X","https://orcid.org/0009-0001-7607-3674"]},"institutions":[{"id":"https://openalex.org/I149910238","display_name":"Kent State University","ror":"https://ror.org/049pfb863","country_code":"US","type":"education","lineage":["https://openalex.org/I149910238"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Quan Li","raw_affiliation_strings":["Advanced Materials and Liquid Crystal Institute and Materials Science Graduate Program, Kent State University, Kent, OH, 44242 USA","Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China"],"raw_orcid":"https://orcid.org/0000-0002-9042-360X","affiliations":[{"raw_affiliation_string":"Advanced Materials and Liquid Crystal Institute and Materials Science Graduate Program, Kent State University, Kent, OH, 44242 USA","institution_ids":["https://openalex.org/I149910238"]},{"raw_affiliation_string":"Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189 China","institution_ids":["https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017421065","https://openalex.org/A5100447154","https://openalex.org/A5100670652"],"corresponding_institution_ids":["https://openalex.org/I149910238","https://openalex.org/I76569877"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":15.0024,"has_fulltext":false,"cited_by_count":224,"citation_normalized_percentile":{"value":0.99817502,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"35","issue":"25","first_page":"e2300232","last_page":"e2300232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":1.0},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.9559999704360962},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":1.0},{"id":"https://openalex.org/keywords/aggregation-induced-emission","display_name":"aggregation-induced emission","score":0.9399999976158142},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6830000281333923},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.6240000128746033},{"id":"https://openalex.org/keywords/4t1-breast-cancer-model","display_name":"4T1 breast cancer","score":0.7570000290870667},{"id":"https://openalex.org/keywords/immunological-memory","display_name":"immunological memory","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.8155035972595215},{"id":"https://openalex.org/C182606246","wikidata":"https://www.wikidata.org/wiki/Q7187926","display_name":"Photothermal therapy","level":2,"score":0.7311877608299255},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.6894724369049072},{"id":"https://openalex.org/C2777877232","wikidata":"https://www.wikidata.org/wiki/Q17144704","display_name":"Immunogenic cell death","level":4,"score":0.6412918567657471},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6330308318138123},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6111077666282654},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5098599791526794},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.47298797965049744},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4492359459400177},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.4427155554294586},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4129208028316498},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41098552942276},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37496858835220337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2941229045391083},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2782406806945801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21322417259216309},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19326409697532654},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1612986922264099},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.053824156522750854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/adma.202300232","doi":"https://doi.org/10.1002/adma.202300232","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adma.202300232","pdf_url":null,"source":{"id":"https://openalex.org/S99352657","display_name":"Advanced Materials","issn_l":"0935-9648","issn":["0935-9648","1521-4095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Materials","raw_type":"journal-article"},{"id":"pmid:36921347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36921347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced materials (Deerfield Beach, Fla.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5255742648","display_name":null,"funder_award_id":"22001035","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1864325817","https://openalex.org/W1882905539","https://openalex.org/W1981826336","https://openalex.org/W1994059973","https://openalex.org/W1996445525","https://openalex.org/W2016612145","https://openalex.org/W2044835625","https://openalex.org/W2046972425","https://openalex.org/W2067632426","https://openalex.org/W2103137500","https://openalex.org/W2133294507","https://openalex.org/W2162036597","https://openalex.org/W2166937531","https://openalex.org/W2175794645","https://openalex.org/W2320574135","https://openalex.org/W2337716945","https://openalex.org/W2431987552","https://openalex.org/W2536322725","https://openalex.org/W2583964565","https://openalex.org/W2586311061","https://openalex.org/W2608687752","https://openalex.org/W2792678490","https://openalex.org/W2808516714","https://openalex.org/W2883164386","https://openalex.org/W2886924087","https://openalex.org/W2896727027","https://openalex.org/W2908119238","https://openalex.org/W2908838385","https://openalex.org/W2923605604","https://openalex.org/W2950071015","https://openalex.org/W2974980488","https://openalex.org/W2982753862","https://openalex.org/W3003428717","https://openalex.org/W3011500848","https://openalex.org/W3011992195","https://openalex.org/W3012485477","https://openalex.org/W3022647289","https://openalex.org/W3030553520","https://openalex.org/W3044858173","https://openalex.org/W3045107785","https://openalex.org/W3048484045","https://openalex.org/W3112558747","https://openalex.org/W3126951727","https://openalex.org/W3128195390","https://openalex.org/W3176085841","https://openalex.org/W3195638873","https://openalex.org/W3201831068","https://openalex.org/W3208991717","https://openalex.org/W4200064797","https://openalex.org/W4211217520","https://openalex.org/W4221090070","https://openalex.org/W4239469437","https://openalex.org/W4296656846","https://openalex.org/W4307341577"],"related_works":["https://openalex.org/W4381885361","https://openalex.org/W4224245260","https://openalex.org/W4289654554","https://openalex.org/W4408938983","https://openalex.org/W4389986550","https://openalex.org/W4411132089","https://openalex.org/W7128356506","https://openalex.org/W4414671594","https://openalex.org/W4200130267","https://openalex.org/W4410955916"],"abstract_inverted_index":{"Overcoming":[0],"the":[1,16,41,80,123,129,134,138,158],"resistance":[2],"to":[3,56,71,74,107],"apoptosis":[4],"and":[5,52,85,143,167],"immunosuppression":[6],"of":[7,18,33,83,141],"tumor":[8,45,62,104,136,173],"cells":[9],"is":[10,29,69,115,155],"a":[11,22,31,61],"significant":[12],"challenge":[13],"in":[14,44,102],"augmenting":[15],"effect":[17,82,126],"cancer":[19,58],"immunotherapy.":[20,59],"Pyroptosis,":[21],"lytic":[23],"programmed":[24],"cell-death":[25],"pathway":[26],"unlike":[27],"apoptosis,":[28],"considered":[30],"type":[32],"immunogenic":[34],"cell":[35,63,111],"death":[36],"(ICD)":[37],"that":[38],"can":[39,91,131,144],"intensify":[40],"ICD":[42,78,125],"process":[43],"cells,":[46],"releasing":[47],"dramatically":[48],"increased":[49],"tumor-associated":[50],"antigens":[51],"damage-associated":[53],"molecular":[54],"patterns":[55],"promote":[57],"Herein,":[60],"membrane-targeted":[64],"aggregation-induced":[65],"emission":[66],"photosensitive":[67,89],"dimer":[68,90,130],"found":[70],"be":[72],"able":[73],"achieve":[75],"highly":[76],"efficient":[77],"under":[79],"synergistic":[81],"photodynamic":[84,100],"photothermal":[86,120],"therapy.":[87],"The":[88],"efficiently":[92],"produce":[93],"type-I":[94],"reactive":[95],"oxygen":[96],"species":[97],"(ROS)":[98],"by":[99,109,118,150,157],"therapy":[101],"hypoxic":[103],"tissue,":[105],"leading":[106],"pyroptosis":[108],"direct":[110],"membrane":[112],"damage,":[113],"which":[114,154],"further":[116],"reinforced":[117],"its":[119],"effect.":[121],"Furthermore,":[122],"enhanced":[124],"based":[127],"on":[128,137,163],"completely":[132],"eliminate":[133],"primary":[135],"seventh":[139],"day":[140],"treatment":[142],"also":[145],"boost":[146],"systemic":[147],"antitumor":[148,160],"immunity":[149],"generating":[151],"immune":[152],"memory,":[153],"demonstrated":[156],"superior":[159],"therapeutic":[161],"effects":[162],"both":[164],"solid":[165],"tumors":[166,169],"metastatic":[168],"when":[170],"healing":[171],"4T1":[172],"mouse":[174],"models":[175],"with":[176],"poor":[177],"immunogenicity.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":34},{"year":2025,"cited_by_count":77},{"year":2024,"cited_by_count":87},{"year":2023,"cited_by_count":26}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-03-16T00:00:00"}